Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

V. M. Petriev, V. K. Tischenko, A. A. Mikhailovskaya, A. A. Popov, G. Tselikov, I. Zelepukin, S. M. Deyev, A. D. Kaprin, S. Ivanov, V. Yu. Timoshenko, P. N. Prasad, I. N. Zavestovskaya, A. V. Kabashin

ABSTRACT

Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188Re takes merely 1 hour, compared to its half-life of 17 hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine. More... »

PAGES

2017

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-38474-7

DOI

http://dx.doi.org/10.1038/s41598-018-38474-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112136057

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30765778


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Moscow Engineering Physics Institute", 
          "id": "https://www.grid.ac/institutes/grid.183446.c", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia", 
            "National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petriev", 
        "givenName": "V. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tischenko", 
        "givenName": "V. K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mikhailovskaya", 
        "givenName": "A. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Aix Marseille Univ, CNRS, LP3, Campus de Luminy \u2013 Case 917, 13288, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Popov", 
        "givenName": "A. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Aix Marseille Univ, CNRS, LP3, Campus de Luminy \u2013 Case 917, 13288, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tselikov", 
        "givenName": "G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Russian Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.4886.2", 
          "name": [
            "Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St, 117997, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zelepukin", 
        "givenName": "I.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tomsk Polytechnic University", 
          "id": "https://www.grid.ac/institutes/grid.27736.37", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia", 
            "Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St, 117997, Moscow, Russia", 
            "National Research Tomsk Polytechnic University, Tomsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deyev", 
        "givenName": "S. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaprin", 
        "givenName": "A. D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ivanov", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moscow State University", 
          "id": "https://www.grid.ac/institutes/grid.14476.30", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia", 
            "Lomonosov Moscow State University, Physics Department, Leninskie Gory 1, 119991, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Timoshenko", 
        "givenName": "V. Yu.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University at Buffalo, State University of New York", 
          "id": "https://www.grid.ac/institutes/grid.273335.3", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia", 
            "Department of Chemistry and Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, 14260, New York, United States"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prasad", 
        "givenName": "P. N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moscow Engineering Physics Institute", 
          "id": "https://www.grid.ac/institutes/grid.183446.c", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zavestovskaya", 
        "givenName": "I. N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia", 
            "Aix Marseille Univ, CNRS, LP3, Campus de Luminy \u2013 Case 917, 13288, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kabashin", 
        "givenName": "A. V.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10967-007-0230-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001012231", 
          "https://doi.org/10.1007/s10967-007-0230-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep25400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003860863", 
          "https://doi.org/10.1038/srep25400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s1066362208020227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007012038", 
          "https://doi.org/10.1134/s1066362208020227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3tb20285b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019500426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneph.2016.156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020737957", 
          "https://doi.org/10.1038/nrneph.2016.156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep07034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028117072", 
          "https://doi.org/10.1038/srep07034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b808500e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030550368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031181885", 
          "https://doi.org/10.1038/ncomms3326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2015.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033043878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acsnano.5b01320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033639011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6tb02623k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037384965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep24732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038014868", 
          "https://doi.org/10.1038/srep24732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.113.133447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038186081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2008.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040597361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043398450", 
