Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Monika Horazna, Lucie Janeckova, Jiri Svec, Olga Babosova, Dusan Hrckulak, Martina Vojtechova, Katerina Galuskova, Eva Sloncova, Michal Kolar, Hynek Strnad, Vladimir Korinek

ABSTRACT

The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to identify genes affected by the Apc loss, we performed expression profiling of intestinal epithelium isolated from mice harboring a conditional Apc allele. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation. Histological analysis of the Apc-deficient epithelium revealed that in the small intestine, the Msx1 protein was localized exclusively in ectopic crypts, i.e., in pockets of proliferating cells abnormally positioned on the villi. Ablation of the Msx1 gene leads to the disappearance of ectopic crypts and loss of differentiated cells. Moreover, tumors arising from Msx1-deficient cells display altered morphology reminiscent of villous adenomas. In human tumor specimens, MSX1 displayed significantly increased expression in colonic neoplasia with a descending tendency during the lesion progression towards colorectal carcinoma. In summary, the results indicate that Msx1 represents a novel marker of intestinal tumorigenesis. In addition, we described the previously unknown relationship between the Msx1-dependent formation of ectopic crypts and cell differentiation. More... »

PAGES

1629

References to SciGraph publications

  • 2010-06. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2011-12. Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? in MOLECULAR CANCER
  • 2011-10. MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma in ONCOGENE
  • 2008-12. Msx1 and Msx2are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium in BMC DEVELOPMENTAL BIOLOGY
  • 2000-04. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation in NATURE GENETICS
  • 2015-01. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche in NATURE MEDICINE
  • 2007-10-25. Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • 2014-08. Improved vectors and genome-wide libraries for CRISPR screening in NATURE METHODS
  • 1977-10. Extreme sensitivity of some intestinal crypt cells to X and γ irradiation in NATURE
  • 2009-05. Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche in NATURE
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2017-10. Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse in TRANSGENIC RESEARCH
  • 2004-09. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • 2017-12. Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2003-03-13. Statistical Methods for Identifying Differentially Expressed Genes in DNA Microarrays in FUNCTIONAL GENOMICS
  • 2013-12. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool in BMC BIOINFORMATICS
  • 2011-08. Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2012-10. TGFβ signalling in context in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-38310-y

    DOI

    http://dx.doi.org/10.1038/s41598-018-38310-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111978368

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30733598


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Charles University", 
              "id": "https://www.grid.ac/institutes/grid.4491.8", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic", 
                "Faculty of Science, Charles University in Prague, Albertov 6, 128 43, Praha 2, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Horazna", 
            "givenName": "Monika", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Janeckova", 
            "givenName": "Lucie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charles University", 
              "id": "https://www.grid.ac/institutes/grid.4491.8", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic", 
                "Department of Radiotherapy and Oncology, Third Faculty of Medicine, Charles University, Prague, Srobarova 50, 100 34, Prague 10, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Svec", 
            "givenName": "Jiri", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Babosova", 
            "givenName": "Olga", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hrckulak", 
            "givenName": "Dusan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vojtechova", 
            "givenName": "Martina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Galuskova", 
            "givenName": "Katerina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sloncova", 
            "givenName": "Eva", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolar", 
            "givenName": "Michal", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strnad", 
            "givenName": "Hynek", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.418827.0", 
              "name": [
                "Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korinek", 
            "givenName": "Vladimir", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0378-1119(00)00081-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000489637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0030486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000596366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.00609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002074310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002489382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003995336", 
              "https://doi.org/10.1038/nmeth.3047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.287404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004027822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2014.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004082333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-364-x:149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005570605", 
              "https://doi.org/10.1385/1-59259-364-x:149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gene.20042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006213848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006414320", 
