The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Kancheng He, Huating Hu, Senlin Ye, Haohui Wang, Rongrong Cui, Lu Yi

ABSTRACT

The relationship between metformin and prostate cancer (PCa) remains controversial. To clarify this association, the PubMed, Embase and Cochrane library databases were systematically searched from their inception dates to May 23, 2018, using the keywords "metformin" and "prostate cancer" to identify the related studies. The results included incidence, overall survival (OS), PCa-specific survival (CSS) and recurrence-free survival (RFS), which were measured as hazard ratios (HR) with a 95% confidence interval (95% CI) using Review Manager 5.3 software. A total of 30 cohort studies, including 1,660,795 patients were included in this study. Our study revealed that metformin treatment improves OS, CSS and RFS in PCa (HR = 0.72, 95% CI: 0.59-0.88, P = 0.001; HR = 0.78, 95% CI: 0.64-0.94, P = 0.009; and HR = 0.60, 95% CI: 0.42-0.87 P = 0.006, respectively) compared with non-metformin treatment. However, metformin usage did not reduce the incidence of PCa (HR = 0.86, 95% CI: 0.55-1.34, P = 0.51). In conclusion, compared with non-metformin treatment, metformin therapy can significantly improve OS, CSS and RFS in PCa patients. No association was noted between metformin therapy and PCa incidence. This study indicates a useful direction for the clinical treatment of PCa. More... »

PAGES

2218

References to SciGraph publications

  • 2008-03. Quantifying the role of PSA screening in the US prostate cancer mortality decline in CANCER CAUSES & CONTROL
  • 2015-12. Metformin and prostate cancer stem cells: a novel therapeutic target in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2014-08. Association of diabetes mellitus and metformin use with biochemical recurrence in patients treated with radical prostatectomy for prostate cancer in WORLD JOURNAL OF UROLOGY
  • 2015-12. Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective in SCIENTIFIC REPORTS
  • 2015-03. Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2016-01. Metformin and prostate cancer mortality: a meta-analysis in CANCER CAUSES & CONTROL
  • 2010-09. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-08. Influence of metformin use on PSA values, free-to-total PSA, prostate cancer incidence and grade and overall survival in a prospective screening trial (ERSPC Aarau) in WORLD JOURNAL OF UROLOGY
  • 2016-12. Tumor features and survival after radical prostatectomy among antidiabetic drug users in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2004-06. Diabetes mellitus and risk of prostate cancer: a meta-analysis in DIABETOLOGIA
  • 2007-03. Impact of differential cyclin D1 expression and localisation in prostate cancer in BRITISH JOURNAL OF CANCER
  • 2017-03. Metformin and the risk of prostate cancer across racial/ethnic groups: a population-based cohort study in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2018-12. Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis in BMC CANCER
  • 2008-06. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level in ONCOGENE
  • 2013-06. Type 2 diabetes and risk of prostate cancer: a meta-analysis of observational studies in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2013-12. Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database in PROSTATE CANCER AND PROSTATIC DISEASES
  • 2008-12. Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial in CANCER CAUSES & CONTROL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-38285-w

    DOI

    http://dx.doi.org/10.1038/s41598-018-38285-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112201700

