Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jing Yong, Jide Tian, Hoa Dang, Ting-Ting Wu, Mark A. Atkinson, Ren Sun, Daniel L. Kaufman

ABSTRACT

There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these mice with EGFP-expressing murine herpes virus-68 (MHV68-EGFP) caused occasional transient elevation in their blood glucose, peri-insulitis, and Th1 responses to EGFP which did not spread to other ß-cell antigens. We hypothesized that obesity-related systemic inflammation and ß-cell stress could exacerbate the MHV68-EGFP-induced ß-cell autoreactivity. We crossed MIP-TF mice with Avy mice which develop obesity and provide models of metabolic disease alongside early stage T2D. Unlike their MIP-TF littermates, MHV68-EGFP-infected Avy/MIP-TF mice developed moderate intra-insulitis and transient hyperglycemia. MHV68-EGFP infection induced a more pronounced intra-insulitis in older, more obese, Avy/MIP-TF mice. Moreover, in MHV68-EGFP-infected Avy/MIP-TF mice, Th1 reactivity spread from EGFP to other ß-cell antigens. Thus, the spreading of autoreactivity among ß-cell antigens corresponded with the transition from peri-insulitis to intra-insulitis and occurred in obese Avy/MIP-TF mice but not lean MIP-TF mice. These observations are consistent with the notion that obesity-associated systemic inflammation and ß-cell stress lowers the threshold necessary for T cell autoreactivity to spread from EGFP to other ß-cell autoantigens. More... »

PAGES

4269

References to SciGraph publications

  • 1997-01. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome in NATURE
  • 2018-06. Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study in DIABETOLOGIA
  • 2016-06. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants in DIABETOLOGIA
  • 1999-02. Melanocortin-4 receptor: A novel signalling pathway involved in body weight regulation in INTERNATIONAL JOURNAL OF OBESITY
  • 2002. Regulation of Virally Induced Autoimmunity and Immunopathology: Contribution of LCMV Transgenic Models to Understanding Autoimmune Insulin-Dependent Diabetes Mellitus in ARENAVIRUSES II
  • 2008-05. Identification of the immunodominant CTL epitope of EGFP in C57BL/6 mice in GENE THERAPY
  • 1996-12. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice in NATURE MEDICINE
  • 2001-07. The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes in DIABETOLOGIA
  • 2005-12. The ‘accelerator hypothesis’: relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus in DIABETOLOGIA
  • 2009-10. Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes? in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-38905-z

    DOI

    http://dx.doi.org/10.1038/s41598-019-38905-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112706452

