Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn’s Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Elizabeth A. Scoville, Margaret M. Allaman, Dawn W. Adams, Amy K. Motley, Shannon C. Peyton, Sarah L. Ferguson, Sara N. Horst, Christopher S. Williams, Dawn B. Beaulieu, David A. Schwartz, Keith T. Wilson, Lori A. Coburn

ABSTRACT

Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty acids were measured by gas chromatography. Serum cytokines and adipokines were measured by Luminex assay. Dietary histories were obtained from a subset of patients. Nine serum cytokines and adipokines were increased in CD versus controls. CD subjects had increased percentage serum monounsaturated fatty acids (MUFA), dihomo-gamma linolenic acid (DGLA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls. The % total n-3 fatty acids and % EPA directly correlated with pro-inflammatory cytokine levels and HBI, whereas the % total n-6 fatty acids were inversely correlated with pro-inflammatory cytokine levels and HBI. CD subjects had increased caloric intake versus controls, but no alterations in total fat or PUFA intake. We found differences in serum fatty acids, most notably PUFA, in CD that correlated both with clinical disease activity and inflammatory cytokines. Our findings indicate that altered fatty acid metabolism or utilization is present in CD and is related to disease activity. More... »

PAGES

2882

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39232-z

DOI

http://dx.doi.org/10.1038/s41598-019-39232-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112395259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30814550


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scoville", 
        "givenName": "Elizabeth A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allaman", 
        "givenName": "Margaret M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA Tennessee Valley Healthcare System", 
          "id": "https://www.grid.ac/institutes/grid.452900.a", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "Dawn W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Motley", 
        "givenName": "Amy K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peyton", 
        "givenName": "Shannon C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferguson", 
        "givenName": "Sarah L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horst", 
        "givenName": "Sara N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Vanderbilt Center for Mucosal Inflammation and Cancer, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA", 
            "Vanderbilt Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Christopher S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaulieu", 
        "givenName": "Dawn B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "David A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Vanderbilt Center for Mucosal Inflammation and Cancer, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA", 
            "Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Keith T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA Tennessee Valley Healthcare System", 
          "id": "https://www.grid.ac/institutes/grid.452900.a", 
          "name": [
            "Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Vanderbilt Center for Mucosal Inflammation and Cancer, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA", 
            "Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coburn", 
        "givenName": "Lori A.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1079/bjn20041213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003461479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra020831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004344000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2015.08.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004488579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acel.12416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004695327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-014-3478-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005202642", 
          "https://doi.org/10.1007/s10620-014-3478-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2009.00290.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006291181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-014-9914-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009144400", 
          "https://doi.org/10.1007/s10753-014-9914-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-014-9914-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009144400", 
          "https://doi.org/10.1007/s10753-014-9914-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.12.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010004776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2013.12.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010004776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013517631", 
          "https://doi.org/10.1038/nature06005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016828335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016828335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016828335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s005350050215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017699346", 
          "https://doi.org/10.1007/s005350050215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.34.10.1370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018368360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.33.10.1365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019139589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021628941", 
          "https://doi.org/10.1038/nri2294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crohns.2013.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022501385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.12670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024350215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.plefa.2009.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024661920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0000000000000790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024715003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0000000000000790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024715003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2016.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026021452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.1073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027410569", 
          "https://doi.org/10.1038/ng.1073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep28418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029028415", 
          "https://doi.org/10.1038/srep28418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nutres.2008.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029906452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0156387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031595424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-199712000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034936437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00054725-199712000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034936437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2013-305304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036628118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mco.0b013e32833cf0f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037909473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mco.0b013e32833cf0f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037909473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mco.0b013e32833cf0f4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037909473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039052955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114507682956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040410322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0007114507682956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040410322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.294.5548.1871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041063406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2013.12.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045892746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0082300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046063811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.299.14.1690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046258427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.26.2.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046506791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd006320.pub4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048290851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20042031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048322618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048509313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048509313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0b013e3182810122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052393667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0b013e3182810122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052393667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00401706.1969.10490657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058284023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075727656", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076348378", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081677143", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/63.5.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082880685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.07.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091052738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0000000000001236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092126063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0000000000001236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092126063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mib.0000000000001236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092126063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2017.01331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092327130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18122619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099754355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11306-017-1311-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100111047", 
          "https://doi.org/10.1007/s11306-017-1311-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11306-017-1311-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100111047", 
          "https://doi.org/10.1007/s11306-017-1311-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2517-6161.1995.tb02031.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110458929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2517-6161.1995.tb02031.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110458929"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty acids were measured by gas chromatography. Serum cytokines and adipokines were measured by Luminex assay. Dietary histories were obtained from a subset of patients. Nine serum cytokines and adipokines were increased in CD versus controls. CD subjects had increased percentage serum monounsaturated fatty acids (MUFA), dihomo-gamma linolenic acid (DGLA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls. The % total n-3 fatty acids and % EPA directly correlated with pro-inflammatory cytokine levels and HBI, whereas the % total n-6 fatty acids were inversely correlated with pro-inflammatory cytokine levels and HBI. CD subjects had increased caloric intake versus controls, but no alterations in total fat or PUFA intake. We found differences in serum fatty acids, most notably PUFA, in CD that correlated both with clinical disease activity and inflammatory cytokines. Our findings indicate that altered fatty acid metabolism or utilization is present in CD and is related to disease activity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-39232-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3801214", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6810173", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2401696", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435828", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2401701", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2684498", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3535886", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2496122", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705238", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2402601", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438970", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435442", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683272", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465694", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439027", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn\u2019s Disease", 
    "pagination": "2882", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b0e9639708b1c28cbc4b7816385d489a54cc1a35e46f12f9cf06ff10d553f733"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30814550"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-39232-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112395259"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-39232-z", 
      "https://app.dimensions.ai/details/publication/pub.1112395259"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77581_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-39232-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39232-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39232-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39232-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39232-z'