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30778081


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "He", 
            "givenName": "Kancheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan University", 
              "id": "https://www.grid.ac/institutes/grid.67293.39", 
              "name": [
                "The First Hospital of Hunan University of Chinese Medicine, 410007, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Huating", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ye", 
            "givenName": "Senlin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Haohui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cui", 
            "givenName": "Rongrong", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yi", 
            "givenName": "Lu", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05679.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000744892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05679.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000744892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/erc-13-0077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002242051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/erc-16-0095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004452731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5114/jcb.2014.45757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005411548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dmrr.2645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005424325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2016.10.066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006764674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008927111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2015.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008946284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2016.10.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010231846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2016.10.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010231846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2016.10.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010231846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-015-0687-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010405378", 
              "https://doi.org/10.1007/s10552-015-0687-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(05)65393-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010450934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2016.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010998865", 
              "https://doi.org/10.1038/pcan.2016.65"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cej.0b013e3283656394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011493560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cej.0b013e3283656394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011493560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pros.23000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011653434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011677102", 
              "https://doi.org/10.1038/sj.bjc.6603615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-10-0157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013537448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-007-9083-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013640649", 
              "https://doi.org/10.1007/s10552-007-9083-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-007-9083-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013640649", 
              "https://doi.org/10.1007/s10552-007-9083-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2014.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016065200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2014.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017843490", 
              "https://doi.org/10.1038/pcan.2014.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018668319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0116327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018715805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0124761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019963480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-008-9198-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994959", 
              "https://doi.org/10.1007/s10552-008-9198-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-008-9198-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994959", 
              "https://doi.org/10.1007/s10552-008-9198-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-008-9198-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994959", 
              "https://doi.org/10.1007/s10552-008-9198-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-008-9198-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994959", 
              "https://doi.org/10.1007/s10552-008-9198-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10552-008-9198-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019994959", 
              "https://doi.org/10.1007/s10552-008-9198-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1464-410x.2002.02982.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020443110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.9881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021314643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2012.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021882819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2010.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021994745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijrobp.2010.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021994745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2013.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023419475", 
              "https://doi.org/10.1038/pcan.2013.48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.46.7043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024040122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clgc.2016.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024276194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.urolonc.2013.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024465439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-014-1426-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024482845", 
              "https://doi.org/10.1007/s00345-014-1426-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2015.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024619023", 
              "https://doi.org/10.1038/pcan.2015.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2016.10.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026055572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-2310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027138181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2012.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028677367", 
              "https://doi.org/10.1038/pcan.2012.40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/2656814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029304620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjms.2016.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029645760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjms.2016.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029645760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0113162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0113162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-12-0053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032404852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-14-0056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033747314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/jme-12-0007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035012208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/pcan.2016.32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035354375", 
              "https://doi.org/10.1038/pcan.2016.32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1211024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036402265", 
              "https://doi.org/10.1038/sj.onc.1211024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-010-9491-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036685756", 
              "https://doi.org/10.1007/s10654-010-9491-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2007.56-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037786557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14779072.5.3.491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038697314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pds.3701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040365219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1415-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044786583", 
              "https://doi.org/10.1007/s00125-004-1415-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-004-1415-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044786583", 
              "https://doi.org/10.1007/s00125-004-1415-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/amiajnl-2014-002649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045244437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-013-1171-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047112766", 
              "https://doi.org/10.1007/s00345-013-1171-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.eururo.2011.11.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047202057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2015.02.798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047634749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2015.02.798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047634749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-06-0477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050076479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07435800.2014.934961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050198260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep15639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050901150", 
              "https://doi.org/10.1038/srep15639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051647965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051658151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-10-0940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052954710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canep.2012.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052974169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2016.1152432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058402266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-15-0141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063279411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1940-6207.capr-15-0425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063279476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.22.9905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5489/cuaj.267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072920551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/21681805.2016.1271353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079391522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.35.6_suppl.181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084254855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.22117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092469628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100164642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12885-017-3934-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100302240", 
              "https://doi.org/10.1186/s12885-017-3934-9"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "The relationship between metformin and prostate cancer (PCa) remains controversial. To clarify this association, the PubMed, Embase and Cochrane library databases were systematically searched from their inception dates to May 23, 2018, using the keywords \"metformin\" and \"prostate cancer\" to identify the related studies. The results included incidence, overall survival (OS), PCa-specific survival (CSS) and recurrence-free survival (RFS), which were measured as hazard ratios (HR) with a 95% confidence interval (95% CI) using Review Manager 5.3 software. A total of 30 cohort studies, including 1,660,795 patients were included in this study. Our study revealed that metformin treatment improves OS, CSS and RFS in PCa (HR\u2009=\u20090.72, 95% CI: 0.59-0.88, P\u2009=\u20090.001; HR\u2009=\u20090.78, 95% CI: 0.64-0.94, P\u2009=\u20090.009; and HR\u2009=\u20090.60, 95% CI: 0.42-0.87\u2009P\u2009=\u20090.006, respectively) compared with non-metformin treatment. However, metformin usage did not reduce the incidence of PCa (HR\u2009=\u20090.86, 95% CI: 0.55-1.34, P\u2009=\u20090.51). In conclusion, compared with non-metformin treatment, metformin therapy can significantly improve OS, CSS and RFS in PCa patients. No association was noted between metformin therapy and PCa incidence. This study indicates a useful direction for the clinical treatment of PCa.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-38285-w", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis", 
        "pagination": "2218", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e2f0249e6ba3999c169043115ca5048f8df718e162b72d100b4f9a9811b9d2ea"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30778081"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-38285-w"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112201700"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-38285-w", 
          "https://app.dimensions.ai/details/publication/pub.1112201700"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:41", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99841_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-38285-w"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38285-w'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38285-w'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38285-w'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-38285-w'


