Ex Vivo1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Omkar B. Ijare, David S. Baskin, Kumar Pichumani

ABSTRACT

Pituitary adenomas (PAs) are benign growths arising from epithelial cells in the adenohypophysis of the pituitary gland. To date, there has been no detailed metabolic characterization of PAs of various subtypes. In this study, we report nuclear magnetic resonance (NMR) based metabolomic analysis of surgically resected tumors from forty five pituitary tumor patients [gonadotropic (LH/FSH-secreting) = 17; prolactinomas (PRL-secreting) = 11, Cushing's disease (ACTH-secreting) = 4, non-functional = 5, and mixed = 8] who underwent transsphenoidal selective adenomectomy. Compared to LH/FSH-secreting tumors, PRL-secreting tumors showed statistically significant decrease in the levels of N-acetylaspartate (NAA), myo-inositol (mI), scyllo-inositol (sI), glycine, taurine, phosphoethanolamine (PE) and increase in the levels of glutamine. When compared with LH/FSH-secreting tumors, ACTH-secreting tumors showed statistically significant decrease in the levels of sI, glycine, PE and increase in the levels of aspartate. Although lipid extracts of PAs showed the presence of many common lipid molecules, only glycerophosphoethanolamine (GPE) showed statistically significant decrease in PRL, ACTH and non-functional subtypes when compared to LH/FSH-secreting tumors. Changes observed in these metabolite concentrations among various subtypes of PAs reflect metabolic heterogeneity in these tumors and may pave the way towards the development of metabolic markers to distinguish various immunohistochemical subtypes of PAs. More... »

PAGES

3007

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-38542-6

DOI

http://dx.doi.org/10.1038/s41598-019-38542-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112437754

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30816132


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ijare", 
        "givenName": "Omkar B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX, USA", 
            "Weill Cornell Medical College, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baskin", 
        "givenName": "David S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX, USA", 
            "Weill Cornell Medical College, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pichumani", 
        "givenName": "Kumar", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2006.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005636252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(81)90045-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006418713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11745-006-5007-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009717920", 
          "https://doi.org/10.1007/s11745-006-5007-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1492(199701)10:1<2::aid-nbm442>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011033702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00430697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013131092", 
          "https://doi.org/10.1007/bf00430697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.76.11.5741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016962006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00873976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018811705", 
          "https://doi.org/10.1007/bf00873976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-13-1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020194890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023612837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1940060116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023743377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910350210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026176547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032265127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-008-9698-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044534109", 
          "https://doi.org/10.1007/s11060-008-9698-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1523306113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047415600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-016-1985-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048781360", 
          "https://doi.org/10.1007/s11064-016-1985-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-016-1985-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048781360", 
          "https://doi.org/10.1007/s11064-016-1985-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpba.2010.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052045464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m115.703959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058214366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns/2008/109/8/0306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082543415", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082771801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.wneu.2017.04.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085090917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1873-3468.12743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090380368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-14559-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092352942", 
          "https://doi.org/10.1038/s41598-017-14559-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0203379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106834883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0203379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106834883"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Pituitary adenomas (PAs) are benign growths arising from epithelial cells in the adenohypophysis of the pituitary gland. To date, there has been no detailed metabolic characterization of PAs of various subtypes. In this study, we report nuclear magnetic resonance (NMR) based metabolomic analysis of surgically resected tumors from forty five pituitary tumor patients [gonadotropic (LH/FSH-secreting)\u2009=\u200917; prolactinomas (PRL-secreting)\u2009=\u200911, Cushing's disease (ACTH-secreting)\u2009=\u20094, non-functional\u2009=\u20095, and mixed\u2009=\u20098] who underwent transsphenoidal selective adenomectomy. Compared to LH/FSH-secreting tumors, PRL-secreting tumors showed statistically significant decrease in the levels of N-acetylaspartate (NAA), myo-inositol (mI), scyllo-inositol (sI), glycine, taurine, phosphoethanolamine (PE) and increase in the levels of glutamine. When compared with LH/FSH-secreting tumors, ACTH-secreting tumors showed statistically significant decrease in the levels of sI, glycine, PE and increase in the levels of aspartate. Although lipid extracts of PAs showed the presence of many common lipid molecules, only glycerophosphoethanolamine (GPE) showed statistically significant decrease in PRL, ACTH and non-functional subtypes when compared to LH/FSH-secreting tumors. Changes observed in these metabolite concentrations among various subtypes of PAs reflect metabolic heterogeneity in these tumors and may pave the way towards the development of metabolic markers to distinguish various immunohistochemical subtypes of PAs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-38542-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Ex Vivo1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes", 
    "pagination": "3007", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "82ff5f5679d828db133c472f6299d92ebab0da0e5d5f6dcd90c2f79f0a918181"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30816132"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-38542-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112437754"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-38542-6", 
      "https://app.dimensions.ai/details/publication/pub.1112437754"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60369_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-38542-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38542-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38542-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38542-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38542-6'


 

This table displays all metadata directly associated to this object as RDF triples.

