Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

De-Xiang Zhang, Chiaki Yoshikawa, Nicholas G. Welch, Paul Pasic, Helmut Thissen, Nicolas H. Voelcker

ABSTRACT

A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment. In addition, copolymers of N-(2-hydroxypropyl) acrylamide (HPAm) and N-benzophenone acrylamide (BPAm) were grafted onto the external pSi surfaces by spin-coating and UV crosslinking. Each modification step was verified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, water contact angle (WCA) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). In order to confirm that the air plasma treatment and silanization step only occurred on the top surface of pSi samples, confocal microscopy was employed after fluorescein isothiocyanate (FITC) conjugation. Drug release studies carried out over 17 h in PBS demonstrated that the modified pSi reservoirs released CPT continuously, while showing excellent stability. Furthermore, protein adsorption and cell attachment studies demonstrated the ability of the graft polymer layer to reduce both significantly. In combination with the biocompatible pSi substrate material, the facile modification strategy described in this study provides access to new multifunctional drug delivery systems (DDS) for applications in cancer therapy. More... »

PAGES

1367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37750-w

DOI

http://dx.doi.org/10.1038/s41598-018-37750-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111912210

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30718670


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Chemistry (incl. Structural)", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 3052, Parkville, Victoria, Australia", 
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "De-Xiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Materials Science", 
          "id": "https://www.grid.ac/institutes/grid.21941.3f", 
          "name": [
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia", 
            "International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, 1-2-1, Sengen, 305-0047, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshikawa", 
        "givenName": "Chiaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welch", 
        "givenName": "Nicholas G.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pasic", 
        "givenName": "Paul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thissen", 
        "givenName": "Helmut", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Melbourne Centre for Nanofabrication", 
          "id": "https://www.grid.ac/institutes/grid.410660.5", 
          "name": [
            "Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 3052, Parkville, Victoria, Australia", 
            "Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia", 
            "Melbourne Centre for Nanofabrication, Victorian Node of Australian National Fabrication Facility, Clayton, 3168, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voelcker", 
        "givenName": "Nicolas H.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.actbio.2012.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003553011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005241540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201100438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005502114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.snb.2011.07.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006352829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2016.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009314186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.201604634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011984658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/1061186x.2015.1051049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012192806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425247.4.2.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014395735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014403342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2011.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014862227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adfm.201000575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014895882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adfm.201000575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014895882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cm500797b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016600071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pj.2014.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018526492", 
          "https://doi.org/10.1038/pj.2014.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pj.2014.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018526492", 
          "https://doi.org/10.1038/pj.2014.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/ch15315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020679087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b901745c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021639468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b901745c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021639468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.05.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023242437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201200335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026409819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2013.10.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030499446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200704784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030767736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031181885", 
