Within-Host Genomic Diversity of Candida albicans in Healthy Carriers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-22

AUTHORS

Emilie Sitterlé, Corinne Maufrais, Natacha Sertour, Matthieu Palayret, Christophe d’Enfert, Marie-Elisabeth Bougnoux

ABSTRACT

Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome. More... »

PAGES

2563

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4

DOI

http://dx.doi.org/10.1038/s41598-019-38768-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112308322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30796326


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Candida albicans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multilocus Sequence Typing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Whole Genome Sequencing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France", 
            "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sitterl\u00e9", 
        "givenName": "Emilie", 
        "id": "sg:person.01014722353.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014722353.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maufrais", 
        "givenName": "Corinne", 
        "id": "sg:person.01222524374.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222524374.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sertour", 
        "givenName": "Natacha", 
        "id": "sg:person.01042247474.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042247474.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biology, Ecole Polytechnique, Palaiseau, France", 
          "id": "http://www.grid.ac/institutes/grid.10877.39", 
          "name": [
            "Department of Biology, Ecole Polytechnique, Palaiseau, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palayret", 
        "givenName": "Matthieu", 
        "id": "sg:person.01272440722.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272440722.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "d\u2019Enfert", 
        "givenName": "Christophe", 
        "id": "sg:person.0760564474.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760564474.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
            "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bougnoux", 
        "givenName": "Marie-Elisabeth", 
        "id": "sg:person.01173731273.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173731273.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.2710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038078657", 
          "https://doi.org/10.1038/ng.2710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-4-r52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009532125", 
          "https://doi.org/10.1186/gb-2007-8-4-r52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037466562", 
          "https://doi.org/10.1038/nature08064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2017.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083733670", 
          "https://doi.org/10.1038/mi.2017.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-014-0100-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033872730", 
          "https://doi.org/10.1186/s13073-014-0100-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010198201", 
          "https://doi.org/10.1038/ng.2737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034023273", 
          "https://doi.org/10.1038/nature11865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature17625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046748950", 
          "https://doi.org/10.1038/nature17625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep22989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024195483", 
          "https://doi.org/10.1038/srep22989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12281-014-0181-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033142173", 
          "https://doi.org/10.1007/s12281-014-0181-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-04787-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104381188", 
          "https://doi.org/10.1038/s41467-018-04787-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-22", 
    "datePublishedReg": "2019-02-22", 
    "description": "Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-019-38768-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "genomic diversity", 
      "genome sequencing", 
      "multilocus sequencing typing", 
      "C. albicans genome", 
      "numerous single nucleotide polymorphisms", 
      "major fungal pathogen", 
      "host genomic diversity", 
      "whole-genome sequencing", 
      "genetic diversity", 
      "genomic variation", 
      "single nucleotide polymorphisms", 
      "predominant lifestyle", 
      "fungal pathogens", 
      "C. albicans", 
      "heterozygosity events", 
      "Candida albicans", 
      "stress conditions", 
      "rapid adaptation", 
      "different stresses", 
      "single human individual", 
      "nucleotide polymorphisms", 
      "diversity", 
      "sequencing", 
      "subsequent adaptation", 
      "single individual", 
      "short-range loss", 
      "C. albicans oral isolates", 
      "isolates", 
      "sequencing typing", 
      "albicans", 
      "genome", 
      "lineages", 
      "yeast", 
      "commensalism", 
      "adaptation", 
      "human individuals", 
      "humans", 
      "pathogens", 
      "human carriage", 
      "stress exposure", 
      "oral isolates", 
      "polymorphism", 
      "experimental infection", 
