Inheritance of Susceptibility to Malignant Blood Disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Viggo Jønsson, Haneef Awan, Neil D. Jones, Tom B. Johannesen, Bjarni á Steig, Gudrid Andosdottir, Geir E. Tjønnfjord

ABSTRACT

Malignant blood disorders depend on heritable susceptibility genes and occur in familial aggregations. We suggest a model of transgenerational segregation of the susceptibility genes based on the study of malignant blood disorders in Norwegian and Danish families with unrelated parents, and in the inbred Faroese population with related parents. This model, consisting of parental genomic imprinting and mother-son microchimerism, can explain the male predominance in most of the diseases, the predominance of affected parent-offspring when parents are not related, and the different modes of segregation in males and females. The model displays a specific pattern in the distribution of affected relatives for each diagnosis, viz. a characteristic distribution in the pedigrees of family members with malignant blood disorder related to the proband. Three such patterns, each reflecting a specific transgenerational passage, were identified: (1) alterations in the number of affected relatives in paternal lines alone, e.g. in patterns for probands with multiple myeloma; (2) alterations in the number of affected relatives in both paternal and maternal lines for probands with chronic lymphocytic leukemia; and (3) no alterations in the numbers of male and female affected relatives in the parental lines, e.g. for probands with some types of malignant lymphoma. More... »

PAGES

2444

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38879-y

DOI

http://dx.doi.org/10.1038/s41598-019-38879-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112286046

