Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSSaid Suleiman, Sergej Klassen, Ira Katz, Galina Balakirski, Julia Krabbe, Saskia von Stillfried, Svetlana Kintsler, Till Braunschweig, Aaron Babendreyer, Jan Spillner, Sebastian Kalverkamp, Thomas Schröder, Manfred Moeller, Mark Coburn, Stefan Uhlig, Christian Martin, Annette D. Rieg
ABSTRACTArgon exerts neuroprotection. Thus, it might improve patients' neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (Pcap) were measured and the precapillary and postcapillary resistance (Rpost) was calculated. In IPLs and PCLS, the pulmonary vessel tone was enhanced with ET-1 or remained unchanged. IPLs were ventilated and PCLS were gassed with argon-mixture or room-air. IPL: Argon reduced the ET-1-induced increase of Pcap, Rpost and oedema formation (p < 0.05). PCLS (rat): Argon relaxed naïve pulmonary arteries (PAs) (p < 0.05). PCLS (rat/human): Argon attenuated the ET-1-induced contraction in PAs (p < 0.05). Inhibition of GABAB-receptors abolished argon-induced relaxation (p < 0.05) in naïve or ET-1-pre-contracted PAs; whereas inhibition of GABAA-receptors only affected ET-1-pre-contracted PAs (p < 0.01). GABAA/B-receptor agonists attenuated ET-1-induced contraction in PAs and baclofen (GABAB-agonist) even in pulmonary veins (p < 0.001). PLCS (rat): Argon did not affect the airways. Finally, argon decreases the pulmonary vessel tone by activation of GABA-receptors. Hence, argon might be applicable in patients with pulmonary hypertension and right ventricular failure. More... »
PAGES1902
http://scigraph.springernature.com/pub.10.1038/s41598-018-38267-y
DOIhttp://dx.doi.org/10.1038/s41598-018-38267-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112086207
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30760775
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