Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Andriniaina Andy Nkili-Meyong, Pamela Moussavou-Boundzanga, Ingrid Labouba, Ismaël Hervé Koumakpayi, Emmanuelle Jeannot, Stéphane Descorps-Declère, Xavier Sastre-Garau, Eric M. Leroy, Ernest Belembaogo, Nicolas Berthet

ABSTRACT

Human papillomavirus (HPV) is recognised as the cause of precancerous and cancerous cervical lesions. Furthermore, in high-grade lesions, HPV is frequently integrated in the host cell genome and associated with the partial or complete loss of the E1 and E2 genes, which regulate the activity of viral oncoproteins E6 and E7. In this study, using a double-capture system followed by high-throughput sequencing, we determined the HPV integration status present in liquid-based cervical smears in an urban Gabonese population. The main inclusion criteria were based on cytological grade and the detection of the HPV16 genotype using molecular assays. The rate of HPV integration in the host genome varied with cytological grade: 85.7% (6/7), 71.4% (5/7), 66.7% (2/3) 60% (3/5) and 30.8% (4/13) for carcinomas, HSIL, ASCH, LSIL and ASCUS, respectively. For high cytological grades (carcinomas and HSIL), genotypes HPV16 and 18 represented 92.9% of the samples (13/14). The integrated form of HPV16 genotype was mainly found in high-grade lesions in 71.4% of samples regardless of cytological grade. Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions. More... »

PAGES

1504

References to SciGraph publications

  • 2016-12. Human papillomavirus genotypes distribution among Gabonese women with normal cytology and cervical abnormalities in INFECTIOUS AGENTS AND CANCER
  • 2014-02. Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer in BRITISH JOURNAL OF CANCER
  • 2016-12. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology in SCIENTIFIC REPORTS
  • 2016-01. Artifacts in the data of Hu et al. in NATURE GENETICS
  • 2011-12. ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer in MEDICAL ONCOLOGY
  • 2016-12. Human papillomavirus genotypes distribution in cervical cancer cases in Gabon in INFECTIOUS AGENTS AND CANCER
  • 2015-06. NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome in BRITISH JOURNAL OF CANCER
  • 2017-03. Integrated genomic and molecular characterization of cervical cancer in NATURE
  • 2016-12. HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2014-12. SummonChimera infers integrated viral genomes with nucleotide precision from NGS data in BMC BIOINFORMATICS
  • 2013-08. The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line in NATURE
  • 2016-12. Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology in BMC GENOMICS
  • 2014-02. Landscape of genomic alterations in cervical carcinomas in NATURE
  • 2015-02. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism in NATURE GENETICS
  • 2016-11. Mechanistic signatures of HPV insertions in cervical carcinomas in NPJ GENOMIC MEDICINE
  • 2016-12. Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol’s iodine (VIA/VILI) in Libreville, Gabon in INFECTIOUS AGENTS AND CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37871-2

    DOI

    http://dx.doi.org/10.1038/s41598-018-37871-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111950484

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30728408


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Centre International de Recherches M\u00e9dicales de Franceville", 
              "id": "https://www.grid.ac/institutes/grid.418115.8", 
              "name": [
                "Centre International de Recherches M\u00e9dicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nkili-Meyong", 
            "givenName": "Andriniaina Andy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre International de Recherches M\u00e9dicales de Franceville", 
              "id": "https://www.grid.ac/institutes/grid.418115.8", 
              "name": [
                "Centre International de Recherches M\u00e9dicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moussavou-Boundzanga", 
            "givenName": "Pamela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre International de Recherches M\u00e9dicales de Franceville", 
              "id": "https://www.grid.ac/institutes/grid.418115.8", 
              "name": [
                "Centre International de Recherches M\u00e9dicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labouba", 
            "givenName": "Ingrid", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de Canc\u00e9rologie de Libreville (ICL), Libreville, Gabon"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koumakpayi", 
            "givenName": "Isma\u00ebl Herv\u00e9", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute Curie", 
              "id": "https://www.grid.ac/institutes/grid.418596.7", 
              "name": [
                "Institut Curie, Department of Biopathology, 26 Rue d\u2019Ulm, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jeannot", 
            "givenName": "Emmanuelle", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur", 
              "id": "https://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Institut Pasteur, Centre de Bioinformatique, Biostatistique et Biologie Int\u00e9grative (C3BI), 25 rue du docteur Roux, 75724, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Descorps-Decl\u00e8re", 
            "givenName": "St\u00e9phane", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Canc\u00e9rologie de Lorraine", 
              "id": "https://www.grid.ac/institutes/grid.452436.2", 
              "name": [
                "Institut de Canc\u00e9rologie de Lorraine (ICL), 6 Avenue de Bourgogne, 54519, Vand\u0153uvre-l\u00e8s-Nancy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sastre-Garau", 
