Aurora A controls CD8+ T cell cytotoxic activity and antiviral response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Eugenio Bustos-Morán, Noelia Blas-Rus, Ana Alcaraz-Serna, Salvador Iborra, José González-Martínez, Marcos Malumbres, Francisco Sánchez-Madrid

ABSTRACT

Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4+ T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8+ T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8+ T cells. This finding was similarly proven for both mice and human CD8+ CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activation of genes classically related to the effector function of cytotoxic T lymphocytes such as granzyme B or perforin1. Finally, we have found that Aurora A is necessary for CD8+ T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection. Thus, we can conclude that Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats. More... »

PAGES

2211

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38647-y

DOI

http://dx.doi.org/10.1038/s41598-019-38647-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112199172

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30778113


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