Within-Host Genomic Diversity of Candida albicans in Healthy Carriers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Emilie Sitterlé, Corinne Maufrais, Natacha Sertour, Matthieu Palayret, Christophe d’Enfert, Marie-Elisabeth Bougnoux

ABSTRACT

Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome. More... »

PAGES

2563

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4

DOI

http://dx.doi.org/10.1038/s41598-019-38768-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112308322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30796326


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Necker-Enfants Malades Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France", 
            "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sitterl\u00e9", 
        "givenName": "Emilie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maufrais", 
        "givenName": "Corinne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sertour", 
        "givenName": "Natacha", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u00c9cole Polytechnique", 
          "id": "https://www.grid.ac/institutes/grid.10877.39", 
          "name": [
            "Department of Biology, Ecole Polytechnique, Palaiseau, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palayret", 
        "givenName": "Matthieu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "d\u2019Enfert", 
        "givenName": "Christophe", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Necker-Enfants Malades Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France", 
            "Unit\u00e9 de Parasitologie-Mycologie, Service de Microbiologie clinique, H\u00f4pital Necker-Enfants-Malades, Assistance Publique des H\u00f4pitaux de Paris (APHP), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bougnoux", 
        "givenName": "Marie-Elisabeth", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/ec.00387-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003196030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/313455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003870138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004323358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1005152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005550339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.00129-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005774504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00934-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007393778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/femsyr/fow020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007428178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-4-r52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009532125", 
          "https://doi.org/10.1186/gb-2007-8-4-r52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010198201", 
          "https://doi.org/10.1038/ng.2737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03852.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010471221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fgb.2008.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012720473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00151-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014122988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.41.11.5265-5266.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014626032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.109.103325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019025950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.109.103325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019025950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.44.5.1810-1820.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019108115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0060110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019820837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2015.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020187291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023014918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00941-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023528238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.115.178020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023829693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.115.178020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023829693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep22989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024195483", 
          "https://doi.org/10.1038/srep22989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1315399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024608276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0401648101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027194079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1567-1364.2008.00438.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028496411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030084615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.11.5601-5613.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030655876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.174623.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030767921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jit389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030900194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.107524.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032096953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01532-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032205404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijmm.2007.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032577889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diagmicrobio.2005.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032763735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.00662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032893657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12281-014-0181-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033142173", 
          "https://doi.org/10.1007/s12281-014-0181-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-014-0100-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033872730", 
          "https://doi.org/10.1186/s13073-014-0100-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13073-014-0100-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033872730", 
          "https://doi.org/10.1186/s13073-014-0100-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034023273", 
          "https://doi.org/10.1038/nature11865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00041-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034422388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.48.6.2223-2227.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037431504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037466562", 
          "https://doi.org/10.1038/nature08064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037466562", 
          "https://doi.org/10.1038/nature08064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038078657", 
          "https://doi.org/10.1038/ng.2710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10156-013-0626-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038576465", 
          "https://doi.org/10.1007/s10156-013-0626-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02153-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038871519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2004.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045046028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/1040841x.2013.813904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045200652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature17625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046748950", 
          "https://doi.org/10.1038/nature17625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/mmi.12471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047267386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048317157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00060-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049379691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-294x.2012.05484.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051038146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051914035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053228451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mmy/myw128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059912147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00221287-143-5-1765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060369490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a019604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1128242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1128242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.01109-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062727395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074551641", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082979644", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.41.7.1488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083112643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.41.7.1488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083112643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2017.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083733670", 
          "https://doi.org/10.1038/mi.2017.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7717/peerj.2997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083855010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2017.00556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084652323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0180246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090305687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.117.300295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091787327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.117.300295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091787327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.117.300295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091787327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mib.2017.10.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092828438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/pathogens7010011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100509472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.118.301019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103797183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-04787-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104381188", 
          "https://doi.org/10.1038/s41467-018-04787-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2018.01179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104393863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1806002115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106367778"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-38768-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Within-Host Genomic Diversity of Candida albicans in Healthy Carriers", 
    "pagination": "2563", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1992581d59e2eeb5671a3a995ba8d888d0ca2d522b289373caf4246c5268a16f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30796326"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-38768-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112308322"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-38768-4", 
      "https://app.dimensions.ai/details/publication/pub.1112308322"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113667_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-38768-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38768-4'


 

