L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ko Fujimori, Kosuke Aritake, Yo Oishi, Nanae Nagata, Toko Maehara, Michael Lazarus, Yoshihiro Urade

ABSTRACT

Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD2 in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS flox/flox and adiponectin (AdipoQ)-Cre/L-PGDS flox/flox mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. The L-PGDS expression and PGD2 production levels decreased in white adipose tissue (WAT) under HFD conditions only in the aP2-Cre/L-PGDS flox/flox mice, but were unchanged in the AdipoQ-Cre/L-PGDS flox/flox mice. When fed an HFD, aP2-Cre/L-PGDS flox/flox mice significantly reduced body weight gain, adipocyte size, and serum cholesterol and triglyceride levels. In WAT of the HFD-fed aP2-Cre/L-PGDS flox/flox mice, the expression levels of the adipogenic, lipogenic, and M1 macrophage marker genes were decreased, whereas those of the lipolytic and M2 macrophage marker genes were enhanced or unchanged. Insulin sensitivity was improved in the HFD-fed aP2-Cre/L-PGDS flox/flox mice. These results indicate that PGD2 produced by L-PGDS in premature adipocytes is involved in the regulation of body weight gain and insulin resistance under nutrient-dense conditions. More... »

PAGES

1931

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-38453-y

DOI

http://dx.doi.org/10.1038/s41598-018-38453-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112094643

