Molecular mechanism of lysophosphatidic acid-induced hypertensive response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Kuniyuki Kano, Hirotaka Matsumoto, Asuka Inoue, Hiroshi Yukiura, Motomu Kanai, Jerold Chun, Satoshi Ishii, Takao Shimizu, Junken Aoki

ABSTRACT

Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA1-LPA6). LPA was first identified as a vasoactive compound because it induced transient hypertension when injected intravenously in rodents. Here, we examined the molecular mechanism underlying the LPA-induced hypertensive response. The LPA-induced hypertensive response was significantly attenuated by pretreatment with a Rho kinase inhibitor, which blocks Gα12/13 signaling. Consistent with this, the response was weakened in KO mice of LPA4, a Gα12/13-coupling LPA receptor. KO mice of another Gα12/13-coupling LPA receptor, LPA6, also showed an attenuated LPA-induced hypertensive response. However, LPA6 KO mice also displayed attenuated pressor responses to an adrenergic agent and abnormal blood vessel formation. Using several LPA analogs with varied affinity for each LPA receptor, we found a good correlation between the hypertensive and LPA4 agonistic activities. Incubated mouse plasma, which contained abundant LPA, also induced a hypertensive response. Interestingly the response was completely abolished when the plasma was incubated in the presence of an ATX inhibitor. Together, these results indicate that circulating LPA produced by ATX contributes to the elevation of blood pressure through multiple LPA receptors, mainly LPA4. More... »

PAGES

2662

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39041-4

DOI

http://dx.doi.org/10.1038/s41598-019-39041-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112366681

