Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Megha Singhal, Benjamin A. Turturice, Christopher R. Manzella, Ravi Ranjan, Ahmed A. Metwally, Juliana Theorell, Yue Huang, Waddah A. Alrefai, Pradeep K. Dudeja, Patricia W. Finn, David L. Perkins, Ravinder K. Gill

ABSTRACT

Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes. To investigate the relationship between the gut microbiome and SERT, this study assessed the fecal and cecal microbiome profile of 11 to 12 week-old SERT+/+ and SERT-/- mice. Microbial DNA was isolated, processed for metagenomics shotgun sequencing, and taxonomic and functional profiles were assessed. 34 differentially abundant bacterial species were identified between SERT+/+ and SERT-/-. SERT-/- mice displayed higher abundances of Bacilli species including genera Lactobacillus, Streptococcus, Enterococcus, and Listeria. Furthermore, SERT-/- mice exhibited significantly lower abundances of Bifidobacterium species and Akkermansia muciniphilia. Bacterial community structure was altered in SERT-/- mice. Differential abundance of bacteria was correlated with changes in host gene expression. Bifidobacterium and Bacilli species exhibited significant associations with host genes involved in lipid metabolism pathways. Our results show that SERT deletion is associated with dysbiosis similar to that observed in obesity. This study contributes to the understanding as to how changes in gut microbiota are associated with metabolic phenotype seen in SERT deficiency. More... »

PAGES

2138

References to SciGraph publications

  • 2016-01. Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity in CURRENT GASTROENTEROLOGY REPORTS
  • 2011-12. Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats in LIPIDS IN HEALTH AND DISEASE
  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2015-12. Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut in SCIENTIFIC REPORTS
  • 2013-11. Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli in INTERNATIONAL JOURNAL OF OBESITY
  • 2017-12. Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance in SCIENTIFIC REPORTS
  • 2014-12. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2008-12. The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes in BMC BIOINFORMATICS
  • 2015-12. CLARK: fast and accurate classification of metagenomic and genomic sequences using discriminative k-mers in BMC GENOMICS
  • 2018-12. Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR in SCIENTIFIC REPORTS
  • 2016-12. Impact of the gut microbiota on inflammation, obesity, and metabolic disease in GENOME MEDICINE
  • 2008-02. Targeting the murine serotonin transporter: insights into human neurobiology in NATURE REVIEWS NEUROSCIENCE
  • 2015-12. Systemic effects of gut microbiota and its relationship with disease and modulation in BMC IMMUNOLOGY
  • 2013-08. Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2018-01. Dietary trehalose enhances virulence of epidemic Clostridium difficile in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-38489-8

    DOI

    http://dx.doi.org/10.1038/s41598-019-38489-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112136481

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30765765


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Singhal", 
            "givenName": "Megha", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA", 
                "Department of Microbiology & Immunology, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turturice", 
            "givenName": "Benjamin A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Manzella", 
            "givenName": "Christopher R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ranjan", 
            "givenName": "Ravi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA", 
                "Department of Bioengineering, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Metwally", 
            "givenName": "Ahmed A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Theorell", 
            "givenName": "Juliana", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Yue", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jesse Brown VA Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.280892.9", 
              "name": [
                "Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA", 
                "Jesse Brown VA Medical Center, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alrefai", 
            "givenName": "Waddah A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jesse Brown VA Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.280892.9", 
              "name": [
                "Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA", 
                "Jesse Brown VA Medical Center, Chicago, IL, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dudeja", 
            "givenName": "Pradeep K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finn", 
            "givenName": "Patricia W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Nephrology, University of Illinois at Chicago, Chicago, USA", 
                "Department of Surgery, University of Illinois at Chicago, Chicago, USA", 
                "Department of Bioengineering, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perkins", 
            "givenName": "David L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Illinois at Chicago", 
              "id": "https://www.grid.ac/institutes/grid.185648.6", 
              "name": [
                "Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gill", 
            "givenName": "Ravinder K.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ijo.2013.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000618463", 
              "https://doi.org/10.1038/ijo.2013.20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003314296", 
              "https://doi.org/10.1038/nrn2284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2015.12.083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005080912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrgastro.2013.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005337109", 
              "https://doi.org/10.1038/nrgastro.2013.105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/en.2002-220416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005910537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006083026", 