              "https://doi.org/10.1038/onc.2011.123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471142735.im1525s104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006832688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1247005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007966801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1247005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007966801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008101893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0020146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010914493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012347371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0925-4773(96)00505-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012720123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1093587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014414968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-213x-8-75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014641686", 
              "https://doi.org/10.1186/1471-213x-8-75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016846561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018457673", 
              "https://doi.org/10.1186/gb-2004-5-10-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019504751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020626779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fphys.2012.00375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021362611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00216-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023361570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tranon.2016.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023934877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082069", 
              "https://doi.org/10.1038/nature07935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082069", 
              "https://doi.org/10.1038/nature07935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0092317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024471236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/269518a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026891740", 
              "https://doi.org/10.1038/269518a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027421226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(00)89124-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027487846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027500995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.20741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027938172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.20741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027938172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wdev.78", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028397809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029021006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2013.11.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032143992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033999306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034485230", 
              "https://doi.org/10.1038/nm.3750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035521246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-13-0625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037158119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2011.07.050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037288352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a002881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037612402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037936629", 
              "https://doi.org/10.1038/74231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/74231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037936629", 
              "https://doi.org/10.1038/74231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1002491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038635862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039170009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.40.10.3753-3756.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039582638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.00793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041557936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0104284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042456684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20120205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043409931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20120205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043409931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-14-128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044758756", 
              "https://doi.org/10.1186/1471-2105-14-128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2016.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045856307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2015.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045937154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047486704", 
              "https://doi.org/10.1038/ejhg.2009.228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047486704", 
              "https://doi.org/10.1038/ejhg.2009.228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-10-101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047879719", 
              "https://doi.org/10.1186/1476-4598-10-101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mod.2007.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049650266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-physiol-030212-183744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049765678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050225537", 
              "https://doi.org/10.1038/nature06196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.20.010403.113126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051113440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052520145", 
              "https://doi.org/10.1038/nrm3434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.088393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052569943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-011-0808-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052944795", 