          "https://doi.org/10.1038/nbt916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043398450", 
          "https://doi.org/10.1038/nbt916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0021364006090128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043861926", 
          "https://doi.org/10.1134/s0021364006090128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-009-0488-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044118975", 
          "https://doi.org/10.1007/s00204-009-0488-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-009-0488-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044118975", 
          "https://doi.org/10.1007/s00204-009-0488-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-009-0488-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044118975", 
          "https://doi.org/10.1007/s00204-009-0488-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050083585", 
          "https://doi.org/10.1038/nnano.2009.242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050083585", 
          "https://doi.org/10.1038/nnano.2009.242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9804386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054055300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr9804386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054055300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl025538c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056215278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl025538c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056215278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn700319z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056226710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1063/1.4829148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058085919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161206779026317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069166094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1874471011205030228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069234552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079469205", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic 188Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive 188Re takes merely 1\u2009hour, compared to its half-life of 17\u2009hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the 188Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of 188Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-38474-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5052571", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy", 
    "pagination": "2017", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "946b095b5c7e59104bff26a9d80a8fa9e3015d7b666326c184bbc83e17a14fc0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30765778"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-38474-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112136057"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-38474-7", 
      "https://app.dimensions.ai/details/publication/pub.1112136057"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47963_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-38474-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38474-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38474-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38474-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38474-7'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-38474-7 schema:about anzsrc-for:10
2 anzsrc-for:1007
3 schema:author N57e92a414b1447f993db5123b44555ce
4 schema:citation sg:pub.10.1007/s00204-009-0488-x
5 sg:pub.10.1007/s10967-007-0230-1
6 sg:pub.10.1038/nbt916
7 sg:pub.10.1038/ncomms3326
8 sg:pub.10.1038/nnano.2009.242
9 sg:pub.10.1038/nrneph.2016.156
10 sg:pub.10.1038/srep07034
11 sg:pub.10.1038/srep24732
12 sg:pub.10.1038/srep25400
13 sg:pub.10.1134/s0021364006090128
14 sg:pub.10.1134/s1066362208020227
15 https://app.dimensions.ai/details/publication/pub.1079469205
16 https://doi.org/10.1016/j.addr.2008.04.013
17 https://doi.org/10.1016/j.addr.2015.09.012
18 https://doi.org/10.1021/acsnano.5b01320
19 https://doi.org/10.1021/cr9804386
20 https://doi.org/10.1021/nl025538c
21 https://doi.org/10.1021/nn700319z
22 https://doi.org/10.1039/b808500e
23 https://doi.org/10.1039/c3tb20285b
24 https://doi.org/10.1039/c6tb02623k
25 https://doi.org/10.1063/1.4829148
26 https://doi.org/10.2174/138161206779026317
27 https://doi.org/10.2174/1874471011205030228
28 https://doi.org/10.2967/jnumed.113.133447
29 schema:datePublished 2019-12
30 schema:datePublishedReg 2019-12-01
31 schema:description Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic <sup>188</sup>Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive <sup>188</sup>Re takes merely 1 hour, compared to its half-life of 17 hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the <sup>188</sup>Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of <sup>188</sup>Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf Ndf15753e4a924fa891bbd4a6a24036f5
36 Nf67b7a4aaaf347459f2c58767364fa9c
37 sg:journal.1045337
38 schema:name Nuclear nanomedicine using Si nanoparticles as safe and effective carriers of 188Re radionuclide for cancer therapy
39 schema:pagination 2017
40 schema:productId N041f47b06696446181bdae5aada25f2e
41 N271a8c9b6067417c9967660d2dbf70c7
42 N7ffb8b3a7bf249efbec033fe24528ba4
43 N92f47f75cb2c428684ac655ef61af73b
44 Nc3cf2766e7464709a670c3589e991811
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112136057
46 https://doi.org/10.1038/s41598-018-38474-7