159 TRIPLES      21 PREDICATES      53 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-38542-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Na24dd4eb75c7445980ef13845ce802b3
4 schema:citation sg:pub.10.1007/bf00430697
5 sg:pub.10.1007/bf00873976
6 sg:pub.10.1007/s11060-008-9698-y
7 sg:pub.10.1007/s11064-016-1985-y
8 sg:pub.10.1007/s11745-006-5007-8
9 sg:pub.10.1038/s41598-017-14559-7
10 https://app.dimensions.ai/details/publication/pub.1082543415
11 https://app.dimensions.ai/details/publication/pub.1082771801
12 https://doi.org/10.1002/(sici)1099-1492(199701)10:1<2::aid-nbm442>3.0.co;2-n
13 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v
14 https://doi.org/10.1002/1873-3468.12743
15 https://doi.org/10.1002/mrm.1910350210
16 https://doi.org/10.1002/nbm.1940060116
17 https://doi.org/10.1002/nbm.740
18 https://doi.org/10.1016/0014-4827(81)90045-8
19 https://doi.org/10.1016/j.jpba.2010.05.028
20 https://doi.org/10.1016/j.pneurobio.2006.12.003
21 https://doi.org/10.1016/j.wneu.2017.04.128
22 https://doi.org/10.1073/pnas.1523306113
23 https://doi.org/10.1073/pnas.76.11.5741
24 https://doi.org/10.1074/jbc.m115.703959
25 https://doi.org/10.1371/journal.pone.0203379
26 https://doi.org/10.1530/eje-13-1031
27 https://doi.org/10.3171/jns/2008/109/8/0306
28 schema:datePublished 2019-12
29 schema:datePublishedReg 2019-12-01
30 schema:description Pituitary adenomas (PAs) are benign growths arising from epithelial cells in the adenohypophysis of the pituitary gland. To date, there has been no detailed metabolic characterization of PAs of various subtypes. In this study, we report nuclear magnetic resonance (NMR) based metabolomic analysis of surgically resected tumors from forty five pituitary tumor patients [gonadotropic (LH/FSH-secreting) = 17; prolactinomas (PRL-secreting) = 11, Cushing's disease (ACTH-secreting) = 4, non-functional = 5, and mixed = 8] who underwent transsphenoidal selective adenomectomy. Compared to LH/FSH-secreting tumors, PRL-secreting tumors showed statistically significant decrease in the levels of N-acetylaspartate (NAA), myo-inositol (mI), scyllo-inositol (sI), glycine, taurine, phosphoethanolamine (PE) and increase in the levels of glutamine. When compared with LH/FSH-secreting tumors, ACTH-secreting tumors showed statistically significant decrease in the levels of sI, glycine, PE and increase in the levels of aspartate. Although lipid extracts of PAs showed the presence of many common lipid molecules, only glycerophosphoethanolamine (GPE) showed statistically significant decrease in PRL, ACTH and non-functional subtypes when compared to LH/FSH-secreting tumors. Changes observed in these metabolite concentrations among various subtypes of PAs reflect metabolic heterogeneity in these tumors and may pave the way towards the development of metabolic markers to distinguish various immunohistochemical subtypes of PAs.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf N190ce137316546ba8614302fb4748319
35 Ndbc191bacfec4cc08c978079abf285e0
36 sg:journal.1045337
37 schema:name Ex Vivo1H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes
38 schema:pagination 3007
39 schema:productId N2d8a094647a34039b7c1afd77576e649
40 N3b43ac6bcc8f4e49906dee178f1629f8
41 N545ec2b99c04412b961764390e7e3c8d
42 N741a7e85b7834067ad093dd55649a130
43 Nd53fb6681bf3467686f1cbb70ac049e4
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112437754
45 https://doi.org/10.1038/s41598-019-38542-6
46 schema:sdDatePublished 2019-04-11T11:05
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher Ncc5dafeb284647278770fd01fe16b24a
49 schema:url https://www.nature.com/articles/s41598-019-38542-6
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N03757ae73c9642e6b0a8bf6450ee34e5 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
54 schema:familyName Ijare
55 schema:givenName Omkar B.
56 rdf:type schema:Person
57 N056d82f50bc2465cb2acac27a3c304f0 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
58 schema:familyName Baskin
59 schema:givenName David S.
60 rdf:type schema:Person
61 N190ce137316546ba8614302fb4748319 schema:issueNumber 1
62 rdf:type schema:PublicationIssue
63 N2d8a094647a34039b7c1afd77576e649 schema:name pubmed_id
64 schema:value 30816132
65 rdf:type schema:PropertyValue
66 N3b43ac6bcc8f4e49906dee178f1629f8 schema:name nlm_unique_id
67 schema:value 101563288
68 rdf:type schema:PropertyValue
69 N545ec2b99c04412b961764390e7e3c8d schema:name readcube_id
70 schema:value 82ff5f5679d828db133c472f6299d92ebab0da0e5d5f6dcd90c2f79f0a918181
71 rdf:type schema:PropertyValue
72 N741a7e85b7834067ad093dd55649a130 schema:name doi
73 schema:value 10.1038/s41598-019-38542-6
74 rdf:type schema:PropertyValue
75 Na24dd4eb75c7445980ef13845ce802b3 rdf:first N03757ae73c9642e6b0a8bf6450ee34e5
76 rdf:rest Ne3b46472c90e44079cea3e16d0db5bce