            "givenName": "Xavier", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre International de Recherches M\u00e9dicales de Franceville", 
              "id": "https://www.grid.ac/institutes/grid.418115.8", 
              "name": [
                "Centre International de Recherches M\u00e9dicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon", 
                "Institut de Recherches et de D\u00e9veloppement (IRD), Maladies Infectieuses et vecteurs: Ecologie, g\u00e9n\u00e9tique, Evolution et Contr\u00f4le (IRD 224 \u2013 CNRS 5290 6 UM1- UM2), Montpellier, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leroy", 
            "givenName": "Eric M.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institut de Canc\u00e9rologie de Libreville (ICL), Libreville, Gabon"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belembaogo", 
            "givenName": "Ernest", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur", 
              "id": "https://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Centre International de Recherches M\u00e9dicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon", 
                "Centre National de Recherche Scientifique (CNRS) UMR3569, 25 rue du docteur Roux, 75724, Paris, France", 
                "Institut Pasteur, Unit\u00e9 Environnement et risques infectieux, Cellule d\u2019Intervention Biologique d\u2019Urgence, 25 rue du Docteur Roux, 75724, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berthet", 
            "givenName": "Nicolas", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.3178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000968113", 
              "https://doi.org/10.1038/ng.3178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.1490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001444744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-010-9553-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005827538", 
              "https://doi.org/10.1007/s12032-010-9553-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npjgenmed.2016.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008803572", 
              "https://doi.org/10.1038/npjgenmed.2016.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-016-0046-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012032141", 
              "https://doi.org/10.1186/s13027-016-0046-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-016-0098-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012487863", 
              "https://doi.org/10.1186/s13027-016-0098-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-016-0098-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012487863", 
              "https://doi.org/10.1186/s13027-016-0098-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1144>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012642855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1144>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012642855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.copbio.2011.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017075472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.44.12.990", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017782733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021762873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)60919-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024871122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep35427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026230779", 
              "https://doi.org/10.1038/srep35427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026631951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.2713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026631951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2015.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028014981", 
              "https://doi.org/10.1038/bjc.2015.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-016-0454-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028554726", 
              "https://doi.org/10.1186/s13046-016-0454-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-016-0454-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028554726", 
              "https://doi.org/10.1186/s13046-016-0454-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.113.005777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028964445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/g3.113.005777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028964445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-016-0091-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035210792", 
              "https://doi.org/10.1186/s13027-016-0091-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-016-0091-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035210792", 
              "https://doi.org/10.1186/s13027-016-0091-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7314/apjcp.2013.14.6.3837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035520777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-014-0348-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039648336", 
              "https://doi.org/10.1186/s12859-014-0348-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12859-014-0348-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039648336", 
              "https://doi.org/10.1186/s12859-014-0348-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040190826", 
