Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sven H. Loosen, Pia Hoening, Niklas Puethe, Mark Luedde, Martina Spehlmann, Tom F. Ulmer, David V. Cardenas, Sanchari Roy, Frank Tacke, Christian Trautwein, Ulf P. Neumann, Tom Luedde, Christoph Roderburg

ABSTRACT

Patients with pancreatic adenocarcinoma (PDAC) still face a very limited prognosis. At early stage, surgical tumor resection might offer long-term survival but disease recurrence is common and the existing stratification algorithms are often unsuitable to identify patients who particularly benefit from surgery. Here, we investigated the potential role of bone sialoprotein (BSP) as a circulating marker in patients undergoing resection of PDAC. We used ELISA to determine serum concentrations of BSP in a cohort of 132 PDAC patients as well as 39 healthy controls. Circulating BSP levels were significantly higher in PDAC patients compared to healthy controls. Notably, elevated preoperative BSP levels above the ideal cut-off value of 4743 pg/ml turned out as a significant predictor for an impaired postoperative survival. The potential of preoperative BSP levels as a prognostic marker was further underlined by uni- and multivariate Cox-regression analyses including various tumour- and patient-specific. Finally, high tumoral BSP expression was also associated with a significantly impaired long-term survival. In conclusion, we identified a novel role of circulating BSP as a biomarker in PDAC patients undergoing tumor resection. Such data might help to establish new preoperative stratification strategies to better identify patients who particularly benefit from tumor resection. More... »

PAGES

1489

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-38352-2

DOI

http://dx.doi.org/10.1038/s41598-018-38352-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111950508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30728413


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loosen", 
        "givenName": "Sven H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoening", 
        "givenName": "Pia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puethe", 
        "givenName": "Niklas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine III, University Hospital of Schleswig Holstein, Campus Kiel, Rosalind-Franklin-Str. 12, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luedde", 
        "givenName": "Mark", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine III, University Hospital of Schleswig Holstein, Campus Kiel, Rosalind-Franklin-Str. 12, 24105, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spehlmann", 
        "givenName": "Martina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ulmer", 
        "givenName": "Tom F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardenas", 
        "givenName": "David V.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roy", 
        "givenName": "Sanchari", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tacke", 
        "givenName": "Frank", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trautwein", 
        "givenName": "Christian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neumann", 
        "givenName": "Ulf P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany", 
            "Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luedde", 
        "givenName": "Tom", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Aachen", 
          "id": "https://www.grid.ac/institutes/grid.412301.5", 
          "name": [
            "Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roderburg", 
        "givenName": "Christoph", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)00141-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002541019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0051862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003445740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1404198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007769668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-015-9724-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012283784", 
          "https://doi.org/10.1007/s12029-015-9724-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-015-9724-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012283784", 
          "https://doi.org/10.1007/s12029-015-9724-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-015-9724-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012283784", 
          "https://doi.org/10.1007/s12029-015-9724-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pan.2014.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014436551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2016.01.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024217510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc10037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029080892", 
          "https://doi.org/10.1186/cc10037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31825e354d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034885316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e31825e354d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034885316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2006.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039130980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2013.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047687953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2015.10.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049830976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049839989", 
          "https://doi.org/10.1038/nrc2345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/cbm-160617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051574854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e318277d9de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053672857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pai.0b013e318277d9de", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053672857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1051/medsci/20132911019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057043288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14694/edbk_160827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067344534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v20.i40.14747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071371707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v22.i9.2678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071374362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.10.1.12161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072292181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.10.1.12452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072292190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5507/bp.2016.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072931915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(16)32409-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074196849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/cbm-140430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079018796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-017-0448-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084251905", 
          "https://doi.org/10.1186/s13045-017-0448-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13045-017-0448-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084251905", 
          "https://doi.org/10.1186/s13045-017-0448-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hpb.2017.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100624106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hpb.2017.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100624106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hpb.2017.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100624106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.25471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104387535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2018.36.18_suppl.lba4001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104470809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-28201-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105054584", 
          "https://doi.org/10.1038/s41598-018-28201-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Patients with pancreatic adenocarcinoma (PDAC) still face a very limited prognosis. At early stage, surgical tumor resection might offer long-term survival but disease recurrence is common and the existing stratification algorithms are often unsuitable to identify patients who particularly benefit from surgery. Here, we investigated the potential role of bone sialoprotein (BSP) as a circulating marker in patients undergoing resection of PDAC. We used ELISA to determine serum concentrations of BSP in a cohort of 132 PDAC patients as well as 39 healthy controls. Circulating BSP levels were significantly higher in PDAC patients compared to healthy controls. Notably, elevated preoperative BSP levels above the ideal cut-off value of 4743\u2009pg/ml turned out as a significant predictor for an impaired postoperative survival. The potential of preoperative BSP levels as a prognostic marker was further underlined by uni- and multivariate Cox-regression analyses including various tumour- and patient-specific. Finally, high tumoral BSP expression was also associated with a significantly impaired long-term survival. In conclusion, we identified a novel role of circulating BSP as a biomarker in PDAC patients undergoing tumor resection. Such data might help to establish new preoperative stratification strategies to better identify patients who particularly benefit from tumor resection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-38352-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma", 
    "pagination": "1489", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9d181a29baeb92cfdd1605cdb93ccbab988f86785b42708c820cb151c9e71471"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30728413"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-38352-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111950508"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-38352-2", 
      "https://app.dimensions.ai/details/publication/pub.1111950508"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000331_0000000331/records_105400_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-38352-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38352-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38352-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38352-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38352-2'