              "https://doi.org/10.1186/1471-2105-9-386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.09.059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006085456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2009.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008262598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-016-0303-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009930375", 
              "https://doi.org/10.1186/s13073-016-0303-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0061217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010556699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0032511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010659138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.103.049668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013222099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(05)80360-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013618994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-014-0550-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015222646", 
              "https://doi.org/10.1186/s13059-014-0550-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2014-308778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016218646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.14-259598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018090495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.194118.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019270710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0024-3205(98)00535-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019407438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019899672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep15782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020464179", 
              "https://doi.org/10.1038/srep15782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2005.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020504485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2005.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020504485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1419-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021400263", 
              "https://doi.org/10.1186/s12864-015-1419-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1419-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021400263", 
              "https://doi.org/10.1186/s12864-015-1419-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1748-1716.2008.01870.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021955149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.112.5.e425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022869016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.02.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023579449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893418", 
              "https://doi.org/10.1038/nature05414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.20.10.2233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028870972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2012.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029283805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.10521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029406799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2012.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029776324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0300-9629(97)00085-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030210638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2012.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030500834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad2571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033792950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12865-015-0083-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034072155", 
              "https://doi.org/10.1186/s12865-015-0083-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12865-015-0083-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034072155", 
              "https://doi.org/10.1186/s12865-015-0083-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1004226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034116643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11894-015-0479-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034777282", 
              "https://doi.org/10.1007/s11894-015-0479-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/apt.13236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034844113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/19490976.2015.1121364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034988688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.90362.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038327826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.micpath.2016.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041132308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000146256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041515474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0145718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041913801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0145718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041913801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0145718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041913801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2009.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043634515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m411553200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045570280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046561580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0163527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047977206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1219451110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049139299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1239303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052744398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-511x-10-116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053428276", 
