Epigenome-wide association study in peripheral white blood cells involving insulin resistance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ana Arpón, Fermín I. Milagro, Omar Ramos-Lopez, M. Luisa Mansego, José Luis Santos, José-Ignacio Riezu-Boj, J. Alfredo Martínez

ABSTRACT

Insulin resistance (IR) is a hallmark of type 2 diabetes, metabolic syndrome and cardiometabolic risk. An epigenetic phenomena such as DNA methylation might be involved in the onset and development of systemic IR. The aim of this study was to explore the genetic DNA methylation levels in peripheral white blood cells with the objective of identifying epigenetic signatures associated with IR measured by the Homeostatic Model Assessment of IR (HOMA-IR) following an epigenome-wide association study approach. DNA methylation levels were assessed using Infinium Methylation Assay (Illumina), and were associated with HOMA-IR values of participants from the Methyl Epigenome Network Association (MENA) project, finding statistical associations for at least 798 CpGs. A stringent statistical analysis revealed that 478 of them showed a differential methylation pattern between individuals with HOMA-IR ≤ 3 and > 3. ROC curves of top four CpGs out of 478 allowed differentiating individuals between both groups (AUC≈0.88). This study demonstrated the association between DNA methylation in some specific CpGs and HOMA-IR values that will help to the understanding and in the development of new strategies for personalized approaches to predict and prevent IR-associated diseases. More... »

PAGES

2445

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38980-2

DOI

http://dx.doi.org/10.1038/s41598-019-38980-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112286059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30792424


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407 rdf:type schema:Organization
408 https://www.grid.ac/institutes/grid.5924.a schema:alternateName University of Navarra
409 schema:name Navarra Institute for Health Research (IdiSNa), Pamplona, Spain
410 University of Navarra, Department of Nutrition, Food Sciences and Physiology & Centre for Nutrition Research, Pamplona, Spain
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.7870.8 schema:alternateName Pontifical Catholic University of Chile
413 schema:name Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
414 rdf:type schema:Organization
 




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