              "https://doi.org/10.1038/nature12064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-0009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041534287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.164806.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042224542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.1440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043886019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-15-1248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044145386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jcm.44.5.1755-1762.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046427632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0000000000000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047762901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0000000000000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047762901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0000000000000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047762901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1702(02)00187-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048156001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048359012", 
              "https://doi.org/10.1038/bjc.2013.817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd008054.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050843289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-3203-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051084568", 
              "https://doi.org/10.1186/s12864-016-3203-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-016-3203-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051084568", 
              "https://doi.org/10.1186/s12864-016-3203-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/med-2015-0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051157680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.29456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051550393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051556390", 
              "https://doi.org/10.1038/ng.3392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmoldx.2011.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051969159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052765735", 
              "https://doi.org/10.1038/nature12881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19970220)74:1<50::aid-ijc9>3.0.co;2-#", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052897490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0042-6822(87)90195-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053546489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/0022-1317-73-8-2059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060358501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/0022-1317-73-9-2327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060358538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/etm.2015.2740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071503741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/etm.2015.2740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071503741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jbm.5000051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072752819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/jbm.5000051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072752819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature21386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074205537", 
              "https://doi.org/10.1038/nature21386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074546906", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074730757", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms18102032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091898753"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Human papillomavirus (HPV) is recognised as the cause of precancerous and cancerous cervical lesions. Furthermore, in high-grade lesions, HPV is frequently integrated in the host cell genome and associated with the partial or complete loss of the E1 and E2 genes, which regulate the activity of viral oncoproteins E6 and E7. In this study, using a double-capture system followed by high-throughput sequencing, we determined the HPV integration status present in liquid-based cervical smears in an urban Gabonese population. The main inclusion criteria were based on cytological grade and the detection of the HPV16 genotype using molecular assays. The rate of HPV integration in the host genome varied with cytological grade: 85.7% (6/7), 71.4% (5/7), 66.7% (2/3) 60% (3/5) and 30.8% (4/13) for carcinomas, HSIL, ASCH, LSIL and ASCUS, respectively. For high cytological grades (carcinomas and HSIL), genotypes HPV16 and 18 represented 92.9% of the samples (13/14). The integrated form of HPV16 genotype was mainly found in high-grade lesions in 71.4% of samples regardless of cytological grade. Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-37871-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology", 
        "pagination": "1504", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2f28f429b0d50be4456a0000aa7811a001e6c5611ef705eab30b259ca8f560c9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30728408"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-37871-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111950484"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-37871-2", 
          "https://app.dimensions.ai/details/publication/pub.1111950484"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000331_0000000331/records_105440_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-37871-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37871-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37871-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37871-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37871-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    287 TRIPLES      21 PREDICATES      74 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-37871-2 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Nf9c8372d6fde45ebbf6ffde8a682cb5d