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30862859


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sanford Burnham Prebys Medical Discovery Institute", 
              "id": "https://www.grid.ac/institutes/grid.479509.6", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States", 
                "Sanford-Burnham-Prebys Medical Discovery Institute, 92037, La Jolla, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yong", 
            "givenName": "Jing", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tian", 
            "givenName": "Jide", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dang", 
            "givenName": "Hoa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Ting-Ting", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Florida", 
              "id": "https://www.grid.ac/institutes/grid.15276.37", 
              "name": [
                "Departments of Pathology and Paediatrics, University of Florida Diabetes Institute, 32610, Gainesville, FL, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atkinson", 
            "givenName": "Mark A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Ren", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaufman", 
            "givenName": "Daniel L.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ecl.2010.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000886817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-016-3924-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004045541", 
              "https://doi.org/10.1007/s00125-016-3924-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-016-3924-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004045541", 
              "https://doi.org/10.1007/s00125-016-3924-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-005-0033-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009104369", 
              "https://doi.org/10.1007/s00125-005-0033-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-005-0033-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009104369", 
              "https://doi.org/10.1007/s00125-005-0033-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-005-0033-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009104369", 
              "https://doi.org/10.1007/s00125-005-0033-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(13)60591-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009429353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diacare.26.10.2865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009974496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymthe.2004.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011595286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3303104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011954262", 
              "https://doi.org/10.1038/sj.gt.3303104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.75.19.9262-9273.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013773249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-56055-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015099122", 
              "https://doi.org/10.1007/978-3-642-56055-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-56055-2_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015099122", 
              "https://doi.org/10.1007/978-3-642-56055-2_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diacare.29.02.06.dc05-1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015317220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1296-1348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015991784", 
              "https://doi.org/10.1038/nm1296-1348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db08-0851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016196436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1998.tb01214.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018806263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1464-5491.2007.02203.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019035358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.11.4728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019742256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021684572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci38503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021684572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01152-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022425396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00321.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022745317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80392-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023221956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2012.01151.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025325141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1461-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727186", 
              "https://doi.org/10.1007/s00125-009-1461-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1461-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727186", 
              "https://doi.org/10.1007/s00125-009-1461-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1461-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727186", 
              "https://doi.org/10.1007/s00125-009-1461-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-009-1461-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727186", 
              "https://doi.org/10.1007/s00125-009-1461-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/385165a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028016940", 
              "https://doi.org/10.1038/385165a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1998.tb01207.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028940298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1464-5491.2004.01368.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034135703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-206-43733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036590591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3181/00379727-206-43733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036590591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-7613(94)90101-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040674993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81865-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044272952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045592258", 
              "https://doi.org/10.1038/sj.ijo.0800796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045592258", 
              "https://doi.org/10.1038/sj.ijo.0800796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-5448.2011.00831.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048240314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001250100548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048570619", 