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30792429


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Hematology, Oslo University Hospital, KG Jebsen Center for B cell malignancies P.O. box 4950, Nydalen, NO 0424, Oslo, Norway", 
            "Institute of Clinical Medicine, University of Oslo, P.O. box 4950, Nydalen, NO 0424, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f8nsson", 
        "givenName": "Viggo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Clinical Medicine, University of Oslo, P.O. box 4950, Nydalen, NO 0424, Oslo, Norway", 
            "Department of Research Computing, University of Oslo, P.O. box 1059, Blindern, NO 0316, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Awan", 
        "givenName": "Haneef", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Computer Science, University of Copenhagen, Universitetsparken 5, Building B, DK 2100, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Neil D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Norwegian Cancer Registry, Ullernchausseen 64, NO 0379, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johannesen", 
        "givenName": "Tom B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Hospital of the Faroe Islands, Medical Department, J.C. Svabos g\u00f8ta 1, FO 100, Torshavn, Faroe Islands", 
            "Genetic Biobank of the Faroe Islands, J.C.Svaboe g\u00f8ta 43, FO 100, Torshavn, Faroe Islands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steig", 
        "givenName": "Bjarni \u00e1", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genetic Biobank of the Faroe Islands, J.C.Svaboe g\u00f8ta 43, FO 100, Torshavn, Faroe Islands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andosdottir", 
        "givenName": "Gudrid", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Hematology, Oslo University Hospital, KG Jebsen Center for B cell malignancies P.O. box 4950, Nydalen, NO 0424, Oslo, Norway", 
            "Institute of Clinical Medicine, University of Oslo, P.O. box 4950, Nydalen, NO 0424, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tj\u00f8nnfjord", 
        "givenName": "Geir E.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ajhg.2014.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000537567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-2126(03)00023-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002803500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-2126(03)00023-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002803500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1527-6465(00)80002-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003133139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2013.101378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004686291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428190600555819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006059867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-09-595744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006657351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2014.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007064166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jech.39.1.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008219518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012966904", 
          "https://doi.org/10.1038/nature05918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.13032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013480147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2006.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013497280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015799763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-01-0341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016184200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016996790", 
          "https://doi.org/10.1038/ng.2843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1119541109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017666344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-06-031948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018583352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0891693031000067304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020678648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025826213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026418435", 
          "https://doi.org/10.1038/ng.510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026418435", 
          "https://doi.org/10.1038/ng.510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms10933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026617157", 
          "https://doi.org/10.1038/ncomms10933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms10933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026617157", 
          "https://doi.org/10.1038/ncomms10933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-04-537498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029352117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-12-191676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029721376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2012.48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030025662", 
          "https://doi.org/10.1038/onc.2012.48"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-8051-8_13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032474311", 
          "https://doi.org/10.1007/978-1-4614-8051-8_13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0010065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033630152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.104.036889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035413251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.104.036889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035413251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.104.036889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035413251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0040-5809(75)90012-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037741539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038115678", 
          "https://doi.org/10.1038/nrg2295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.103.021303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038758378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.103.021303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038758378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.b.10013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039056109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428190600647806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039489933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0548-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040496049", 
          "https://doi.org/10.1007/s10549-009-0548-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0548-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040496049", 