 

This table displays all metadata directly associated to this object as RDF triples.

233 TRIPLES      21 PREDICATES      57 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-38352-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N5fbecca1ab7d4e5c8c8ae62a1c0bb008
4 schema:citation sg:pub.10.1007/s12029-015-9724-1
5 sg:pub.10.1038/nrc2345
6 sg:pub.10.1038/s41598-018-28201-7
7 sg:pub.10.1186/cc10037
8 sg:pub.10.1186/s13045-017-0448-5
9 https://doi.org/10.1016/j.canlet.2006.01.002
10 https://doi.org/10.1016/j.canlet.2015.10.035
11 https://doi.org/10.1016/j.canlet.2016.01.042
12 https://doi.org/10.1016/j.critrevonc.2013.08.013
13 https://doi.org/10.1016/j.hpb.2017.11.009
14 https://doi.org/10.1016/j.pan.2014.10.001
15 https://doi.org/10.1016/s0140-6736(16)00141-0
16 https://doi.org/10.1016/s0140-6736(16)32409-6
17 https://doi.org/10.1051/medsci/20132911019
18 https://doi.org/10.1056/nejmra1404198
19 https://doi.org/10.1097/mpa.0b013e31825e354d
20 https://doi.org/10.1097/pai.0b013e318277d9de
21 https://doi.org/10.1200/jco.2018.36.18_suppl.lba4001
22 https://doi.org/10.1371/journal.pone.0051862
23 https://doi.org/10.14694/edbk_160827
24 https://doi.org/10.18632/oncotarget.25471
25 https://doi.org/10.3233/cbm-140430
26 https://doi.org/10.3233/cbm-160617
27 https://doi.org/10.3748/wjg.v20.i40.14747
28 https://doi.org/10.3748/wjg.v22.i9.2678
29 https://doi.org/10.4161/cbt.10.1.12161
30 https://doi.org/10.4161/cbt.10.1.12452
31 https://doi.org/10.5507/bp.2016.011
32 schema:datePublished 2019-12
33 schema:datePublishedReg 2019-12-01
34 schema:description Patients with pancreatic adenocarcinoma (PDAC) still face a very limited prognosis. At early stage, surgical tumor resection might offer long-term survival but disease recurrence is common and the existing stratification algorithms are often unsuitable to identify patients who particularly benefit from surgery. Here, we investigated the potential role of bone sialoprotein (BSP) as a circulating marker in patients undergoing resection of PDAC. We used ELISA to determine serum concentrations of BSP in a cohort of 132 PDAC patients as well as 39 healthy controls. Circulating BSP levels were significantly higher in PDAC patients compared to healthy controls. Notably, elevated preoperative BSP levels above the ideal cut-off value of 4743 pg/ml turned out as a significant predictor for an impaired postoperative survival. The potential of preoperative BSP levels as a prognostic marker was further underlined by uni- and multivariate Cox-regression analyses including various tumour- and patient-specific. Finally, high tumoral BSP expression was also associated with a significantly impaired long-term survival. In conclusion, we identified a novel role of circulating BSP as a biomarker in PDAC patients undergoing tumor resection. Such data might help to establish new preoperative stratification strategies to better identify patients who particularly benefit from tumor resection.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N99772bef8d12491ab8d8a35bddf61412
39 Nfe3404963b6f4b0e9242985498c04359
40 sg:journal.1045337
41 schema:name Elevated serum levels of bone sialoprotein (BSP) predict long-term mortality in patients with pancreatic adenocarcinoma
42 schema:pagination 1489
43 schema:productId N00076ad9e6b841918c4c1c5617f2dcf0
44 N5bb22518b27a4ce880355619ed357849
45 N8428ab63e087415588d42046073a8203
46 Neacdd84181344110bc8ffebf719279db
47 Nef1d3ac49efd4adb9dceb2267a869f67
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111950508
49 https://doi.org/10.1038/s41598-018-38352-2
50 schema:sdDatePublished 2019-04-11T09:02
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N87320cf5e4d14a1784d37ee3da918e65
53 schema:url https://www.nature.com/articles/s41598-018-38352-2
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N00076ad9e6b841918c4c1c5617f2dcf0 schema:name pubmed_id
58 schema:value 30728413
59 rdf:type schema:PropertyValue
60 N05aa0d2e812a44528191f083ee17818b rdf:first N3de38bd6e8d5496585ac12418fd6d295
61 rdf:rest rdf:nil
62 N10dcc6a513544113a1918e2df0ee7167 rdf:first Nc5c419e8136c43db91ee5e3d608c9734
63 rdf:rest N8ad3028b37f3478e811cb53b43d0c1e6
64 N122b8a98fe9544b6a734d87d90a0b45c rdf:first N85f4dd2275504d8080cd3de2b20fc02c
65 rdf:rest N95f87b74f27c43bf89dd48f64864e781
66 N14399c4e78384a50b158cb8b5c67140d schema:affiliation https://www.grid.ac/institutes/grid.412301.5
67 schema:familyName Loosen
68 schema:givenName Sven H.
69 rdf:type schema:Person
