Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Leonardo Gil-Santana, Luís A. B. Cruz, María B. Arriaga, Pryscila F. C. Miranda, Kiyoshi F. Fukutani, Paulo S. Silveira-Mattos, Elisangela C. Silva, Marina G. Oliveira, Eliene D. D. Mesquita, Anneloek Rauwerdink, Frank Cobelens, Martha M. Oliveira, Afranio Kritski, Bruno B. Andrade

ABSTRACT

Pulmonary tuberculosis (PTB) is associated with chronic inflammation and anemia. How anemia impacts systemic inflammation in PTB patients undergoing antitubercular therapy (ATT) is not fully understood. In the present study, data on several blood biochemical parameters were retrospectively analyzed from 118 PTB patients during the first 60 days of ATT. Multidimensional statistical analyses were employed to perform detailed inflammatory profiling of patients stratified by anemia status prior to treatment. Anemia was defined as hemoglobin levels <12.5 g/dL for female and <13.5 g/dL for male individuals. The findings revealed that most of anemia cases were likely caused by chronic inflammation. A distinct biosignature related to anemia was detected, defined by increased values of uric acid, C-reactive protein, and erythrocyte sedimentation rate. Importantly, anemic patients sustained increased levels of several biochemical markers at day 60 of therapy. Preliminary analysis failed to demonstrate association between persistent inflammation during ATT with frequency of positive sputum cultures at day 60. Thus, TB patients with anemia exhibit a distinct inflammatory profile, which is only partially reverted at day 60 of ATT. More... »

PAGES

1381

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37860-5

DOI

http://dx.doi.org/10.1038/s41598-018-37860-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111908988