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30804442


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Japan Science and Technology Agency", 
          "id": "https://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan", 
            "AMED-CREST, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan", 
            "AMED-LEAP, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kano", 
        "givenName": "Kuniyuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Hirotaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Science and Technology Agency", 
          "id": "https://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan", 
            "AMED-LEAP, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan", 
            "AMED-PRIME, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Asuka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tohoku University", 
          "id": "https://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yukiura", 
        "givenName": "Hiroshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Synthetic Organic Chemistry Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanai", 
        "givenName": "Motomu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
          "id": "https://www.grid.ac/institutes/grid.479509.6", 
          "name": [
            "Sanford Burnham Prebys Medical Discovery Institute, 92037, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chun", 
        "givenName": "Jerold", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Immunology, Akita University Graduate School of Medicine, 010-8543, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishii", 
        "givenName": "Satoshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Lipid Signaling, National Center for Global Health and Medicine, 162-8655, Shinjuku-ku, Tokyo, Japan", 
            "Lipidomics, Graduate School of Medicine, University of Tokyo, 113-0033, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Takao", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Science and Technology Agency", 
          "id": "https://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan", 
            "AMED-CREST, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan", 
            "AMED-LEAP, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "Junken", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/circresaha.108.180778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000815118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.180778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000815118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001325351", 
          "https://doi.org/10.1038/nmeth.2172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200454065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002976382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.19.6921-6929.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003451211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005480336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0093230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006386742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-03-272443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014761359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0126734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014980027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jb/mvu077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015601651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2008.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016627361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017249703", 
          "https://doi.org/10.1038/nature03505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017249703", 
          "https://doi.org/10.1038/nature03505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e3182a3718f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022466702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e3182a3718f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022466702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2014.11.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024814766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024928332", 
          "https://doi.org/10.1038/nchembio.712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01914651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026803765", 
          "https://doi.org/10.1007/bf01914651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01914651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026803765", 
          "https://doi.org/10.1007/bf01914651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.114.304748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028246760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.114.304748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028246760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02533598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031494615", 
          "https://doi.org/10.1007/bf02533598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2016.12.088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031654277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.d048439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035643469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02533615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044937800", 
          "https://doi.org/10.1007/bf02533615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2013.01.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049779230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205623200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050776771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m605142200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051801189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986708785747562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069161302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4238/2014.february.21.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072392337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074362764", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081575273", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.15252/embj.201696290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085902066"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA1-LPA6). LPA was first identified as a vasoactive compound because it induced transient hypertension when injected intravenously in rodents. Here, we examined the molecular mechanism underlying the LPA-induced hypertensive response. The LPA-induced hypertensive response was significantly attenuated by pretreatment with\u00a0a Rho kinase inhibitor, which blocks G\u03b112/13 signaling. Consistent with this, the response was weakened in KO mice of LPA4, a G\u03b112/13-coupling LPA receptor. KO mice of another G\u03b112/13-coupling LPA receptor, LPA6, also showed an attenuated LPA-induced hypertensive response. However, LPA6 KO mice also displayed attenuated pressor responses to an adrenergic agent and abnormal blood vessel formation. Using several LPA analogs with varied affinity for each LPA receptor, we found a good correlation between the hypertensive and LPA4 agonistic activities. Incubated mouse plasma, which contained abundant LPA, also induced a\u00a0hypertensive response. Interestingly the response was completely abolished when the plasma was incubated in the presence of an ATX inhibitor. Together, these results indicate that circulating LPA produced by ATX contributes to the elevation of blood pressure through multiple LPA receptors, mainly LPA4.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-39041-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5863230", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3625432", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6833834", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Molecular mechanism of lysophosphatidic acid-induced hypertensive response", 