    4 schema:citation sg:pub.10.1007/s12032-010-9553-9
    5 sg:pub.10.1038/bjc.2013.817
    6 sg:pub.10.1038/bjc.2015.121
    7 sg:pub.10.1038/nature12064
    8 sg:pub.10.1038/nature12881
    9 sg:pub.10.1038/nature21386
    10 sg:pub.10.1038/ng.3178
    11 sg:pub.10.1038/ng.3392
    12 sg:pub.10.1038/npjgenmed.2016.4
    13 sg:pub.10.1038/srep35427
    14 sg:pub.10.1186/s12859-014-0348-4
    15 sg:pub.10.1186/s12864-016-3203-3
    16 sg:pub.10.1186/s13027-016-0046-0
    17 sg:pub.10.1186/s13027-016-0091-8
    18 sg:pub.10.1186/s13027-016-0098-1
    19 sg:pub.10.1186/s13046-016-0454-4
    20 https://app.dimensions.ai/details/publication/pub.1074546906
    21 https://app.dimensions.ai/details/publication/pub.1074730757
    22 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f
    23 https://doi.org/10.1002/(sici)1097-0215(19970220)74:1<50::aid-ijc9>3.0.co;2-#
    24 https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1144>3.0.co;2-l
    25 https://doi.org/10.1002/14651858.cd008054.pub2
    26 https://doi.org/10.1002/ijc.1440
    27 https://doi.org/10.1002/ijc.29456
    28 https://doi.org/10.1002/path.1490
    29 https://doi.org/10.1002/path.2713
    30 https://doi.org/10.1016/0042-6822(87)90195-4
    31 https://doi.org/10.1016/j.copbio.2011.11.013
    32 https://doi.org/10.1016/j.jmoldx.2011.01.006
    33 https://doi.org/10.1016/s0140-6736(12)60919-2
    34 https://doi.org/10.1016/s0168-1702(02)00187-9
    35 https://doi.org/10.1097/igc.0000000000000049
    36 https://doi.org/10.1099/0022-1317-73-8-2059
    37 https://doi.org/10.1099/0022-1317-73-9-2327
    38 https://doi.org/10.1101/gr.164806.113
    39 https://doi.org/10.1128/jcm.44.5.1755-1762.2006
    40 https://doi.org/10.1136/jcp.44.12.990
    41 https://doi.org/10.1158/0008-5472.can-04-0009
    42 https://doi.org/10.1158/1055-9965.epi-15-1248
    43 https://doi.org/10.1515/med-2015-0001
    44 https://doi.org/10.1534/g3.113.005777
    45 https://doi.org/10.3390/ijms18102032
    46 https://doi.org/10.3892/etm.2015.2740
    47 https://doi.org/10.5301/jbm.5000051
    48 https://doi.org/10.7314/apjcp.2013.14.6.3837
    49 schema:datePublished 2019-12
    50 schema:datePublishedReg 2019-12-01
    51 schema:description Human papillomavirus (HPV) is recognised as the cause of precancerous and cancerous cervical lesions. Furthermore, in high-grade lesions, HPV is frequently integrated in the host cell genome and associated with the partial or complete loss of the E1 and E2 genes, which regulate the activity of viral oncoproteins E6 and E7. In this study, using a double-capture system followed by high-throughput sequencing, we determined the HPV integration status present in liquid-based cervical smears in an urban Gabonese population. The main inclusion criteria were based on cytological grade and the detection of the HPV16 genotype using molecular assays. The rate of HPV integration in the host genome varied with cytological grade: 85.7% (6/7), 71.4% (5/7), 66.7% (2/3) 60% (3/5) and 30.8% (4/13) for carcinomas, HSIL, ASCH, LSIL and ASCUS, respectively. For high cytological grades (carcinomas and HSIL), genotypes HPV16 and 18 represented 92.9% of the samples (13/14). The integrated form of HPV16 genotype was mainly found in high-grade lesions in 71.4% of samples regardless of cytological grade. Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree true
    55 schema:isPartOf N50990e336c974ba2b3b17cd7024d8a00
    56 Ne43fea1c4bd94ed38648e3693ae7159d
    57 sg:journal.1045337
    58 schema:name Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology
    59 schema:pagination 1504
    60 schema:productId N061bd06a4302485b8c2d4ba82c82ad73
    61 N13e82ec1aa82423f8268c2ec889a12ca
    62 N7729048371e34cf6953987a95aed116e
    63 Nb55de78b8a6144ad84f2240c6346e378
    64 Ndbb61729002e4b5fa5b9b3606730c9ad
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111950484
    66 https://doi.org/10.1038/s41598-018-37871-2
    67 schema:sdDatePublished 2019-04-11T09:02
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher Nf79a5918180c479fa3307a733ca3b005
    70 schema:url https://www.nature.com/articles/s41598-018-37871-2
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N061bd06a4302485b8c2d4ba82c82ad73 schema:name pubmed_id
    75 schema:value 30728408
    76 rdf:type schema:PropertyValue
    77 N06390fbdbd3a49b8881893ea0fd10bde rdf:first Ne05d6106618e4a65bea26bb3a48806d1
    78 rdf:rest Nd993c77e23a14dc1abe0177876640b95
    79 N13e82ec1aa82423f8268c2ec889a12ca schema:name dimensions_id
    80 schema:value pub.1111950484
    81 rdf:type schema:PropertyValue
    82 N14a14298b8b84a518b7c7d3c6ad8dc11 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
    83 schema:familyName Berthet
    84 schema:givenName Nicolas
    85 rdf:type schema:Person
    86 N1d4263c845d74dea91e21db41b14fa2a rdf:first Nad26e1d6512f4363b23fc9c3444ee0e7
    87 rdf:rest Na177f56ff68d407cb021bd50bb9adcc9
    88 N50990e336c974ba2b3b17cd7024d8a00 schema:volumeNumber 9
    89 rdf:type schema:PublicationVolume
    90 N50eff52b09b3472e95c74947b0106370 schema:affiliation https://www.grid.ac/institutes/grid.418115.8
    91 schema:familyName Labouba
    92 schema:givenName Ingrid
    93 rdf:type schema:Person
    94 N51e9fff15c59459db56a604aa0a251f5 rdf:first N14a14298b8b84a518b7c7d3c6ad8dc11
    95 rdf:rest rdf:nil
    96 N57738cbf062f43a69529d589afd82759 schema:name Institut de Cancérologie de Libreville (ICL), Libreville, Gabon
    97 rdf:type schema:Organization
    98 N588d523fb0a54ca5b669d1e46c4f3f2d schema:affiliation https://www.grid.ac/institutes/grid.418596.7
    99 schema:familyName Jeannot
    100 schema:givenName Emmanuelle
    101 rdf:type schema:Person
    102 N7729048371e34cf6953987a95aed116e schema:name doi
    103 schema:value 10.1038/s41598-018-37871-2
