A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Takuya Hayakawa, Shizuka Kawasaki, Yutaka Hirayama, Takuya Tsutsui, Eiji Sugiyama, Kiyo Adachi, Ryo Kon, Makoto Suematsu, Yuki Sugiura

ABSTRACT

Sucralfate is effective for the treatment of gastric and duodenal ulcers owing to its protective gel-forming ability. However, the mechanism by which sucralfate protects the oesophageal mucosa against reflux oesophagitis has not been clarified. We aimed to investigate the mechanisms of action of sucralfate and sucrose octasulfate (SOS), a component of sucralfate. SOS and sucralfate were administered to oesophagitis-induced rats, and the ulcer lesion size was macroscopically examined and scored. Effective pepsin activity in the gastric juices obtained from the animal model was evaluated by a casein digestion test. Sucralfate and SOS improved the pathology scores in a dose-dependent manner, whereas gastric juice pepsin activity was not impaired by therapeutic doses of SOS. As SOS lacks the ability to form a thick gel layer by polymerisation, we examined the distribution of SOS in the mucosal lumen by imaging mass spectrometry (IMS) to determine whether SOS directly adheres to the mucosal surface. A clear homogeneous thin-layer SOS film (>100 μm thick) was visualized on the oesophageal mucosal surface. Moreover, this SOS film formation was enhanced at ulcer lesion sites. Taken together, SOS appears to protect oesophageal mucosa against reflux oesophagitis via thin-layer formation on the mucosal surface. More... »

PAGES

3559

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39087-4

DOI

http://dx.doi.org/10.1038/s41598-019-39087-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112543961

