Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Surangrat Thongkorn, Songphon Kanlayaprasit, Depicha Jindatip, Tewin Tencomnao, Valerie W. Hu, Tewarit Sarachana

ABSTRACT

Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related genes in the developing brain remains unclear. In this study, transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed to BPA was conducted and revealed a list of differentially expressed genes (DEGs) associated with ASD. Among the DEGs, several ASD candidate genes, including Auts2 and Foxp2, were dysregulated and showed sex differences in response to BPA exposure. The interactome and pathway analyses of DEGs using Ingenuity Pathway Analysis software revealed significant associations between the DEGs in males and neurological functions/disorders associated with ASD. Moreover, the reanalysis of transcriptome profiling data from previously published BPA studies consistently showed that BPA-responsive genes were significantly associated with ASD-related genes. The findings from this study indicate that prenatal BPA exposure alters the expression of ASD-linked genes in the hippocampus and suggest that maternal BPA exposure may increase ASD susceptibility by dysregulating genes associated with neurological functions known to be negatively impacted in ASD, which deserves further investigations. More... »

PAGES

3038

References to SciGraph publications

  • 2002-08. Molecular evolution of FOXP2, a gene involved in speech and language in NATURE
  • 2014-01. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum in TRANSLATIONAL PSYCHIATRY
  • 2009-02. GABAA Receptor Downregulation in Brains of Subjects with Autism in JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
  • 2005-01. X-linked mental retardation in NATURE REVIEWS GENETICS
  • 2018-12. Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder in MOLECULAR AUTISM
  • 2012-11. Isolation of multipotent neural stem or progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse in NATURE PROTOCOLS
  • 2011-12. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome in BMC BIOINFORMATICS
  • 2010-04. Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines in GENOME MEDICINE
  • 2014-08. Common DNA methylation alterations in multiple brain regions in autism in MOLECULAR PSYCHIATRY
  • 2011-06. Transcriptomic analysis of autistic brain reveals convergent molecular pathology in NATURE
  • 2012-04-04. Patterns and rates of exonic de novo mutations in autism spectrum disorders in NATURE
  • 2016-11. Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder in NATURE NEUROSCIENCE
  • 2013-02. Toxicological Status of Children with Autism vs. Neurotypical Children and the Association with Autism Severity in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 2011-12. Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism in MOLECULAR AUTISM
  • 2016-12. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism in NATURE
  • 1998-05. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex in NATURE
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-39386-w

    DOI

    http://dx.doi.org/10.1038/s41598-019-39386-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112439640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30816183


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Chulalongkorn University", 
              "id": "https://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thongkorn", 
            "givenName": "Surangrat", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chulalongkorn University", 
              "id": "https://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanlayaprasit", 
            "givenName": "Songphon", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chulalongkorn University", 
              "id": "https://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jindatip", 
            "givenName": "Depicha", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chulalongkorn University", 
              "id": "https://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Age-related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tencomnao", 
            "givenName": "Tewin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "George Washington University", 
              "id": "https://www.grid.ac/institutes/grid.253615.6", 
              "name": [
                "Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Valerie W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chulalongkorn University", 
              "id": "https://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Age-related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sarachana", 
            "givenName": "Tewarit", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1289/ehp.0901575", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000988801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.10168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001123021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.10.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001298230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.1104556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001432159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bmc.161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002871772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2040-2392-2-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005434666", 
              "https://doi.org/10.1186/2040-2392-2-14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005546919", 
              "https://doi.org/10.1038/30764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2010.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005994307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006541515", 
              "https://doi.org/10.1038/nmeth.1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006881089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0894-4105.20.1.21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009114061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0894-4105.20.1.21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009114061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tox.2017.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009849716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0883073815609150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010415311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0883073815609150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010415311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010523987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10803-008-0646-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011875300", 