    104 rdf:type schema:PropertyValue
    105 N7eee0a320dbc404ba557802c3e49d7ef schema:affiliation N57738cbf062f43a69529d589afd82759
    106 schema:familyName Koumakpayi
    107 schema:givenName Ismaël Hervé
    108 rdf:type schema:Person
    109 N8fdfc7dacc274e3a8ec587b5ede091c5 rdf:first Na7610657eebc443d94df4843be0f71ff
    110 rdf:rest Nb391af0de9cb47ac900a42d5d6ce9703
    111 N93e2dd57e5f745db9f378093ea295497 schema:affiliation https://www.grid.ac/institutes/grid.452436.2
    112 schema:familyName Sastre-Garau
    113 schema:givenName Xavier
    114 rdf:type schema:Person
    115 N9488bbdc037444a389757c4614f5194f rdf:first N7eee0a320dbc404ba557802c3e49d7ef
    116 rdf:rest Nc41bdefceb644810b26bc3d1c01dbc83
    117 Na177f56ff68d407cb021bd50bb9adcc9 rdf:first Neeb6212e00d248e9bb3cb47815d64589
    118 rdf:rest N51e9fff15c59459db56a604aa0a251f5
    119 Na7610657eebc443d94df4843be0f71ff schema:affiliation https://www.grid.ac/institutes/grid.428999.7
    120 schema:familyName Descorps-Declère
    121 schema:givenName Stéphane
    122 rdf:type schema:Person
    123 Nad26e1d6512f4363b23fc9c3444ee0e7 schema:affiliation https://www.grid.ac/institutes/grid.418115.8
    124 schema:familyName Leroy
    125 schema:givenName Eric M.
    126 rdf:type schema:Person
    127 Nb391af0de9cb47ac900a42d5d6ce9703 rdf:first N93e2dd57e5f745db9f378093ea295497
    128 rdf:rest N1d4263c845d74dea91e21db41b14fa2a
    129 Nb55de78b8a6144ad84f2240c6346e378 schema:name readcube_id
    130 schema:value 2f28f429b0d50be4456a0000aa7811a001e6c5611ef705eab30b259ca8f560c9
    131 rdf:type schema:PropertyValue
    132 Nbd1407b0334a4d0ca26364a978ba1315 schema:name Institut de Cancérologie de Libreville (ICL), Libreville, Gabon
    133 rdf:type schema:Organization
    134 Nc41bdefceb644810b26bc3d1c01dbc83 rdf:first N588d523fb0a54ca5b669d1e46c4f3f2d
    135 rdf:rest N8fdfc7dacc274e3a8ec587b5ede091c5
    136 Nd720871928a3436bb41d4044f858e258 schema:affiliation https://www.grid.ac/institutes/grid.418115.8
    137 schema:familyName Nkili-Meyong
    138 schema:givenName Andriniaina Andy
    139 rdf:type schema:Person
    140 Nd993c77e23a14dc1abe0177876640b95 rdf:first N50eff52b09b3472e95c74947b0106370
    141 rdf:rest N9488bbdc037444a389757c4614f5194f
    142 Ndbb61729002e4b5fa5b9b3606730c9ad schema:name nlm_unique_id
    143 schema:value 101563288
    144 rdf:type schema:PropertyValue
    145 Ne05d6106618e4a65bea26bb3a48806d1 schema:affiliation https://www.grid.ac/institutes/grid.418115.8
    146 schema:familyName Moussavou-Boundzanga
    147 schema:givenName Pamela
    148 rdf:type schema:Person
    149 Ne43fea1c4bd94ed38648e3693ae7159d schema:issueNumber 1
    150 rdf:type schema:PublicationIssue
    151 Neeb6212e00d248e9bb3cb47815d64589 schema:affiliation Nbd1407b0334a4d0ca26364a978ba1315
    152 schema:familyName Belembaogo
    153 schema:givenName Ernest
    154 rdf:type schema:Person
    155 Nf79a5918180c479fa3307a733ca3b005 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 Nf9c8372d6fde45ebbf6ffde8a682cb5d rdf:first Nd720871928a3436bb41d4044f858e258
    158 rdf:rest N06390fbdbd3a49b8881893ea0fd10bde
    159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Biological Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Genetics
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1045337 schema:issn 2045-2322
    166 schema:name Scientific Reports
    167 rdf:type schema:Periodical
    168 sg:pub.10.1007/s12032-010-9553-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005827538
    169 https://doi.org/10.1007/s12032-010-9553-9
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1038/bjc.2013.817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048359012
    172 https://doi.org/10.1038/bjc.2013.817
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/bjc.2015.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028014981
    175 https://doi.org/10.1038/bjc.2015.121
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/nature12064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040190826
    178 https://doi.org/10.1038/nature12064
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/nature12881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765735
    181 https://doi.org/10.1038/nature12881
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/nature21386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074205537
    184 https://doi.org/10.1038/nature21386
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/ng.3178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000968113
    187 https://doi.org/10.1038/ng.3178
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/ng.3392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051556390
    190 https://doi.org/10.1038/ng.3392
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/npjgenmed.2016.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008803572
    193 https://doi.org/10.1038/npjgenmed.2016.4
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/srep35427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026230779
    196 https://doi.org/10.1038/srep35427
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1186/s12859-014-0348-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039648336
    199 https://doi.org/10.1186/s12859-014-0348-4
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1186/s12864-016-3203-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051084568
    202 https://doi.org/10.1186/s12864-016-3203-3
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1186/s13027-016-0046-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012032141
    205 https://doi.org/10.1186/s13027-016-0046-0
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1186/s13027-016-0091-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035210792