77 Ncc5dafeb284647278770fd01fe16b24a schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 Nd53fb6681bf3467686f1cbb70ac049e4 schema:name dimensions_id
80 schema:value pub.1112437754
81 rdf:type schema:PropertyValue
82 Nd92a1a896faf4d7e8b66dee190381b41 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
83 schema:familyName Pichumani
84 schema:givenName Kumar
85 rdf:type schema:Person
86 Ndb49fe9575bc4b3cb59a5169a7ac88be rdf:first Nd92a1a896faf4d7e8b66dee190381b41
87 rdf:rest rdf:nil
88 Ndbc191bacfec4cc08c978079abf285e0 schema:volumeNumber 9
89 rdf:type schema:PublicationVolume
90 Ne3b46472c90e44079cea3e16d0db5bce rdf:first N056d82f50bc2465cb2acac27a3c304f0
91 rdf:rest Ndb49fe9575bc4b3cb59a5169a7ac88be
92 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
93 schema:name Medical and Health Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
96 schema:name Clinical Sciences
97 rdf:type schema:DefinedTerm
98 sg:journal.1045337 schema:issn 2045-2322
99 schema:name Scientific Reports
100 rdf:type schema:Periodical
101 sg:pub.10.1007/bf00430697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013131092
102 https://doi.org/10.1007/bf00430697
103 rdf:type schema:CreativeWork
104 sg:pub.10.1007/bf00873976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018811705
105 https://doi.org/10.1007/bf00873976
106 rdf:type schema:CreativeWork
107 sg:pub.10.1007/s11060-008-9698-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1044534109
108 https://doi.org/10.1007/s11060-008-9698-y
109 rdf:type schema:CreativeWork
110 sg:pub.10.1007/s11064-016-1985-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048781360
111 https://doi.org/10.1007/s11064-016-1985-y
112 rdf:type schema:CreativeWork
113 sg:pub.10.1007/s11745-006-5007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009717920
114 https://doi.org/10.1007/s11745-006-5007-8
115 rdf:type schema:CreativeWork
116 sg:pub.10.1038/s41598-017-14559-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092352942
117 https://doi.org/10.1038/s41598-017-14559-7
118 rdf:type schema:CreativeWork
119 https://app.dimensions.ai/details/publication/pub.1082543415 schema:CreativeWork
120 https://app.dimensions.ai/details/publication/pub.1082771801 schema:CreativeWork
121 https://doi.org/10.1002/(sici)1099-1492(199701)10:1<2::aid-nbm442>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1011033702
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1032265127
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1002/1873-3468.12743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090380368
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1002/mrm.1910350210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026176547
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1002/nbm.1940060116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023743377
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1002/nbm.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023612837
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1016/0014-4827(81)90045-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006418713
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1016/j.jpba.2010.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052045464
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/j.pneurobio.2006.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005636252
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/j.wneu.2017.04.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085090917
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1073/pnas.1523306113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047415600
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1073/pnas.76.11.5741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016962006
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1074/jbc.m115.703959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058214366
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1371/journal.pone.0203379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106834883
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1530/eje-13-1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020194890
150 rdf:type schema:CreativeWork
151 https://doi.org/10.3171/jns/2008/109/8/0306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083812
152 rdf:type schema:CreativeWork
153 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
154 schema:name Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX, USA
155 Weill Cornell Medical College, New York, NY, USA
156 rdf:type schema:Organization
157 https://www.grid.ac/institutes/grid.63368.38 schema:alternateName Houston Methodist
158 schema:name Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston Methodist Hospital and Research Institute, Houston, TX, USA
159 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...