      "occasional differences", 
      "individuals", 
      "evolution", 
      "stress", 
      "manipulation", 
      "exposure", 
      "variation", 
      "healthy individuals", 
      "loss", 
      "typing", 
      "events", 
      "study", 
      "differences", 
      "infection", 
      "healthy carriers", 
      "extent", 
      "lifestyle", 
      "conditions", 
      "longitudinal study", 
      "results", 
      "carriers", 
      "carriage", 
      "interpretation"
    ], 
    "name": "Within-Host Genomic Diversity of Candida albicans in Healthy Carriers", 
    "pagination": "2563", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112308322"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-38768-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30796326"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-38768-4", 
      "https://app.dimensions.ai/details/publication/pub.1112308322"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_808.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-019-38768-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      111 URIs      92 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-38768-4 schema:about N068beca0489a4cfabfc5a161b8e533ce
2 N132cf9926c7243148e8bb6ff2b0cec0e
3 N56cff5585e0b43598f97f2f3aa306afd
4 N787cf8b2c86d4837bb60da7079c47d42
5 N7c881f342c6b40698742d3fe770993fd
6 N91c0089f607940feaaf576c19506b0ba
7 Na594cf84ee1547a2addcaa93f7a78ea2
8 Nda851f6e0f5b45dfbbd3e46add96cc00
9 Ne41deebe57754560ab2d6fc403f28fb3
10 anzsrc-for:06
11 anzsrc-for:0604
12 schema:author Nfee5aad26c4842149f1e78a637f3065f
13 schema:citation sg:pub.10.1007/s12281-014-0181-2
14 sg:pub.10.1038/mi.2017.2
15 sg:pub.10.1038/nature08064
16 sg:pub.10.1038/nature11865
17 sg:pub.10.1038/nature17625
18 sg:pub.10.1038/ng.2710
19 sg:pub.10.1038/ng.2737
20 sg:pub.10.1038/s41467-018-04787-4
21 sg:pub.10.1038/srep22989
22 sg:pub.10.1186/gb-2007-8-4-r52
23 sg:pub.10.1186/s13073-014-0100-8
24 schema:datePublished 2019-02-22
25 schema:datePublishedReg 2019-02-22
26 schema:description Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome.
27 schema:genre article
28 schema:isAccessibleForFree true
29 schema:isPartOf N0d7526a4450a4bb19cbe9e5af162920b
30 N0dd83359c73d4b2cb6d09ab98b37f57f
31 sg:journal.1045337
32 schema:keywords C. albicans
33 C. albicans genome
34 C. albicans oral isolates
35 Candida albicans
36 adaptation
37 albicans
38 carriage
39 carriers
40 commensalism
41 conditions
42 differences
43 different stresses
44 diversity
45 events
46 evolution
47 experimental infection
48 exposure
49 extent
50 fungal pathogens
51 genetic diversity
52 genome
53 genome sequencing
54 genomic diversity
55 genomic variation
56 healthy carriers
57 healthy individuals
58 heterozygosity events
59 host genomic diversity
60 human carriage
61 human individuals
62 humans
63 individuals
64 infection
65 interpretation
66 isolates
67 lifestyle
68 lineages
69 longitudinal study
70 loss
71 major fungal pathogen
72 manipulation
73 multilocus sequencing typing
74 nucleotide polymorphisms
75 numerous single nucleotide polymorphisms
76 occasional differences
77 oral isolates
78 pathogens
79 polymorphism
80 predominant lifestyle
81 rapid adaptation
82 results
83 sequencing
84 sequencing typing
85 short-range loss
86 single human individual
87 single individual
88 single nucleotide polymorphisms
89 stress
90 stress conditions
91 stress exposure
92 study
93 subsequent adaptation
94 typing
95 variation
96 whole-genome sequencing
97 yeast
98 schema:name Within-Host Genomic Diversity of Candida albicans in Healthy Carriers
99 schema:pagination 2563
100 schema:productId N61d78e79faa04377b00170c6e6051e9c
101 N9e0b48f47b02467aa836a6dbe5ee1b29
102 Nacc23c713143459f9476a1f5a3357f6a
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112308322
104 https://doi.org/10.1038/s41598-019-38768-4
105 schema:sdDatePublished 2022-12-01T06:39
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N3d7206188d444d4cb264aa986d5c5c3c
108 schema:url https://doi.org/10.1038/s41598-019-38768-4
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N068beca0489a4cfabfc5a161b8e533ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Adult
114 rdf:type schema:DefinedTerm
115 N0d7526a4450a4bb19cbe9e5af162920b schema:issueNumber 1
116 rdf:type schema:PublicationIssue
117 N0dd83359c73d4b2cb6d09ab98b37f57f schema:volumeNumber 9
118 rdf:type schema:PublicationVolume
119 N132cf9926c7243148e8bb6ff2b0cec0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Multilocus Sequence Typing
121 rdf:type schema:DefinedTerm
122 N1ffee80fbac3405ba1702ef6e45dee77 rdf:first sg:person.01222524374.72
123 rdf:rest Nbc08eb69c90b4cccb1e4dd27c6eb4c5e
124 N3d7206188d444d4cb264aa986d5c5c3c schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N56cff5585e0b43598f97f2f3aa306afd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N61d78e79faa04377b00170c6e6051e9c schema:name doi
130 schema:value 10.1038/s41598-019-38768-4
131 rdf:type schema:PropertyValue
132 N660db6ebce304e96ae58e841ff439a51 rdf:first sg:person.01173731273.36
133 rdf:rest rdf:nil
134 N787cf8b2c86d4837bb60da7079c47d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Whole Genome Sequencing
136 rdf:type schema:DefinedTerm
137 N7c881f342c6b40698742d3fe770993fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Polymorphism, Single Nucleotide
139 rdf:type schema:DefinedTerm
140 N91c0089f607940feaaf576c19506b0ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 N9e0b48f47b02467aa836a6dbe5ee1b29 schema:name dimensions_id