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30760783


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Osaka University of Pharmaceutical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.444888.c", 
          "name": [
            "Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, 569-1094, Takatsuki, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimori", 
        "givenName": "Ko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi University of Pharmacy", 
          "id": "https://www.grid.ac/institutes/grid.417740.1", 
          "name": [
            "Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, 815-8511, Minami-ku, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aritake", 
        "givenName": "Kosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oishi", 
        "givenName": "Yo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Animal Radiology and Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, 113-8657, Bunkyo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Nanae", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University of Pharmaceutical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.444888.c", 
          "name": [
            "Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, 569-1094, Takatsuki, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maehara", 
        "givenName": "Toko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tsukuba", 
          "id": "https://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazarus", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kitasato University", 
          "id": "https://www.grid.ac/institutes/grid.410786.c", 
          "name": [
            "The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
            "Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, 108-8641, Minato-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urade", 
        "givenName": "Yoshihiro", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3389/fendo.2013.00093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000115752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2014.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000483077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90194-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002104062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.11.152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005837363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00240-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006731795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2011.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007414763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2011.08213.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007655032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-0436.1996.6040203.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008405660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2536828100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010670878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0044698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014682635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4838(00)00161-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015439415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2005.02.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017860233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2005.02.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017860233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/527607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018301872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-411619-1.00001-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022175847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502927200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023094934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502927200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023094934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2009.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024486471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2015.00637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025990174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2008-0024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026162587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m013615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027711661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m701141200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029038690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2009.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029286829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db12-0015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030256551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.077164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030888175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.21128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031209138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032104004", 
          "https://doi.org/10.1038/nrm2391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2008.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034207305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2013.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034273966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(02)00042-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034687729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2004.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034784159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.25.15789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034897189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90193-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035230198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.18.10697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035318566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-3278(03)00077-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039042989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-3278(03)00077-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039042989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.01.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040414535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728220903039706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042208698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2014.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045910685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2014.127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045910685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0604-563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046050506", 
          "https://doi.org/10.1038/nm0604-563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0604-563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046050506", 
          "https://doi.org/10.1038/nm0604-563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2010.07565.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048039503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2012.05.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048114040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2006.03753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048121914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2006.03753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048121914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.525220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051437922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cmi.12336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052799363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr2002992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053785687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr2002992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053785687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi990261p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055217462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi990261p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055217462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20131476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056716674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20131476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056716674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.137.12.8940395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064280678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080040128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2017.06.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086027126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu10020130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100671015"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD2 in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS flox/flox and adiponectin (AdipoQ)-Cre/L-PGDS flox/flox mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. The L-PGDS expression and PGD2 production levels decreased in white adipose tissue (WAT) under HFD conditions only in the aP2-Cre/L-PGDS flox/flox mice, but were unchanged in the AdipoQ-Cre/L-PGDS flox/flox mice. When fed an HFD, aP2-Cre/L-PGDS flox/flox mice significantly reduced body weight gain, adipocyte size, and serum cholesterol and triglyceride levels. In WAT of the HFD-fed aP2-Cre/L-PGDS flox/flox mice, the expression levels of the adipogenic, lipogenic, and M1 macrophage marker genes were decreased, whereas those of the lipolytic and M2 macrophage marker genes were enhanced or unchanged. Insulin sensitivity was improved in the HFD-fed aP2-Cre/L-PGDS flox/flox mice. These results indicate that PGD2 produced by L-PGDS in premature adipocytes is involved in the regulation of body weight gain and insulin resistance under nutrient-dense conditions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-38453-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5902376", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6055009", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5913653", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance", 