 

This table displays all metadata directly associated to this object as RDF triples.

322 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-39232-z schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nd278244f943341799e07e2c901d29a0b
4 schema:citation sg:pub.10.1007/s005350050215
5 sg:pub.10.1007/s10620-014-3478-7
6 sg:pub.10.1007/s10753-014-9914-1
7 sg:pub.10.1007/s11306-017-1311-y
8 sg:pub.10.1038/nature06005
9 sg:pub.10.1038/ng.1073
10 sg:pub.10.1038/nri2294
11 sg:pub.10.1038/srep28418
12 https://app.dimensions.ai/details/publication/pub.1075727656
13 https://app.dimensions.ai/details/publication/pub.1076348378
14 https://app.dimensions.ai/details/publication/pub.1081677143
15 https://doi.org/10.1001/jama.299.14.1690
16 https://doi.org/10.1002/14651858.cd006320.pub4
17 https://doi.org/10.1002/ibd.20094
18 https://doi.org/10.1002/ibd.21560
19 https://doi.org/10.1016/j.atherosclerosis.2013.12.053
20 https://doi.org/10.1016/j.crohns.2013.03.013
21 https://doi.org/10.1016/j.ejphar.2015.08.050
22 https://doi.org/10.1016/j.ejphar.2016.04.020
23 https://doi.org/10.1016/j.nutres.2008.02.005
24 https://doi.org/10.1016/j.plefa.2009.05.010
25 https://doi.org/10.1017/s0007114507682956
26 https://doi.org/10.1053/j.gastro.2013.12.034
27 https://doi.org/10.1053/j.gastro.2017.07.048
28 https://doi.org/10.1056/nejmra020831
29 https://doi.org/10.1079/bjn20041213
30 https://doi.org/10.1080/00401706.1969.10490657
31 https://doi.org/10.1084/jem.20042031
32 https://doi.org/10.1093/ajcn/63.5.741
33 https://doi.org/10.1097/00054725-199712000-00004
34 https://doi.org/10.1097/mco.0b013e32833cf0f4
35 https://doi.org/10.1097/mib.0000000000000790
36 https://doi.org/10.1097/mib.0000000000001236
37 https://doi.org/10.1097/mib.0b013e3182810122
38 https://doi.org/10.1111/acel.12416
39 https://doi.org/10.1111/apt.12670
40 https://doi.org/10.1111/j.1476-5381.2009.00290.x
41 https://doi.org/10.1111/j.2517-6161.1995.tb02031.x
42 https://doi.org/10.1126/science.294.5548.1871
43 https://doi.org/10.1136/gut.26.2.158
44 https://doi.org/10.1136/gut.33.10.1365
45 https://doi.org/10.1136/gut.34.10.1370
46 https://doi.org/10.1136/gutjnl-2013-305304
47 https://doi.org/10.1371/journal.pone.0015672
48 https://doi.org/10.1371/journal.pone.0082300
49 https://doi.org/10.1371/journal.pone.0156387
50 https://doi.org/10.3389/fimmu.2017.01331
51 https://doi.org/10.3390/ijms18122619
52 schema:datePublished 2019-12
53 schema:datePublishedReg 2019-12-01
54 schema:description Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty acids were measured by gas chromatography. Serum cytokines and adipokines were measured by Luminex assay. Dietary histories were obtained from a subset of patients. Nine serum cytokines and adipokines were increased in CD versus controls. CD subjects had increased percentage serum monounsaturated fatty acids (MUFA), dihomo-gamma linolenic acid (DGLA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls. The % total n-3 fatty acids and % EPA directly correlated with pro-inflammatory cytokine levels and HBI, whereas the % total n-6 fatty acids were inversely correlated with pro-inflammatory cytokine levels and HBI. CD subjects had increased caloric intake versus controls, but no alterations in total fat or PUFA intake. We found differences in serum fatty acids, most notably PUFA, in CD that correlated both with clinical disease activity and inflammatory cytokines. Our findings indicate that altered fatty acid metabolism or utilization is present in CD and is related to disease activity.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N5f42827914154af295a915bdb102ebe7
59 N90eafea9117d473c92bd96cdf4efa930
60 sg:journal.1045337
61 schema:name Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn’s Disease
62 schema:pagination 2882
63 schema:productId N1396fb31c889469ba70d9e31465beaff
64 N32b514bd08784d3e95c2ed9e83b56f12
65 N8a2bd834c926489f9a945efa64d67d35
66 Ndf3c26459eee4fae8f3f8fbfac5ba296
67 Ndf3f30266bca4b6ca2d38d50e1d03d2f
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112395259
69 https://doi.org/10.1038/s41598-019-39232-z
70 schema:sdDatePublished 2019-04-11T10:50
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N0ada9e50eab349d49d127e3b68eaa27e
73 schema:url https://www.nature.com/articles/s41598-019-39232-z
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N04b59a269bf04643a5671fe8b0c0ba06 rdf:first Nb8a3161253ff449498d516a7bca94f9d
78 rdf:rest Nef579e4719a547ef887ead6681f1b0cb
79 N0ada9e50eab349d49d127e3b68eaa27e schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N119f8a8eee8842768ee1d7921b87faa6 schema:affiliation https://www.grid.ac/institutes/grid.452900.a