              "https://doi.org/10.1007/s001250100548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001250100548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048570619", 
              "https://doi.org/10.1007/s001250100548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.78.17.9215-9223.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049821643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.peptides.2005.02.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051132685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db10-0907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051444243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2011.01014.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053117913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.147.3662.1145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062484723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db15-1180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070729711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.11.7325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077521281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080324356", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.8.8.8181666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082689812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082831469", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/127.9.1897s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083139030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc16-2331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083841633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc16-2331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083841633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1002362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090935866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-018-4596-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101785725", 
              "https://doi.org/10.1007/s00125-018-4596-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-018-4596-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101785725", 
              "https://doi.org/10.1007/s00125-018-4596-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-018-4596-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101785725", 
              "https://doi.org/10.1007/s00125-018-4596-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose \u00df-cells express enhanced green fluorescent protein (EGFP). Infecting these mice with EGFP-expressing murine herpes virus-68 (MHV68-EGFP) caused occasional transient elevation in their blood glucose, peri-insulitis, and Th1 responses to EGFP which did not spread to other \u00df-cell antigens. We hypothesized that obesity-related systemic inflammation and \u00df-cell stress could exacerbate the MHV68-EGFP-induced \u00df-cell autoreactivity. We crossed MIP-TF mice with Avy mice which develop obesity and provide models of metabolic disease alongside early stage T2D. Unlike their MIP-TF littermates, MHV68-EGFP-infected Avy/MIP-TF mice developed moderate intra-insulitis and transient hyperglycemia. MHV68-EGFP infection induced a more pronounced intra-insulitis in older, more obese, Avy/MIP-TF mice. Moreover, in MHV68-EGFP-infected Avy/MIP-TF mice, Th1 reactivity spread from EGFP to other \u00df-cell antigens. Thus, the spreading of autoreactivity among \u00df-cell antigens corresponded with the transition from peri-insulitis to intra-insulitis and occurred in obese Avy/MIP-TF mice but not lean MIP-TF mice. These observations are consistent with the notion that obesity-associated systemic inflammation and \u00df-cell stress lowers the threshold necessary for T cell autoreactivity to spread from EGFP to other \u00df-cell autoantigens.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-38905-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2500458", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3803761", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2491546", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Increased risk for T cell autoreactivity to \u00df-cell antigens in the mice expressing the Avy obesity-associated gene", 
        "pagination": "4269", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f284f6214c72be04b920f20566d3756e6be52b7b424620fccdf9c145ef6e72a4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30862859"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-38905-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112706452"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-38905-z", 
          "https://app.dimensions.ai/details/publication/pub.1112706452"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78947_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-019-38905-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38905-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38905-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38905-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38905-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    256 TRIPLES      21 PREDICATES      73 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-38905-z schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author Nca83ba2b02824ddeaa16b2ca7f507c63
    4 schema:citation sg:pub.10.1007/978-3-642-56055-2_8
    5 sg:pub.10.1007/s00125-005-0033-2
    6 sg:pub.10.1007/s00125-009-1461-1
    7 sg:pub.10.1007/s00125-016-3924-5
    8 sg:pub.10.1007/s00125-018-4596-0
    9 sg:pub.10.1007/s001250100548
    10 sg:pub.10.1038/385165a0
    11 sg:pub.10.1038/nm1296-1348
    12 sg:pub.10.1038/sj.gt.3303104
    13 sg:pub.10.1038/sj.ijo.0800796
    14 https://app.dimensions.ai/details/publication/pub.1080324356
    15 https://app.dimensions.ai/details/publication/pub.1082831469
    16 https://doi.org/10.1016/1074-7613(94)90101-5
    17 https://doi.org/10.1016/j.ecl.2010.05.011
    18 https://doi.org/10.1016/j.peptides.2005.02.029
    19 https://doi.org/10.1016/j.ymthe.2004.01.008
    20 https://doi.org/10.1016/s0092-8674(00)81865-6
    21 https://doi.org/10.1016/s0140-6736(13)60591-7
    22 https://doi.org/10.1016/s1074-7613(00)80392-1
    23 https://doi.org/10.1073/pnas.92.11.4728
    24 https://doi.org/10.1093/jn/127.9.1897s
    25 https://doi.org/10.1096/fasebj.8.8.8181666
    26 https://doi.org/10.1111/j.1399-5448.2011.00831.x
    27 https://doi.org/10.1111/j.1464-5491.2004.01368.x
    28 https://doi.org/10.1111/j.1464-5491.2007.02203.x
    29 https://doi.org/10.1111/j.1600-065x.1998.tb01207.x
    30 https://doi.org/10.1111/j.1600-065x.1998.tb01214.x
    31 https://doi.org/10.1111/j.1600-065x.2011.01014.x
    32 https://doi.org/10.1111/j.1600-065x.2012.01151.x
    33 https://doi.org/10.1126/science.147.3662.1145
    34 https://doi.org/10.1128/jvi.01152-08
    35 https://doi.org/10.1128/jvi.75.19.9262-9273.2001
    36 https://doi.org/10.1128/jvi.78.17.9215-9223.2004
    37 https://doi.org/10.1152/ajpendo.00321.2002
    38 https://doi.org/10.1172/jci38503
    39 https://doi.org/10.1371/journal.pmed.1002362
    40 https://doi.org/10.2337/db08-0851