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      21 PREDICATES      99 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-38768-4 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nbd641bf6668f4b22865bdc627d0d3338
4 schema:citation sg:pub.10.1007/s10156-013-0626-5
5 sg:pub.10.1007/s12281-014-0181-2
6 sg:pub.10.1038/mi.2017.2
7 sg:pub.10.1038/nature08064
8 sg:pub.10.1038/nature11865
9 sg:pub.10.1038/nature17625
10 sg:pub.10.1038/ng.2710
11 sg:pub.10.1038/ng.2737
12 sg:pub.10.1038/s41467-018-04787-4
13 sg:pub.10.1038/srep22989
14 sg:pub.10.1186/gb-2007-8-4-r52
15 sg:pub.10.1186/s13073-014-0100-8
16 https://app.dimensions.ai/details/publication/pub.1074551641
17 https://app.dimensions.ai/details/publication/pub.1082979644
18 https://doi.org/10.1016/j.diagmicrobio.2005.03.013
19 https://doi.org/10.1016/j.fgb.2008.11.005
20 https://doi.org/10.1016/j.ijmm.2007.11.002
21 https://doi.org/10.1016/j.mib.2004.06.003
22 https://doi.org/10.1016/j.mib.2015.06.017
23 https://doi.org/10.1016/j.mib.2017.10.030
24 https://doi.org/10.1046/j.1365-2958.2003.03852.x
25 https://doi.org/10.1056/nejmra1315399
26 https://doi.org/10.1073/pnas.0401648101
27 https://doi.org/10.1073/pnas.1806002115
28 https://doi.org/10.1086/313455
29 https://doi.org/10.1093/bioinformatics/btp352
30 https://doi.org/10.1093/emboj/cdg235
31 https://doi.org/10.1093/femsyr/fow020
32 https://doi.org/10.1093/infdis/jit389
33 https://doi.org/10.1093/mmy/myw128
34 https://doi.org/10.1093/nar/gkt1046
35 https://doi.org/10.1099/00221287-143-5-1765
36 https://doi.org/10.1101/cshperspect.a019604
37 https://doi.org/10.1101/gr.107524.110
38 https://doi.org/10.1101/gr.174623.114
39 https://doi.org/10.1111/j.1365-294x.2012.05484.x
40 https://doi.org/10.1111/j.1567-1364.2008.00438.x
41 https://doi.org/10.1111/mmi.12471
42 https://doi.org/10.1126/science.1128242
43 https://doi.org/10.1128/aac.41.7.1488
44 https://doi.org/10.1128/aac.48.6.2223-2227.2004
45 https://doi.org/10.1128/ec.00041-07
46 https://doi.org/10.1128/ec.00060-10
47 https://doi.org/10.1128/ec.00151-07
48 https://doi.org/10.1128/ec.00387-08
49 https://doi.org/10.1128/jcm.00934-06
50 https://doi.org/10.1128/jcm.00941-11
51 https://doi.org/10.1128/jcm.01532-12
52 https://doi.org/10.1128/jcm.02153-10
53 https://doi.org/10.1128/jcm.41.11.5265-5266.2003
54 https://doi.org/10.1128/jcm.43.11.5601-5613.2005
55 https://doi.org/10.1128/jcm.44.5.1810-1820.2006
56 https://doi.org/10.1128/mbio.00129-11
57 https://doi.org/10.1128/mbio.01109-16
58 https://doi.org/10.1371/journal.pbio.0060110
59 https://doi.org/10.1371/journal.pgen.1000705
60 https://doi.org/10.1371/journal.pgen.1005152
61 https://doi.org/10.1371/journal.pone.0066019
62 https://doi.org/10.1371/journal.pone.0180246
63 https://doi.org/10.1371/journal.ppat.1000713
64 https://doi.org/10.1534/genetics.109.103325
65 https://doi.org/10.1534/genetics.115.178020
66 https://doi.org/10.1534/genetics.117.300295
67 https://doi.org/10.1534/genetics.118.301019
68 https://doi.org/10.3109/1040841x.2013.813904
69 https://doi.org/10.3389/fmicb.2017.00556
70 https://doi.org/10.3389/fmicb.2018.01179
71 https://doi.org/10.3390/pathogens7010011
72 https://doi.org/10.7554/elife.00662
73 https://doi.org/10.7717/peerj.2997
74 schema:datePublished 2019-12
75 schema:datePublishedReg 2019-12-01
76 schema:description Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N75864ba4122c4b39a76a45e6ef28a6f8
81 N81be35452fc64a65bd60edb33be30063
82 sg:journal.1045337
83 schema:name Within-Host Genomic Diversity of Candida albicans in Healthy Carriers
84 schema:pagination 2563
85 schema:productId N1d159abc1af04ef4b56c9e42d3e8ab16
86 N410f4d8a4c8247949977fbdc6ac0e3af
87 N6207412794e749f8b0800687074aca9c
88 N7e26632f6b01497ba0992510bd29ffe1
89 Nd1ef69fb6fcc40248d9f0f7607e8117f
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112308322
91 https://doi.org/10.1038/s41598-019-38768-4
92 schema:sdDatePublished 2019-04-11T10:35
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Ncbb4ff6a2112461a936915d6d4bdf906
95 schema:url https://www.nature.com/articles/s41598-019-38768-4
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N04506c17d8b54b6fb903d7219f1d7b80 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
100 schema:familyName Sitterlé
101 schema:givenName Emilie
102 rdf:type schema:Person
103 N0d7450796f044eb0bccb4c2486f6d833 rdf:first N0f4b9a45d0f04c129b8ddee2c4aaaca5
104 rdf:rest N87a77ae707e5442dbfe00c0f60856b53
105 N0f4b9a45d0f04c129b8ddee2c4aaaca5 schema:affiliation Nba231af274ab46058250407396163407
106 schema:familyName Sertour
107 schema:givenName Natacha
108 rdf:type schema:Person
109 N1d159abc1af04ef4b56c9e42d3e8ab16 schema:name doi
110 schema:value 10.1038/s41598-019-38768-4
111 rdf:type schema:PropertyValue
112 N375682afd1684a4397928eb1cd8d7ece schema:affiliation https://www.grid.ac/institutes/grid.428999.7
113 schema:familyName Maufrais
114 schema:givenName Corinne
115 rdf:type schema:Person
116 N410f4d8a4c8247949977fbdc6ac0e3af schema:name readcube_id
117 schema:value 1992581d59e2eeb5671a3a995ba8d888d0ca2d522b289373caf4246c5268a16f
118 rdf:type schema:PropertyValue
119 N6207412794e749f8b0800687074aca9c schema:name dimensions_id
120 schema:value pub.1112308322
121 rdf:type schema:PropertyValue
122 N644477474abc45b582f283dba1108b63 rdf:first N375682afd1684a4397928eb1cd8d7ece
123 rdf:rest N0d7450796f044eb0bccb4c2486f6d833
124 N6caf8c68a0864ef5858fbc70a25d03eb schema:affiliation https://www.grid.ac/institutes/grid.10877.39
125 schema:familyName Palayret
126 schema:givenName Matthieu
127 rdf:type schema:Person
128 N707126f5b7b6426fa02a54b9996d0f57 rdf:first Na3c1903a36bf4d75ad383efe38f39a82
129 rdf:rest N7f1ac1407ac649c3b9ab40a4cff15e3d
130 N75864ba4122c4b39a76a45e6ef28a6f8 schema:volumeNumber 9
131 rdf:type schema:PublicationVolume
132 N7e26632f6b01497ba0992510bd29ffe1 schema:name pubmed_id
133 schema:value 30796326