47 schema:sdDatePublished 2019-04-11T09:09
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N6bd25a7a284c4ec29ba730e1b203a418
50 schema:url https://www.nature.com/articles/s41598-018-38474-7
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N041f47b06696446181bdae5aada25f2e schema:name doi
55 schema:value 10.1038/s41598-018-38474-7
56 rdf:type schema:PropertyValue
57 N0f38430947e14e76aa6197be6b68747c schema:affiliation Nbf12e916fd30455094deab8b9bf4916c
58 schema:familyName Kaprin
59 schema:givenName A. D.
60 rdf:type schema:Person
61 N1020a023e52e4e4b9d6fbd70abdd6254 schema:affiliation https://www.grid.ac/institutes/grid.4886.2
62 schema:familyName Zelepukin
63 schema:givenName I.
64 rdf:type schema:Person
65 N11b0516d76944499b27711a9ed541c48 rdf:first N5e5ca8e6752e4808aca8062229c32136
66 rdf:rest N6eb5418859984af39d637e3ebd4eced0
67 N240e5a594d71445eb5b9fd9ff72235dc schema:affiliation https://www.grid.ac/institutes/grid.5399.6
68 schema:familyName Popov
69 schema:givenName A. A.
70 rdf:type schema:Person
71 N267ba8e98bf042918d4c34f6b9dd3a35 schema:name National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia
72 rdf:type schema:Organization
73 N271a8c9b6067417c9967660d2dbf70c7 schema:name readcube_id
74 schema:value 946b095b5c7e59104bff26a9d80a8fa9e3015d7b666326c184bbc83e17a14fc0
75 rdf:type schema:PropertyValue
76 N2b1ff61b07194ffca7d356e614ece68e rdf:first N1020a023e52e4e4b9d6fbd70abdd6254
77 rdf:rest N11b0516d76944499b27711a9ed541c48
78 N370e475a07074935b80cd9548726aebb rdf:first Nb419d4a403f24353b3a9619bbd4e298c
79 rdf:rest N9ce5188cc0444c32b404f32b349c152f
80 N45c05cdb4cf44c7ea12f93196b2dd2ce rdf:first N5fa7d4a13d3149d3b634baee059244e2
81 rdf:rest Nf30c381108544ecb94646c969225725a
82 N537e8d1f148d416fa660e1ff3062cafe rdf:first Nf8932b4a766049af9f405b95ace2f7af
83 rdf:rest N2b1ff61b07194ffca7d356e614ece68e
84 N57e92a414b1447f993db5123b44555ce rdf:first N67bc3aa0f0174879abd9bec70ada27ae
85 rdf:rest Nc67d0141e22d4682bcb9ff9f5de52aa2
86 N5db81700e5044ae5a1acdf293e078f54 schema:affiliation Nf082aef760c245268b47189029468c44
87 schema:familyName Ivanov
88 schema:givenName S.
89 rdf:type schema:Person
90 N5e5ca8e6752e4808aca8062229c32136 schema:affiliation https://www.grid.ac/institutes/grid.27736.37
91 schema:familyName Deyev
92 schema:givenName S. M.
93 rdf:type schema:Person
94 N5fa7d4a13d3149d3b634baee059244e2 schema:affiliation N267ba8e98bf042918d4c34f6b9dd3a35
95 schema:familyName Mikhailovskaya
96 schema:givenName A. A.
97 rdf:type schema:Person
98 N67bc3aa0f0174879abd9bec70ada27ae schema:affiliation https://www.grid.ac/institutes/grid.183446.c
99 schema:familyName Petriev
100 schema:givenName V. M.
101 rdf:type schema:Person
102 N6bd25a7a284c4ec29ba730e1b203a418 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N6eb5418859984af39d637e3ebd4eced0 rdf:first N0f38430947e14e76aa6197be6b68747c
105 rdf:rest N96444a84a52a4470b5c99fe3c6ebf627
106 N7ffb8b3a7bf249efbec033fe24528ba4 schema:name pubmed_id
107 schema:value 30765778
108 rdf:type schema:PropertyValue
109 N844f53166f2a4257990d2d034428ae20 schema:affiliation Na4c6ebfafd9a47bf98f2e43958022225
110 schema:familyName Tischenko
111 schema:givenName V. K.
112 rdf:type schema:Person
113 N8fb86b7b70064913b2f9307cebd979cb rdf:first Na6610a0c877c4a379f328668bea2788a
114 rdf:rest N370e475a07074935b80cd9548726aebb
115 N92f47f75cb2c428684ac655ef61af73b schema:name nlm_unique_id
116 schema:value 101563288
117 rdf:type schema:PropertyValue
118 N96444a84a52a4470b5c99fe3c6ebf627 rdf:first N5db81700e5044ae5a1acdf293e078f54
119 rdf:rest N8fb86b7b70064913b2f9307cebd979cb
120 N9ce5188cc0444c32b404f32b349c152f rdf:first Nf1183da9c53a4eec80ebb2d76babc643
121 rdf:rest Nc3f9a4c29858498e91e8d18b2861d06a
122 Na4c6ebfafd9a47bf98f2e43958022225 schema:name National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia
123 rdf:type schema:Organization
124 Na6610a0c877c4a379f328668bea2788a schema:affiliation https://www.grid.ac/institutes/grid.14476.30
125 schema:familyName Timoshenko
126 schema:givenName V. Yu.
127 rdf:type schema:Person
128 Nb419d4a403f24353b3a9619bbd4e298c schema:affiliation https://www.grid.ac/institutes/grid.273335.3
129 schema:familyName Prasad
130 schema:givenName P. N.
131 rdf:type schema:Person
132 Nbf12e916fd30455094deab8b9bf4916c schema:name National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia
133 rdf:type schema:Organization
134 Nc3cf2766e7464709a670c3589e991811 schema:name dimensions_id
135 schema:value pub.1112136057
136 rdf:type schema:PropertyValue
137 Nc3f9a4c29858498e91e8d18b2861d06a rdf:first Nd85ddf6ba40040a0a441d4f038632948
138 rdf:rest rdf:nil
139 Nc67d0141e22d4682bcb9ff9f5de52aa2 rdf:first N844f53166f2a4257990d2d034428ae20
140 rdf:rest N45c05cdb4cf44c7ea12f93196b2dd2ce
141 Nd85ddf6ba40040a0a441d4f038632948 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
142 schema:familyName Kabashin
143 schema:givenName A. V.
144 rdf:type schema:Person
145 Ndf15753e4a924fa891bbd4a6a24036f5 schema:issueNumber 1
146 rdf:type schema:PublicationIssue
147 Nf082aef760c245268b47189029468c44 schema:name National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia
148 rdf:type schema:Organization
149 Nf1183da9c53a4eec80ebb2d76babc643 schema:affiliation https://www.grid.ac/institutes/grid.183446.c
150 schema:familyName Zavestovskaya
151 schema:givenName I. N.
152 rdf:type schema:Person
153 Nf30c381108544ecb94646c969225725a rdf:first N240e5a594d71445eb5b9fd9ff72235dc
154 rdf:rest N537e8d1f148d416fa660e1ff3062cafe
155 Nf67b7a4aaaf347459f2c58767364fa9c schema:volumeNumber 9
156 rdf:type schema:PublicationVolume
157 Nf8932b4a766049af9f405b95ace2f7af schema:affiliation https://www.grid.ac/institutes/grid.5399.6
158 schema:familyName Tselikov
159 schema:givenName G.
160 rdf:type schema:Person
161 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