    "pagination": "2662", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ffa89eb83143c09a5fb6a1ddc04f2d44ad2c76d335ed0878864d393b961d18d2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30804442"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-39041-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112366681"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-39041-4", 
      "https://app.dimensions.ai/details/publication/pub.1112366681"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113677_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-39041-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39041-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39041-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39041-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39041-4'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      58 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-39041-4 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N834bbeec40e7441da578a42bd9f14b6d
4 schema:citation sg:pub.10.1007/bf01914651
5 sg:pub.10.1007/bf02533598
6 sg:pub.10.1007/bf02533615
7 sg:pub.10.1038/nature03505
8 sg:pub.10.1038/nchembio.712
9 sg:pub.10.1038/nmeth.2172
10 https://app.dimensions.ai/details/publication/pub.1074362764
11 https://app.dimensions.ai/details/publication/pub.1081575273
12 https://doi.org/10.1002/anie.200454065
13 https://doi.org/10.1016/j.atherosclerosis.2013.01.032
14 https://doi.org/10.1016/j.bbalip.2008.06.005
15 https://doi.org/10.1016/j.bbrc.2016.12.088
16 https://doi.org/10.1016/j.bmcl.2013.01.002
17 https://doi.org/10.1016/j.yexcr.2014.11.020
18 https://doi.org/10.1074/jbc.m205623200
19 https://doi.org/10.1074/jbc.m605142200
20 https://doi.org/10.1093/jb/mvu077
21 https://doi.org/10.1097/fjc.0b013e3182a3718f
22 https://doi.org/10.1128/mcb.22.19.6921-6929.2002
23 https://doi.org/10.1161/atvbaha.114.304748
24 https://doi.org/10.1161/circresaha.108.180778
25 https://doi.org/10.1161/circresaha.115.306532
26 https://doi.org/10.1182/blood-2010-03-272443
27 https://doi.org/10.1194/jlr.d048439
28 https://doi.org/10.1371/journal.pone.0093230
29 https://doi.org/10.1371/journal.pone.0126734
30 https://doi.org/10.15252/embj.201696290
31 https://doi.org/10.2174/092986708785747562
32 https://doi.org/10.4238/2014.february.21.16
33 schema:datePublished 2019-12
34 schema:datePublishedReg 2019-12-01
35 schema:description Lysophosphatidic acid (LPA) is a blood-derived bioactive lipid with numerous biological activities exerted mainly through six defined G protein-coupled receptors (LPA<sub>1</sub>-LPA<sub>6</sub>). LPA was first identified as a vasoactive compound because it induced transient hypertension when injected intravenously in rodents. Here, we examined the molecular mechanism underlying the LPA-induced hypertensive response. The LPA-induced hypertensive response was significantly attenuated by pretreatment with a Rho kinase inhibitor, which blocks Gα<sub>12/13</sub> signaling. Consistent with this, the response was weakened in KO mice of LPA<sub>4</sub>, a Gα<sub>12/13</sub>-coupling LPA receptor. KO mice of another Gα<sub>12/13</sub>-coupling LPA receptor, LPA<sub>6</sub>, also showed an attenuated LPA-induced hypertensive response. However, LPA<sub>6</sub> KO mice also displayed attenuated pressor responses to an adrenergic agent and abnormal blood vessel formation. Using several LPA analogs with varied affinity for each LPA receptor, we found a good correlation between the hypertensive and LPA<sub>4</sub> agonistic activities. Incubated mouse plasma, which contained abundant LPA, also induced a hypertensive response. Interestingly the response was completely abolished when the plasma was incubated in the presence of an ATX inhibitor. Together, these results indicate that circulating LPA produced by ATX contributes to the elevation of blood pressure through multiple LPA receptors, mainly LPA<sub>4</sub>.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N135e2e1149e84f4cab075e56e8694d2d
40 Nc9f64523b1504395867cb5f54e5b6c29
41 sg:journal.1045337
42 schema:name Molecular mechanism of lysophosphatidic acid-induced hypertensive response
43 schema:pagination 2662
44 schema:productId N146a60c01cd7495e9bb9c7b27099f3e1
45 N77713255c1b04f668a6d202142638149
46 N8d6df0b25da742169fe6c157a924ec05
47 Na031091229f94574900a1ee2f8504d23
48 Nd339360ea1414071bb630abd4dba9bdf
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112366681
50 https://doi.org/10.1038/s41598-019-39041-4
51 schema:sdDatePublished 2019-04-11T10:39
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher Nf004d60878e9491c84b75f2b3901d87f
54 schema:url https://www.nature.com/articles/s41598-019-39041-4
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N135e2e1149e84f4cab075e56e8694d2d schema:volumeNumber 9
59 rdf:type schema:PublicationVolume
60 N146a60c01cd7495e9bb9c7b27099f3e1 schema:name dimensions_id
61 schema:value pub.1112366681
62 rdf:type schema:PropertyValue
63 N19f1de760fb341e79556f3750c51d6d1 rdf:first Nf9acba915f334a81a7459492e6506041
64 rdf:rest rdf:nil
65 N1cc3a268bec54009aa67a2082201cba5 rdf:first N9771f110bac54d8a839173031f826938
66 rdf:rest Nf14a4423d4cd4f91b349472fbe00e513
67 N1d880f7251f34530bb3d6ef6231e3b45 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
68 schema:familyName Kano
69 schema:givenName Kuniyuki
70 rdf:type schema:Person
71 N290302cd886e4b5f851a6c36bbb97da1 rdf:first N5d952a6fde824d0f91d1c97cf10a4149
72 rdf:rest Nb1bf4e9372fc495d9407ed2a76552499
73 N2e1e77a8fd7b4d958f48871197d918a6 rdf:first N4cbd7d29c3ea49e296bb149bcab0d78e
74 rdf:rest N99589367d7b34c04a18ec509741f674c
75 N3808c33806624f5da81465817ce0d641 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
76 schema:familyName Ishii
77 schema:givenName Satoshi
78 rdf:type schema:Person
79 N483331c069524abcb145bd88463db4bc schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
80 schema:familyName Kanai
81 schema:givenName Motomu
82 rdf:type schema:Person
83 N4cbd7d29c3ea49e296bb149bcab0d78e schema:affiliation https://www.grid.ac/institutes/grid.479509.6
84 schema:familyName Chun
85 schema:givenName Jerold
86 rdf:type schema:Person
87 N5d952a6fde824d0f91d1c97cf10a4149 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
88 schema:familyName Matsumoto
89 schema:givenName Hirotaka
90 rdf:type schema:Person
91 N71bef506171349c6be8126b7b606b149 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
92 schema:familyName Inoue
93 schema:givenName Asuka
94 rdf:type schema:Person
95 N77713255c1b04f668a6d202142638149 schema:name pubmed_id
96 schema:value 30804442
97 rdf:type schema:PropertyValue
98 N834bbeec40e7441da578a42bd9f14b6d rdf:first N1d880f7251f34530bb3d6ef6231e3b45
99 rdf:rest N290302cd886e4b5f851a6c36bbb97da1
100 N8d6df0b25da742169fe6c157a924ec05 schema:name nlm_unique_id
101 schema:value 101563288
102 rdf:type schema:PropertyValue
103 N9771f110bac54d8a839173031f826938 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
