Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Claudio Araya, Hanna-Maria Häkkinen, Luis Carcamo, Mauricio Cerda, Thierry Savy, Christopher Rookyard, Nadine Peyriéras, Jonathan D. W. Clarke

ABSTRACT

Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and a number of studies of epithelia have outlined a general view of tissue internalisation. Here we have used quantitative live imaging and mutant analysis to determine whether similar mechanisms are responsible for internalisation in a tissue that apparently does not have a typical epithelial organisation - the zebrafish neural plate. We found that although zebrafish embryos begin neurulation without a conventional epithelium, medially located neural plate cells adopt strategies typical of epithelia in order to constrict their dorsal surface membrane during cell internalisation. Furthermore, we show that Myosin-II activity is a significant driver of this transient cell remodeling which also depends on Cdh2 (N-cadherin). Abrogation of Cdh2 results in defective Myosin-II distribution, mislocalised internalisation events and defective neural plate morphogenesis. Our work suggests Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate. More... »

PAGES

1835

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-38455-w

DOI

http://dx.doi.org/10.1038/s41598-018-38455-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112063472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30755665


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