          "https://doi.org/10.1007/s10549-009-0548-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0548-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040496049", 
          "https://doi.org/10.1007/s10549-009-0548-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/dyu265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040922800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2008.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041303794", 
          "https://doi.org/10.1038/ejhg.2008.165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2006.09.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043392181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043950703", 
          "https://doi.org/10.1038/ng.696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043950703", 
          "https://doi.org/10.1038/ng.696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046136424", 
          "https://doi.org/10.1038/leu.2013.344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2013.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046136424", 
          "https://doi.org/10.1038/leu.2013.344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2015.1026455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046175104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.6896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047901898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048513460", 
          "https://doi.org/10.1038/ng.626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-1809.1981.tb00339.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050153847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051206493", 
          "https://doi.org/10.1038/sj.leu.2403727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051206493", 
          "https://doi.org/10.1038/sj.leu.2403727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052401784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-02-556399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052522865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminhematol.2013.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053671888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/86.21.1600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059818953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cam.4082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072292048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078045640", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Malignant blood disorders depend on heritable susceptibility genes and occur in familial aggregations. We suggest a model of transgenerational segregation of the susceptibility genes based on the study of malignant blood disorders in Norwegian and Danish families with unrelated parents, and in the inbred Faroese population with related parents. This model, consisting of parental genomic imprinting and mother-son microchimerism, can explain the male predominance in most of the diseases, the predominance of affected parent-offspring when parents are not related, and the different modes of segregation in males and females. The model displays a specific pattern in the distribution of affected relatives for each diagnosis, viz. a characteristic distribution in the pedigrees of family members with malignant blood disorder related to the proband. Three such patterns, each reflecting a specific transgenerational passage, were identified: (1) alterations in the number of affected relatives in paternal lines alone, e.g. in patterns for probands with multiple myeloma; (2) alterations in the number of affected relatives in both paternal and maternal lines for probands with chronic lymphocytic leukemia; and (3) no alterations in the numbers of male and female affected relatives in the parental lines, e.g. for probands with some types of malignant lymphoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-38879-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Inheritance of Susceptibility to Malignant Blood Disorders", 
    "pagination": "2444", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e7bba72660bf75d9e67ca50604088c1cca4ec44ae2a3a49e4bcc66ff26f638f9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30792429"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-38879-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112286046"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-38879-y", 
      "https://app.dimensions.ai/details/publication/pub.1112286046"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113679_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-38879-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38879-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38879-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38879-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38879-y'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      77 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-38879-y schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N73a11dcfd0c64a9a8a015f0e7c697dc7
4 schema:citation sg:pub.10.1007/978-1-4614-8051-8_13
5 sg:pub.10.1007/s10549-009-0548-1
6 sg:pub.10.1038/ejhg.2008.165
7 sg:pub.10.1038/leu.2013.344
8 sg:pub.10.1038/nature05918
9 sg:pub.10.1038/ncomms10933
10 sg:pub.10.1038/ng.2843
11 sg:pub.10.1038/ng.510
12 sg:pub.10.1038/ng.626
13 sg:pub.10.1038/ng.696
14 sg:pub.10.1038/nrg2295
15 sg:pub.10.1038/onc.2012.48
16 sg:pub.10.1038/sj.leu.2403727
17 https://app.dimensions.ai/details/publication/pub.1078045640
18 https://doi.org/10.1002/art.501
19 https://doi.org/10.1002/cncr.20189
20 https://doi.org/10.1002/cyto.b.10013
21 https://doi.org/10.1016/0040-5809(75)90012-x
22 https://doi.org/10.1016/j.ajhg.2014.09.004
23 https://doi.org/10.1016/j.ejca.2012.11.017
24 https://doi.org/10.1016/j.jpedsurg.2006.09.047
25 https://doi.org/10.1016/j.placenta.2006.07.003
26 https://doi.org/10.1016/j.tig.2014.03.003
27 https://doi.org/10.1016/s0145-2126(03)00023-7
28 https://doi.org/10.1016/s1527-6465(00)80002-7
29 https://doi.org/10.1053/j.seminhematol.2013.09.007
30 https://doi.org/10.1073/pnas.1119541109
31 https://doi.org/10.1080/0891693031000067304
32 https://doi.org/10.1080/10428190600555819
33 https://doi.org/10.1080/10428190600647806
34 https://doi.org/10.1093/ije/dyu265
35 https://doi.org/10.1093/jnci/86.21.1600
36 https://doi.org/10.1111/bjh.13032
37 https://doi.org/10.1111/j.1469-1809.1981.tb00339.x
38 https://doi.org/10.1136/jech.39.1.27
39 https://doi.org/10.1182/blood-2004-01-0341
40 https://doi.org/10.1182/blood-2006-06-031948
41 https://doi.org/10.1182/blood-2008-12-191676
42 https://doi.org/10.1182/blood-2014-02-556399
43 https://doi.org/10.1182/blood-2014-09-595744
44 https://doi.org/10.1182/blood-2015-04-537498
45 https://doi.org/10.1200/jco.2007.12.6896
46 https://doi.org/10.1371/journal.pmed.0010065
47 https://doi.org/10.1534/genetics.103.021303