              "https://doi.org/10.1007/s10803-008-0646-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gep.2009.11.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012863901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jfma.2016.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012905850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.2004.024646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013176159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013383518", 
              "https://doi.org/10.1038/nrg1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013383518", 
              "https://doi.org/10.1038/nrg1501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.braindev.2006.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014087485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2013.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014625003", 
              "https://doi.org/10.1038/tp.2013.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsbmb.2011.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015157160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gdata.2015.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015214710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2010.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017217533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017513951", 
              "https://doi.org/10.1038/mp.2013.114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017513951", 
              "https://doi.org/10.1038/mp.2013.114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jat.3176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017521237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210256200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017827262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2014.11.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018875611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tox.2012.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019662311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0503739102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019832831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021093950", 
              "https://doi.org/10.1038/nature11011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2009-0002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021194372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-12-323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021902674", 
              "https://doi.org/10.1186/1471-2105-12-323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021903763", 
              "https://doi.org/10.1038/nature01025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021903763", 
              "https://doi.org/10.1038/nature01025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1001081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022276849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cppeds.2014.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023123292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1408355111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023656428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025289337", 
              "https://doi.org/10.1038/nprot.2012.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/aur.33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026057207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1102233108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026264084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2011.1638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026745010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gm144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026797754", 
              "https://doi.org/10.1186/gm144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1214056110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026827429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature20612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027404357", 
              "https://doi.org/10.1038/nature20612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.37454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028293368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030400360", 
              "https://doi.org/10.1038/nature10110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/aur.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032268513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/aur.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032268513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1316-12.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032873289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.37050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034553434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12011-012-9551-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035609930", 
              "https://doi.org/10.1007/s12011-012-9551-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/aur.1444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035735527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711555105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035798756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15287390903212501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040144350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tox.2012.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041534464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.10-154484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041962757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2016.00174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043846611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cpr.2009.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043927836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.etap.2016.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045278336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2014.07.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045938070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2009.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046608308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.20162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047075551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051738015", 