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30718725


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Faculdade de Tecnologia e Ci\u00eancias", 
          "id": "https://www.grid.ac/institutes/grid.467298.6", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil", 
            "Curso de Medicina, Faculdade de Tecnologia e Ci\u00eancias, Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gil-Santana", 
        "givenName": "Leonardo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Tecnologia e Ci\u00eancias", 
          "id": "https://www.grid.ac/institutes/grid.467298.6", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil", 
            "Curso de Medicina, Faculdade de Tecnologia e Ci\u00eancias, Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cruz", 
        "givenName": "Lu\u00eds A. B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arriaga", 
        "givenName": "Mar\u00eda B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miranda", 
        "givenName": "Pryscila F. C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidade Salvador", 
          "id": "https://www.grid.ac/institutes/grid.442056.1", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil", 
            "Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukutani", 
        "givenName": "Kiyoshi F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silveira-Mattos", 
        "givenName": "Paulo S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil", 
            "Recognize the Biology Laboratory, Center of Bioscience and Biotechnology, State University of North Fluminense Darcy Ribeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva", 
        "givenName": "Elisangela C.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliveira", 
        "givenName": "Marina G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ary Parreira Institute, State Secretary of Health of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mesquita", 
        "givenName": "Eliene D. D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amsterdam Institute for Global Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.450091.9", 
          "name": [
            "Amsterdam Institute for Global Health and Development, Amsterdam University Academic Medical Centre, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rauwerdink", 
        "givenName": "Anneloek", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Amsterdam Institute for Global Health and Development", 
          "id": "https://www.grid.ac/institutes/grid.450091.9", 
          "name": [
            "Amsterdam Institute for Global Health and Development, Amsterdam University Academic Medical Centre, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cobelens", 
        "givenName": "Frank", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oswaldo Cruz Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418068.3", 
          "name": [
            "Centro de Desenvolvimento Tecnol\u00f3gico em Sa\u00fade (CDTS), Funda\u00e7\u00e3o Oswaldo Cruz, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliveira", 
        "givenName": "Martha M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kritski", 
        "givenName": "Afranio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Escola Bahiana de Medicina e Sa\u00fade P\u00fablica", 
          "id": "https://www.grid.ac/institutes/grid.414171.6", 
          "name": [
            "Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz, Salvador, Brazil", 
            "Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Funda\u00e7\u00e3o Jos\u00e9 Silveira, Salvador, Brazil", 
            "Curso de Medicina, Faculdade de Tecnologia e Ci\u00eancias, Salvador, Brazil", 
            "Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil", 
            "Escola Bahiana de Medicina e Sa\u00fade P\u00fablica (EBMSP), Salvador, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade", 
        "givenName": "Bruno B.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12879-016-1736-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001241782", 
          "https://doi.org/10.1186/s12879-016-1736-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12879-016-1736-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001241782", 
          "https://doi.org/10.1186/s12879-016-1736-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1806-37132014000400008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002815418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2008.570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007590985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008800680", 
          "https://doi.org/10.1038/nm.4177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008800680", 
          "https://doi.org/10.1038/nm.4177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2458-10-259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009821725", 
          "https://doi.org/10.1186/1471-2458-10-259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci77990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010175295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/jn.111.144287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012804570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra041809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015838411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1995.tb00267.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018455812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1995.tb00267.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018455812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2006.21.6.1028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020466973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3346/jkms.2006.21.6.1028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020466973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/cclm.2011.621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022084684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/joim.12256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022509037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ofid/ofv098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024098167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024925310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0000000000001607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035208404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ccm.0000000000001607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035208404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1758-2652-14-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040866279", 
