Blubber transcriptome responses to repeated ACTH administration in a marine mammal View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jared S. Deyarmin, Molly C. McCormley, Cory D. Champagne, Alicia P. Stephan, Laura Pujade Busqueta, Daniel E. Crocker, Dorian S. Houser, Jane I. Khudyakov

ABSTRACT

Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction. This can be especially deleterious for capital breeding carnivores such as marine mammals, with potential for ecosystem-wide effects. However, the impacts and indicators of chronic stress in animals are currently poorly understood. To identify downstream mediators of repeated stress responses in marine mammals, we administered adrenocorticotropic hormone (ACTH) once daily for four days to free-ranging juvenile northern elephant seals (Mirounga angustirostris) to stimulate endogenous corticosteroid release, and compared blubber tissue transcriptome responses to the first and fourth ACTH administrations. Gene expression profiles were distinct between blubber responses to single and repeated ACTH administration, despite similarities in circulating cortisol profiles. We identified 61 and 12 genes that were differentially expressed (DEGs) in response to the first ACTH and fourth administrations, respectively, 24 DEGs between the first and fourth pre-ACTH samples, and 12 DEGs between ACTH response samples from the first and fourth days. Annotated DEGs were associated with functions in redox and lipid homeostasis, suggesting potential negative impacts of repeated stress on capital breeding, diving mammals. DEGs identified in this study are potential markers of repeated stress in marine mammals, which may not be detectable by endocrine profiles alone. More... »

PAGES

2718

References to SciGraph publications

  • 2015-12. Transcriptome analysis of northern elephant seal (Mirounga angustirostris) muscle tissue provides a novel molecular resource and physiological insights in BMC GENOMICS
  • 2010-10. Differential expression analysis for sequence count data in GENOME BIOLOGY
  • 2013-08. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis in NATURE PROTOCOLS
  • 2012. Fasting Physiology of the Pinnipeds: The Challenges of Fasting While Maintaining High Energy Expenditure and Nutrient Delivery for Lactation in COMPARATIVE PHYSIOLOGY OF FASTING, STARVATION, AND FOOD LIMITATION
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2001-11. Demography of the endangered North Atlantic right whale in NATURE
  • 2011-07. Full-length transcriptome assembly from RNA-Seq data without a reference genome in NATURE BIOTECHNOLOGY
  • 2015-01. Fast and sensitive protein alignment using DIAMOND in NATURE METHODS
  • 2015-07. Stress physiology in marine mammals: how well do they fit the terrestrial model? in JOURNAL OF COMPARATIVE PHYSIOLOGY B
  • 2014-12. Effect of RNA integrity on uniquely mapped reads in RNA-Seq in BMC RESEARCH NOTES
  • 2016-12. A survey of best practices for RNA-seq data analysis in GENOME BIOLOGY
  • 2015-12. SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling in NATURE COMMUNICATIONS
  • 2013-12. Cumulative human impacts on marine predators in NATURE COMMUNICATIONS
  • 2017-12. Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal in SCIENTIFIC REPORTS
  • 2012-09. Zbtb16 has a role in brown adipocyte bioenergetics in NUTRITION & DIABETES
  • 2016-05. Near-optimal probabilistic RNA-seq quantification in NATURE BIOTECHNOLOGY
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-39089-2

    DOI

    http://dx.doi.org/10.1038/s41598-019-39089-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112364092

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30804370


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