Translocation of promoter-conserved hatching enzyme genes with intron-loss provides a new insight in the role of retrocopy during teleostean evolution View Full Text


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Article Info

DATE

2019-12

AUTHORS

Tatsuki Nagasawa, Mari Kawaguchi, Tohru Yano, Sho Isoyama, Shigeki Yasumasu, Masataka Okabe

ABSTRACT

The hatcing enzyme gene (HE) encodes a protease that is indispensable for the hatching process and is conserved during vertebrate evolution. During teleostean evolution, it is known that HE experienced a drastic transfiguration of gene structure, namely, losing all of its introns. However, these facts are contradiction with each other, since intron-less genes typically lose their original promoter because of duplication via mature mRNA, called retrocopy. Here, using a comparative genomic assay, we showed that HEs have changed their genomic location several times, with the evolutionary timings of these translocations being identical to those of intron-loss. We further showed that HEs maintain the promoter sequence upstream of them after translocation. Therefore, teleostean HEs are unique genes which have changed intra- (exon-intron) and extra-genomic structure (genomic loci) several times, although their indispensability for the reproductive process of hatching implies that HE genes are translocated by retrocopy with their promoter sequence. More... »

PAGES

2448

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    9

    Author Affiliations

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-38693-6

    DOI

    http://dx.doi.org/10.1038/s41598-019-38693-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112286030

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30792427


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