          "https://doi.org/10.1186/1758-2652-14-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-07-3046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041144427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041318076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043550399", 
          "https://doi.org/10.1038/nature13489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756283x11398736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064076421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1756283x11398736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064076421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-104-4-515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073690873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3305/nh.2015.32.6.9827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079194463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081334197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0175278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084626886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(18)30111-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101722579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(18)30111-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101722579"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Pulmonary tuberculosis (PTB) is associated with chronic inflammation and anemia. How anemia impacts systemic inflammation in PTB patients undergoing antitubercular therapy (ATT) is not fully understood. In the present study, data on several blood biochemical parameters were retrospectively analyzed from 118 PTB patients during the first 60 days of ATT. Multidimensional statistical analyses were employed to perform detailed inflammatory profiling of patients stratified by anemia status prior to treatment. Anemia was defined as hemoglobin levels <12.5\u2009g/dL for female and <13.5\u2009g/dL for male individuals. The findings revealed that most of anemia cases were likely caused by chronic inflammation. A distinct biosignature related to anemia was detected, defined by increased values of uric acid, C-reactive protein, and erythrocyte sedimentation rate. Importantly, anemic patients sustained increased levels of several biochemical markers at day 60 of therapy. Preliminary analysis failed to demonstrate association between persistent inflammation during ATT with frequency of positive sputum cultures at day 60. Thus, TB patients with anemia exhibit a distinct inflammatory profile, which is only partially reverted at day 60 of ATT.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-37860-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3933633", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy", 
    "pagination": "1381", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3549efb21a2937ec845eec2ec57e46144dc0fb99abe678f84cc1761e01b7ad7e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30718725"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-37860-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111908988"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-37860-5", 
      "https://app.dimensions.ai/details/publication/pub.1111908988"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000330_0000000330/records_116355_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-37860-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37860-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37860-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37860-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37860-5'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-37860-5 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N04350a334e1a47b780d48d25a12f3abb
4 schema:citation sg:pub.10.1038/nature13489
5 sg:pub.10.1038/nm.4177
6 sg:pub.10.1186/1471-2458-10-259
7 sg:pub.10.1186/1758-2652-14-19
8 sg:pub.10.1186/s12879-016-1736-3
9 https://app.dimensions.ai/details/publication/pub.1081334197
10 https://doi.org/10.1001/jama.2008.570
11 https://doi.org/10.1016/s1473-3099(18)30111-7
12 https://doi.org/10.1056/nejmra041809
13 https://doi.org/10.1093/cid/ciu945
14 https://doi.org/10.1093/ofid/ofv098
15 https://doi.org/10.1097/ccm.0000000000001607
16 https://doi.org/10.1111/j.1600-0609.1995.tb00267.x
17 https://doi.org/10.1111/joim.12256
18 https://doi.org/10.1172/jci77990
19 https://doi.org/10.1177/1756283x11398736
20 https://doi.org/10.1182/blood-2005-07-3046
21 https://doi.org/10.1371/journal.pone.0175278
22 https://doi.org/10.1371/journal.ppat.1004433
23 https://doi.org/10.1515/cclm.2011.621
24 https://doi.org/10.1590/s1806-37132014000400008
25 https://doi.org/10.3305/nh.2015.32.6.9827
26 https://doi.org/10.3346/jkms.2006.21.6.1028
27 https://doi.org/10.3945/jn.111.144287
28 https://doi.org/10.7326/0003-4819-104-4-515
29 schema:datePublished 2019-12
30 schema:datePublishedReg 2019-12-01
31 schema:description Pulmonary tuberculosis (PTB) is associated with chronic inflammation and anemia. How anemia impacts systemic inflammation in PTB patients undergoing antitubercular therapy (ATT) is not fully understood. In the present study, data on several blood biochemical parameters were retrospectively analyzed from 118 PTB patients during the first 60 days of ATT. Multidimensional statistical analyses were employed to perform detailed inflammatory profiling of patients stratified by anemia status prior to treatment. Anemia was defined as hemoglobin levels <12.5 g/dL for female and <13.5 g/dL for male individuals. The findings revealed that most of anemia cases were likely caused by chronic inflammation. A distinct biosignature related to anemia was detected, defined by increased values of uric acid, C-reactive protein, and erythrocyte sedimentation rate. Importantly, anemic patients sustained increased levels of several biochemical markers at day 60 of therapy. Preliminary analysis failed to demonstrate association between persistent inflammation during ATT with frequency of positive sputum cultures at day 60. Thus, TB patients with anemia exhibit a distinct inflammatory profile, which is only partially reverted at day 60 of ATT.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N1c1140e8b9484b46a26f65e772f9666d