134 rdf:type schema:PropertyValue
135 N7f1ac1407ac649c3b9ab40a4cff15e3d rdf:first Nf4cf5114f6af4e37926726fd39c73934
136 rdf:rest rdf:nil
137 N81be35452fc64a65bd60edb33be30063 schema:issueNumber 1
138 rdf:type schema:PublicationIssue
139 N87a77ae707e5442dbfe00c0f60856b53 rdf:first N6caf8c68a0864ef5858fbc70a25d03eb
140 rdf:rest N707126f5b7b6426fa02a54b9996d0f57
141 Na3c1903a36bf4d75ad383efe38f39a82 schema:affiliation Nc9868a6ec53841a986cc21bb5820493b
142 schema:familyName d’Enfert
143 schema:givenName Christophe
144 rdf:type schema:Person
145 Nba231af274ab46058250407396163407 schema:name Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
146 rdf:type schema:Organization
147 Nbd641bf6668f4b22865bdc627d0d3338 rdf:first N04506c17d8b54b6fb903d7219f1d7b80
148 rdf:rest N644477474abc45b582f283dba1108b63
149 Nc9868a6ec53841a986cc21bb5820493b schema:name Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
150 rdf:type schema:Organization
151 Ncbb4ff6a2112461a936915d6d4bdf906 schema:name Springer Nature - SN SciGraph project
152 rdf:type schema:Organization
153 Nd1ef69fb6fcc40248d9f0f7607e8117f schema:name nlm_unique_id
154 schema:value 101563288
155 rdf:type schema:PropertyValue
156 Nf4cf5114f6af4e37926726fd39c73934 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
157 schema:familyName Bougnoux
158 schema:givenName Marie-Elisabeth
159 rdf:type schema:Person
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
164 schema:name Genetics
165 rdf:type schema:DefinedTerm
166 sg:journal.1045337 schema:issn 2045-2322
167 schema:name Scientific Reports
168 rdf:type schema:Periodical
169 sg:pub.10.1007/s10156-013-0626-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576465
170 https://doi.org/10.1007/s10156-013-0626-5
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/s12281-014-0181-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033142173
173 https://doi.org/10.1007/s12281-014-0181-2
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/mi.2017.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083733670
176 https://doi.org/10.1038/mi.2017.2
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nature08064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037466562
179 https://doi.org/10.1038/nature08064
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nature11865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034023273
182 https://doi.org/10.1038/nature11865
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nature17625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046748950
185 https://doi.org/10.1038/nature17625
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/ng.2710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038078657
188 https://doi.org/10.1038/ng.2710
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/ng.2737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010198201
191 https://doi.org/10.1038/ng.2737
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/s41467-018-04787-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104381188
194 https://doi.org/10.1038/s41467-018-04787-4
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/srep22989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024195483
197 https://doi.org/10.1038/srep22989
198 rdf:type schema:CreativeWork
199 sg:pub.10.1186/gb-2007-8-4-r52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009532125
200 https://doi.org/10.1186/gb-2007-8-4-r52
201 rdf:type schema:CreativeWork
202 sg:pub.10.1186/s13073-014-0100-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033872730
203 https://doi.org/10.1186/s13073-014-0100-8
204 rdf:type schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1074551641 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1082979644 schema:CreativeWork
207 https://doi.org/10.1016/j.diagmicrobio.2005.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032763735
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.fgb.2008.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012720473
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.ijmm.2007.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032577889
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.mib.2004.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045046028
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.mib.2015.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020187291
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.mib.2017.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092828438
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1365-2958.2003.03852.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010471221
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejmra1315399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024608276
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.0401648101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027194079
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.1806002115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106367778
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1086/313455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003870138
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/emboj/cdg235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004323358
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/femsyr/fow020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007428178
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/infdis/jit389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030900194
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1093/mmy/myw128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059912147
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/nar/gkt1046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030084615
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1099/00221287-143-5-1765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060369490