    208 https://doi.org/10.1186/s13027-016-0091-8
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1186/s13027-016-0098-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012487863
    211 https://doi.org/10.1186/s13027-016-0098-1
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1186/s13046-016-0454-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028554726
    214 https://doi.org/10.1186/s13046-016-0454-4
    215 rdf:type schema:CreativeWork
    216 https://app.dimensions.ai/details/publication/pub.1074546906 schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1074730757 schema:CreativeWork
    218 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1021762873
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1002/(sici)1097-0215(19970220)74:1<50::aid-ijc9>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897490
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1144>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1012642855
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1002/14651858.cd008054.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050843289
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/ijc.1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043886019
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/ijc.29456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051550393
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/path.1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001444744
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/path.2713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026631951
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/0042-6822(87)90195-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053546489
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.copbio.2011.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017075472
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.jmoldx.2011.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051969159
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/s0140-6736(12)60919-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024871122
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/s0168-1702(02)00187-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048156001
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1097/igc.0000000000000049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047762901
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1099/0022-1317-73-8-2059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060358501
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1099/0022-1317-73-9-2327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060358538
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1101/gr.164806.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042224542
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1128/jcm.44.5.1755-1762.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046427632
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1136/jcp.44.12.990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017782733
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1158/0008-5472.can-04-0009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041534287
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1158/1055-9965.epi-15-1248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044145386
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1515/med-2015-0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051157680
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1534/g3.113.005777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028964445
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.3390/ijms18102032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091898753
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.3892/etm.2015.2740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071503741
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.5301/jbm.5000051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072752819
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.7314/apjcp.2013.14.6.3837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035520777
    271 rdf:type schema:CreativeWork
    272 https://www.grid.ac/institutes/grid.418115.8 schema:alternateName Centre International de Recherches Médicales de Franceville
    273 schema:name Centre International de Recherches Médicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon
    274 Institut de Recherches et de Développement (IRD), Maladies Infectieuses et vecteurs: Ecologie, génétique, Evolution et Contrôle (IRD 224 – CNRS 5290 6 UM1- UM2), Montpellier, France
    275 rdf:type schema:Organization
    276 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
    277 schema:name Institut Curie, Department of Biopathology, 26 Rue d’Ulm, 75005, Paris, France
    278 rdf:type schema:Organization
    279 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
    280 schema:name Centre International de Recherches Médicales de Franceville (CIRMF) Department of Zoonosis and Emerging Diseases, Franceville, Gabon
    281 Centre National de Recherche Scientifique (CNRS) UMR3569, 25 rue du docteur Roux, 75724, Paris, France
    282 Institut Pasteur, Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), 25 rue du docteur Roux, 75724, Paris, France
    283 Institut Pasteur, Unité Environnement et risques infectieux, Cellule d’Intervention Biologique d’Urgence, 25 rue du Docteur Roux, 75724, Paris, France
    284 rdf:type schema:Organization
    285 https://www.grid.ac/institutes/grid.452436.2 schema:alternateName Institut de Cancérologie de Lorraine
    286 schema:name Institut de Cancérologie de Lorraine (ICL), 6 Avenue de Bourgogne, 54519, Vandœuvre-lès-Nancy, France
    287 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...