              "https://doi.org/10.1007/s11010-011-0808-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1350108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062477270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2016-5285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063270101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2202/1544-6115.1027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069289261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4149/neo_2012_090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072262473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074250297", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075309872", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077137542", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13045-017-0445-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084251902", 
              "https://doi.org/10.1186/s13045-017-0445-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13045-017-0445-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084251902", 
              "https://doi.org/10.1186/s13045-017-0445-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1085617322", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11248-017-0027-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086100314", 
              "https://doi.org/10.1007/s11248-017-0027-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11248-017-0027-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086100314", 
              "https://doi.org/10.1007/s11248-017-0027-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to identify genes affected by the Apc loss, we performed expression profiling of intestinal epithelium isolated from mice harboring a conditional Apc allele. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation. Histological analysis of the Apc-deficient epithelium revealed that in the small intestine, the Msx1 protein was localized exclusively in ectopic crypts, i.e., in pockets of proliferating cells abnormally positioned on the villi. Ablation of the Msx1 gene leads to the disappearance of ectopic crypts and loss of differentiated cells. Moreover, tumors arising from Msx1-deficient cells display altered morphology reminiscent of villous adenomas. In human tumor specimens, MSX1 displayed significantly increased expression in colonic neoplasia with a descending tendency during the lesion progression towards colorectal carcinoma. In summary, the results indicate that Msx1 represents a novel marker of intestinal tumorigenesis. In addition, we described the previously unknown relationship between the Msx1-dependent formation of ectopic crypts and cell differentiation.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-38310-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6886516", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium", 
        "pagination": "1629", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6eaaac6e03ae3674a0e88f9ebcee1e6e724241cec6c9051e3e6114d517cfac12"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30733598"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-38310-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111978368"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-38310-y", 
          "https://app.dimensions.ai/details/publication/pub.1111978368"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000334_0000000334/records_127816_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-38310-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38310-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38310-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38310-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38310-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    361 TRIPLES      21 PREDICATES      100 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-38310-y schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N104fdda527bd47858f6f836f97edb24b
    4 schema:citation sg:pub.10.1007/s11010-011-0808-3
    5 sg:pub.10.1007/s11248-017-0027-0
    6 sg:pub.10.1038/269518a0
    7 sg:pub.10.1038/74231
    8 sg:pub.10.1038/ejhg.2009.228
    9 sg:pub.10.1038/nature06196
    10 sg:pub.10.1038/nature07935
    11 sg:pub.10.1038/nature11252
    12 sg:pub.10.1038/nm.3750
    13 sg:pub.10.1038/nmeth.3047
    14 sg:pub.10.1038/nrm3434
    15 sg:pub.10.1038/onc.2011.123
    16 sg:pub.10.1186/1471-2105-14-128
    17 sg:pub.10.1186/1471-213x-8-75
    18 sg:pub.10.1186/1476-4598-10-101
    19 sg:pub.10.1186/gb-2004-5-10-r80
    20 sg:pub.10.1186/s13045-017-0445-8
    21 sg:pub.10.1385/1-59259-364-x:149
    22 https://app.dimensions.ai/details/publication/pub.1074250297
    23 https://app.dimensions.ai/details/publication/pub.1075309872
    24 https://app.dimensions.ai/details/publication/pub.1077137542
    25 https://app.dimensions.ai/details/publication/pub.1085617322
    26 https://doi.org/10.1002/0471142735.im1525s104
    27 https://doi.org/10.1002/dvdy.20741
    28 https://doi.org/10.1002/gene.20042
    29 https://doi.org/10.1002/wdev.78
    30 https://doi.org/10.1016/0925-4773(96)00505-9
    31 https://doi.org/10.1016/j.cell.2012.12.012
    32 https://doi.org/10.1016/j.cellsig.2013.11.032
    33 https://doi.org/10.1016/j.febslet.2014.09.014
    34 https://doi.org/10.1016/j.humpath.2015.04.002
    35 https://doi.org/10.1016/j.mod.2007.06.006
    36 https://doi.org/10.1016/j.stem.2014.12.006
    37 https://doi.org/10.1016/j.tranon.2016.01.005
    38 https://doi.org/10.1016/s0092-8674(04)00216-8
    39 https://doi.org/10.1016/s0168-9525(00)89124-6
    40 https://doi.org/10.1016/s0378-1119(00)00081-0
    41 https://doi.org/10.1038/sj.emboj.7600191
    42 https://doi.org/10.1042/bj20120205
    43 https://doi.org/10.1053/j.gastro.2011.07.050
    44 https://doi.org/10.1053/j.gastro.2016.06.020
    45 https://doi.org/10.1093/bioinformatics/btq431
    46 https://doi.org/10.1093/emboj/cdg105
    47 https://doi.org/10.1093/nar/gkp179
    48 https://doi.org/10.1093/nar/gks690
    49 https://doi.org/10.1093/nar/gkw377
    50 https://doi.org/10.1101/cshperspect.a002881
    51 https://doi.org/10.1101/gad.287404
    52 https://doi.org/10.1126/science.1093587