    41 https://doi.org/10.2337/db10-0907
    42 https://doi.org/10.2337/db15-1180
    43 https://doi.org/10.2337/dc16-2331
    44 https://doi.org/10.2337/diacare.26.10.2865
    45 https://doi.org/10.2337/diacare.29.02.06.dc05-1339
    46 https://doi.org/10.3181/00379727-206-43733
    47 https://doi.org/10.4049/jimmunol.179.11.7325
    48 schema:datePublished 2019-12
    49 schema:datePublishedReg 2019-12-01
    50 schema:description There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these mice with EGFP-expressing murine herpes virus-68 (MHV68-EGFP) caused occasional transient elevation in their blood glucose, peri-insulitis, and Th1 responses to EGFP which did not spread to other ß-cell antigens. We hypothesized that obesity-related systemic inflammation and ß-cell stress could exacerbate the MHV68-EGFP-induced ß-cell autoreactivity. We crossed MIP-TF mice with A<sup>vy</sup> mice which develop obesity and provide models of metabolic disease alongside early stage T2D. Unlike their MIP-TF littermates, MHV68-EGFP-infected A<sup>vy</sup>/MIP-TF mice developed moderate intra-insulitis and transient hyperglycemia. MHV68-EGFP infection induced a more pronounced intra-insulitis in older, more obese, A<sup>vy</sup>/MIP-TF mice. Moreover, in MHV68-EGFP-infected A<sup>vy</sup>/MIP-TF mice, Th1 reactivity spread from EGFP to other ß-cell antigens. Thus, the spreading of autoreactivity among ß-cell antigens corresponded with the transition from peri-insulitis to intra-insulitis and occurred in obese A<sup>vy</sup>/MIP-TF mice but not lean MIP-TF mice. These observations are consistent with the notion that obesity-associated systemic inflammation and ß-cell stress lowers the threshold necessary for T cell autoreactivity to spread from EGFP to other ß-cell autoantigens.
    51 schema:genre research_article
    52 schema:inLanguage en
    53 schema:isAccessibleForFree true
    54 schema:isPartOf N128dc09446a047af9b7a215760801827
    55 N4a0ec933518342acb2bdca762be0c87e
    56 sg:journal.1045337
    57 schema:name Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene
    58 schema:pagination 4269
    59 schema:productId N09f9d5645c434760ae37a2631f0e3ea0
    60 N14ec3c44229e40fc829fe84448b12333
    61 N8032ed61b12847629bf4e5feb0bcffad
    62 N8f5a64e438994234960cf857971affac
    63 N9376420e6e4d4aad9918b2b9e38ad685
    64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112706452
    65 https://doi.org/10.1038/s41598-019-38905-z
    66 schema:sdDatePublished 2019-04-11T13:18
    67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    68 schema:sdPublisher N4c8b38354acb4491873e4946b828a6d5
    69 schema:url https://www.nature.com/articles/s41598-019-38905-z
    70 sgo:license sg:explorer/license/
    71 sgo:sdDataset articles
    72 rdf:type schema:ScholarlyArticle
    73 N019ee7ba82a84994bd39ce2820f6b0c6 rdf:first N19a05190916b49b995a63caffc39d0cf
    74 rdf:rest Nf2b393864c8242e0a7f9be5bd28f65ca
    75 N09f9d5645c434760ae37a2631f0e3ea0 schema:name nlm_unique_id
    76 schema:value 101563288
    77 rdf:type schema:PropertyValue
    78 N128dc09446a047af9b7a215760801827 schema:volumeNumber 9
    79 rdf:type schema:PublicationVolume
    80 N14ec3c44229e40fc829fe84448b12333 schema:name doi
    81 schema:value 10.1038/s41598-019-38905-z
    82 rdf:type schema:PropertyValue
    83 N1962eee1c5724caab639a4b67419e011 rdf:first Nfe51fdbef6184cf9ab3804b165d4b25e
    84 rdf:rest N42411d4e680143619e66e13f8805a455
    85 N19a05190916b49b995a63caffc39d0cf schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    86 schema:familyName Dang
    87 schema:givenName Hoa
    88 rdf:type schema:Person
    89 N42411d4e680143619e66e13f8805a455 rdf:first Nef7d8ae0584c4d69b3358c91243faf97
    90 rdf:rest rdf:nil
    91 N4a0ec933518342acb2bdca762be0c87e schema:issueNumber 1
    92 rdf:type schema:PublicationIssue
    93 N4c8b38354acb4491873e4946b828a6d5 schema:name Springer Nature - SN SciGraph project
    94 rdf:type schema:Organization
    95 N65d61e236de24470964c26bc4bff4359 rdf:first Ne67d967bacab4a248f2c2cf0a63a172d
    96 rdf:rest N1962eee1c5724caab639a4b67419e011
    97 N8032ed61b12847629bf4e5feb0bcffad schema:name dimensions_id
    98 schema:value pub.1112706452
    99 rdf:type schema:PropertyValue
    100 N8f5a64e438994234960cf857971affac schema:name readcube_id
    101 schema:value f284f6214c72be04b920f20566d3756e6be52b7b424620fccdf9c145ef6e72a4
    102 rdf:type schema:PropertyValue
    103 N9376420e6e4d4aad9918b2b9e38ad685 schema:name pubmed_id
    104 schema:value 30862859
    105 rdf:type schema:PropertyValue
    106 N94ecc11ada4e4c9b8cc40670e0e75615 schema:affiliation https://www.grid.ac/institutes/grid.479509.6
    107 schema:familyName Yong
    108 schema:givenName Jing
    109 rdf:type schema:Person
    110 N9fa5e74c6c49402fa7d49f02d2602fd9 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    111 schema:familyName Tian
    112 schema:givenName Jide
    113 rdf:type schema:Person
    114 Nc4a55bc29691468e984f3b4730febe2e schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    115 schema:familyName Wu
    116 schema:givenName Ting-Ting
    117 rdf:type schema:Person
    118 Nca83ba2b02824ddeaa16b2ca7f507c63 rdf:first N94ecc11ada4e4c9b8cc40670e0e75615
    119 rdf:rest Nd244b1fb4ca74d8a8657407db40b81b6
    120 Nd244b1fb4ca74d8a8657407db40b81b6 rdf:first N9fa5e74c6c49402fa7d49f02d2602fd9
    121 rdf:rest N019ee7ba82a84994bd39ce2820f6b0c6
    122 Ne67d967bacab4a248f2c2cf0a63a172d schema:affiliation https://www.grid.ac/institutes/grid.15276.37
    123 schema:familyName Atkinson
    124 schema:givenName Mark A.
    125 rdf:type schema:Person
    126 Nef7d8ae0584c4d69b3358c91243faf97 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    127 schema:familyName Kaufman
    128 schema:givenName Daniel L.
    129 rdf:type schema:Person
    130 Nf2b393864c8242e0a7f9be5bd28f65ca rdf:first Nc4a55bc29691468e984f3b4730febe2e
    131 rdf:rest N65d61e236de24470964c26bc4bff4359
    132 Nfe51fdbef6184cf9ab3804b165d4b25e schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    133 schema:familyName Sun
    134 schema:givenName Ren
    135 rdf:type schema:Person
    136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Medical and Health Sciences
    138 rdf:type schema:DefinedTerm
    139 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    140 schema:name Immunology
    141 rdf:type schema:DefinedTerm
    142 sg:grant.2491546 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38905-z
    143 rdf:type schema:MonetaryGrant
    144 sg:grant.2500458 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38905-z
    145 rdf:type schema:MonetaryGrant
    146 sg:grant.3803761 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38905-z
    147 rdf:type schema:MonetaryGrant
    148 sg:journal.1045337 schema:issn 2045-2322
    149 schema:name Scientific Reports
    150 rdf:type schema:Periodical
    151 sg:pub.10.1007/978-3-642-56055-2_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015099122
    152 https://doi.org/10.1007/978-3-642-56055-2_8
    153 rdf:type schema:CreativeWork