82 schema:familyName Coburn
83 schema:givenName Lori A.
84 rdf:type schema:Person
85 N1396fb31c889469ba70d9e31465beaff schema:name pubmed_id
86 schema:value 30814550
87 rdf:type schema:PropertyValue
88 N164056e5b8ee4e2088684fc09d66f239 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
89 schema:familyName Peyton
90 schema:givenName Shannon C.
91 rdf:type schema:Person
92 N217b8db732524b5da763e2f11caf3e0b schema:affiliation https://www.grid.ac/institutes/grid.412807.8
93 schema:familyName Scoville
94 schema:givenName Elizabeth A.
95 rdf:type schema:Person
96 N2460e69499ef4a23bfe2cec825ad0b02 rdf:first Nde13fd5e0e3b4127ab7565f549634ba4
97 rdf:rest N2affc10b2ffa4e0497fc0f05412684c7
98 N29724a80510b416c8ef8384261bf53ba rdf:first Ndca355cf6b3c4b7a8c241c04a17aeb63
99 rdf:rest Nf1d3d82e3d6f46caaa2731cc6292101d
100 N2affc10b2ffa4e0497fc0f05412684c7 rdf:first Nd20360cf0f104e0b90c1fe11f2567458
101 rdf:rest N29724a80510b416c8ef8384261bf53ba
102 N309792d2822a49b9be7ca5bd3b3982ce schema:affiliation https://www.grid.ac/institutes/grid.412807.8
103 schema:familyName Horst
104 schema:givenName Sara N.
105 rdf:type schema:Person
106 N32b514bd08784d3e95c2ed9e83b56f12 schema:name readcube_id
107 schema:value b0e9639708b1c28cbc4b7816385d489a54cc1a35e46f12f9cf06ff10d553f733
108 rdf:type schema:PropertyValue
109 N34d73479fd2d4bfaa655a083c9ae7112 rdf:first N8a820335257c42c995946cfdf6818f2e
110 rdf:rest Nfd0cc30d2d894332aeb340241805c830
111 N42ee4206214e439a8392f8df81a541e5 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
112 schema:familyName Williams
113 schema:givenName Christopher S.
114 rdf:type schema:Person
115 N5f42827914154af295a915bdb102ebe7 schema:volumeNumber 9
116 rdf:type schema:PublicationVolume
117 N7e9d968f84304f7f844fe6e6ff00121a schema:affiliation https://www.grid.ac/institutes/grid.412807.8
118 schema:familyName Motley
119 schema:givenName Amy K.
120 rdf:type schema:Person
121 N8a2bd834c926489f9a945efa64d67d35 schema:name doi
122 schema:value 10.1038/s41598-019-39232-z
123 rdf:type schema:PropertyValue
124 N8a820335257c42c995946cfdf6818f2e schema:affiliation https://www.grid.ac/institutes/grid.452900.a
125 schema:familyName Adams
126 schema:givenName Dawn W.
127 rdf:type schema:Person
128 N8e3d67b7637c408c993bbfcd2c1bc14d schema:affiliation https://www.grid.ac/institutes/grid.412807.8
129 schema:familyName Allaman
130 schema:givenName Margaret M.
131 rdf:type schema:Person
132 N90eafea9117d473c92bd96cdf4efa930 schema:issueNumber 1
133 rdf:type schema:PublicationIssue
134 Nb8a3161253ff449498d516a7bca94f9d schema:affiliation https://www.grid.ac/institutes/grid.412807.8
135 schema:familyName Ferguson
136 schema:givenName Sarah L.
137 rdf:type schema:Person
138 Nd20360cf0f104e0b90c1fe11f2567458 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
139 schema:familyName Schwartz
140 schema:givenName David A.
141 rdf:type schema:Person
142 Nd278244f943341799e07e2c901d29a0b rdf:first N217b8db732524b5da763e2f11caf3e0b
143 rdf:rest Nd89887cb754244fea7b9686a2e33c096
144 Nd89887cb754244fea7b9686a2e33c096 rdf:first N8e3d67b7637c408c993bbfcd2c1bc14d
145 rdf:rest N34d73479fd2d4bfaa655a083c9ae7112
146 Ndca355cf6b3c4b7a8c241c04a17aeb63 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
147 schema:familyName Wilson
148 schema:givenName Keith T.
149 rdf:type schema:Person
150 Nde13fd5e0e3b4127ab7565f549634ba4 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
151 schema:familyName Beaulieu
152 schema:givenName Dawn B.
153 rdf:type schema:Person
154 Ndf3c26459eee4fae8f3f8fbfac5ba296 schema:name dimensions_id
155 schema:value pub.1112395259
156 rdf:type schema:PropertyValue
157 Ndf3f30266bca4b6ca2d38d50e1d03d2f schema:name nlm_unique_id
158 schema:value 101563288
159 rdf:type schema:PropertyValue
160 Nef579e4719a547ef887ead6681f1b0cb rdf:first N309792d2822a49b9be7ca5bd3b3982ce
161 rdf:rest Nf6f86cddccf84daaa900ebaeed12cb63
162 Nf1d3d82e3d6f46caaa2731cc6292101d rdf:first N119f8a8eee8842768ee1d7921b87faa6
163 rdf:rest rdf:nil
164 Nf6f86cddccf84daaa900ebaeed12cb63 rdf:first N42ee4206214e439a8392f8df81a541e5
165 rdf:rest N2460e69499ef4a23bfe2cec825ad0b02
166 Nfa946ea62e124abf9a84bce1218dbcb0 rdf:first N164056e5b8ee4e2088684fc09d66f239
167 rdf:rest N04b59a269bf04643a5671fe8b0c0ba06
168 Nfd0cc30d2d894332aeb340241805c830 rdf:first N7e9d968f84304f7f844fe6e6ff00121a
169 rdf:rest Nfa946ea62e124abf9a84bce1218dbcb0
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
174 schema:name Clinical Sciences
