Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yun Hye Kim, Ju Hee Lee, Joanna Lan-Hing Yeung, Eashita Das, Ri Youn Kim, Yanqing Jiang, Joon Ho Moon, Hyerin Jeong, Nikita Thakkar, Joe Eun Son, Natasha Trzaskalski, Chi-chung Hui, Kyung-Oh Doh, Erin E. Mulvihill, Jae-Ryong Kim, Kyoung-Han Kim, Hoon-Ki Sung

ABSTRACT

Intermittent fasting (IF) is an effective dietary intervention to counteract obesity-associated metabolic abnormalities. Previously, we and others have highlighted white adipose tissue (WAT) browning as the main underlying mechanism of IF-mediated metabolic benefits. However, whether IF retains its efficacy in different models, such as genetically obese/diabetic animals, is unknown. Here, leptin-deficient ob/ob mice were subjected to 16 weeks of isocaloric IF, and comprehensive metabolic phenotyping was conducted to assess the metabolic effects of IF. Unlike our previous study, isocaloric IF-subjected ob/ob animals failed to exhibit reduced body weight gain, lower fat mass, or decreased liver lipid accumulation. Moreover, isocaloric IF did not result in increased thermogenesis nor induce WAT browning in ob/ob mice. These findings indicate that isocaloric IF may not be an effective approach for regulating body weight in ob/ob animals, posing the possible limitations of IF to treat obesity. However, despite the lack of improvement in insulin sensitivity, isocaloric IF-subjected ob/ob animals displayed improved glucose tolerance as well as higher postprandial insulin level, with elevated incretin expression, suggesting that isocaloric IF is effective in improving nutrient-stimulated insulin secretion. Together, this study uncovers the insulinotropic effect of isocaloric IF, independent of adipose thermogenesis, which is potentially complementary for the treatment of type 2 diabetes. More... »

PAGES

2479

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39380-2

DOI

http://dx.doi.org/10.1038/s41598-019-39380-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112286096

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30792482


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