     

    This table displays all metadata directly associated to this object as RDF triples.

    334 TRIPLES      21 PREDICATES      99 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-38285-w schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N1c23cb0740734e4e98b5b6bb4c365b2d
    4 schema:citation sg:pub.10.1007/s00125-004-1415-6
    5 sg:pub.10.1007/s00345-013-1171-7
    6 sg:pub.10.1007/s00345-014-1426-y
    7 sg:pub.10.1007/s10552-007-9083-8
    8 sg:pub.10.1007/s10552-008-9198-6
    9 sg:pub.10.1007/s10552-015-0687-0
    10 sg:pub.10.1007/s10654-010-9491-z
    11 sg:pub.10.1038/pcan.2012.40
    12 sg:pub.10.1038/pcan.2013.48
    13 sg:pub.10.1038/pcan.2014.47
    14 sg:pub.10.1038/pcan.2015.35
    15 sg:pub.10.1038/pcan.2016.32
    16 sg:pub.10.1038/pcan.2016.65
    17 sg:pub.10.1038/sj.bjc.6603615
    18 sg:pub.10.1038/sj.onc.1211024
    19 sg:pub.10.1038/srep15639
    20 sg:pub.10.1186/s12885-017-3934-9
    21 https://doi.org/10.1001/jama.2007.56-b
    22 https://doi.org/10.1002/dmrr.2645
    23 https://doi.org/10.1002/ijc.24044
    24 https://doi.org/10.1002/ijc.30403
    25 https://doi.org/10.1002/ijc.30480
    26 https://doi.org/10.1002/pds.3701
    27 https://doi.org/10.1002/pros.23000
    28 https://doi.org/10.1016/j.amjms.2016.01.013
    29 https://doi.org/10.1016/j.canep.2012.12.009
    30 https://doi.org/10.1016/j.canlet.2016.10.019
    31 https://doi.org/10.1016/j.clgc.2016.08.020
    32 https://doi.org/10.1016/j.ejca.2014.08.007
    33 https://doi.org/10.1016/j.ejca.2015.02.003
    34 https://doi.org/10.1016/j.eururo.2011.11.053
    35 https://doi.org/10.1016/j.eururo.2012.12.004
    36 https://doi.org/10.1016/j.ijrobp.2010.03.005
    37 https://doi.org/10.1016/j.juro.2015.02.798
    38 https://doi.org/10.1016/j.juro.2016.10.066
    39 https://doi.org/10.1016/j.juro.2016.10.069
    40 https://doi.org/10.1016/j.urolonc.2013.05.005
    41 https://doi.org/10.1016/s0022-5347(05)65393-1
    42 https://doi.org/10.1046/j.1464-410x.2002.02982.x
    43 https://doi.org/10.1080/15384101.2016.1152432
    44 https://doi.org/10.1080/21681805.2016.1271353
    45 https://doi.org/10.1097/cej.0b013e3283656394
    46 https://doi.org/10.1111/j.1749-6632.2010.05679.x
    47 https://doi.org/10.1136/amiajnl-2014-002649
    48 https://doi.org/10.1155/2016/2656814
    49 https://doi.org/10.1158/0008-5472.can-07-2310
    50 https://doi.org/10.1158/1055-9965.epi-06-0477
    51 https://doi.org/10.1158/1055-9965.epi-10-0940
    52 https://doi.org/10.1158/1055-9965.epi-14-0056
    53 https://doi.org/10.1158/1078-0432.ccr-13-1787
    54 https://doi.org/10.1158/1940-6207.capr-10-0157
    55 https://doi.org/10.1158/1940-6207.capr-15-0141
    56 https://doi.org/10.1158/1940-6207.capr-15-0425
    57 https://doi.org/10.1200/jco.2007.13.9881
    58 https://doi.org/10.1200/jco.2012.46.7043
    59 https://doi.org/10.1200/jco.2017.35.6_suppl.181
    60 https://doi.org/10.1371/journal.pone.0113162
    61 https://doi.org/10.1371/journal.pone.0116327
    62 https://doi.org/10.1371/journal.pone.0124761
    63 https://doi.org/10.1530/eje-12-0053
    64 https://doi.org/10.1530/erc-13-0077
    65 https://doi.org/10.1530/erc-16-0095
    66 https://doi.org/10.1530/jme-12-0007
    67 https://doi.org/10.1586/14779072.5.3.491
    68 https://doi.org/10.18632/oncotarget.22117
    69 https://doi.org/10.3109/07435800.2014.934961
    70 https://doi.org/10.3322/caac.21442
    71 https://doi.org/10.4161/cc.8.22.9905
    72 https://doi.org/10.5114/jcb.2014.45757
    73 https://doi.org/10.5489/cuaj.267
    74 schema:datePublished 2019-12
    75 schema:datePublishedReg 2019-12-01
    76 schema:description The relationship between metformin and prostate cancer (PCa) remains controversial. To clarify this association, the PubMed, Embase and Cochrane library databases were systematically searched from their inception dates to May 23, 2018, using the keywords "metformin" and "prostate cancer" to identify the related studies. The results included incidence, overall survival (OS), PCa-specific survival (CSS) and recurrence-free survival (RFS), which were measured as hazard ratios (HR) with a 95% confidence interval (95% CI) using Review Manager 5.3 software. A total of 30 cohort studies, including 1,660,795 patients were included in this study. Our study revealed that metformin treatment improves OS, CSS and RFS in PCa (HR = 0.72, 95% CI: 0.59-0.88, P = 0.001; HR = 0.78, 95% CI: 0.64-0.94, P = 0.009; and HR = 0.60, 95% CI: 0.42-0.87 P = 0.006, respectively) compared with non-metformin treatment. However, metformin usage did not reduce the incidence of PCa (HR = 0.86, 95% CI: 0.55-1.34, P = 0.51). In conclusion, compared with non-metformin treatment, metformin therapy can significantly improve OS, CSS and RFS in PCa patients. No association was noted between metformin therapy and PCa incidence. This study indicates a useful direction for the clinical treatment of PCa.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree true
    80 schema:isPartOf N3a2b78b46f7749989d55aac6b1b9da78
    81 Nb98e4512964a4ff6bb59fbdb230062c6