              "https://doi.org/10.1038/nn.4373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.828000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060407370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2012-1195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064251452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2016-1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064252760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.132.6.8504731", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064278464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.95103608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064745896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1289/ehp.96104298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064746300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.13172/2052-7810-1-2-610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065007522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/03342mt01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075245738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078187509", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079062544", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/advs.201600493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084974405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.taap.2017.05.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085706523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.placenta.2017.07.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090383267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tiv.2017.07.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090921962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/bhx250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091638271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/bhx250", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091638271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2017.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092249114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yhbeh.2017.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092249114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2017.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092418047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2017.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092418047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2017.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092418047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0192434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100915274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.envres.2018.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101168543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13229-018-0213-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103379315", 
              "https://doi.org/10.1186/s13229-018-0213-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13229-018-0213-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103379315", 
              "https://doi.org/10.1186/s13229-018-0213-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15585/mmwr.ss6706a1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15585/mmwr.ss6706a1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103654627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0201071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105775566"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related genes in the developing brain remains unclear. In this study, transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed to BPA was conducted and revealed a list of differentially expressed genes (DEGs) associated with ASD. Among the DEGs, several ASD candidate genes, including Auts2 and Foxp2, were dysregulated and showed sex differences in response to BPA exposure. The interactome and pathway analyses of DEGs using Ingenuity Pathway Analysis software revealed significant associations between the DEGs in males and neurological functions/disorders associated with ASD. Moreover, the reanalysis of transcriptome profiling data from previously published BPA studies consistently showed that BPA-responsive genes were significantly associated with ASD-related genes. The findings from this study indicate that prenatal BPA exposure alters the expression of ASD-linked genes in the hippocampus and suggest that maternal BPA exposure may increase ASD susceptibility by dysregulating genes associated with neurological functions known to be negatively impacted in ASD, which deserves further investigations.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-39386-w", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3537270", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7026396", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus", 
        "pagination": "3038", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b5dda2c5caea26d24bd3f2e5e26094d6b6b185bdda28aa1b1038f6d816210339"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30816183"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-39386-w"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112439640"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-39386-w", 
          "https://app.dimensions.ai/details/publication/pub.1112439640"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60339_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-019-39386-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39386-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39386-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39386-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39386-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    373 TRIPLES      21 PREDICATES      113 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-39386-w schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N87fc92fc6c594a5681f2a9a284d0c327
    4 schema:citation sg:pub.10.1007/s10803-008-0646-7
    5 sg:pub.10.1007/s12011-012-9551-1
    6 sg:pub.10.1038/30764
    7 sg:pub.10.1038/mp.2013.114
    8 sg:pub.10.1038/nature01025
    9 sg:pub.10.1038/nature10110
    10 sg:pub.10.1038/nature11011
    11 sg:pub.10.1038/nature20612
    12 sg:pub.10.1038/nmeth.1923
    13 sg:pub.10.1038/nn.4373
    14 sg:pub.10.1038/nprot.2012.123
    15 sg:pub.10.1038/nrg1501
    16 sg:pub.10.1038/tp.2013.123
    17 sg:pub.10.1186/1471-2105-12-323
    18 sg:pub.10.1186/2040-2392-2-14
    19 sg:pub.10.1186/gm144
    20 sg:pub.10.1186/s13229-018-0213-9
    21 https://app.dimensions.ai/details/publication/pub.1078187509
    22 https://app.dimensions.ai/details/publication/pub.1079062544
    23 https://doi.org/10.1001/jama.2011.1638
    24 https://doi.org/10.1002/advs.201600493
    25 https://doi.org/10.1002/ajmg.a.37050
    26 https://doi.org/10.1002/ajmg.a.37454
    27 https://doi.org/10.1002/ajmg.b.20162
    28 https://doi.org/10.1002/aur.1444
    29 https://doi.org/10.1002/aur.33
    30 https://doi.org/10.1002/aur.73
    31 https://doi.org/10.1002/bmc.161
    32 https://doi.org/10.1002/jat.3176
    33 https://doi.org/10.1016/j.biopsych.2014.11.020
    34 https://doi.org/10.1016/j.braindev.2006.10.003
    35 https://doi.org/10.1016/j.cell.2016.10.031