70 N160a571e10d94943a8cbbb3a35d0215c schema:affiliation https://www.grid.ac/institutes/grid.412301.5
71 schema:familyName Trautwein
72 schema:givenName Christian
73 rdf:type schema:Person
74 N18baa87db0b64727ac2b29be96db1522 rdf:first N9fe84b10986f422f9e2c514cf0c95f6e
75 rdf:rest N10dcc6a513544113a1918e2df0ee7167
76 N2f6086b78f854f7c883abf2d3563c394 rdf:first N5662c9e907b04673a941125ddc29deed
77 rdf:rest N05aa0d2e812a44528191f083ee17818b
78 N364141948e334519935eb39cc0d4a303 rdf:first N160a571e10d94943a8cbbb3a35d0215c
79 rdf:rest N54f16ac0aaeb4ecabd13eac4d6a8d274
80 N3de38bd6e8d5496585ac12418fd6d295 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
81 schema:familyName Roderburg
82 schema:givenName Christoph
83 rdf:type schema:Person
84 N4c9f73ceb86644a281195a8a7ef5cc8c schema:affiliation https://www.grid.ac/institutes/grid.412301.5
85 schema:familyName Ulmer
86 schema:givenName Tom F.
87 rdf:type schema:Person
88 N54f16ac0aaeb4ecabd13eac4d6a8d274 rdf:first N5dbbba98039341489fc5df5915c3b290
89 rdf:rest N2f6086b78f854f7c883abf2d3563c394
90 N5662c9e907b04673a941125ddc29deed schema:affiliation https://www.grid.ac/institutes/grid.412301.5
91 schema:familyName Luedde
92 schema:givenName Tom
93 rdf:type schema:Person
94 N5bb22518b27a4ce880355619ed357849 schema:name dimensions_id
95 schema:value pub.1111950508
96 rdf:type schema:PropertyValue
97 N5dbbba98039341489fc5df5915c3b290 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
98 schema:familyName Neumann
99 schema:givenName Ulf P.
100 rdf:type schema:Person
101 N5fbecca1ab7d4e5c8c8ae62a1c0bb008 rdf:first N14399c4e78384a50b158cb8b5c67140d
102 rdf:rest N7c55fcfca6054ee49ad574907c878f3a
103 N681cd9deea164f118ba1d71a40fa6864 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
104 schema:familyName Hoening
105 schema:givenName Pia
106 rdf:type schema:Person
107 N7c55fcfca6054ee49ad574907c878f3a rdf:first N681cd9deea164f118ba1d71a40fa6864
108 rdf:rest N18baa87db0b64727ac2b29be96db1522
109 N8416c0b36ee54caca144fb8dd5744c79 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
110 schema:familyName Spehlmann
111 schema:givenName Martina
112 rdf:type schema:Person
113 N8428ab63e087415588d42046073a8203 schema:name readcube_id
114 schema:value 9d181a29baeb92cfdd1605cdb93ccbab988f86785b42708c820cb151c9e71471
115 rdf:type schema:PropertyValue
116 N85f4dd2275504d8080cd3de2b20fc02c schema:affiliation https://www.grid.ac/institutes/grid.412301.5
117 schema:familyName Roy
118 schema:givenName Sanchari
119 rdf:type schema:Person
120 N87320cf5e4d14a1784d37ee3da918e65 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N8ad3028b37f3478e811cb53b43d0c1e6 rdf:first N8416c0b36ee54caca144fb8dd5744c79
123 rdf:rest N8fa02970548f4d429b1771056d094c07
124 N8fa02970548f4d429b1771056d094c07 rdf:first N4c9f73ceb86644a281195a8a7ef5cc8c
125 rdf:rest Na61ca095feeb46d083fcbdadec287866
126 N95f87b74f27c43bf89dd48f64864e781 rdf:first Na81cc998a11c43d79e3b70138fd1bd23
127 rdf:rest N364141948e334519935eb39cc0d4a303
128 N99772bef8d12491ab8d8a35bddf61412 schema:volumeNumber 9
129 rdf:type schema:PublicationVolume
130 N9fe84b10986f422f9e2c514cf0c95f6e schema:affiliation https://www.grid.ac/institutes/grid.412301.5
131 schema:familyName Puethe
132 schema:givenName Niklas
133 rdf:type schema:Person
134 Na61ca095feeb46d083fcbdadec287866 rdf:first Ne9cdab91aeb34f2aa4550c9438f6903d
135 rdf:rest N122b8a98fe9544b6a734d87d90a0b45c
136 Na81cc998a11c43d79e3b70138fd1bd23 schema:affiliation https://www.grid.ac/institutes/grid.412301.5
137 schema:familyName Tacke
138 schema:givenName Frank
139 rdf:type schema:Person
140 Nc5c419e8136c43db91ee5e3d608c9734 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
141 schema:familyName Luedde
142 schema:givenName Mark
143 rdf:type schema:Person
144 Ne9cdab91aeb34f2aa4550c9438f6903d schema:affiliation https://www.grid.ac/institutes/grid.412301.5
145 schema:familyName Cardenas
146 schema:givenName David V.
147 rdf:type schema:Person
148 Neacdd84181344110bc8ffebf719279db schema:name nlm_unique_id
149 schema:value 101563288
150 rdf:type schema:PropertyValue
151 Nef1d3ac49efd4adb9dceb2267a869f67 schema:name doi
152 schema:value 10.1038/s41598-018-38352-2
153 rdf:type schema:PropertyValue
154 Nfe3404963b6f4b0e9242985498c04359 schema:issueNumber 1
155 rdf:type schema:PublicationIssue
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
160 schema:name Clinical Sciences
161 rdf:type schema:DefinedTerm
162 sg:journal.1045337 schema:issn 2045-2322
163 schema:name Scientific Reports
164 rdf:type schema:Periodical
