Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Soo Sang Chae, Joo Hyun Jung, Won Jin Choi, Joung Kyu Park, Hong Koo Baik, Jongjin Jung, Hyuk Wan Ko

ABSTRACT

Precise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors. More... »

PAGES

1834

References to SciGraph publications

  • 2012-03. Wetting transparency of graphene in NATURE MATERIALS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37893-w

    DOI

    http://dx.doi.org/10.1038/s41598-018-37893-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112072405

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30755647


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