Physical-chemical measurement method development for self-assembled, core-shell nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Natalia Farkas, Puthupparampil V. Scaria, Martin C. Woodle, John A. Dagata

ABSTRACT

Improvements in dimensional metrology and innovations in physical-chemical characterization of functionalized nanoparticles are critically important for the realization of enhanced performance and benefits of nanomaterials. Toward this goal, we propose a multi-technique measurement approach, in which correlated atomic force microscopy, dynamic light scattering, high performance liquid chromatography and mass spectroscopy measurements are used to assess molecular and structural properties of self-assembled polyplex nanoparticles with a core-shell structure. In this approach, measurement methods are first validated with a model system consisting of gold nanoparticles functionalized with synthetic polycationic branched polyethylenimine macromolecules. Shell thickness is measured by atomic force microscopy and dynamic light scattering, and the polyelectrolyte uptake determined by chromatographic separation and mass spectrometric analysis. Statistical correlation between size, structure and stability provide a basis for extending the methods to more complex self-assembly of nucleic acids and macromolecules via a condensation reaction. From these size and analytical chemical measurements, we obtain a comprehensive spatial description of these assemblies, obtain a detailed interpretation of the core-shell evolution, and identify regions of the parameter space where stable, discrete particle formation occurs. More... »

PAGES

1655

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-38194-y

DOI

http://dx.doi.org/10.1038/s41598-018-38194-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111978383

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30733537


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