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1101/cshperspect.a019604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407001
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1101/gr.174623.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767921
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1365-294x.2012.05484.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051038146
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1567-1364.2008.00438.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028496411
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/mmi.12471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047267386
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1126/science.1128242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453845
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1128/aac.41.7.1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083112643
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1128/aac.48.6.2223-2227.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037431504
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/ec.00041-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034422388
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/ec.00060-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049379691
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1128/ec.00151-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014122988
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1128/ec.00387-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003196030
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1128/jcm.00934-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007393778
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1128/jcm.00941-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023528238
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1128/jcm.01532-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032205404
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1128/jcm.02153-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038871519
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1128/jcm.41.11.5265-5266.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014626032
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1128/jcm.43.11.5601-5613.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030655876
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1128/jcm.44.5.1810-1820.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019108115
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1128/mbio.00129-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005774504
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1128/mbio.01109-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062727395
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1371/journal.pbio.0060110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019820837
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1371/journal.pgen.1000705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053228451
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1371/journal.pgen.1005152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005550339
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1371/journal.pone.0066019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048317157
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1371/journal.pone.0180246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090305687
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1371/journal.ppat.1000713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051914035
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1534/genetics.109.103325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019025950
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1534/genetics.115.178020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023829693
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1534/genetics.117.300295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091787327
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1534/genetics.118.301019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103797183
306 rdf:type schema:CreativeWork
307 https://doi.org/10.3109/1040841x.2013.813904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045200652
308 rdf:type schema:CreativeWork
309 https://doi.org/10.3389/fmicb.2017.00556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084652323
310 rdf:type schema:CreativeWork
311 https://doi.org/10.3389/fmicb.2018.01179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104393863
312 rdf:type schema:CreativeWork
313 https://doi.org/10.3390/pathogens7010011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100509472
314 rdf:type schema:CreativeWork
315 https://doi.org/10.7554/elife.00662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032893657
316 rdf:type schema:CreativeWork
317 https://doi.org/10.7717/peerj.2997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083855010
318 rdf:type schema:CreativeWork
319 https://www.grid.ac/institutes/grid.10877.39 schema:alternateName École Polytechnique
320 schema:name Department of Biology, Ecole Polytechnique, Palaiseau, France
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.412134.1 schema:alternateName Necker-Enfants Malades Hospital
323 schema:name Fungal Biology and Pathogenicity Unit, Department of Mycology, Institut Pasteur, INRA, Paris, France
324 Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
325 Université Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, Paris, France
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
328 schema:name Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur, Paris, France
329 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...