104 schema:familyName Yukiura
105 schema:givenName Hiroshi
106 rdf:type schema:Person
107 N99589367d7b34c04a18ec509741f674c rdf:first N3808c33806624f5da81465817ce0d641
108 rdf:rest Nefd78b500ecb4d909363ce4bfcdbdc28
109 Na031091229f94574900a1ee2f8504d23 schema:name doi
110 schema:value 10.1038/s41598-019-39041-4
111 rdf:type schema:PropertyValue
112 Nb1bf4e9372fc495d9407ed2a76552499 rdf:first N71bef506171349c6be8126b7b606b149
113 rdf:rest N1cc3a268bec54009aa67a2082201cba5
114 Nc9f64523b1504395867cb5f54e5b6c29 schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 Nd339360ea1414071bb630abd4dba9bdf schema:name readcube_id
117 schema:value ffa89eb83143c09a5fb6a1ddc04f2d44ad2c76d335ed0878864d393b961d18d2
118 rdf:type schema:PropertyValue
119 Nd3674e34a9cd4741b2bd1b9e87a3e607 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
120 schema:familyName Shimizu
121 schema:givenName Takao
122 rdf:type schema:Person
123 Nefd78b500ecb4d909363ce4bfcdbdc28 rdf:first Nd3674e34a9cd4741b2bd1b9e87a3e607
124 rdf:rest N19f1de760fb341e79556f3750c51d6d1
125 Nf004d60878e9491c84b75f2b3901d87f schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 Nf14a4423d4cd4f91b349472fbe00e513 rdf:first N483331c069524abcb145bd88463db4bc
128 rdf:rest N2e1e77a8fd7b4d958f48871197d918a6
129 Nf9acba915f334a81a7459492e6506041 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
130 schema:familyName Aoki
131 schema:givenName Junken
132 rdf:type schema:Person
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
137 schema:name Cardiorespiratory Medicine and Haematology
138 rdf:type schema:DefinedTerm
139 sg:grant.3625432 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39041-4
140 rdf:type schema:MonetaryGrant
141 sg:grant.5863230 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39041-4
142 rdf:type schema:MonetaryGrant
143 sg:grant.6833834 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39041-4
144 rdf:type schema:MonetaryGrant
145 sg:journal.1045337 schema:issn 2045-2322
146 schema:name Scientific Reports
147 rdf:type schema:Periodical
148 sg:pub.10.1007/bf01914651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026803765
149 https://doi.org/10.1007/bf01914651
150 rdf:type schema:CreativeWork
151 sg:pub.10.1007/bf02533598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031494615
152 https://doi.org/10.1007/bf02533598
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/bf02533615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044937800
155 https://doi.org/10.1007/bf02533615
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/nature03505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017249703
158 https://doi.org/10.1038/nature03505
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/nchembio.712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024928332
161 https://doi.org/10.1038/nchembio.712
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nmeth.2172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001325351
164 https://doi.org/10.1038/nmeth.2172
165 rdf:type schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1074362764 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1081575273 schema:CreativeWork
168 https://doi.org/10.1002/anie.200454065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002976382
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.atherosclerosis.2013.01.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049779230
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.bbalip.2008.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016627361
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.bbrc.2016.12.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031654277
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.bmcl.2013.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005480336
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.yexcr.2014.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024814766
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1074/jbc.m205623200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050776771
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1074/jbc.m605142200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051801189
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/jb/mvu077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015601651
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1097/fjc.0b013e3182a3718f schema:sameAs https://app.dimensions.ai/details/publication/pub.1022466702
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1128/mcb.22.19.6921-6929.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003451211
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1161/atvbaha.114.304748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028246760
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1161/circresaha.108.180778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000815118
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1161/circresaha.115.306532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343765
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1182/blood-2010-03-272443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014761359
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1194/jlr.d048439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035643469
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1371/journal.pone.0093230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006386742
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1371/journal.pone.0126734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014980027
203 rdf:type schema:CreativeWork
204 https://doi.org/10.15252/embj.201696290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085902066
205 rdf:type schema:CreativeWork
206 https://doi.org/10.2174/092986708785747562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069161302
207 rdf:type schema:CreativeWork
208 https://doi.org/10.4238/2014.february.21.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072392337
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.251924.9 schema:alternateName Akita University
211 schema:name Department of Immunology, Akita University Graduate School of Medicine, 010-8543, Akita, Japan
212 rdf:type schema:Organization
213 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
214 schema:name Department of Lipid Signaling, National Center for Global Health and Medicine, 162-8655, Shinjuku-ku, Tokyo, Japan
215 Lipidomics, Graduate School of Medicine, University of Tokyo, 113-0033, Bunkyo-ku, Tokyo, Japan
216 Synthetic Organic Chemistry Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokyo, 113-0033, Bunkyo-ku, Tokyo, Japan
217 rdf:type schema:Organization
218 https://www.grid.ac/institutes/grid.419082.6 schema:alternateName Japan Science and Technology Agency
219 schema:name AMED-CREST, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan
220 AMED-LEAP, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan
221 AMED-PRIME, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan
222 Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan
223 rdf:type schema:Organization
224 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
225 schema:name Sanford Burnham Prebys Medical Discovery Institute, 92037, La Jolla, CA, USA
226 rdf:type schema:Organization
227 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
228 schema:name Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578, Sendai, Japan
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...