    53 https://doi.org/10.1126/science.1247005
    54 https://doi.org/10.1126/science.1350108
    55 https://doi.org/10.1128/jcm.40.10.3753-3756.2002
    56 https://doi.org/10.1146/annurev-physiol-030212-183744
    57 https://doi.org/10.1146/annurev.cellbio.20.010403.113126
    58 https://doi.org/10.1158/1535-7163.mct-13-0625
    59 https://doi.org/10.1158/1538-7445.am2016-5285
    60 https://doi.org/10.1242/dev.00609
    61 https://doi.org/10.1242/dev.00793
    62 https://doi.org/10.1242/dev.01576
    63 https://doi.org/10.1242/dev.01700
    64 https://doi.org/10.1242/dev.01877
    65 https://doi.org/10.1242/dev.088393
    66 https://doi.org/10.1371/journal.pbio.1002491
    67 https://doi.org/10.1371/journal.pgen.0020146
    68 https://doi.org/10.1371/journal.pmed.0030486
    69 https://doi.org/10.1371/journal.pone.0092317
    70 https://doi.org/10.1371/journal.pone.0104284
    71 https://doi.org/10.2202/1544-6115.1027
    72 https://doi.org/10.3322/caac.20138
    73 https://doi.org/10.3389/fphys.2012.00375
    74 https://doi.org/10.4149/neo_2012_090
    75 schema:datePublished 2019-12
    76 schema:datePublishedReg 2019-12-01
    77 schema:description The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to identify genes affected by the Apc loss, we performed expression profiling of intestinal epithelium isolated from mice harboring a conditional Apc allele. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation. Histological analysis of the Apc-deficient epithelium revealed that in the small intestine, the Msx1 protein was localized exclusively in ectopic crypts, i.e., in pockets of proliferating cells abnormally positioned on the villi. Ablation of the Msx1 gene leads to the disappearance of ectopic crypts and loss of differentiated cells. Moreover, tumors arising from Msx1-deficient cells display altered morphology reminiscent of villous adenomas. In human tumor specimens, MSX1 displayed significantly increased expression in colonic neoplasia with a descending tendency during the lesion progression towards colorectal carcinoma. In summary, the results indicate that Msx1 represents a novel marker of intestinal tumorigenesis. In addition, we described the previously unknown relationship between the Msx1-dependent formation of ectopic crypts and cell differentiation.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree true
    81 schema:isPartOf N12ed797abd9a4fd8a5e6932986b76982
    82 N20fc70773d5a48e8a8538a2784c4346f
    83 sg:journal.1045337
    84 schema:name Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium
    85 schema:pagination 1629
    86 schema:productId N319033c467f74ae2a7709aeabee93829
    87 N642209b12fb2495198d4cff80cc58c31
    88 N86a042982991497ea33a18e106b4171c
    89 Nb69492586b3b4cc2bf314f467ba104e6
    90 Nb8125c0ef3ce4f849927d42ab8289819
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111978368
    92 https://doi.org/10.1038/s41598-018-38310-y
    93 schema:sdDatePublished 2019-04-11T09:04
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher Ndb9304b03969444b97921d6c7ae04fb4
    96 schema:url https://www.nature.com/articles/s41598-018-38310-y
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N0e17b7201597459196d4f7c479907d84 rdf:first N9797746d41234527b041df5303f76116
    101 rdf:rest N8708d9d72a07413d9aadd9c9d61edbb0
    102 N104fdda527bd47858f6f836f97edb24b rdf:first N56b5fe1c55c84d5b82644ab1608e509d
    103 rdf:rest N0e17b7201597459196d4f7c479907d84
    104 N12277cb92ef84383809e65797bc613e2 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    105 schema:familyName Korinek
    106 schema:givenName Vladimir
    107 rdf:type schema:Person
    108 N12ed797abd9a4fd8a5e6932986b76982 schema:issueNumber 1
    109 rdf:type schema:PublicationIssue
    110 N1f01e53ca2d0464a9323b1d495ffffd8 rdf:first N12277cb92ef84383809e65797bc613e2
    111 rdf:rest rdf:nil
    112 N20fc70773d5a48e8a8538a2784c4346f schema:volumeNumber 9
    113 rdf:type schema:PublicationVolume
    114 N254e8a7391a24921a618edc262a06fc9 rdf:first Nf6b0a1fe578d48df8efca36c71b2a4b4
    115 rdf:rest Nde606f9e5971486cb711493800d319fc
    116 N30c39ac5a79c4b7cbfc9db25da22cad3 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    117 schema:familyName Sloncova
    118 schema:givenName Eva
    119 rdf:type schema:Person
    120 N319033c467f74ae2a7709aeabee93829 schema:name pubmed_id
    121 schema:value 30733598
    122 rdf:type schema:PropertyValue
    123 N42ce30046a6b4bf384a139d3d094792b rdf:first Nd723797e6b534802877a39130ef4cea9
    124 rdf:rest N9c5cf15e84c441cda62981d9a55f4735
    125 N56b5fe1c55c84d5b82644ab1608e509d schema:affiliation https://www.grid.ac/institutes/grid.4491.8
    126 schema:familyName Horazna
    127 schema:givenName Monika
    128 rdf:type schema:Person
    129 N5cab5f59260948ab9960c09bbeac31aa schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    130 schema:familyName Strnad
    131 schema:givenName Hynek
    132 rdf:type schema:Person
    133 N642209b12fb2495198d4cff80cc58c31 schema:name dimensions_id
    134 schema:value pub.1111978368
    135 rdf:type schema:PropertyValue
    136 N7b490571d4be42dc883cfacb7ff010fc rdf:first N9f486986ca2b4cc98067744822c1d418
    137 rdf:rest Nb37eb52a54fc4ad79a1bc6253d0390ec
    138 N86a042982991497ea33a18e106b4171c schema:name readcube_id
    139 schema:value 6eaaac6e03ae3674a0e88f9ebcee1e6e724241cec6c9051e3e6114d517cfac12
    140 rdf:type schema:PropertyValue
    141 N8708d9d72a07413d9aadd9c9d61edbb0 rdf:first Nde40eeda280349dfaafb45a0e96eae45
    142 rdf:rest N42ce30046a6b4bf384a139d3d094792b
    143 N9797746d41234527b041df5303f76116 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    144 schema:familyName Janeckova
    145 schema:givenName Lucie
    146 rdf:type schema:Person
    147 N9c5cf15e84c441cda62981d9a55f4735 rdf:first Nc4bc241a5d184effa6c4aa6c26aca7e2
    148 rdf:rest N254e8a7391a24921a618edc262a06fc9
    149 N9f486986ca2b4cc98067744822c1d418 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    150 schema:familyName Kolar
    151 schema:givenName Michal
    152 rdf:type schema:Person
    153 Nb37eb52a54fc4ad79a1bc6253d0390ec rdf:first N5cab5f59260948ab9960c09bbeac31aa
    154 rdf:rest N1f01e53ca2d0464a9323b1d495ffffd8
    155 Nb69492586b3b4cc2bf314f467ba104e6 schema:name nlm_unique_id
