Argon reduces the pulmonary vascular tone in rats and humans by GABA-receptor activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Said Suleiman, Sergej Klassen, Ira Katz, Galina Balakirski, Julia Krabbe, Saskia von Stillfried, Svetlana Kintsler, Till Braunschweig, Aaron Babendreyer, Jan Spillner, Sebastian Kalverkamp, Thomas Schröder, Manfred Moeller, Mark Coburn, Stefan Uhlig, Christian Martin, Annette D. Rieg

ABSTRACT

Argon exerts neuroprotection. Thus, it might improve patients' neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (Pcap) were measured and the precapillary and postcapillary resistance (Rpost) was calculated. In IPLs and PCLS, the pulmonary vessel tone was enhanced with ET-1 or remained unchanged. IPLs were ventilated and PCLS were gassed with argon-mixture or room-air. IPL: Argon reduced the ET-1-induced increase of Pcap, Rpost and oedema formation (p < 0.05). PCLS (rat): Argon relaxed naïve pulmonary arteries (PAs) (p < 0.05). PCLS (rat/human): Argon attenuated the ET-1-induced contraction in PAs (p < 0.05). Inhibition of GABAB-receptors abolished argon-induced relaxation (p < 0.05) in naïve or ET-1-pre-contracted PAs; whereas inhibition of GABAA-receptors only affected ET-1-pre-contracted PAs (p < 0.01). GABAA/B-receptor agonists attenuated ET-1-induced contraction in PAs and baclofen (GABAB-agonist) even in pulmonary veins (p < 0.001). PLCS (rat): Argon did not affect the airways. Finally, argon decreases the pulmonary vessel tone by activation of GABA-receptors. Hence, argon might be applicable in patients with pulmonary hypertension and right ventricular failure. More... »

PAGES

1902

References to SciGraph publications

  • 2009-12. Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury in CRITICAL CARE
  • 2005-12. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture in CRITICAL CARE
  • 2003-06. Pulmonary capillary pressure in INTENSIVE CARE MEDICINE
  • 2015-02. Delayed Argon Administration Provides Robust Protection Against Cardiac Arrest-Induced Neurological Damage in NEUROCRITICAL CARE
  • 2012-12. The role of catecholamines in the pathogenesis of neurogenic pulmonary edema associated with subarachnoid hemorrhage in ACTA NEUROCHIRURGICA
  • 2010-08. Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection in CRITICAL CARE
  • 1998-05. Rare-gas solids in the Earth's deep interior in NATURE
  • 2000-09. Inhaled endothelin A antagonist improves arterial oxygenation in experimental acute lung injury in INTENSIVE CARE MEDICINE
  • 2016-12. Adrenomedullin and endothelin-1 are associated with myocardial injury and death in septic shock patients in CRITICAL CARE
  • 2017-12. Imatinib relaxes the pulmonary venous bed of guinea pigs in RESPIRATORY RESEARCH
  • 2012-04. GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance in CRITICAL CARE
  • 2016-06. Effects of Propofol on Excitatory and Inhibitory Amino Acid Neurotransmitter Balance in Rats with Neurogenic Pulmonary Edema Induced by Subarachnoid Hemorrhage in NEUROCRITICAL CARE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-38267-y

    DOI

    http://dx.doi.org/10.1038/s41598-018-38267-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112086207

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30760775


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