    36 https://doi.org/10.1016/j.cppeds.2014.06.001
    37 https://doi.org/10.1016/j.cpr.2009.01.003
    38 https://doi.org/10.1016/j.envres.2018.02.011
    39 https://doi.org/10.1016/j.etap.2016.03.006
    40 https://doi.org/10.1016/j.freeradbiomed.2014.07.030
    41 https://doi.org/10.1016/j.gdata.2015.04.004
    42 https://doi.org/10.1016/j.gep.2009.11.005
    43 https://doi.org/10.1016/j.jfma.2016.11.015
    44 https://doi.org/10.1016/j.jsbmb.2011.08.007
    45 https://doi.org/10.1016/j.neuro.2010.12.009
    46 https://doi.org/10.1016/j.neuro.2017.10.005
    47 https://doi.org/10.1016/j.neuron.2007.08.018
    48 https://doi.org/10.1016/j.placenta.2017.07.006
    49 https://doi.org/10.1016/j.taap.2017.05.035
    50 https://doi.org/10.1016/j.tig.2009.05.002
    51 https://doi.org/10.1016/j.tiv.2017.07.028
    52 https://doi.org/10.1016/j.tox.2012.02.013
    53 https://doi.org/10.1016/j.tox.2012.03.007
    54 https://doi.org/10.1016/j.tox.2017.01.010
    55 https://doi.org/10.1016/j.yhbeh.2010.02.012
    56 https://doi.org/10.1016/j.yhbeh.2017.10.003
    57 https://doi.org/10.1037/0894-4105.20.1.21
    58 https://doi.org/10.1073/pnas.0503739102
    59 https://doi.org/10.1073/pnas.0711555105
    60 https://doi.org/10.1073/pnas.1102233108
    61 https://doi.org/10.1073/pnas.1214056110
    62 https://doi.org/10.1073/pnas.1408355111
    63 https://doi.org/10.1074/jbc.m210256200
    64 https://doi.org/10.1080/15287390903212501
    65 https://doi.org/10.1093/cercor/bhx250
    66 https://doi.org/10.1096/fj.10-154484
    67 https://doi.org/10.1101/gad.828000
    68 https://doi.org/10.1136/jmg.2004.024646
    69 https://doi.org/10.1177/0883073815609150
    70 https://doi.org/10.1210/en.2012-1195
    71 https://doi.org/10.1210/en.2016-1339
    72 https://doi.org/10.1210/endo.132.6.8504731
    73 https://doi.org/10.1210/er.2009-0002
    74 https://doi.org/10.1289/ehp.0901575
    75 https://doi.org/10.1289/ehp.10168
    76 https://doi.org/10.1289/ehp.1104556
    77 https://doi.org/10.1289/ehp.95103608
    78 https://doi.org/10.1289/ehp.96104298
    79 https://doi.org/10.13172/2052-7810-1-2-610
    80 https://doi.org/10.1371/journal.pbio.1001081
    81 https://doi.org/10.1371/journal.pgen.1003221
    82 https://doi.org/10.1371/journal.pone.0192434
    83 https://doi.org/10.1371/journal.pone.0201071
    84 https://doi.org/10.1523/jneurosci.1316-12.2012
    85 https://doi.org/10.15585/mmwr.ss6706a1
    86 https://doi.org/10.2144/03342mt01
    87 https://doi.org/10.3389/fnins.2016.00174
    88 schema:datePublished 2019-12
    89 schema:datePublishedReg 2019-12-01
    90 schema:description Autism spectrum disorder (ASD) is a neurodevelopmental disorder inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related genes in the developing brain remains unclear. In this study, transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed to BPA was conducted and revealed a list of differentially expressed genes (DEGs) associated with ASD. Among the DEGs, several ASD candidate genes, including Auts2 and Foxp2, were dysregulated and showed sex differences in response to BPA exposure. The interactome and pathway analyses of DEGs using Ingenuity Pathway Analysis software revealed significant associations between the DEGs in males and neurological functions/disorders associated with ASD. Moreover, the reanalysis of transcriptome profiling data from previously published BPA studies consistently showed that BPA-responsive genes were significantly associated with ASD-related genes. The findings from this study indicate that prenatal BPA exposure alters the expression of ASD-linked genes in the hippocampus and suggest that maternal BPA exposure may increase ASD susceptibility by dysregulating genes associated with neurological functions known to be negatively impacted in ASD, which deserves further investigations.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree true
    94 schema:isPartOf N35c2f82bffd34694897c6ad07e9cf9c9
    95 Nec254bf2a0d04beab65a1dec1aa98ca9
    96 sg:journal.1045337
    97 schema:name Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus
    98 schema:pagination 3038
    99 schema:productId N1bc66f4eef7a495084c433dd99b587d9
    100 N6d12c46ee0de4a3baca4e561197ffdb2
    101 N737a2a016b9e49a2b9ae0283c843f3fa
    102 N7bf17ed5c23440049bf39d9faff9bea8
    103 Nef084f2616ff4ef38ae69290cf196fcc
    104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112439640
    105 https://doi.org/10.1038/s41598-019-39386-w
    106 schema:sdDatePublished 2019-04-11T11:00
    107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    108 schema:sdPublisher N12b3f6a1892a4d13a09ef152e059722a
    109 schema:url https://www.nature.com/articles/s41598-019-39386-w
    110 sgo:license sg:explorer/license/
    111 sgo:sdDataset articles
    112 rdf:type schema:ScholarlyArticle
    113 N12b3f6a1892a4d13a09ef152e059722a schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N1bc66f4eef7a495084c433dd99b587d9 schema:name nlm_unique_id
    116 schema:value 101563288
    117 rdf:type schema:PropertyValue
    118 N35c2f82bffd34694897c6ad07e9cf9c9 schema:volumeNumber 9
    119 rdf:type schema:PublicationVolume
    120 N39f868c98c6a4c8fb57e5c1e378fe299 schema:affiliation https://www.grid.ac/institutes/grid.7922.e
    121 schema:familyName Kanlayaprasit
    122 schema:givenName Songphon
    123 rdf:type schema:Person
    124 N5b5537197b4d4a5c93d99c10a756b10d rdf:first Ne3550a173d0d4d4098ebfe4324a41988
    125 rdf:rest Ne4a4ce79e5f648fd99878b5c282730f9
    126 N6d12c46ee0de4a3baca4e561197ffdb2 schema:name readcube_id
    127 schema:value b5dda2c5caea26d24bd3f2e5e26094d6b6b185bdda28aa1b1038f6d816210339
    128 rdf:type schema:PropertyValue
    129 N6e931b2ba785445dbd7ab1f1f3e3e094 schema:affiliation https://www.grid.ac/institutes/grid.7922.e
    130 schema:familyName Thongkorn
    131 schema:givenName Surangrat
    132 rdf:type schema:Person
    133 N737a2a016b9e49a2b9ae0283c843f3fa schema:name dimensions_id
    134 schema:value pub.1112439640
    135 rdf:type schema:PropertyValue
    136 N7bf17ed5c23440049bf39d9faff9bea8 schema:name pubmed_id
    137 schema:value 30816183
    138 rdf:type schema:PropertyValue
    139 N87fc92fc6c594a5681f2a9a284d0c327 rdf:first N6e931b2ba785445dbd7ab1f1f3e3e094
    140 rdf:rest Ncf6f2fbec43c491c85e5ef96503af1c6
    141 N8cf53dc3356b4a6ea9bad8ccd3137df4 schema:affiliation https://www.grid.ac/institutes/grid.7922.e
    142 schema:familyName Sarachana
    143 schema:givenName Tewarit
    144 rdf:type schema:Person
    145 Na46bd5b529884f68a74027e322ad6885 schema:affiliation https://www.grid.ac/institutes/grid.7922.e
    146 schema:familyName Tencomnao
    147 schema:givenName Tewin
    148 rdf:type schema:Person
    149 Naa3df11034624c7c93fb0fe67a7446ca schema:affiliation https://www.grid.ac/institutes/grid.7922.e