175 rdf:type schema:DefinedTerm
176 sg:grant.2401696 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
177 rdf:type schema:MonetaryGrant
178 sg:grant.2401701 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
179 rdf:type schema:MonetaryGrant
180 sg:grant.2402601 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
181 rdf:type schema:MonetaryGrant
182 sg:grant.2435442 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
183 rdf:type schema:MonetaryGrant
184 sg:grant.2435828 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
185 rdf:type schema:MonetaryGrant
186 sg:grant.2438970 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
187 rdf:type schema:MonetaryGrant
188 sg:grant.2439027 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
189 rdf:type schema:MonetaryGrant
190 sg:grant.2465694 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
191 rdf:type schema:MonetaryGrant
192 sg:grant.2496122 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
193 rdf:type schema:MonetaryGrant
194 sg:grant.2683272 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
195 rdf:type schema:MonetaryGrant
196 sg:grant.2684498 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
197 rdf:type schema:MonetaryGrant
198 sg:grant.2705238 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
199 rdf:type schema:MonetaryGrant
200 sg:grant.3535886 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
201 rdf:type schema:MonetaryGrant
202 sg:grant.3801214 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
203 rdf:type schema:MonetaryGrant
204 sg:grant.6810173 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39232-z
205 rdf:type schema:MonetaryGrant
206 sg:journal.1045337 schema:issn 2045-2322
207 schema:name Scientific Reports
208 rdf:type schema:Periodical
209 sg:pub.10.1007/s005350050215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017699346
210 https://doi.org/10.1007/s005350050215
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s10620-014-3478-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005202642
213 https://doi.org/10.1007/s10620-014-3478-7
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s10753-014-9914-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009144400
216 https://doi.org/10.1007/s10753-014-9914-1
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s11306-017-1311-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1100111047
219 https://doi.org/10.1007/s11306-017-1311-y
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nature06005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013517631
222 https://doi.org/10.1038/nature06005
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ng.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027410569
225 https://doi.org/10.1038/ng.1073
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/nri2294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021628941
228 https://doi.org/10.1038/nri2294
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/srep28418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029028415
231 https://doi.org/10.1038/srep28418
232 rdf:type schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1075727656 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1076348378 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1081677143 schema:CreativeWork
236 https://doi.org/10.1001/jama.299.14.1690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046258427
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/14651858.cd006320.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048290851
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/ibd.20094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048509313
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/ibd.21560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016828335
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.atherosclerosis.2013.12.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045892746
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.crohns.2013.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022501385
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.ejphar.2015.08.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004488579
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.ejphar.2016.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026021452
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.nutres.2008.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029906452
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.plefa.2009.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024661920