    82 sg:journal.1045337
    83 schema:name The effect of metformin therapy on incidence and prognosis in prostate cancer: A systematic review and meta-analysis
    84 schema:pagination 2218
    85 schema:productId N7092fd652abd48679d8e708b0f97fcfe
    86 N93b05c91486343a7983f608064869260
    87 Ncac29d0790324aef9e2613d4f35571c7
    88 Nd1b707dcdad9400d8a35987688d2e0fb
    89 Nfe5900457e1940b8942b55e2b452a835
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112201700
    91 https://doi.org/10.1038/s41598-018-38285-w
    92 schema:sdDatePublished 2019-04-11T09:41
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N9d1403e6d1d1405b9df82e06d79b7e36
    95 schema:url https://www.nature.com/articles/s41598-018-38285-w
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N1c23cb0740734e4e98b5b6bb4c365b2d rdf:first Ned556f5642474464a56368d6a65b951b
    100 rdf:rest Nbde72ed0adc14509ba654b28a333bb33
    101 N3a2b78b46f7749989d55aac6b1b9da78 schema:volumeNumber 9
    102 rdf:type schema:PublicationVolume
    103 N580775b342df4df2b3437edba009ee5e schema:name Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    104 rdf:type schema:Organization
    105 N687dfd3d2ea5477ab1d1cc79662987ec rdf:first N9bc378460d794da6b87e864a0487019e
    106 rdf:rest N95df8d518910465f81d554a6664304cb
    107 N7092fd652abd48679d8e708b0f97fcfe schema:name nlm_unique_id
    108 schema:value 101563288
    109 rdf:type schema:PropertyValue
    110 N76e3b64d712141408fc4ace74857c697 rdf:first Nbb1c88ef41db4b0e982820adc1cb7c14
    111 rdf:rest rdf:nil
    112 N8d335a47a6c849908f9e64047b716333 schema:name Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    113 rdf:type schema:Organization
    114 N907efdc900fb4615bf2bb8c1dde06e2e schema:name Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    115 rdf:type schema:Organization
    116 N922e23291f41491c92b759dbf26157a4 schema:name Department of Urology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    117 rdf:type schema:Organization
    118 N93b05c91486343a7983f608064869260 schema:name readcube_id
    119 schema:value e2f0249e6ba3999c169043115ca5048f8df718e162b72d100b4f9a9811b9d2ea
    120 rdf:type schema:PropertyValue
    121 N95df8d518910465f81d554a6664304cb rdf:first Nccdbac3b04014f5ba070b11c9a31da2c
    122 rdf:rest N76e3b64d712141408fc4ace74857c697
    123 N9a8ed33281a94034a5d851c07973b298 rdf:first Ne267bf702a8348d9a47d3e2e3d7e119e
    124 rdf:rest N687dfd3d2ea5477ab1d1cc79662987ec
    125 N9bc378460d794da6b87e864a0487019e schema:affiliation N580775b342df4df2b3437edba009ee5e
    126 schema:familyName Wang
    127 schema:givenName Haohui
    128 rdf:type schema:Person
    129 N9d1403e6d1d1405b9df82e06d79b7e36 schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 Na109b3b0d811417fa1589be8b739f32f schema:name Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, 410011, Changsha, China
    132 rdf:type schema:Organization
    133 Nb11ff6cfb3c54387be2d528b9084d5db schema:affiliation https://www.grid.ac/institutes/grid.67293.39
    134 schema:familyName Hu
    135 schema:givenName Huating
    136 rdf:type schema:Person
    137 Nb98e4512964a4ff6bb59fbdb230062c6 schema:issueNumber 1
    138 rdf:type schema:PublicationIssue
    139 Nbb1c88ef41db4b0e982820adc1cb7c14 schema:affiliation N907efdc900fb4615bf2bb8c1dde06e2e
    140 schema:familyName Yi
    141 schema:givenName Lu
    142 rdf:type schema:Person
    143 Nbde72ed0adc14509ba654b28a333bb33 rdf:first Nb11ff6cfb3c54387be2d528b9084d5db
    144 rdf:rest N9a8ed33281a94034a5d851c07973b298
    145 Ncac29d0790324aef9e2613d4f35571c7 schema:name doi
    146 schema:value 10.1038/s41598-018-38285-w
    147 rdf:type schema:PropertyValue
    148 Nccdbac3b04014f5ba070b11c9a31da2c schema:affiliation Na109b3b0d811417fa1589be8b739f32f
    149 schema:familyName Cui
    150 schema:givenName Rongrong
    151 rdf:type schema:Person
    152 Nd1b707dcdad9400d8a35987688d2e0fb schema:name pubmed_id
    153 schema:value 30778081
    154 rdf:type schema:PropertyValue
    155 Ne267bf702a8348d9a47d3e2e3d7e119e schema:affiliation N8d335a47a6c849908f9e64047b716333
    156 schema:familyName Ye
    157 schema:givenName Senlin
    158 rdf:type schema:Person
    159 Ned556f5642474464a56368d6a65b951b schema:affiliation N922e23291f41491c92b759dbf26157a4
    160 schema:familyName He
    161 schema:givenName Kancheng
    162 rdf:type schema:Person
    163 Nfe5900457e1940b8942b55e2b452a835 schema:name dimensions_id
    164 schema:value pub.1112201700
    165 rdf:type schema:PropertyValue
    166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Medical and Health Sciences
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Oncology and Carcinogenesis
    171 rdf:type schema:DefinedTerm
    172 sg:journal.1045337 schema:issn 2045-2322
    173 schema:name Scientific Reports
    174 rdf:type schema:Periodical
    175 sg:pub.10.1007/s00125-004-1415-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044786583
    176 https://doi.org/10.1007/s00125-004-1415-6
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/s00345-013-1171-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047112766