          "https://doi.org/10.1038/ncomms3326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2000.tb07020.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031578146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bm500654q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035194590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/marc.201100189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040158954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c4ob00164h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041387576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6nr08486a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044556399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201002504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046266922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201002504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046266922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.201600634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050878109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pssa.200881080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051377055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pssa.200881080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051377055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201600707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051379378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat2398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051411109", 
          "https://doi.org/10.1038/nmat2398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cis.2012.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051769218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2011.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052036768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.115.012070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052472227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.05.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052925977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.langmuir.5b01372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055116043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.langmuir.5b03794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055116726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acsami.5b12433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055129330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/am300621k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055142417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la102033d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056152651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la102033d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056152651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la200551g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056154090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la200551g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056154090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la201760w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056154517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la201760w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056154517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la303649u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056157028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn305574e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056224980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn901657w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056227550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.apsusc.2017.02.099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083908486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/asia.201700427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085414715"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment. In addition, copolymers of N-(2-hydroxypropyl) acrylamide (HPAm) and N-benzophenone acrylamide (BPAm) were grafted onto the external pSi surfaces by spin-coating and UV crosslinking. Each modification step was verified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, water contact angle (WCA) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). In order to confirm that the air plasma treatment and silanization step only occurred on the top surface of pSi samples, confocal microscopy was employed after fluorescein isothiocyanate (FITC) conjugation. Drug release studies carried out over 17\u2009h in PBS demonstrated that the modified pSi reservoirs released CPT continuously, while showing excellent stability. Furthermore, protein adsorption and cell attachment studies demonstrated the ability of the graft polymer layer to reduce both significantly. In combination with the biocompatible pSi substrate material, the facile modification strategy described in this study provides access to new multifunctional drug delivery systems (DDS) for applications in cancer therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-37750-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications", 
    "pagination": "1367", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "72d05bb6e08a8ce2d5b2a1f179fc66937a2f42ace721d9a4fd182f48b915ac27"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30718670"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-37750-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111912210"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-37750-w", 
      "https://app.dimensions.ai/details/publication/pub.1111912210"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000330_0000000330/records_116367_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-37750-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37750-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37750-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37750-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37750-w'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      75 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-37750-w schema:about anzsrc-for:03