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1017/s0007114507682956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040410322
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1053/j.gastro.2013.12.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010004776
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1053/j.gastro.2017.07.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091052738
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejmra020831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004344000
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1079/bjn20041213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003461479
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1080/00401706.1969.10490657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058284023
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1084/jem.20042031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048322618
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/ajcn/63.5.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082880685
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/00054725-199712000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034936437
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1097/mco.0b013e32833cf0f4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037909473
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1097/mib.0000000000000790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024715003
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1097/mib.0000000000001236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092126063
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1097/mib.0b013e3182810122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052393667
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/acel.12416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004695327
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/apt.12670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024350215
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/j.1476-5381.2009.00290.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006291181
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1111/j.2517-6161.1995.tb02031.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1110458929
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1126/science.294.5548.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041063406
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1136/gut.26.2.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046506791
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1136/gut.33.10.1365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019139589
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/gut.34.10.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018368360
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1136/gutjnl-2013-305304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036628118
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1371/journal.pone.0015672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039052955
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1371/journal.pone.0082300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046063811
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.pone.0156387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031595424
305 rdf:type schema:CreativeWork
306 https://doi.org/10.3389/fimmu.2017.01331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092327130
307 rdf:type schema:CreativeWork
308 https://doi.org/10.3390/ijms18122619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099754355
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
311 schema:name Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA
312 Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
313 Vanderbilt Center for Mucosal Inflammation and Cancer, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
314 Vanderbilt Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA
315 Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
316 Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.452900.a schema:alternateName VA Tennessee Valley Healthcare System
319 schema:name Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
320 Vanderbilt Center for Mucosal Inflammation and Cancer, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
321 Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA
322 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...