              "https://doi.org/10.1186/1476-511x-10-116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/19490976.2015.1019693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058414010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v20.i43.16079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071371845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4291/wjgp.v6.i4.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072443468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.21-16-06348.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074859342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077674307", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.53.4.649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083244755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0171521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083686873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0171521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083686873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00011.2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083845070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-01291-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085054975", 
              "https://doi.org/10.1038/s41598-017-01291-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2017.00222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090955833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fmicb.2017.02079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092336823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2017.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092597324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1264/jsme2.me17017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092617398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100152694", 
              "https://doi.org/10.1038/nature25178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100152694", 
              "https://doi.org/10.1038/nature25178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-24213-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103353459", 
              "https://doi.org/10.1038/s41598-018-24213-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes. To investigate the relationship between the gut microbiome and SERT, this study assessed the fecal and cecal microbiome profile of 11 to 12 week-old SERT+/+ and SERT-/- mice. Microbial DNA was isolated, processed for metagenomics shotgun sequencing, and taxonomic and functional profiles were assessed. 34 differentially abundant bacterial species were identified between SERT+/+ and SERT-/-. SERT-/- mice displayed higher abundances of Bacilli species including genera Lactobacillus, Streptococcus, Enterococcus, and Listeria. Furthermore, SERT-/- mice exhibited significantly lower abundances of Bifidobacterium species and Akkermansia muciniphilia. Bacterial community structure was altered in SERT-/- mice. Differential abundance of bacteria was correlated with changes in host gene expression. Bifidobacterium and Bacilli species exhibited significant associations with host genes involved in lipid metabolism pathways. Our results show that SERT deletion is associated with dysbiosis similar to that observed in obesity. This study contributes to the understanding as to how changes in gut microbiota are associated with metabolic phenotype seen in SERT deficiency.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-38489-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2401831", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7171404", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6953619", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7030102", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2496213", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2499704", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2498704", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2500449", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2401159", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2500829", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5475454", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5503871", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7439331", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome", 
        "pagination": "2138", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a7d44eb35cfa73bc7bb40dd24270428dc81b4dc362e4766d68850c631a26399d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30765765"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-38489-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112136481"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-38489-8", 
          "https://app.dimensions.ai/details/publication/pub.1112136481"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99833_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-019-38489-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38489-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38489-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38489-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-38489-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    375 TRIPLES      21 PREDICATES      93 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-38489-8 schema:about anzsrc-for:06
    2 anzsrc-for:0605
    3 schema:author N62e646bb475447e0af76491d41aa24e2
    4 schema:citation sg:pub.10.1007/s11894-015-0479-4
    5 sg:pub.10.1038/ijo.2013.20
    6 sg:pub.10.1038/nature05414
    7 sg:pub.10.1038/nature25178
    8 sg:pub.10.1038/nrgastro.2013.105
    9 sg:pub.10.1038/nrn2284
    10 sg:pub.10.1038/s41598-017-01291-5
    11 sg:pub.10.1038/s41598-018-24213-5
    12 sg:pub.10.1038/srep15782
    13 sg:pub.10.1186/1471-2105-9-386
    14 sg:pub.10.1186/1476-511x-10-116
    15 sg:pub.10.1186/s12864-015-1419-2
    16 sg:pub.10.1186/s12865-015-0083-2
    17 sg:pub.10.1186/s13059-014-0550-8
    18 sg:pub.10.1186/s13073-016-0303-2
    19 https://app.dimensions.ai/details/publication/pub.1077674307
    20 https://doi.org/10.1002/jnr.10521
    21 https://doi.org/10.1016/j.bbrc.2015.12.083
    22 https://doi.org/10.1016/j.cell.2008.09.059
    23 https://doi.org/10.1016/j.cell.2015.02.047
    24 https://doi.org/10.1016/j.chom.2012.08.003
    25 https://doi.org/10.1016/j.chom.2017.10.005
    26 https://doi.org/10.1016/j.cmet.2012.09.014
    27 https://doi.org/10.1016/j.micpath.2016.02.005
    28 https://doi.org/10.1016/j.neuropharm.2005.08.010