    150 schema:familyName Jindatip
    151 schema:givenName Depicha
    152 rdf:type schema:Person
    153 Naddd270fcc624e4e9bfd23b234a3b432 rdf:first Na46bd5b529884f68a74027e322ad6885
    154 rdf:rest N5b5537197b4d4a5c93d99c10a756b10d
    155 Ncf6f2fbec43c491c85e5ef96503af1c6 rdf:first N39f868c98c6a4c8fb57e5c1e378fe299
    156 rdf:rest Ne2d60a53618f4718a9dcd90f9c26eab2
    157 Ne2d60a53618f4718a9dcd90f9c26eab2 rdf:first Naa3df11034624c7c93fb0fe67a7446ca
    158 rdf:rest Naddd270fcc624e4e9bfd23b234a3b432
    159 Ne3550a173d0d4d4098ebfe4324a41988 schema:affiliation https://www.grid.ac/institutes/grid.253615.6
    160 schema:familyName Hu
    161 schema:givenName Valerie W.
    162 rdf:type schema:Person
    163 Ne4a4ce79e5f648fd99878b5c282730f9 rdf:first N8cf53dc3356b4a6ea9bad8ccd3137df4
    164 rdf:rest rdf:nil
    165 Nec254bf2a0d04beab65a1dec1aa98ca9 schema:issueNumber 1
    166 rdf:type schema:PublicationIssue
    167 Nef084f2616ff4ef38ae69290cf196fcc schema:name doi
    168 schema:value 10.1038/s41598-019-39386-w
    169 rdf:type schema:PropertyValue
    170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Biological Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Genetics
    175 rdf:type schema:DefinedTerm
    176 sg:grant.3537270 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39386-w
    177 rdf:type schema:MonetaryGrant
    178 sg:grant.7026396 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39386-w
    179 rdf:type schema:MonetaryGrant
    180 sg:journal.1045337 schema:issn 2045-2322
    181 schema:name Scientific Reports
    182 rdf:type schema:Periodical
    183 sg:pub.10.1007/s10803-008-0646-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011875300
    184 https://doi.org/10.1007/s10803-008-0646-7
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s12011-012-9551-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035609930
    187 https://doi.org/10.1007/s12011-012-9551-1
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/30764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005546919
    190 https://doi.org/10.1038/30764
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/mp.2013.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017513951
    193 https://doi.org/10.1038/mp.2013.114
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature01025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021903763
    196 https://doi.org/10.1038/nature01025
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nature10110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400360
    199 https://doi.org/10.1038/nature10110
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nature11011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021093950
    202 https://doi.org/10.1038/nature11011
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nature20612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027404357
    205 https://doi.org/10.1038/nature20612
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
    208 https://doi.org/10.1038/nmeth.1923
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nn.4373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051738015
    211 https://doi.org/10.1038/nn.4373
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nprot.2012.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025289337
    214 https://doi.org/10.1038/nprot.2012.123
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nrg1501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013383518
    217 https://doi.org/10.1038/nrg1501
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/tp.2013.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014625003
    220 https://doi.org/10.1038/tp.2013.123
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1186/1471-2105-12-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902674
    223 https://doi.org/10.1186/1471-2105-12-323
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1186/2040-2392-2-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005434666
    226 https://doi.org/10.1186/2040-2392-2-14
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1186/gm144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026797754
    229 https://doi.org/10.1186/gm144
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1186/s13229-018-0213-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103379315
    232 https://doi.org/10.1186/s13229-018-0213-9
    233 rdf:type schema:CreativeWork
    234 https://app.dimensions.ai/details/publication/pub.1078187509 schema:CreativeWork
    235 https://app.dimensions.ai/details/publication/pub.1079062544 schema:CreativeWork
    236 https://doi.org/10.1001/jama.2011.1638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026745010
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/advs.201600493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084974405
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/ajmg.a.37050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553434
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/ajmg.a.37454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028293368
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/ajmg.b.20162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047075551
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1002/aur.1444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035735527
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1002/aur.33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026057207
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1002/aur.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032268513
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1002/bmc.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002871772
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1002/jat.3176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017521237
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.biopsych.2014.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018875611
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.braindev.2006.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014087485
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.cell.2016.10.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001298230
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.cppeds.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023123292
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.cpr.2009.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043927836
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.envres.2018.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101168543
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.etap.2016.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045278336