    "pagination": "1931", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9d1ecd2126764c486c673104ef2a650bb715b79d13047f83d4595177c23a1a3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30760783"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-38453-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112094643"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-38453-y", 
      "https://app.dimensions.ai/details/publication/pub.1112094643"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47966_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-38453-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38453-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38453-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38453-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38453-y'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      79 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-38453-y schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nfecdf6a935b6453886e074d8aa248197
4 schema:citation sg:pub.10.1038/nm0604-563
5 sg:pub.10.1038/nrm2391
6 https://app.dimensions.ai/details/publication/pub.1080040128
7 https://doi.org/10.1002/glia.21128
8 https://doi.org/10.1016/0092-8674(95)90193-0
9 https://doi.org/10.1016/0092-8674(95)90194-9
10 https://doi.org/10.1016/b978-0-12-411619-1.00001-x
11 https://doi.org/10.1016/j.bbalip.2014.09.023
12 https://doi.org/10.1016/j.bbrc.2004.08.018
13 https://doi.org/10.1016/j.bbrc.2008.11.152
14 https://doi.org/10.1016/j.bbrc.2017.06.053
15 https://doi.org/10.1016/j.cell.2013.01.041
16 https://doi.org/10.1016/j.cmet.2011.02.005
17 https://doi.org/10.1016/j.gene.2012.05.052
18 https://doi.org/10.1016/j.lfs.2005.02.037
19 https://doi.org/10.1016/j.mce.2009.08.018
20 https://doi.org/10.1016/j.mce.2009.08.023
21 https://doi.org/10.1016/j.mce.2013.12.014
22 https://doi.org/10.1016/j.tem.2008.11.005
23 https://doi.org/10.1016/s0090-6980(02)00042-4
24 https://doi.org/10.1016/s0092-8674(01)00240-9
25 https://doi.org/10.1016/s0167-4838(00)00161-8
26 https://doi.org/10.1016/s0952-3278(03)00077-2
27 https://doi.org/10.1021/bi990261p
28 https://doi.org/10.1021/cr2002992
29 https://doi.org/10.1038/jcbfm.2014.127
30 https://doi.org/10.1042/bj20131476
31 https://doi.org/10.1046/j.1432-0436.1996.6040203.x
32 https://doi.org/10.1073/pnas.2536828100
33 https://doi.org/10.1074/jbc.271.18.10697
34 https://doi.org/10.1074/jbc.272.25.15789
35 https://doi.org/10.1074/jbc.m109.077164
36 https://doi.org/10.1074/jbc.m113.525220
37 https://doi.org/10.1074/jbc.m502927200
38 https://doi.org/10.1074/jbc.m701141200
39 https://doi.org/10.1111/cmi.12336
40 https://doi.org/10.1111/j.1471-4159.2006.03753.x
41 https://doi.org/10.1111/j.1742-4658.2010.07565.x
42 https://doi.org/10.1111/j.1742-4658.2011.08213.x
43 https://doi.org/10.1155/2012/527607
44 https://doi.org/10.1194/jlr.m013615
45 https://doi.org/10.1210/en.2006-1707
46 https://doi.org/10.1210/endo.137.12.8940395
47 https://doi.org/10.1210/er.2008-0024
48 https://doi.org/10.1371/journal.pone.0044698
49 https://doi.org/10.1517/14728220903039706
50 https://doi.org/10.2337/db12-0015
51 https://doi.org/10.3389/fendo.2013.00093
52 https://doi.org/10.3389/fimmu.2015.00637
53 https://doi.org/10.3390/nu10020130
54 schema:datePublished 2019-12
55 schema:datePublishedReg 2019-12-01
56 schema:description Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is responsible for the production of PGD<sub>2</sub> in adipocytes and is selectively induced by a high-fat diet (HFD) in adipose tissue. In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS <sup>flox/flox</sup> and adiponectin (AdipoQ)-Cre/L-PGDS <sup>flox/flox</sup> mice. The L-PGDS gene was deleted in adipocytes in the premature stage of the former strain and after maturation of the latter strain. The L-PGDS expression and PGD<sub>2</sub> production levels decreased in white adipose tissue (WAT) under HFD conditions only in the aP2-Cre/L-PGDS <sup>flox/flox</sup> mice, but were unchanged in the AdipoQ-Cre/L-PGDS <sup>flox/flox</sup> mice. When fed an HFD, aP2-Cre/L-PGDS <sup>flox/flox</sup> mice significantly reduced body weight gain, adipocyte size, and serum cholesterol and triglyceride levels. In WAT of the HFD-fed aP2-Cre/L-PGDS <sup>flox/flox</sup> mice, the expression levels of the adipogenic, lipogenic, and M1 macrophage marker genes were decreased, whereas those of the lipolytic and M2 macrophage marker genes were enhanced or unchanged. Insulin sensitivity was improved in the HFD-fed aP2-Cre/L-PGDS <sup>flox/flox</sup> mice. These results indicate that PGD<sub>2</sub> produced by L-PGDS in premature adipocytes is involved in the regulation of body weight gain and insulin resistance under nutrient-dense conditions.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N53e18f32e43044babe27fe0a16c099a6
61 N73e4691befcc456d97255598b36b41c7
62 sg:journal.1045337
63 schema:name L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance
64 schema:pagination 1931
65 schema:productId N03e53ed484a64fc686e7ce34df080e8e
66 N2984d8dde8ae42e182cb19baffb89ddc
67 N686a292933284ac793cad4cead22fbf3
68 Nb7c4b50bfc3344c483b500071539c6c2
69 Nd8468ca2c6a24cbb916e55cbaa07bc0e
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112094643
71 https://doi.org/10.1038/s41598-018-38453-y
72 schema:sdDatePublished 2019-04-11T09:09
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N1afbca5062d3490fa57b3e6c0fbab722
75 schema:url https://www.nature.com/articles/s41598-018-38453-y
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0073bd7a171a468588277d59000be475 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
80 schema:familyName Nagata
81 schema:givenName Nanae
82 rdf:type schema:Person
83 N03e53ed484a64fc686e7ce34df080e8e schema:name doi
84 schema:value 10.1038/s41598-018-38453-y
85 rdf:type schema:PropertyValue
86 N119a5d7b2bbf4a9e8ba92eec9c32b8d4 schema:affiliation https://www.grid.ac/institutes/grid.417740.1
87 schema:familyName Aritake
88 schema:givenName Kosuke
89 rdf:type schema:Person
90 N1afbca5062d3490fa57b3e6c0fbab722 schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N294cc6681c8e467eb56f80e73e5e236b schema:affiliation https://www.grid.ac/institutes/grid.444888.c
93 schema:familyName Maehara
94 schema:givenName Toko
95 rdf:type schema:Person
96 N2984d8dde8ae42e182cb19baffb89ddc schema:name dimensions_id
97 schema:value pub.1112094643
98 rdf:type schema:PropertyValue
99 N2fc4d7eb0ee54e638d93a0ddece586f5 rdf:first N294cc6681c8e467eb56f80e73e5e236b
100 rdf:rest Na9fa1bbc541b4268b3f3449f41409082
101 N53e18f32e43044babe27fe0a16c099a6 schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 N686a292933284ac793cad4cead22fbf3 schema:name readcube_id
104 schema:value e9d1ecd2126764c486c673104ef2a650bb715b79d13047f83d4595177c23a1a3
105 rdf:type schema:PropertyValue
106 N73e4691befcc456d97255598b36b41c7 schema:volumeNumber 9
107 rdf:type schema:PublicationVolume
108 N78f0d3fb7db849ff9511bd80346f9aa4 schema:affiliation https://www.grid.ac/institutes/grid.410786.c
109 schema:familyName Urade
110 schema:givenName Yoshihiro
111 rdf:type schema:Person
112 N7fbcd165d2984c9cb95774a112655206 rdf:first N0073bd7a171a468588277d59000be475
113 rdf:rest N2fc4d7eb0ee54e638d93a0ddece586f5
114 Na9fa1bbc541b4268b3f3449f41409082 rdf:first Nc7d7b36e07164560bb3f2d8d7b739a24
115 rdf:rest Nd4a9e9ad729a4f3d8d65c0abce07a943
116 Nb0d2a39aefd54e11b104b72fe5166c96 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
117 schema:familyName Oishi
118 schema:givenName Yo
119 rdf:type schema:Person
120 Nb7c4b50bfc3344c483b500071539c6c2 schema:name nlm_unique_id
121 schema:value 101563288
122 rdf:type schema:PropertyValue
123 Nc7d7b36e07164560bb3f2d8d7b739a24 schema:affiliation https://www.grid.ac/institutes/grid.20515.33
124 schema:familyName Lazarus
125 schema:givenName Michael