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30837505


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Pharmaceutical Research Laboratories, Lion Corporation, 100 Tajima, 256-0811, Odawara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayakawa", 
        "givenName": "Takuya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Analytical Technology Research Center, Lion Corporation, 7-2-1 Hirai, Edogawa-ku, 132-0035, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawasaki", 
        "givenName": "Shizuka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Pharmaceutical Research Laboratories, Lion Corporation, 100 Tajima, 256-0811, Odawara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirayama", 
        "givenName": "Yutaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Analytical Technology Research Center, Lion Corporation, 7-2-1 Hirai, Edogawa-ku, 132-0035, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsutsui", 
        "givenName": "Takuya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiyama", 
        "givenName": "Eiji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Pharmaceutical Research Laboratories, Lion Corporation, 100 Tajima, 256-0811, Odawara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adachi", 
        "givenName": "Kiyo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lion Corporation (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.419306.9", 
          "name": [
            "Research & Development Headquarters, Pharmaceutical Research Laboratories, Lion Corporation, 100 Tajima, 256-0811, Odawara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kon", 
        "givenName": "Ryo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suematsu", 
        "givenName": "Makoto", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiura", 
        "givenName": "Yuki", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01308368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006212182", 
          "https://doi.org/10.1007/bf01308368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01308368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006212182", 
          "https://doi.org/10.1007/bf01308368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(85)90128-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010206057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac970888i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010251835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac970888i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010251835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0017952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013537570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-011-4924-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013794080", 
          "https://doi.org/10.1007/s00216-011-4924-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-185-4-rc1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014574052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-185-4-rc1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014574052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529109025024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015726405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep32361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016240753", 
          "https://doi.org/10.1038/srep32361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0953-0673.1996.00441.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016381680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529009091919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017754730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(87)91026-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017858989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd003245.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018892533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000403200510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023063305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323000403200510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023063305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365529309098293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034515379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1254/jjp.75.21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035837201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1254/jjp.69.317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041962798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365528709090959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048169062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02654.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049085512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2005.02654.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049085512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1986.251.6.g866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079952882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080023858", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080351742", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082015465", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082015466", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082017732", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.20524/aog.2017.0187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091275603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5152/tjg.2017.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093147997"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Sucralfate is effective for the treatment of gastric and duodenal ulcers owing to its protective gel-forming ability. However, the mechanism by which sucralfate protects the oesophageal mucosa against reflux oesophagitis has not been clarified. We aimed to investigate the mechanisms of action of sucralfate and sucrose octasulfate (SOS), a component of sucralfate. SOS and sucralfate were administered to oesophagitis-induced rats, and the ulcer lesion size was macroscopically examined and scored. Effective pepsin activity in the gastric juices obtained from the animal model was evaluated by a casein digestion test. Sucralfate and SOS improved the pathology scores in a dose-dependent manner, whereas gastric juice pepsin activity was not impaired by therapeutic doses of SOS. As SOS lacks the ability to form a thick gel layer by polymerisation, we examined the distribution of SOS in the mucosal lumen by imaging mass spectrometry (IMS) to determine whether SOS directly adheres to the mucosal surface. A clear homogeneous thin-layer SOS film (>100 \u03bcm thick) was visualized on the oesophageal mucosal surface. Moreover, this SOS film formation was enhanced at ulcer lesion sites. Taken together, SOS appears to protect oesophageal mucosa against reflux oesophagitis via thin-layer formation on the mucosal surface.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-39087-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis", 