2 anzsrc-for:0306
3 schema:author N7242d6f3b67042aea418a87e8b8fde37
4 schema:citation sg:pub.10.1038/ncomms3326
5 sg:pub.10.1038/nmat2398
6 sg:pub.10.1038/pj.2014.46
7 https://doi.org/10.1002/adfm.201000575
8 https://doi.org/10.1002/adhm.201200335
9 https://doi.org/10.1002/adhm.201600707
10 https://doi.org/10.1002/adma.201600634
11 https://doi.org/10.1002/adma.201604634
12 https://doi.org/10.1002/anie.200704784
13 https://doi.org/10.1002/anie.201002504
14 https://doi.org/10.1002/asia.201700427
15 https://doi.org/10.1002/marc.201100189
16 https://doi.org/10.1002/pssa.200881080
17 https://doi.org/10.1002/smll.201100438
18 https://doi.org/10.1016/j.actbio.2011.10.006
19 https://doi.org/10.1016/j.actbio.2012.12.010
20 https://doi.org/10.1016/j.apsusc.2017.02.099
21 https://doi.org/10.1016/j.biomaterials.2009.02.008
22 https://doi.org/10.1016/j.biomaterials.2010.11.013
23 https://doi.org/10.1016/j.biomaterials.2013.10.065
24 https://doi.org/10.1016/j.biomaterials.2014.05.020
25 https://doi.org/10.1016/j.biomaterials.2014.05.078
26 https://doi.org/10.1016/j.cis.2012.03.006
27 https://doi.org/10.1016/j.jconrel.2011.06.004
28 https://doi.org/10.1016/j.jconrel.2016.12.008
29 https://doi.org/10.1016/j.snb.2011.07.059
30 https://doi.org/10.1021/acs.langmuir.5b01372
31 https://doi.org/10.1021/acs.langmuir.5b03794
32 https://doi.org/10.1021/acsami.5b12433
33 https://doi.org/10.1021/am300621k
34 https://doi.org/10.1021/bm500654q
35 https://doi.org/10.1021/cm500797b
36 https://doi.org/10.1021/la102033d
37 https://doi.org/10.1021/la200551g
38 https://doi.org/10.1021/la201760w
39 https://doi.org/10.1021/la303649u
40 https://doi.org/10.1021/nn305574e
41 https://doi.org/10.1021/nn901657w
42 https://doi.org/10.1039/b901745c
43 https://doi.org/10.1039/c4ob00164h
44 https://doi.org/10.1039/c6nr08486a
45 https://doi.org/10.1071/ch15315
46 https://doi.org/10.1111/j.1749-6632.2000.tb07020.x
47 https://doi.org/10.1124/pr.115.012070
48 https://doi.org/10.1517/17425247.4.2.101
49 https://doi.org/10.3109/1061186x.2015.1051049
50 schema:datePublished 2019-12
51 schema:datePublishedReg 2019-12-01
52 schema:description A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment. In addition, copolymers of N-(2-hydroxypropyl) acrylamide (HPAm) and N-benzophenone acrylamide (BPAm) were grafted onto the external pSi surfaces by spin-coating and UV crosslinking. Each modification step was verified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, water contact angle (WCA) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). In order to confirm that the air plasma treatment and silanization step only occurred on the top surface of pSi samples, confocal microscopy was employed after fluorescein isothiocyanate (FITC) conjugation. Drug release studies carried out over 17 h in PBS demonstrated that the modified pSi reservoirs released CPT continuously, while showing excellent stability. Furthermore, protein adsorption and cell attachment studies demonstrated the ability of the graft polymer layer to reduce both significantly. In combination with the biocompatible pSi substrate material, the facile modification strategy described in this study provides access to new multifunctional drug delivery systems (DDS) for applications in cancer therapy.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N1f00c188991e4de79576efae97ddec65
57 N8f6a23c9c8e34d5eb89b5890d77d7ce2
58 sg:journal.1045337
59 schema:name Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications
60 schema:pagination 1367
61 schema:productId N0150da46f52e4f139b9bffc4d4902b19
62 Ncfc01d118a454654ae11312f84e5cf06
63 Neb1f8557382245f18f5e5c51605d97da
64 Nf6cf8c63bbcd47229337ca0e33b6a035
65 Nfd5ad7153b6849c8a94ae253b18e12d4
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111912210
67 https://doi.org/10.1038/s41598-018-37750-w
68 schema:sdDatePublished 2019-04-11T09:01
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N3e6d682e3ee8480b8f3348fc29012e70
71 schema:url https://www.nature.com/articles/s41598-018-37750-w
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0150da46f52e4f139b9bffc4d4902b19 schema:name doi
76 schema:value 10.1038/s41598-018-37750-w
77 rdf:type schema:PropertyValue
78 N1f00c188991e4de79576efae97ddec65 schema:volumeNumber 9
79 rdf:type schema:PublicationVolume
80 N2e1db268c26a43cd84636a60d2638854 rdf:first Neaedb4aef38e475bb1420ab9fedc87e0
81 rdf:rest Nd33be281949a4129bb709cf57ea753ff
82 N3e6d682e3ee8480b8f3348fc29012e70 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N3eca0fe38c514bbaa1d044de71f503f2 rdf:first N3ef68369bb9348ada3e9145035d6cc61
85 rdf:rest N2e1db268c26a43cd84636a60d2638854
86 N3ef68369bb9348ada3e9145035d6cc61 schema:affiliation N979b3e16ffff4415b53f6feb1d2080bf
87 schema:familyName Pasic
88 schema:givenName Paul
89 rdf:type schema:Person
90 N4d13c362ed73490eaeb42066d6799261 schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
91 rdf:type schema:Organization
92 N6c1ba2fcd4974cff875e9e5333f2834b rdf:first N9563c996e0ed477da60eb9ccf13c6ba3
93 rdf:rest Nf209eceb04c4492a96d34d46918d4bdf
94 N7242d6f3b67042aea418a87e8b8fde37 rdf:first N726cc42b558e4fb4aa36226fcba7a8ac
95 rdf:rest N6c1ba2fcd4974cff875e9e5333f2834b
96 N726cc42b558e4fb4aa36226fcba7a8ac schema:affiliation https://www.grid.ac/institutes/grid.1002.3
97 schema:familyName Zhang
98 schema:givenName De-Xiang
99 rdf:type schema:Person
100 N8f6a23c9c8e34d5eb89b5890d77d7ce2 schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N9563c996e0ed477da60eb9ccf13c6ba3 schema:affiliation https://www.grid.ac/institutes/grid.21941.3f
103 schema:familyName Yoshikawa
104 schema:givenName Chiaki
105 rdf:type schema:Person
106 N979b3e16ffff4415b53f6feb1d2080bf schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
107 rdf:type schema:Organization
108 Nba0ac87476b441a0a5a8629fb956397a schema:affiliation N4d13c362ed73490eaeb42066d6799261
109 schema:familyName Welch
110 schema:givenName Nicholas G.
111 rdf:type schema:Person