126 rdf:type schema:Person
127 Ncce0edb2abe443dbb470abb59994cde2 rdf:first N119a5d7b2bbf4a9e8ba92eec9c32b8d4
128 rdf:rest Nf3e07f5054024feebf2b2ba11a5414da
129 Ncd7fa9f50ff84cecb3f73a57f7214bbf schema:affiliation https://www.grid.ac/institutes/grid.444888.c
130 schema:familyName Fujimori
131 schema:givenName Ko
132 rdf:type schema:Person
133 Nd4a9e9ad729a4f3d8d65c0abce07a943 rdf:first N78f0d3fb7db849ff9511bd80346f9aa4
134 rdf:rest rdf:nil
135 Nd8468ca2c6a24cbb916e55cbaa07bc0e schema:name pubmed_id
136 schema:value 30760783
137 rdf:type schema:PropertyValue
138 Nf3e07f5054024feebf2b2ba11a5414da rdf:first Nb0d2a39aefd54e11b104b72fe5166c96
139 rdf:rest N7fbcd165d2984c9cb95774a112655206
140 Nfecdf6a935b6453886e074d8aa248197 rdf:first Ncd7fa9f50ff84cecb3f73a57f7214bbf
141 rdf:rest Ncce0edb2abe443dbb470abb59994cde2
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
146 schema:name Clinical Sciences
147 rdf:type schema:DefinedTerm
148 sg:grant.5902376 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-38453-y
149 rdf:type schema:MonetaryGrant
150 sg:grant.5913653 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-38453-y
151 rdf:type schema:MonetaryGrant
152 sg:grant.6055009 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-38453-y
153 rdf:type schema:MonetaryGrant
154 sg:journal.1045337 schema:issn 2045-2322
155 schema:name Scientific Reports
156 rdf:type schema:Periodical
157 sg:pub.10.1038/nm0604-563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046050506
158 https://doi.org/10.1038/nm0604-563
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/nrm2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032104004
161 https://doi.org/10.1038/nrm2391
162 rdf:type schema:CreativeWork
163 https://app.dimensions.ai/details/publication/pub.1080040128 schema:CreativeWork
164 https://doi.org/10.1002/glia.21128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031209138
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/0092-8674(95)90193-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035230198
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0092-8674(95)90194-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002104062
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/b978-0-12-411619-1.00001-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022175847
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.bbalip.2014.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000483077
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.bbrc.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034784159
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.bbrc.2008.11.152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005837363
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.bbrc.2017.06.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086027126
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.cell.2013.01.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040414535
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.cmet.2011.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007414763
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.gene.2012.05.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048114040
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.lfs.2005.02.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017860233
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.mce.2009.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029286829
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.mce.2009.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024486471
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.mce.2013.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034273966
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.tem.2008.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034207305
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0090-6980(02)00042-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034687729
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0092-8674(01)00240-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006731795
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0167-4838(00)00161-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015439415
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0952-3278(03)00077-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039042989
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1021/bi990261p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055217462
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1021/cr2002992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053785687
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1038/jcbfm.2014.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045910685
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1042/bj20131476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056716674
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1046/j.1432-0436.1996.6040203.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008405660
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.2536828100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010670878
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1074/jbc.271.18.10697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035318566
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1074/jbc.272.25.15789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034897189
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1074/jbc.m109.077164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030888175
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1074/jbc.m113.525220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051437922
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1074/jbc.m502927200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023094934
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1074/jbc.m701141200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029038690
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/cmi.12336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052799363
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/j.1471-4159.2006.03753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048121914
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1742-4658.2010.07565.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048039503
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1742-4658.2011.08213.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007655032
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1155/2012/527607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018301872
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1194/jlr.m013615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027711661
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1210/en.2006-1707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248479
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1210/endo.137.12.8940395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064280678
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1210/er.2008-0024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026162587
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1371/journal.pone.0044698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014682635
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1517/14728220903039706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042208698
249 rdf:type schema:CreativeWork
250 https://doi.org/10.2337/db12-0015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030256551
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3389/fendo.2013.00093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000115752
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3389/fimmu.2015.00637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025990174
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3390/nu10020130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100671015
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.20515.33 schema:alternateName University of Tsukuba
259 schema:name International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Ibaraki, Japan
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
262 schema:name Department of Animal Radiology and Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, 113-8657, Bunkyo-ku, Tokyo, Japan
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.410786.c schema:alternateName Kitasato University
265 schema:name Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, 108-8641, Minato-ku, Tokyo, Japan
266 The University of Tokyo Hospital, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.417740.1 schema:alternateName Daiichi University of Pharmacy
269 schema:name Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, 815-8511, Minami-ku, Fukuoka, Japan
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.444888.c schema:alternateName Osaka University of Pharmaceutical Sciences
272 schema:name Department of Pathobiochemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, 569-1094, Takatsuki, Osaka, Japan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...