    29 https://doi.org/10.1016/j.yjmcc.2012.02.004
    30 https://doi.org/10.1016/s0022-2836(05)80360-2
    31 https://doi.org/10.1016/s0024-3205(98)00535-9
    32 https://doi.org/10.1016/s0300-9629(97)00085-6
    33 https://doi.org/10.1038/oby.2009.139
    34 https://doi.org/10.1053/j.gastro.2005.02.011
    35 https://doi.org/10.1053/j.gastro.2009.09.002
    36 https://doi.org/10.1073/pnas.1219451110
    37 https://doi.org/10.1074/jbc.m411553200
    38 https://doi.org/10.1080/19490976.2015.1019693
    39 https://doi.org/10.1080/19490976.2015.1121364
    40 https://doi.org/10.1093/nar/gks678
    41 https://doi.org/10.1096/fj.14-259598
    42 https://doi.org/10.1101/gr.1239303
    43 https://doi.org/10.1101/gr.194118.115
    44 https://doi.org/10.1111/apt.13236
    45 https://doi.org/10.1111/j.1748-1716.2008.01870.x
    46 https://doi.org/10.1124/jpet.103.049668
    47 https://doi.org/10.1124/mol.53.4.649
    48 https://doi.org/10.1126/science.aad2571
    49 https://doi.org/10.1136/gutjnl-2014-308778
    50 https://doi.org/10.1152/ajpgi.00011.2017
    51 https://doi.org/10.1152/ajpgi.90362.2008
    52 https://doi.org/10.1159/000146256
    53 https://doi.org/10.1161/01.atv.20.10.2233
    54 https://doi.org/10.1210/en.2002-220416
    55 https://doi.org/10.1264/jsme2.me17017
    56 https://doi.org/10.1371/journal.pcbi.1004226
    57 https://doi.org/10.1371/journal.pone.0032511
    58 https://doi.org/10.1371/journal.pone.0061217
    59 https://doi.org/10.1371/journal.pone.0145718
    60 https://doi.org/10.1371/journal.pone.0163527
    61 https://doi.org/10.1371/journal.pone.0171521
    62 https://doi.org/10.1523/jneurosci.21-16-06348.2001
    63 https://doi.org/10.1542/peds.112.5.e425
    64 https://doi.org/10.3389/fmicb.2017.02079
    65 https://doi.org/10.3389/fncel.2017.00222
    66 https://doi.org/10.3748/wjg.v20.i43.16079
    67 https://doi.org/10.4291/wjgp.v6.i4.110
    68 schema:datePublished 2019-12
    69 schema:datePublishedReg 2019-12-01
    70 schema:description Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes. To investigate the relationship between the gut microbiome and SERT, this study assessed the fecal and cecal microbiome profile of 11 to 12 week-old SERT<sup>+/+</sup> and SERT<sup>-/-</sup> mice. Microbial DNA was isolated, processed for metagenomics shotgun sequencing, and taxonomic and functional profiles were assessed. 34 differentially abundant bacterial species were identified between SERT<sup>+/+</sup> and SERT<sup>-/-</sup>. SERT<sup>-/-</sup> mice displayed higher abundances of Bacilli species including genera Lactobacillus, Streptococcus, Enterococcus, and Listeria. Furthermore, SERT<sup>-/-</sup> mice exhibited significantly lower abundances of Bifidobacterium species and Akkermansia muciniphilia. Bacterial community structure was altered in SERT<sup>-/-</sup> mice. Differential abundance of bacteria was correlated with changes in host gene expression. Bifidobacterium and Bacilli species exhibited significant associations with host genes involved in lipid metabolism pathways. Our results show that SERT deletion is associated with dysbiosis similar to that observed in obesity. This study contributes to the understanding as to how changes in gut microbiota are associated with metabolic phenotype seen in SERT deficiency.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N1ab9e52043d84c9793fe4bbd913472b1
    75 N58cc6c0b6a2b4c07b25a41c7befacfaf
    76 sg:journal.1045337
    77 schema:name Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome
    78 schema:pagination 2138
    79 schema:productId N1653b02b9b2048a88366c1abed2d0bf8
    80 N1d94e1a28f6b4fd08b6aea2bd4d9b2e0
    81 N2697e31388ec44f699682a4920973f22
    82 Nb43671f017b84279958ab32e2955d1c0
    83 Nced3d0bccc5041c8bfef77ab9ca25043
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112136481
    85 https://doi.org/10.1038/s41598-019-38489-8
    86 schema:sdDatePublished 2019-04-11T09:39
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher N9ca4a8a3be9b4d80935567062a35003f
    89 schema:url https://www.nature.com/articles/s41598-019-38489-8
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N06c30904664145548e96f3ffd0c2bf44 schema:affiliation https://www.grid.ac/institutes/grid.280892.9
    94 schema:familyName Alrefai
    95 schema:givenName Waddah A.
    96 rdf:type schema:Person
    97 N1087a0b372844a6abf627eb7a60297d5 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    98 schema:familyName Metwally
    99 schema:givenName Ahmed A.
    100 rdf:type schema:Person
    101 N1653b02b9b2048a88366c1abed2d0bf8 schema:name pubmed_id
    102 schema:value 30765765
    103 rdf:type schema:PropertyValue
    104 N1ab9e52043d84c9793fe4bbd913472b1 schema:issueNumber 1
    105 rdf:type schema:PublicationIssue
    106 N1d94e1a28f6b4fd08b6aea2bd4d9b2e0 schema:name doi
    107 schema:value 10.1038/s41598-019-38489-8
    108 rdf:type schema:PropertyValue
    109 N2336d553b4f24abbbbb860dfa2e2cafb rdf:first N661c96ff48c44ee4be36d09039c1ab7a
    110 rdf:rest N546ab528f3f248b199e5a602bee390e3
    111 N2697e31388ec44f699682a4920973f22 schema:name nlm_unique_id
    112 schema:value 101563288
    113 rdf:type schema:PropertyValue
    114 N2bbc2e6a848b4311a828e20e503b1c2d rdf:first N7732295fe9e540669e4058cd10374da9
    115 rdf:rest N654a60a9286445aaa4d73ba300c9cf9d
    116 N2f575d5c03084a419d55a81ad3dea7dd schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    117 schema:familyName Manzella
    118 schema:givenName Christopher R.
    119 rdf:type schema:Person
    120 N43150aa69ac0459db3c3808011176368 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    121 schema:familyName Singhal
    122 schema:givenName Megha
    123 rdf:type schema:Person
    124 N4bdf9b8625834e8490fd47bdfeca71ef rdf:first N6fb3b3ed9f754f7c958a3945782cba1b
    125 rdf:rest N575e5c950f4e4df1b6bf721bb76591ac
    126 N546ab528f3f248b199e5a602bee390e3 rdf:first Nf84a2e199e35462fb9421fbada7bf6bc
    127 rdf:rest Nad22364b55eb4f348bf2c1bd93a33f9c
    128 N575e5c950f4e4df1b6bf721bb76591ac rdf:first Nc084a26c05c047f8bc41bd30d5999c26
    129 rdf:rest Ne402d69be398454ba6cbeb03d9d4c33b
    130 N58cc6c0b6a2b4c07b25a41c7befacfaf schema:volumeNumber 9
    131 rdf:type schema:PublicationVolume
    132 N59461d66cb214afdb36b7caa494bb502 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    133 schema:familyName Gill
    134 schema:givenName Ravinder K.