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.freeradbiomed.2014.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045938070
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.gdata.2015.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015214710
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.gep.2009.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012863901
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.jfma.2016.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012905850
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.jsbmb.2011.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015157160
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.neuro.2010.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017217533
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.neuro.2017.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092418047
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.neuron.2007.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006881089
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.placenta.2017.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090383267
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.taap.2017.05.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085706523
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.tig.2009.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046608308
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.tiv.2017.07.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090921962
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.tox.2012.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041534464
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.tox.2012.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019662311
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.tox.2017.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009849716
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.yhbeh.2010.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005994307
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.yhbeh.2017.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092249114
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1037/0894-4105.20.1.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009114061
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1073/pnas.0503739102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832831
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1073/pnas.0711555105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035798756
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1073/pnas.1102233108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026264084
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1073/pnas.1214056110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026827429
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1073/pnas.1408355111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023656428
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1074/jbc.m210256200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017827262
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1080/15287390903212501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040144350
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1093/cercor/bhx250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091638271
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1096/fj.10-154484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041962757
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1101/gad.828000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407370
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1136/jmg.2004.024646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013176159
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1177/0883073815609150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010415311
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1210/en.2012-1195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064251452
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1210/en.2016-1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064252760
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1210/endo.132.6.8504731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064278464
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1210/er.2009-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021194372
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1289/ehp.0901575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000988801
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1289/ehp.10168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001123021
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1289/ehp.1104556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001432159
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1289/ehp.95103608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064745896
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1289/ehp.96104298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064746300
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.13172/2052-7810-1-2-610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065007522
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1371/journal.pbio.1001081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022276849
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1371/journal.pgen.1003221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010523987
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1371/journal.pone.0192434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100915274
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1371/journal.pone.0201071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105775566
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1523/jneurosci.1316-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032873289
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.15585/mmwr.ss6706a1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103654627
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.2144/03342mt01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075245738
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.3389/fnins.2016.00174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043846611
    365 rdf:type schema:CreativeWork
    366 https://www.grid.ac/institutes/grid.253615.6 schema:alternateName George Washington University
    367 schema:name Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.7922.e schema:alternateName Chulalongkorn University
    370 schema:name Age-related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
    371 Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    372 The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
    373 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...