48 https://doi.org/10.1534/genetics.104.036889
49 https://doi.org/10.3109/0284186x.2015.1026455
50 https://doi.org/10.3324/haematol.2013.101378
51 https://doi.org/10.4161/cam.4082
52 schema:datePublished 2019-12
53 schema:datePublishedReg 2019-12-01
54 schema:description Malignant blood disorders depend on heritable susceptibility genes and occur in familial aggregations. We suggest a model of transgenerational segregation of the susceptibility genes based on the study of malignant blood disorders in Norwegian and Danish families with unrelated parents, and in the inbred Faroese population with related parents. This model, consisting of parental genomic imprinting and mother-son microchimerism, can explain the male predominance in most of the diseases, the predominance of affected parent-offspring when parents are not related, and the different modes of segregation in males and females. The model displays a specific pattern in the distribution of affected relatives for each diagnosis, viz. a characteristic distribution in the pedigrees of family members with malignant blood disorder related to the proband. Three such patterns, each reflecting a specific transgenerational passage, were identified: (1) alterations in the number of affected relatives in paternal lines alone, e.g. in patterns for probands with multiple myeloma; (2) alterations in the number of affected relatives in both paternal and maternal lines for probands with chronic lymphocytic leukemia; and (3) no alterations in the numbers of male and female affected relatives in the parental lines, e.g. for probands with some types of malignant lymphoma.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N17ad229ba35649c994da0ac729d308a0
59 N18ef49fcf3dd48f0b1d191d4470c7ed7
60 sg:journal.1045337
61 schema:name Inheritance of Susceptibility to Malignant Blood Disorders
62 schema:pagination 2444
63 schema:productId N3ef8e8a5d6cb4cda996d879954473a56
64 N438bd46368f14de6928cd7179db9331c
65 N68d84d56862e4712bbcb6cc139156a5c
66 N7c48e53865eb496b8aed4d3d3db50845
67 Ndc36e6bf191e48d5b03ef761ef328792
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112286046
69 https://doi.org/10.1038/s41598-019-38879-y
70 schema:sdDatePublished 2019-04-11T10:40
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N180ebaa546a048c18020d445f7dad306
73 schema:url https://www.nature.com/articles/s41598-019-38879-y
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N00a6a0f25023445a9270bcef54191c77 schema:name Norwegian Cancer Registry, Ullernchausseen 64, NO 0379, Oslo, Norway
78 rdf:type schema:Organization
79 N00ed6fed926d429fa86f4c37f19703d2 schema:affiliation Nd0176b01cb8b43df8ccd14e1a14fbeae
80 schema:familyName Awan
81 schema:givenName Haneef
82 rdf:type schema:Person
83 N17ad229ba35649c994da0ac729d308a0 schema:issueNumber 1
84 rdf:type schema:PublicationIssue
85 N180ebaa546a048c18020d445f7dad306 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N18ef49fcf3dd48f0b1d191d4470c7ed7 schema:volumeNumber 9
88 rdf:type schema:PublicationVolume
89 N2d9fcb0453ad4901af469638fb37453f schema:name Genetic Biobank of the Faroe Islands, J.C.Svaboe gøta 43, FO 100, Torshavn, Faroe Islands
90 National Hospital of the Faroe Islands, Medical Department, J.C. Svabos gøta 1, FO 100, Torshavn, Faroe Islands
91 rdf:type schema:Organization
92 N2eb1fbae32354efc9fde5ff2d2c409fa rdf:first N380267a03f6042e4baced118bef61407
93 rdf:rest Na2f46244a32047ddbf64a6eb21d1edc6
94 N380267a03f6042e4baced118bef61407 schema:affiliation N2d9fcb0453ad4901af469638fb37453f
95 schema:familyName Steig
96 schema:givenName Bjarni á
97 rdf:type schema:Person
98 N3ef8e8a5d6cb4cda996d879954473a56 schema:name dimensions_id
99 schema:value pub.1112286046
100 rdf:type schema:PropertyValue
101 N438bd46368f14de6928cd7179db9331c schema:name readcube_id
102 schema:value e7bba72660bf75d9e67ca50604088c1cca4ec44ae2a3a49e4bcc66ff26f638f9
103 rdf:type schema:PropertyValue
104 N49026176df494c9ab2fa70694f607566 rdf:first Na1f7fc67e1da4454bcc6dced78397b0f
105 rdf:rest rdf:nil
106 N66776809f31548589ed7482bbb45544b schema:affiliation Nbe78d33b5f5b4ca1aaba5f6f492299a5
107 schema:familyName Andosdottir
108 schema:givenName Gudrid
109 rdf:type schema:Person
110 N68d84d56862e4712bbcb6cc139156a5c schema:name pubmed_id
111 schema:value 30792429
112 rdf:type schema:PropertyValue
113 N73a11dcfd0c64a9a8a015f0e7c697dc7 rdf:first Nc00dbec013c143b688fee87d894c3afe
114 rdf:rest Na58de804471b4c0fa209d533d98b70ee
115 N7c48e53865eb496b8aed4d3d3db50845 schema:name nlm_unique_id
116 schema:value 101563288
117 rdf:type schema:PropertyValue
118 N8446bdaf5111472f9dafe842add34a84 rdf:first Ned9c53184b934aeeb883400038548be9
119 rdf:rest N2eb1fbae32354efc9fde5ff2d2c409fa
120 N9503a3658c8f4760a74db4e4e40b878a schema:affiliation https://www.grid.ac/institutes/grid.5254.6
121 schema:familyName Jones
122 schema:givenName Neil D.
123 rdf:type schema:Person
124 Na1f7fc67e1da4454bcc6dced78397b0f schema:affiliation https://www.grid.ac/institutes/grid.55325.34
125 schema:familyName Tjønnfjord
126 schema:givenName Geir E.
127 rdf:type schema:Person
128 Na2f46244a32047ddbf64a6eb21d1edc6 rdf:first N66776809f31548589ed7482bbb45544b
129 rdf:rest N49026176df494c9ab2fa70694f607566
130 Na58de804471b4c0fa209d533d98b70ee rdf:first N00ed6fed926d429fa86f4c37f19703d2
131 rdf:rest Nd728c6f332024d0ea6691bc4090ccab2
132 Nbe78d33b5f5b4ca1aaba5f6f492299a5 schema:name Genetic Biobank of the Faroe Islands, J.C.Svaboe gøta 43, FO 100, Torshavn, Faroe Islands
133 rdf:type schema:Organization
134 Nc00dbec013c143b688fee87d894c3afe schema:affiliation https://www.grid.ac/institutes/grid.55325.34
135 schema:familyName Jønsson
136 schema:givenName Viggo
137 rdf:type schema:Person
138 Nd0176b01cb8b43df8ccd14e1a14fbeae schema:name Department of Research Computing, University of Oslo, P.O. box 1059, Blindern, NO 0316, Oslo, Norway
139 Institute of Clinical Medicine, University of Oslo, P.O. box 4950, Nydalen, NO 0424, Oslo, Norway
140 rdf:type schema:Organization
141 Nd728c6f332024d0ea6691bc4090ccab2 rdf:first N9503a3658c8f4760a74db4e4e40b878a
142 rdf:rest N8446bdaf5111472f9dafe842add34a84
143 Ndc36e6bf191e48d5b03ef761ef328792 schema:name doi
144 schema:value 10.1038/s41598-019-38879-y
145 rdf:type schema:PropertyValue
146 Ned9c53184b934aeeb883400038548be9 schema:affiliation N00a6a0f25023445a9270bcef54191c77
147 schema:familyName Johannesen
148 schema:givenName Tom B.
149 rdf:type schema:Person
150 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
151 schema:name Biological Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
154 schema:name Genetics
155 rdf:type schema:DefinedTerm
156 sg:journal.1045337 schema:issn 2045-2322
157 schema:name Scientific Reports
158 rdf:type schema:Periodical
159 sg:pub.10.1007/978-1-4614-8051-8_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032474311
160 https://doi.org/10.1007/978-1-4614-8051-8_13
161 rdf:type schema:CreativeWork
162 sg:pub.10.1007/s10549-009-0548-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040496049