36 Nd560ab48879b441a96bef72ecc3d30fd
37 sg:journal.1045337
38 schema:name Tuberculosis-associated anemia is linked to a distinct inflammatory profile that persists after initiation of antitubercular therapy
39 schema:pagination 1381
40 schema:productId N69d1717124774fa186026703d39dc5d6
41 N80afb3ad264945c997836e985bf9850f
42 Nbaf10486d34d49e6b757e5909feb3fdc
43 Nd0b34d28f75a4e0098ef4bdd2afc2433
44 Ndf0892a6eb634584808729a624ccaaf5
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111908988
46 https://doi.org/10.1038/s41598-018-37860-5
47 schema:sdDatePublished 2019-04-11T09:01
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N66a0ca8a868541c2a860130ca21b8dc9
50 schema:url https://www.nature.com/articles/s41598-018-37860-5
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N04350a334e1a47b780d48d25a12f3abb rdf:first N5da7d3623a03476aae52c52d788af282
55 rdf:rest N4d355821aeaa49c5a5a5950772a779da
56 N05934137092c4275b4cca7ada1fd5785 schema:affiliation https://www.grid.ac/institutes/grid.450091.9
57 schema:familyName Rauwerdink
58 schema:givenName Anneloek
59 rdf:type schema:Person
60 N0d540d059397452da147d096d2660865 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
61 schema:familyName Silveira-Mattos
62 schema:givenName Paulo S.
63 rdf:type schema:Person
64 N1b7aefdb431f4d2eb63af6cd33c94d3f rdf:first N82156f6dcfe54ca290dea46c51e3dfa3
65 rdf:rest N4dfd0e60637c4fd2bae09819d4fb3039
66 N1c1140e8b9484b46a26f65e772f9666d schema:volumeNumber 9
67 rdf:type schema:PublicationVolume
68 N25c1051f979b4298b0bf90f8f8cef384 rdf:first N3a9ccdb891e64176802663bd6df1576e
69 rdf:rest N64ae2ab136af483ca1f9881f6d936cbc
70 N273518f291bd4eeea95c838339c00e19 rdf:first N990ed57d2e854ba7af4c521d0c5e644b
71 rdf:rest N91db06a3d0744e9aa838f07f2cfc9dfe
72 N361538564cfc4c209f505a89ed299018 rdf:first Ne46b3336b7374ea797121966f4a79ea3
73 rdf:rest Nd66f96b04bc046a3b1c2d63801a55d82
74 N39359bb5ec1846abaaa3fdda6d495eec rdf:first N05934137092c4275b4cca7ada1fd5785
75 rdf:rest N7ab2ffff65ca4ed5b13bf6ae9b16583a
76 N3a9ccdb891e64176802663bd6df1576e schema:affiliation https://www.grid.ac/institutes/grid.8536.8
77 schema:familyName Kritski
78 schema:givenName Afranio
79 rdf:type schema:Person
80 N4adc80a882f44fb8aa15be74a0e7cbbf schema:affiliation https://www.grid.ac/institutes/grid.418068.3
81 schema:familyName Oliveira
82 schema:givenName Martha M.
83 rdf:type schema:Person
84 N4d355821aeaa49c5a5a5950772a779da rdf:first N75aea0053fe449ecaefdfe59e934ca49
85 rdf:rest N361538564cfc4c209f505a89ed299018
86 N4dfd0e60637c4fd2bae09819d4fb3039 rdf:first N9700cb125b154e89bfb87c42a5b8442d
87 rdf:rest Nd6c1da0ebd9941659e19ca65e3d011f4
88 N5b5fe45fe03f47b9bbb70ab3c50a2b0f rdf:first N4adc80a882f44fb8aa15be74a0e7cbbf
89 rdf:rest N25c1051f979b4298b0bf90f8f8cef384
90 N5da7d3623a03476aae52c52d788af282 schema:affiliation https://www.grid.ac/institutes/grid.467298.6
91 schema:familyName Gil-Santana
92 schema:givenName Leonardo
93 rdf:type schema:Person
94 N64ae2ab136af483ca1f9881f6d936cbc rdf:first Nfde121b7d6f44f80ab7670e1f30351d8
95 rdf:rest rdf:nil
96 N66a0ca8a868541c2a860130ca21b8dc9 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N69d1717124774fa186026703d39dc5d6 schema:name pubmed_id
99 schema:value 30718725
100 rdf:type schema:PropertyValue
101 N75aea0053fe449ecaefdfe59e934ca49 schema:affiliation https://www.grid.ac/institutes/grid.467298.6
102 schema:familyName Cruz
103 schema:givenName Luís A. B.
104 rdf:type schema:Person
105 N7ab2ffff65ca4ed5b13bf6ae9b16583a rdf:first Nbb78d5f1edd2411a8cd3fde19c3afeb2
106 rdf:rest N5b5fe45fe03f47b9bbb70ab3c50a2b0f
107 N7df8c41aaae64c6bb3c69718b1eceb96 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
108 schema:familyName Miranda
109 schema:givenName Pryscila F. C.
110 rdf:type schema:Person
111 N80afb3ad264945c997836e985bf9850f schema:name readcube_id
112 schema:value 3549efb21a2937ec845eec2ec57e46144dc0fb99abe678f84cc1761e01b7ad7e
113 rdf:type schema:PropertyValue
114 N82156f6dcfe54ca290dea46c51e3dfa3 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
115 schema:familyName Silva
116 schema:givenName Elisangela C.
117 rdf:type schema:Person
118 N8f7d08a29485448981de7b424f129112 schema:affiliation Nb2adc07d9d5944e1aaa31887b9797012
119 schema:familyName Mesquita
120 schema:givenName Eliene D. D.
121 rdf:type schema:Person
122 N91db06a3d0744e9aa838f07f2cfc9dfe rdf:first N0d540d059397452da147d096d2660865
123 rdf:rest N1b7aefdb431f4d2eb63af6cd33c94d3f
124 N9700cb125b154e89bfb87c42a5b8442d schema:affiliation https://www.grid.ac/institutes/grid.8536.8
125 schema:familyName Oliveira
126 schema:givenName Marina G.
127 rdf:type schema:Person
128 N990ed57d2e854ba7af4c521d0c5e644b schema:affiliation https://www.grid.ac/institutes/grid.442056.1
129 schema:familyName Fukutani
130 schema:givenName Kiyoshi F.
131 rdf:type schema:Person
132 Nb2adc07d9d5944e1aaa31887b9797012 schema:name Ary Parreira Institute, State Secretary of Health of Rio de Janeiro, Rio de Janeiro, Brazil
133 rdf:type schema:Organization
134 Nbaf10486d34d49e6b757e5909feb3fdc schema:name nlm_unique_id
135 schema:value 101563288
136 rdf:type schema:PropertyValue
137 Nbb78d5f1edd2411a8cd3fde19c3afeb2 schema:affiliation https://www.grid.ac/institutes/grid.450091.9
138 schema:familyName Cobelens
139 schema:givenName Frank
140 rdf:type schema:Person
141 Nd0b34d28f75a4e0098ef4bdd2afc2433 schema:name doi
142 schema:value 10.1038/s41598-018-37860-5
143 rdf:type schema:PropertyValue
144 Nd560ab48879b441a96bef72ecc3d30fd schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 Nd66f96b04bc046a3b1c2d63801a55d82 rdf:first N7df8c41aaae64c6bb3c69718b1eceb96
147 rdf:rest N273518f291bd4eeea95c838339c00e19
148 Nd6c1da0ebd9941659e19ca65e3d011f4 rdf:first N8f7d08a29485448981de7b424f129112