    156 schema:value 101563288
    157 rdf:type schema:PropertyValue
    158 Nb8125c0ef3ce4f849927d42ab8289819 schema:name doi
    159 schema:value 10.1038/s41598-018-38310-y
    160 rdf:type schema:PropertyValue
    161 Nc4bc241a5d184effa6c4aa6c26aca7e2 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    162 schema:familyName Hrckulak
    163 schema:givenName Dusan
    164 rdf:type schema:Person
    165 Nd723797e6b534802877a39130ef4cea9 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    166 schema:familyName Babosova
    167 schema:givenName Olga
    168 rdf:type schema:Person
    169 Ndb9304b03969444b97921d6c7ae04fb4 schema:name Springer Nature - SN SciGraph project
    170 rdf:type schema:Organization
    171 Nde40eeda280349dfaafb45a0e96eae45 schema:affiliation https://www.grid.ac/institutes/grid.4491.8
    172 schema:familyName Svec
    173 schema:givenName Jiri
    174 rdf:type schema:Person
    175 Nde606f9e5971486cb711493800d319fc rdf:first Nefdf53352b794fcfb6c4357f3fc25dfb
    176 rdf:rest Nfe5fe59d0e4b429083952ac7486766b1
    177 Nefdf53352b794fcfb6c4357f3fc25dfb schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    178 schema:familyName Galuskova
    179 schema:givenName Katerina
    180 rdf:type schema:Person
    181 Nf6b0a1fe578d48df8efca36c71b2a4b4 schema:affiliation https://www.grid.ac/institutes/grid.418827.0
    182 schema:familyName Vojtechova
    183 schema:givenName Martina
    184 rdf:type schema:Person
    185 Nfe5fe59d0e4b429083952ac7486766b1 rdf:first N30c39ac5a79c4b7cbfc9db25da22cad3
    186 rdf:rest N7b490571d4be42dc883cfacb7ff010fc
    187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Medical and Health Sciences
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Oncology and Carcinogenesis
    192 rdf:type schema:DefinedTerm
    193 sg:grant.6886516 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-38310-y
    194 rdf:type schema:MonetaryGrant
    195 sg:journal.1045337 schema:issn 2045-2322
    196 schema:name Scientific Reports
    197 rdf:type schema:Periodical
    198 sg:pub.10.1007/s11010-011-0808-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944795
    199 https://doi.org/10.1007/s11010-011-0808-3
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s11248-017-0027-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086100314
    202 https://doi.org/10.1007/s11248-017-0027-0
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/269518a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026891740
    205 https://doi.org/10.1038/269518a0
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/74231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037936629
    208 https://doi.org/10.1038/74231
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/ejhg.2009.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047486704
    211 https://doi.org/10.1038/ejhg.2009.228
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nature06196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225537
    214 https://doi.org/10.1038/nature06196
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nature07935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024082069
    217 https://doi.org/10.1038/nature07935
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    220 https://doi.org/10.1038/nature11252
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nm.3750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034485230
    223 https://doi.org/10.1038/nm.3750
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nmeth.3047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003995336
    226 https://doi.org/10.1038/nmeth.3047
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nrm3434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052520145
    229 https://doi.org/10.1038/nrm3434
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/onc.2011.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006414320
    232 https://doi.org/10.1038/onc.2011.123
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1186/1471-2105-14-128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044758756
    235 https://doi.org/10.1186/1471-2105-14-128
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1186/1471-213x-8-75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014641686
    238 https://doi.org/10.1186/1471-213x-8-75
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1186/1476-4598-10-101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047879719
    241 https://doi.org/10.1186/1476-4598-10-101
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
    244 https://doi.org/10.1186/gb-2004-5-10-r80
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1186/s13045-017-0445-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251902
    247 https://doi.org/10.1186/s13045-017-0445-8
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1385/1-59259-364-x:149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005570605
    250 https://doi.org/10.1385/1-59259-364-x:149
    251 rdf:type schema:CreativeWork
    252 https://app.dimensions.ai/details/publication/pub.1074250297 schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1075309872 schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1077137542 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1085617322 schema:CreativeWork
    256 https://doi.org/10.1002/0471142735.im1525s104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006832688
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1002/dvdy.20741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027938172
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1002/gene.20042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006213848
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1002/wdev.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028397809
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/0925-4773(96)00505-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012720123
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.cell.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012347371
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.cellsig.2013.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032143992