144 schema:value pub.1112308322
145 rdf:type schema:PropertyValue
146 Na594cf84ee1547a2addcaa93f7a78ea2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 Nacc23c713143459f9476a1f5a3357f6a schema:name pubmed_id
150 schema:value 30796326
151 rdf:type schema:PropertyValue
152 Nb09f6a1e981942c7a6d4bececb484828 rdf:first sg:person.01272440722.42
153 rdf:rest Nc450669a4ba647208fdea44a089d8fb9
154 Nbc08eb69c90b4cccb1e4dd27c6eb4c5e rdf:first sg:person.01042247474.20
155 rdf:rest Nb09f6a1e981942c7a6d4bececb484828
156 Nc450669a4ba647208fdea44a089d8fb9 rdf:first sg:person.0760564474.73
157 rdf:rest N660db6ebce304e96ae58e841ff439a51
158 Nda851f6e0f5b45dfbbd3e46add96cc00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Candida albicans
160 rdf:type schema:DefinedTerm
161 Ne41deebe57754560ab2d6fc403f28fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Phylogeny
163 rdf:type schema:DefinedTerm
164 Nfee5aad26c4842149f1e78a637f3065f rdf:first sg:person.01014722353.17
165 rdf:rest N1ffee80fbac3405ba1702ef6e45dee77
166 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biological Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
170 schema:name Genetics
171 rdf:type schema:DefinedTerm
172 sg:journal.1045337 schema:issn 2045-2322
173 schema:name Scientific Reports
174 schema:publisher Springer Nature
175 rdf:type schema:Periodical
176 sg:person.01014722353.17 schema:affiliation grid-institutes:grid.412134.1
177 schema:familyName Sitterlé
178 schema:givenName Emilie
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014722353.17
180 rdf:type schema:Person
181 sg:person.01042247474.20 schema:affiliation grid-institutes:None
182 schema:familyName Sertour
183 schema:givenName Natacha
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042247474.20
185 rdf:type schema:Person
186 sg:person.01173731273.36 schema:affiliation grid-institutes:grid.412134.1
187 schema:familyName Bougnoux
188 schema:givenName Marie-Elisabeth
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173731273.36
190 rdf:type schema:Person
191 sg:person.01222524374.72 schema:affiliation grid-institutes:grid.428999.7
192 schema:familyName Maufrais
193 schema:givenName Corinne
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222524374.72
195 rdf:type schema:Person
196 sg:person.01272440722.42 schema:affiliation grid-institutes:grid.10877.39
197 schema:familyName Palayret
198 schema:givenName Matthieu
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272440722.42
200 rdf:type schema:Person
201 sg:person.0760564474.73 schema:affiliation grid-institutes:None
202 schema:familyName d’Enfert
203 schema:givenName Christophe
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760564474.73
205 rdf:type schema:Person
206 sg:pub.10.1007/s12281-014-0181-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033142173
207 https://doi.org/10.1007/s12281-014-0181-2
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/mi.2017.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083733670
210 https://doi.org/10.1038/mi.2017.2
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nature08064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037466562
213 https://doi.org/10.1038/nature08064
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nature11865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034023273
216 https://doi.org/10.1038/nature11865
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nature17625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046748950
219 https://doi.org/10.1038/nature17625
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/ng.2710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038078657
222 https://doi.org/10.1038/ng.2710
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ng.2737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010198201
225 https://doi.org/10.1038/ng.2737
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/s41467-018-04787-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104381188
228 https://doi.org/10.1038/s41467-018-04787-4
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/srep22989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024195483
231 https://doi.org/10.1038/srep22989
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/gb-2007-8-4-r52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009532125
234 https://doi.org/10.1186/gb-2007-8-4-r52
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/s13073-014-0100-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033872730
237 https://doi.org/10.1186/s13073-014-0100-8
238 rdf:type schema:CreativeWork
239 grid-institutes:None schema:alternateName Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
240 schema:name Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
241 rdf:type schema:Organization
242 grid-institutes:grid.10877.39 schema:alternateName Department of Biology, Ecole Polytechnique, Palaiseau, France
243 schema:name Department of Biology, Ecole Polytechnique, Palaiseau, France
244 rdf:type schema:Organization
245 grid-institutes:grid.412134.1 schema:alternateName Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
246 schema:name Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
247 Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
248 Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France
249 rdf:type schema:Organization
250 grid-institutes:grid.428999.7 schema:alternateName Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France
251 schema:name Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...