    179 https://doi.org/10.1007/s00345-013-1171-7
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s00345-014-1426-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1024482845
    182 https://doi.org/10.1007/s00345-014-1426-y
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s10552-007-9083-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013640649
    185 https://doi.org/10.1007/s10552-007-9083-8
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s10552-008-9198-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019994959
    188 https://doi.org/10.1007/s10552-008-9198-6
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s10552-015-0687-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010405378
    191 https://doi.org/10.1007/s10552-015-0687-0
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s10654-010-9491-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1036685756
    194 https://doi.org/10.1007/s10654-010-9491-z
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/pcan.2012.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028677367
    197 https://doi.org/10.1038/pcan.2012.40
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/pcan.2013.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023419475
    200 https://doi.org/10.1038/pcan.2013.48
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/pcan.2014.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017843490
    203 https://doi.org/10.1038/pcan.2014.47
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/pcan.2015.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024619023
    206 https://doi.org/10.1038/pcan.2015.35
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/pcan.2016.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035354375
    209 https://doi.org/10.1038/pcan.2016.32
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/pcan.2016.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010998865
    212 https://doi.org/10.1038/pcan.2016.65
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/sj.bjc.6603615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011677102
    215 https://doi.org/10.1038/sj.bjc.6603615
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/sj.onc.1211024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036402265
    218 https://doi.org/10.1038/sj.onc.1211024
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/srep15639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050901150
    221 https://doi.org/10.1038/srep15639
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/s12885-017-3934-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100302240
    224 https://doi.org/10.1186/s12885-017-3934-9
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1001/jama.2007.56-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1037786557
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/dmrr.2645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005424325
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/ijc.24044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051658151
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/ijc.30403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008927111
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/ijc.30480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018668319
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/pds.3701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040365219
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/pros.23000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011653434
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.amjms.2016.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029645760
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.canep.2012.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052974169
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.canlet.2016.10.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026055572
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.clgc.2016.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024276194
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.ejca.2014.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016065200
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.ejca.2015.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008946284
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.eururo.2011.11.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047202057
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.eururo.2012.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021882819
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.ijrobp.2010.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021994745
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.juro.2015.02.798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047634749
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.juro.2016.10.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006764674