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.febslet.2014.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004082333
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.humpath.2015.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045937154
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.mod.2007.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049650266
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.stem.2014.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039170009
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.tranon.2016.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023934877
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/s0092-8674(04)00216-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023361570
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s0168-9525(00)89124-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027487846
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/s0378-1119(00)00081-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000489637
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1038/sj.emboj.7600191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027421226
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1042/bj20120205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043409931
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1053/j.gastro.2011.07.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037288352
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1053/j.gastro.2016.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045856307
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1093/bioinformatics/btq431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027500995
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/emboj/cdg105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008101893
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/nar/gkp179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033999306
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/nar/gks690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016846561
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1093/nar/gkw377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029021006
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1101/cshperspect.a002881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037612402
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1101/gad.287404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004027822
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1126/science.1093587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014414968
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1126/science.1247005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007966801
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1126/science.1350108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477270
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1128/jcm.40.10.3753-3756.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039582638
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1146/annurev-physiol-030212-183744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049765678
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1146/annurev.cellbio.20.010403.113126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051113440
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1158/1535-7163.mct-13-0625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037158119
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1158/1538-7445.am2016-5285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063270101
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1242/dev.00609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002074310
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1242/dev.00793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041557936
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1242/dev.01576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035521246
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1242/dev.01700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002489382
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1242/dev.01877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019504751
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1242/dev.088393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052569943
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1371/journal.pbio.1002491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038635862
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1371/journal.pgen.0020146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010914493
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1371/journal.pmed.0030486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000596366
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1371/journal.pone.0092317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024471236
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1371/journal.pone.0104284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042456684
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.2202/1544-6115.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069289261
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.3389/fphys.2012.00375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021362611
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.4149/neo_2012_090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072262473
    353 rdf:type schema:CreativeWork
    354 https://www.grid.ac/institutes/grid.418827.0 schema:alternateName Institute of Molecular Genetics
    355 schema:name Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic
    356 rdf:type schema:Organization
    357 https://www.grid.ac/institutes/grid.4491.8 schema:alternateName Charles University
    358 schema:name Department of Radiotherapy and Oncology, Third Faculty of Medicine, Charles University, Prague, Srobarova 50, 100 34, Prague 10, Czech Republic
    359 Faculty of Science, Charles University in Prague, Albertov 6, 128 43, Praha 2, Czech Republic
    360 Institute of Molecular Genetics of the ASCR, v. v. i., Videnska 1083, 142 20, Prague 4, Czech Republic
    361 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...