    135 rdf:type schema:Person
    136 N62e646bb475447e0af76491d41aa24e2 rdf:first N43150aa69ac0459db3c3808011176368
    137 rdf:rest N8867da4dcb0c4ee58d286ad00a53847b
    138 N654a60a9286445aaa4d73ba300c9cf9d rdf:first N1087a0b372844a6abf627eb7a60297d5
    139 rdf:rest N2336d553b4f24abbbbb860dfa2e2cafb
    140 N661c96ff48c44ee4be36d09039c1ab7a schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    141 schema:familyName Theorell
    142 schema:givenName Juliana
    143 rdf:type schema:Person
    144 N6fb3b3ed9f754f7c958a3945782cba1b schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    145 schema:familyName Finn
    146 schema:givenName Patricia W.
    147 rdf:type schema:Person
    148 N7732295fe9e540669e4058cd10374da9 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    149 schema:familyName Ranjan
    150 schema:givenName Ravi
    151 rdf:type schema:Person
    152 N8867da4dcb0c4ee58d286ad00a53847b rdf:first N8f35baaf50234aeab47dc6564e710955
    153 rdf:rest Na9fc0b1f0d5640bbb06a8f97fca1edfe
    154 N8f35baaf50234aeab47dc6564e710955 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    155 schema:familyName Turturice
    156 schema:givenName Benjamin A.
    157 rdf:type schema:Person
    158 N9ca4a8a3be9b4d80935567062a35003f schema:name Springer Nature - SN SciGraph project
    159 rdf:type schema:Organization
    160 Na9fc0b1f0d5640bbb06a8f97fca1edfe rdf:first N2f575d5c03084a419d55a81ad3dea7dd
    161 rdf:rest N2bbc2e6a848b4311a828e20e503b1c2d
    162 Nad22364b55eb4f348bf2c1bd93a33f9c rdf:first N06c30904664145548e96f3ffd0c2bf44
    163 rdf:rest Nba4db8d1dffa47c0b4907a20b791004c
    164 Nb43671f017b84279958ab32e2955d1c0 schema:name readcube_id
    165 schema:value a7d44eb35cfa73bc7bb40dd24270428dc81b4dc362e4766d68850c631a26399d
    166 rdf:type schema:PropertyValue
    167 Nba4db8d1dffa47c0b4907a20b791004c rdf:first Nda8c6cc529e643c6a7fec556e77f5db5
    168 rdf:rest N4bdf9b8625834e8490fd47bdfeca71ef
    169 Nc084a26c05c047f8bc41bd30d5999c26 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    170 schema:familyName Perkins
    171 schema:givenName David L.
    172 rdf:type schema:Person
    173 Nced3d0bccc5041c8bfef77ab9ca25043 schema:name dimensions_id
    174 schema:value pub.1112136481
    175 rdf:type schema:PropertyValue
    176 Nda8c6cc529e643c6a7fec556e77f5db5 schema:affiliation https://www.grid.ac/institutes/grid.280892.9
    177 schema:familyName Dudeja
    178 schema:givenName Pradeep K.