163 https://doi.org/10.1007/s10549-009-0548-1
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/ejhg.2008.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041303794
166 https://doi.org/10.1038/ejhg.2008.165
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/leu.2013.344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046136424
169 https://doi.org/10.1038/leu.2013.344
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/nature05918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012966904
172 https://doi.org/10.1038/nature05918
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/ncomms10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026617157
175 https://doi.org/10.1038/ncomms10933
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/ng.2843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016996790
178 https://doi.org/10.1038/ng.2843
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/ng.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026418435
181 https://doi.org/10.1038/ng.510
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/ng.626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048513460
184 https://doi.org/10.1038/ng.626
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/ng.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043950703
187 https://doi.org/10.1038/ng.696
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nrg2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038115678
190 https://doi.org/10.1038/nrg2295
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/onc.2012.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030025662
193 https://doi.org/10.1038/onc.2012.48
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/sj.leu.2403727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051206493
196 https://doi.org/10.1038/sj.leu.2403727
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1078045640 schema:CreativeWork
199 https://doi.org/10.1002/art.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052401784
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/cncr.20189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025826213
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/cyto.b.10013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039056109
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0040-5809(75)90012-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037741539
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.ajhg.2014.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000537567
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.ejca.2012.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015799763
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jpedsurg.2006.09.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043392181
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.placenta.2006.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013497280
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.tig.2014.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007064166
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0145-2126(03)00023-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002803500
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s1527-6465(00)80002-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003133139
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1053/j.seminhematol.2013.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053671888
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.1119541109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017666344
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1080/0891693031000067304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678648
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1080/10428190600555819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006059867
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1080/10428190600647806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039489933
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/ije/dyu265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040922800
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/jnci/86.21.1600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059818953
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/bjh.13032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013480147
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1469-1809.1981.tb00339.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050153847
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1136/jech.39.1.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008219518
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1182/blood-2004-01-0341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016184200
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1182/blood-2006-06-031948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018583352
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1182/blood-2008-12-191676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029721376
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1182/blood-2014-02-556399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052522865
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1182/blood-2014-09-595744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006657351
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1182/blood-2015-04-537498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029352117
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.2007.12.6896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047901898
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1371/journal.pmed.0010065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033630152
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1534/genetics.103.021303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038758378
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1534/genetics.104.036889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035413251
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3109/0284186x.2015.1026455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046175104
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3324/haematol.2013.101378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004686291
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4161/cam.4082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072292048
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
268 schema:name Department of Computer Science, University of Copenhagen, Universitetsparken 5, Building B, DK 2100, Copenhagen, Denmark
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
271 schema:name Department of Hematology, Oslo University Hospital, KG Jebsen Center for B cell malignancies P.O. box 4950, Nydalen, NO 0424, Oslo, Norway
272 Institute of Clinical Medicine, University of Oslo, P.O. box 4950, Nydalen, NO 0424, Oslo, Norway
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...