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.juro.2016.10.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010231846
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.urolonc.2013.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024465439
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/s0022-5347(05)65393-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010450934
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1046/j.1464-410x.2002.02982.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020443110
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1080/15384101.2016.1152432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058402266
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1080/21681805.2016.1271353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079391522
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1097/cej.0b013e3283656394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011493560
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1111/j.1749-6632.2010.05679.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000744892
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1136/amiajnl-2014-002649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045244437
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1155/2016/2656814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029304620
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1158/0008-5472.can-07-2310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027138181
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1158/1055-9965.epi-06-0477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050076479
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1158/1055-9965.epi-10-0940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052954710
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1158/1055-9965.epi-14-0056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033747314
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1158/1078-0432.ccr-13-1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051647965
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1158/1940-6207.capr-10-0157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013537448
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1158/1940-6207.capr-15-0141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063279411
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1158/1940-6207.capr-15-0425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063279476
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1200/jco.2007.13.9881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021314643
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1200/jco.2012.46.7043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024040122
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1200/jco.2017.35.6_suppl.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084254855
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1371/journal.pone.0113162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839927
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1371/journal.pone.0116327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018715805
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1371/journal.pone.0124761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019963480
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1530/eje-12-0053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032404852
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1530/erc-13-0077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002242051
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1530/erc-16-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004452731
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1530/jme-12-0007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035012208
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1586/14779072.5.3.491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038697314
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.18632/oncotarget.22117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092469628
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.3109/07435800.2014.934961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050198260
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.3322/caac.21442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100164642
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.4161/cc.8.22.9905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300432
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.5114/jcb.2014.45757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005411548
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.5489/cuaj.267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072920551
    331 rdf:type schema:CreativeWork
    332 https://www.grid.ac/institutes/grid.67293.39 schema:alternateName Hunan University
    333 schema:name The First Hospital of Hunan University of Chinese Medicine, 410007, Changsha, China
    334 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...