    179 rdf:type schema:Person
    180 Ne402d69be398454ba6cbeb03d9d4c33b rdf:first N59461d66cb214afdb36b7caa494bb502
    181 rdf:rest rdf:nil
    182 Nf84a2e199e35462fb9421fbada7bf6bc schema:affiliation https://www.grid.ac/institutes/grid.185648.6
    183 schema:familyName Huang
    184 schema:givenName Yue
    185 rdf:type schema:Person
    186 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Biological Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Microbiology
    191 rdf:type schema:DefinedTerm
    192 sg:grant.2401159 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    193 rdf:type schema:MonetaryGrant
    194 sg:grant.2401831 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2496213 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.2498704 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.2499704 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.2500449 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.2500829 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.5475454 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.5503871 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.6953619 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.7030102 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.7171404 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.7439331 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-38489-8
    217 rdf:type schema:MonetaryGrant
    218 sg:journal.1045337 schema:issn 2045-2322
    219 schema:name Scientific Reports
    220 rdf:type schema:Periodical
    221 sg:pub.10.1007/s11894-015-0479-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034777282
    222 https://doi.org/10.1007/s11894-015-0479-4
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/ijo.2013.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000618463
    225 https://doi.org/10.1038/ijo.2013.20
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature05414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023893418
    228 https://doi.org/10.1038/nature05414
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature25178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100152694
    231 https://doi.org/10.1038/nature25178
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nrgastro.2013.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005337109
    234 https://doi.org/10.1038/nrgastro.2013.105
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nrn2284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003314296
    237 https://doi.org/10.1038/nrn2284
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/s41598-017-01291-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085054975
    240 https://doi.org/10.1038/s41598-017-01291-5
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/s41598-018-24213-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103353459
    243 https://doi.org/10.1038/s41598-018-24213-5
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/srep15782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020464179
    246 https://doi.org/10.1038/srep15782
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/1471-2105-9-386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006083026
    249 https://doi.org/10.1186/1471-2105-9-386
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/1476-511x-10-116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053428276
    252 https://doi.org/10.1186/1476-511x-10-116
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/s12864-015-1419-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021400263
    255 https://doi.org/10.1186/s12864-015-1419-2
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/s12865-015-0083-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034072155
    258 https://doi.org/10.1186/s12865-015-0083-2
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
    261 https://doi.org/10.1186/s13059-014-0550-8
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/s13073-016-0303-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009930375
    264 https://doi.org/10.1186/s13073-016-0303-2
    265 rdf:type schema:CreativeWork
    266 https://app.dimensions.ai/details/publication/pub.1077674307 schema:CreativeWork
    267 https://doi.org/10.1002/jnr.10521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029406799
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.bbrc.2015.12.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005080912
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.cell.2008.09.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006085456
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.cell.2015.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023579449
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.chom.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029776324
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.chom.2017.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092597324
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.cmet.2012.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030500834
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.micpath.2016.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041132308
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.neuropharm.2005.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020504485
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.yjmcc.2012.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029283805
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/s0022-2836(05)80360-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618994
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/s0024-3205(98)00535-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019407438
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s0300-9629(97)00085-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030210638
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1038/oby.2009.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008262598
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1053/j.gastro.2005.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046561580
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1053/j.gastro.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043634515
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1073/pnas.1219451110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049139299
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1074/jbc.m411553200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045570280
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1080/19490976.2015.1019693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058414010
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1080/19490976.2015.1121364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034988688
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/nar/gks678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019899672
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1096/fj.14-259598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018090495
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1101/gr.194118.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019270710
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/apt.13236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034844113
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1111/j.1748-1716.2008.01870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021955149
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1124/jpet.103.049668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013222099
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1124/mol.53.4.649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083244755
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1126/science.aad2571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033792950
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1136/gutjnl-2014-308778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016218646
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1152/ajpgi.00011.2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083845070
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1152/ajpgi.90362.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038327826
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1159/000146256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041515474
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1161/01.atv.20.10.2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028870972
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1210/en.2002-220416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005910537
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1264/jsme2.me17017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092617398
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1371/journal.pcbi.1004226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034116643
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1371/journal.pone.0032511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010659138
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1371/journal.pone.0061217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010556699
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1371/journal.pone.0145718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041913801
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1371/journal.pone.0163527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047977206
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1371/journal.pone.0171521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083686873
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1523/jneurosci.21-16-06348.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074859342
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1542/peds.112.5.e425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022869016
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.3389/fmicb.2017.02079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092336823
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.3389/fncel.2017.00222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090955833
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.3748/wjg.v20.i43.16079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371845
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.4291/wjgp.v6.i4.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072443468
    362 rdf:type schema:CreativeWork
    363 https://www.grid.ac/institutes/grid.185648.6 schema:alternateName University of Illinois at Chicago
    364 schema:name Department of Bioengineering, University of Illinois at Chicago, Chicago, USA
    365 Department of Microbiology & Immunology, University of Illinois at Chicago, Chicago, USA
    366 Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, USA
    367 Department of Surgery, University of Illinois at Chicago, Chicago, USA
    368 Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA
    369 Division of Nephrology, University of Illinois at Chicago, Chicago, USA
    370 Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, USA
    371 rdf:type schema:Organization
    372 https://www.grid.ac/institutes/grid.280892.9 schema:alternateName Jesse Brown VA Medical Center
    373 schema:name Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA
    374 Jesse Brown VA Medical Center, Chicago, IL, USA
    375 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...