165 sg:pub.10.1007/s12029-015-9724-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012283784
166 https://doi.org/10.1007/s12029-015-9724-1
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/nrc2345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049839989
169 https://doi.org/10.1038/nrc2345
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/s41598-018-28201-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105054584
172 https://doi.org/10.1038/s41598-018-28201-7
173 rdf:type schema:CreativeWork
174 sg:pub.10.1186/cc10037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029080892
175 https://doi.org/10.1186/cc10037
176 rdf:type schema:CreativeWork
177 sg:pub.10.1186/s13045-017-0448-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251905
178 https://doi.org/10.1186/s13045-017-0448-5
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.canlet.2006.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039130980
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.canlet.2015.10.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049830976
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.canlet.2016.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024217510
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.critrevonc.2013.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047687953
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.hpb.2017.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100624106
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.pan.2014.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014436551
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0140-6736(16)00141-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002541019
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0140-6736(16)32409-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074196849
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1051/medsci/20132911019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057043288
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1056/nejmra1404198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007769668
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/mpa.0b013e31825e354d schema:sameAs https://app.dimensions.ai/details/publication/pub.1034885316
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/pai.0b013e318277d9de schema:sameAs https://app.dimensions.ai/details/publication/pub.1053672857
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1200/jco.2018.36.18_suppl.lba4001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104470809
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1371/journal.pone.0051862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003445740
207 rdf:type schema:CreativeWork
208 https://doi.org/10.14694/edbk_160827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067344534
209 rdf:type schema:CreativeWork
210 https://doi.org/10.18632/oncotarget.25471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104387535
211 rdf:type schema:CreativeWork
212 https://doi.org/10.3233/cbm-140430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079018796
213 rdf:type schema:CreativeWork
214 https://doi.org/10.3233/cbm-160617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051574854
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3748/wjg.v20.i40.14747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371707
217 rdf:type schema:CreativeWork
218 https://doi.org/10.3748/wjg.v22.i9.2678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071374362
219 rdf:type schema:CreativeWork
220 https://doi.org/10.4161/cbt.10.1.12161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072292181
221 rdf:type schema:CreativeWork
222 https://doi.org/10.4161/cbt.10.1.12452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072292190
223 rdf:type schema:CreativeWork
224 https://doi.org/10.5507/bp.2016.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072931915
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.412301.5 schema:alternateName Universitätsklinikum Aachen
227 schema:name Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
228 Department of Visceral and Transplantation Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
229 Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
232 schema:name Department of Internal Medicine III, University Hospital of Schleswig Holstein, Campus Kiel, Rosalind-Franklin-Str. 12, 24105, Kiel, Germany
233 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...