    154 sg:pub.10.1007/s00125-005-0033-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009104369
    155 https://doi.org/10.1007/s00125-005-0033-2
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1007/s00125-009-1461-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025727186
    158 https://doi.org/10.1007/s00125-009-1461-1
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1007/s00125-016-3924-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004045541
    161 https://doi.org/10.1007/s00125-016-3924-5
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1007/s00125-018-4596-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101785725
    164 https://doi.org/10.1007/s00125-018-4596-0
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1007/s001250100548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048570619
    167 https://doi.org/10.1007/s001250100548
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/385165a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028016940
    170 https://doi.org/10.1038/385165a0
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/nm1296-1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015991784
    173 https://doi.org/10.1038/nm1296-1348
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/sj.gt.3303104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011954262
    176 https://doi.org/10.1038/sj.gt.3303104
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/sj.ijo.0800796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045592258
    179 https://doi.org/10.1038/sj.ijo.0800796
    180 rdf:type schema:CreativeWork
    181 https://app.dimensions.ai/details/publication/pub.1080324356 schema:CreativeWork
    182 https://app.dimensions.ai/details/publication/pub.1082831469 schema:CreativeWork
    183 https://doi.org/10.1016/1074-7613(94)90101-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040674993
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.ecl.2010.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000886817
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.peptides.2005.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051132685
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.ymthe.2004.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011595286
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/s0092-8674(00)81865-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044272952
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/s0140-6736(13)60591-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009429353
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/s1074-7613(00)80392-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023221956
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1073/pnas.92.11.4728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019742256
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1093/jn/127.9.1897s schema:sameAs https://app.dimensions.ai/details/publication/pub.1083139030
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1096/fasebj.8.8.8181666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082689812
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1111/j.1399-5448.2011.00831.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048240314
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1111/j.1464-5491.2004.01368.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034135703
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1111/j.1464-5491.2007.02203.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019035358
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1111/j.1600-065x.1998.tb01207.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028940298
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1111/j.1600-065x.1998.tb01214.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018806263
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1111/j.1600-065x.2011.01014.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053117913
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1111/j.1600-065x.2012.01151.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025325141
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1126/science.147.3662.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062484723
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1128/jvi.01152-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022425396
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1128/jvi.75.19.9262-9273.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013773249
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1128/jvi.78.17.9215-9223.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049821643
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1152/ajpendo.00321.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022745317
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1172/jci38503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021684572
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1371/journal.pmed.1002362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090935866
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.2337/db08-0851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016196436
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.2337/db10-0907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051444243
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.2337/db15-1180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070729711
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.2337/dc16-2331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083841633
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.2337/diacare.26.10.2865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009974496
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.2337/diacare.29.02.06.dc05-1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015317220
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.3181/00379727-206-43733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036590591
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.4049/jimmunol.179.11.7325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077521281
    246 rdf:type schema:CreativeWork
    247 https://www.grid.ac/institutes/grid.15276.37 schema:alternateName University of Florida
    248 schema:name Departments of Pathology and Paediatrics, University of Florida Diabetes Institute, 32610, Gainesville, FL, United States
    249 rdf:type schema:Organization
    250 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
    251 schema:name Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States
    252 rdf:type schema:Organization
    253 https://www.grid.ac/institutes/grid.479509.6 schema:alternateName Sanford Burnham Prebys Medical Discovery Institute
    254 schema:name Department of Molecular and Medical Pharmacology, University of California, 90095-1735, Los Angeles, CA, United States
    255 Sanford-Burnham-Prebys Medical Discovery Institute, 92037, La Jolla, CA, United States
    256 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...