See-through observation of malaria parasite behaviors in the mosquito vector View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Toshiyuki Mori, Makoto Hirai, Toshihiro Mita

ABSTRACT

Although it is known that malaria parasites proliferate in the midgut of mosquito vector, their detailed behaviors, from gamete maturation to formation of next generation sporozoite, have not been fully understood at cellular or molecular level. This is mainly attributed to technical difficulties of dissection and whole-mount observation, of delicate and opaque mosquito body contents. In addition, blood pigment surrounding parasites immediately after blood meal also complicates tracing mosquito-stage parasites. Recent revolutionary studies have overcome such negative factors in tissue observation by clearing organisms. CUBIC reagents succeeded to remove both light scattering and blood pigment from various mouse tissues, and to whole-organ image fluorescence-labeled cell structures. In this study, we utilized the advanced version of CUBIC technology and high sensitivity fluorescent markers for see-through observation of mosquito vector after engulfment of rodent malaria parasites to clarify their behaviors during mosquito stage. As a result, we succeeded to visualize oocysts, sporozoites, female gametes and ookinetes in the mosquito bodies without any dissection. More... »

PAGES

1768

References to SciGraph publications

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

9

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-38529-3

    DOI

    http://dx.doi.org/10.1038/s41598-019-38529-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112058290

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30742010


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