    "pagination": "3559", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1bcad3cc87857e88583b189ab851410e26509d30928919fb30e36d2daa41ec66"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30837505"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-39087-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112543961"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-39087-4", 
      "https://app.dimensions.ai/details/publication/pub.1112543961"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11691_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-39087-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39087-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39087-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39087-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39087-4'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      21 PREDICATES      55 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-39087-4 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nb060472ca16a40bf8a2f8d7d7904c7e3
4 schema:citation sg:pub.10.1007/bf01308368
5 sg:pub.10.1007/s00216-011-4924-4
6 sg:pub.10.1038/srep32361
7 https://app.dimensions.ai/details/publication/pub.1080023858
8 https://app.dimensions.ai/details/publication/pub.1080351742
9 https://app.dimensions.ai/details/publication/pub.1082015465
10 https://app.dimensions.ai/details/publication/pub.1082015466
11 https://app.dimensions.ai/details/publication/pub.1082017732
12 https://doi.org/10.1002/14651858.cd003245.pub3
13 https://doi.org/10.1016/0016-5085(85)90128-3
14 https://doi.org/10.1016/0016-5085(87)91026-2
15 https://doi.org/10.1021/ac970888i
16 https://doi.org/10.1111/j.0953-0673.1996.00441.x
17 https://doi.org/10.1111/j.1365-2036.2005.02654.x
18 https://doi.org/10.1152/ajpgi.1986.251.6.g866
19 https://doi.org/10.1177/147323000403200510
20 https://doi.org/10.1254/jjp.69.317
21 https://doi.org/10.1254/jjp.75.21
22 https://doi.org/10.1371/journal.pone.0017952
23 https://doi.org/10.20524/aog.2017.0187
24 https://doi.org/10.3109/00365528709090959
25 https://doi.org/10.3109/00365529009091919
26 https://doi.org/10.3109/00365529109025024
27 https://doi.org/10.3109/00365529309098293
28 https://doi.org/10.3181/00379727-185-4-rc1
29 https://doi.org/10.5152/tjg.2017.14
30 schema:datePublished 2019-12
31 schema:datePublishedReg 2019-12-01
32 schema:description Sucralfate is effective for the treatment of gastric and duodenal ulcers owing to its protective gel-forming ability. However, the mechanism by which sucralfate protects the oesophageal mucosa against reflux oesophagitis has not been clarified. We aimed to investigate the mechanisms of action of sucralfate and sucrose octasulfate (SOS), a component of sucralfate. SOS and sucralfate were administered to oesophagitis-induced rats, and the ulcer lesion size was macroscopically examined and scored. Effective pepsin activity in the gastric juices obtained from the animal model was evaluated by a casein digestion test. Sucralfate and SOS improved the pathology scores in a dose-dependent manner, whereas gastric juice pepsin activity was not impaired by therapeutic doses of SOS. As SOS lacks the ability to form a thick gel layer by polymerisation, we examined the distribution of SOS in the mucosal lumen by imaging mass spectrometry (IMS) to determine whether SOS directly adheres to the mucosal surface. A clear homogeneous thin-layer SOS film (>100 μm thick) was visualized on the oesophageal mucosal surface. Moreover, this SOS film formation was enhanced at ulcer lesion sites. Taken together, SOS appears to protect oesophageal mucosa against reflux oesophagitis via thin-layer formation on the mucosal surface.
33 schema:genre research_article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N6f8a26c6063c46f8bf00cbe6a983a553
37 N728360f63e5042178f637b34c5bebd85
38 sg:journal.1045337
39 schema:name A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis
40 schema:pagination 3559
41 schema:productId N3b925f1d546a44a68e963281b3204339
42 N7abe5856d3744261885ec5835a33bece
43 N8ac5c18ec9b444d9906a4eaaa9ea3a4d
44 Na5986c8afbd24227a36e9f9a11261635
45 Nde20b24f31564f4db6359a6424475be0
46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112543961
47 https://doi.org/10.1038/s41598-019-39087-4
48 schema:sdDatePublished 2019-04-11T11:16
49 schema:sdLicense https://scigraph.springernature.com/explorer/license/
50 schema:sdPublisher Nd4439c34db2d44919c08477dadd02339
51 schema:url https://www.nature.com/articles/s41598-019-39087-4
52 sgo:license sg:explorer/license/
53 sgo:sdDataset articles
54 rdf:type schema:ScholarlyArticle
55 N1b89ddddbbe74e26b5c9d91aa45907f1 rdf:first N74de6b8a5c4845b991994cd6159c832d
56 rdf:rest rdf:nil
57 N22f863a2fcb14fd6831e5279224c6532 rdf:first Nf48e9466ace24485b844b9c22677c439
58 rdf:rest N1b89ddddbbe74e26b5c9d91aa45907f1
59 N2647ab61b7894a25a4ff39849f7e543e schema:affiliation https://www.grid.ac/institutes/grid.419306.9
60 schema:familyName Tsutsui
61 schema:givenName Takuya
62 rdf:type schema:Person
63 N3b925f1d546a44a68e963281b3204339 schema:name dimensions_id
64 schema:value pub.1112543961
65 rdf:type schema:PropertyValue
66 N516a902afc7349acabe63b68f7200aa3 schema:affiliation https://www.grid.ac/institutes/grid.419306.9
67 schema:familyName Kawasaki
68 schema:givenName Shizuka
69 rdf:type schema:Person
70 N5404159d4c8b4665b4297905f2b2e7b3 rdf:first N2647ab61b7894a25a4ff39849f7e543e
71 rdf:rest Nf9acefd5a4f04c308e38ea8821f76c0c
72 N62041d4bdc7141a89693494eb534a9d8 rdf:first Nda31fc7d3dc14370918c1a824a6d7dac
73 rdf:rest N22f863a2fcb14fd6831e5279224c6532
74 N6f8a26c6063c46f8bf00cbe6a983a553 schema:volumeNumber 9
75 rdf:type schema:PublicationVolume
76 N728360f63e5042178f637b34c5bebd85 schema:issueNumber 1
77 rdf:type schema:PublicationIssue
78 N74de6b8a5c4845b991994cd6159c832d schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
79 schema:familyName Sugiura
80 schema:givenName Yuki
81 rdf:type schema:Person