162 schema:name Technology
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1007 schema:inDefinedTermSet anzsrc-for:
165 schema:name Nanotechnology
166 rdf:type schema:DefinedTerm
167 sg:grant.5052571 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-38474-7
168 rdf:type schema:MonetaryGrant
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 rdf:type schema:Periodical
172 sg:pub.10.1007/s00204-009-0488-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044118975
173 https://doi.org/10.1007/s00204-009-0488-x
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/s10967-007-0230-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001012231
176 https://doi.org/10.1007/s10967-007-0230-1
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nbt916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043398450
179 https://doi.org/10.1038/nbt916
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/ncomms3326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031181885
182 https://doi.org/10.1038/ncomms3326
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nnano.2009.242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050083585
185 https://doi.org/10.1038/nnano.2009.242
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nrneph.2016.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020737957
188 https://doi.org/10.1038/nrneph.2016.156
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/srep07034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028117072
191 https://doi.org/10.1038/srep07034
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/srep24732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038014868
194 https://doi.org/10.1038/srep24732
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/srep25400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003860863
197 https://doi.org/10.1038/srep25400
198 rdf:type schema:CreativeWork
199 sg:pub.10.1134/s0021364006090128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043861926
200 https://doi.org/10.1134/s0021364006090128
201 rdf:type schema:CreativeWork
202 sg:pub.10.1134/s1066362208020227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007012038
203 https://doi.org/10.1134/s1066362208020227
204 rdf:type schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1079469205 schema:CreativeWork
206 https://doi.org/10.1016/j.addr.2008.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040597361
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.addr.2015.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033043878
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1021/acsnano.5b01320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033639011
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1021/cr9804386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054055300
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1021/nl025538c schema:sameAs https://app.dimensions.ai/details/publication/pub.1056215278
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1021/nn700319z schema:sameAs https://app.dimensions.ai/details/publication/pub.1056226710
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1039/b808500e schema:sameAs https://app.dimensions.ai/details/publication/pub.1030550368
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1039/c3tb20285b schema:sameAs https://app.dimensions.ai/details/publication/pub.1019500426
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1039/c6tb02623k schema:sameAs https://app.dimensions.ai/details/publication/pub.1037384965
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1063/1.4829148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058085919
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2174/138161206779026317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166094
227 rdf:type schema:CreativeWork
228 https://doi.org/10.2174/1874471011205030228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069234552
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2967/jnumed.113.133447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038186081
231 rdf:type schema:CreativeWork
232 https://www.grid.ac/institutes/grid.14476.30 schema:alternateName Moscow State University
233 schema:name Lomonosov Moscow State University, Physics Department, Leninskie Gory 1, 119991, Moscow, Russia
234 MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia
235 rdf:type schema:Organization
236 https://www.grid.ac/institutes/grid.183446.c schema:alternateName Moscow Engineering Physics Institute
237 schema:name MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia
238 National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Obninsk, Russia
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.273335.3 schema:alternateName University at Buffalo, State University of New York
241 schema:name Department of Chemistry and Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, 14260, New York, United States
242 MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.27736.37 schema:alternateName Tomsk Polytechnic University
245 schema:name MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia
246 National Research Tomsk Polytechnic University, Tomsk, Russia
247 Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St, 117997, Moscow, Russia
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.4886.2 schema:alternateName Russian Academy of Sciences
250 schema:name Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St, 117997, Moscow, Russia
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
253 schema:name Aix Marseille Univ, CNRS, LP3, Campus de Luminy – Case 917, 13288, Marseille, France
254 MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), 115409, Moscow, Russia
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...