149 rdf:rest N39359bb5ec1846abaaa3fdda6d495eec
150 Ndf0892a6eb634584808729a624ccaaf5 schema:name dimensions_id
151 schema:value pub.1111908988
152 rdf:type schema:PropertyValue
153 Ne46b3336b7374ea797121966f4a79ea3 schema:affiliation https://www.grid.ac/institutes/grid.418068.3
154 schema:familyName Arriaga
155 schema:givenName María B.
156 rdf:type schema:Person
157 Nfde121b7d6f44f80ab7670e1f30351d8 schema:affiliation https://www.grid.ac/institutes/grid.414171.6
158 schema:familyName Andrade
159 schema:givenName Bruno B.
160 rdf:type schema:Person
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
165 schema:name Cardiorespiratory Medicine and Haematology
166 rdf:type schema:DefinedTerm
167 sg:grant.3933633 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-37860-5
168 rdf:type schema:MonetaryGrant
169 sg:journal.1045337 schema:issn 2045-2322
170 schema:name Scientific Reports
171 rdf:type schema:Periodical
172 sg:pub.10.1038/nature13489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043550399
173 https://doi.org/10.1038/nature13489
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nm.4177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008800680
176 https://doi.org/10.1038/nm.4177
177 rdf:type schema:CreativeWork
178 sg:pub.10.1186/1471-2458-10-259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009821725
179 https://doi.org/10.1186/1471-2458-10-259
180 rdf:type schema:CreativeWork
181 sg:pub.10.1186/1758-2652-14-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040866279
182 https://doi.org/10.1186/1758-2652-14-19
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/s12879-016-1736-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001241782
185 https://doi.org/10.1186/s12879-016-1736-3
186 rdf:type schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1081334197 schema:CreativeWork
188 https://doi.org/10.1001/jama.2008.570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007590985
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s1473-3099(18)30111-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101722579
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1056/nejmra041809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015838411
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1093/cid/ciu945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024925310
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1093/ofid/ofv098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024098167
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/ccm.0000000000001607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035208404
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1111/j.1600-0609.1995.tb00267.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018455812
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1111/joim.12256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022509037
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1172/jci77990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010175295
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1177/1756283x11398736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064076421
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1182/blood-2005-07-3046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041144427
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1371/journal.pone.0175278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084626886
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1371/journal.ppat.1004433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041318076
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1515/cclm.2011.621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022084684
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1590/s1806-37132014000400008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815418
217 rdf:type schema:CreativeWork
218 https://doi.org/10.3305/nh.2015.32.6.9827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079194463
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3346/jkms.2006.21.6.1028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020466973
221 rdf:type schema:CreativeWork
222 https://doi.org/10.3945/jn.111.144287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012804570
223 rdf:type schema:CreativeWork
224 https://doi.org/10.7326/0003-4819-104-4-515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073690873
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.414171.6 schema:alternateName Escola Bahiana de Medicina e Saúde Pública
227 schema:name Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Brazil
228 Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil
229 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil
230 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil
231 Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.418068.3 schema:alternateName Oswaldo Cruz Foundation
234 schema:name Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
235 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil
236 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.442056.1 schema:alternateName Universidade Salvador
239 schema:name Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil
240 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil
241 Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.450091.9 schema:alternateName Amsterdam Institute for Global Health and Development
244 schema:name Amsterdam Institute for Global Health and Development, Amsterdam University Academic Medical Centre, Amsterdam, The Netherlands
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.467298.6 schema:alternateName Faculdade de Tecnologia e Ciências
247 schema:name Curso de Medicina, Faculdade de Tecnologia e Ciências, Salvador, Brazil
248 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil
249 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil
250 rdf:type schema:Organization
251 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
252 schema:name Recognize the Biology Laboratory, Center of Bioscience and Biotechnology, State University of North Fluminense Darcy Ribeiro, Rio de Janeiro, Brazil
253 Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...