82 N7abe5856d3744261885ec5835a33bece schema:name nlm_unique_id
83 schema:value 101563288
84 rdf:type schema:PropertyValue
85 N8174ae63daa74e39a0f044124bfe74f9 schema:affiliation https://www.grid.ac/institutes/grid.419306.9
86 schema:familyName Hirayama
87 schema:givenName Yutaka
88 rdf:type schema:Person
89 N83c9c6866bbe465f8f97e77325c24749 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
90 schema:familyName Sugiyama
91 schema:givenName Eiji
92 rdf:type schema:Person
93 N8ac5c18ec9b444d9906a4eaaa9ea3a4d schema:name readcube_id
94 schema:value 1bcad3cc87857e88583b189ab851410e26509d30928919fb30e36d2daa41ec66
95 rdf:type schema:PropertyValue
96 N9c94f4fe66fd4772bd0840564f469bb0 rdf:first Nf86eb318a34f40769ab82263e361d4dc
97 rdf:rest N62041d4bdc7141a89693494eb534a9d8
98 Na5986c8afbd24227a36e9f9a11261635 schema:name pubmed_id
99 schema:value 30837505
100 rdf:type schema:PropertyValue
101 Na8063ef1c6944627994dcb73708087c7 rdf:first N8174ae63daa74e39a0f044124bfe74f9
102 rdf:rest N5404159d4c8b4665b4297905f2b2e7b3
103 Nb060472ca16a40bf8a2f8d7d7904c7e3 rdf:first Nfccf7ac0ee1d441da072b64b2958d3d3
104 rdf:rest Ne94b3f93c5dd4079a3bd41cdfc6eaa83
105 Nd4439c34db2d44919c08477dadd02339 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 Nda31fc7d3dc14370918c1a824a6d7dac schema:affiliation https://www.grid.ac/institutes/grid.419306.9
108 schema:familyName Kon
109 schema:givenName Ryo
110 rdf:type schema:Person
111 Nde20b24f31564f4db6359a6424475be0 schema:name doi
112 schema:value 10.1038/s41598-019-39087-4
113 rdf:type schema:PropertyValue
114 Ne94b3f93c5dd4079a3bd41cdfc6eaa83 rdf:first N516a902afc7349acabe63b68f7200aa3
115 rdf:rest Na8063ef1c6944627994dcb73708087c7
116 Nf48e9466ace24485b844b9c22677c439 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
117 schema:familyName Suematsu
118 schema:givenName Makoto
119 rdf:type schema:Person
120 Nf86eb318a34f40769ab82263e361d4dc schema:affiliation https://www.grid.ac/institutes/grid.419306.9
121 schema:familyName Adachi
122 schema:givenName Kiyo
123 rdf:type schema:Person
124 Nf9acefd5a4f04c308e38ea8821f76c0c rdf:first N83c9c6866bbe465f8f97e77325c24749
125 rdf:rest N9c94f4fe66fd4772bd0840564f469bb0
126 Nfccf7ac0ee1d441da072b64b2958d3d3 schema:affiliation https://www.grid.ac/institutes/grid.419306.9
127 schema:familyName Hayakawa
128 schema:givenName Takuya
129 rdf:type schema:Person
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
134 schema:name Clinical Sciences
135 rdf:type schema:DefinedTerm
136 sg:journal.1045337 schema:issn 2045-2322
137 schema:name Scientific Reports
138 rdf:type schema:Periodical
139 sg:pub.10.1007/bf01308368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006212182
140 https://doi.org/10.1007/bf01308368
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s00216-011-4924-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013794080
143 https://doi.org/10.1007/s00216-011-4924-4
144 rdf:type schema:CreativeWork
145 sg:pub.10.1038/srep32361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016240753
146 https://doi.org/10.1038/srep32361
147 rdf:type schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1080023858 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1080351742 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1082015465 schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1082015466 schema:CreativeWork
152 https://app.dimensions.ai/details/publication/pub.1082017732 schema:CreativeWork
153 https://doi.org/10.1002/14651858.cd003245.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018892533
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/0016-5085(85)90128-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010206057
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/0016-5085(87)91026-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017858989
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1021/ac970888i schema:sameAs https://app.dimensions.ai/details/publication/pub.1010251835
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1111/j.0953-0673.1996.00441.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016381680
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1111/j.1365-2036.2005.02654.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049085512
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1152/ajpgi.1986.251.6.g866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079952882
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1177/147323000403200510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023063305
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1254/jjp.69.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041962798
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1254/jjp.75.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035837201
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1371/journal.pone.0017952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013537570
174 rdf:type schema:CreativeWork
175 https://doi.org/10.20524/aog.2017.0187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091275603
176 rdf:type schema:CreativeWork
177 https://doi.org/10.3109/00365528709090959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048169062
178 rdf:type schema:CreativeWork
179 https://doi.org/10.3109/00365529009091919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017754730
180 rdf:type schema:CreativeWork
181 https://doi.org/10.3109/00365529109025024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015726405
182 rdf:type schema:CreativeWork
183 https://doi.org/10.3109/00365529309098293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034515379
184 rdf:type schema:CreativeWork
185 https://doi.org/10.3181/00379727-185-4-rc1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014574052
186 rdf:type schema:CreativeWork
187 https://doi.org/10.5152/tjg.2017.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093147997
188 rdf:type schema:CreativeWork
189 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
190 schema:name Department of Biochemistry, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan
191 rdf:type schema:Organization
192 https://www.grid.ac/institutes/grid.419306.9 schema:alternateName Lion Corporation (Japan)
193 schema:name Research & Development Headquarters, Analytical Technology Research Center, Lion Corporation, 7-2-1 Hirai, Edogawa-ku, 132-0035, Tokyo, Japan
194 Research & Development Headquarters, Pharmaceutical Research Laboratories, Lion Corporation, 100 Tajima, 256-0811, Odawara, Kanagawa, Japan
195 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...