112 Ncfc01d118a454654ae11312f84e5cf06 schema:name nlm_unique_id
113 schema:value 101563288
114 rdf:type schema:PropertyValue
115 Nd33be281949a4129bb709cf57ea753ff rdf:first Nfe58a4adfc9e4ed198c0b2518e5f3dd0
116 rdf:rest rdf:nil
117 Ne5c531d994ef4b50a5db7b4bb814fa65 schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
118 rdf:type schema:Organization
119 Neaedb4aef38e475bb1420ab9fedc87e0 schema:affiliation Ne5c531d994ef4b50a5db7b4bb814fa65
120 schema:familyName Thissen
121 schema:givenName Helmut
122 rdf:type schema:Person
123 Neb1f8557382245f18f5e5c51605d97da schema:name dimensions_id
124 schema:value pub.1111912210
125 rdf:type schema:PropertyValue
126 Nf209eceb04c4492a96d34d46918d4bdf rdf:first Nba0ac87476b441a0a5a8629fb956397a
127 rdf:rest N3eca0fe38c514bbaa1d044de71f503f2
128 Nf6cf8c63bbcd47229337ca0e33b6a035 schema:name readcube_id
129 schema:value 72d05bb6e08a8ce2d5b2a1f179fc66937a2f42ace721d9a4fd182f48b915ac27
130 rdf:type schema:PropertyValue
131 Nfd5ad7153b6849c8a94ae253b18e12d4 schema:name pubmed_id
132 schema:value 30718670
133 rdf:type schema:PropertyValue
134 Nfe58a4adfc9e4ed198c0b2518e5f3dd0 schema:affiliation https://www.grid.ac/institutes/grid.410660.5
135 schema:familyName Voelcker
136 schema:givenName Nicolas H.
137 rdf:type schema:Person
138 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
139 schema:name Chemical Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
142 schema:name Physical Chemistry (incl. Structural)
143 rdf:type schema:DefinedTerm
144 sg:journal.1045337 schema:issn 2045-2322
145 schema:name Scientific Reports
146 rdf:type schema:Periodical
147 sg:pub.10.1038/ncomms3326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031181885
148 https://doi.org/10.1038/ncomms3326
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/nmat2398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051411109
151 https://doi.org/10.1038/nmat2398
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/pj.2014.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018526492
154 https://doi.org/10.1038/pj.2014.46
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1002/adfm.201000575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014895882
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1002/adhm.201200335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026409819
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/adhm.201600707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051379378
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1002/adma.201600634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050878109
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/adma.201604634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011984658
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/anie.200704784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030767736
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/anie.201002504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046266922
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/asia.201700427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085414715
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/marc.201100189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040158954
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/pssa.200881080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051377055
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/smll.201100438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005502114
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.actbio.2011.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014862227
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.actbio.2012.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003553011
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.apsusc.2017.02.099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083908486
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.biomaterials.2009.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014403342
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.biomaterials.2010.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005241540
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.biomaterials.2013.10.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499446
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.biomaterials.2014.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052925977
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.biomaterials.2014.05.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023242437
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.cis.2012.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051769218
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jconrel.2011.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052036768
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.jconrel.2016.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009314186
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.snb.2011.07.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006352829
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1021/acs.langmuir.5b01372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055116043
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1021/acs.langmuir.5b03794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055116726
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1021/acsami.5b12433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055129330
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1021/am300621k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055142417
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1021/bm500654q schema:sameAs https://app.dimensions.ai/details/publication/pub.1035194590
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1021/cm500797b schema:sameAs https://app.dimensions.ai/details/publication/pub.1016600071
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1021/la102033d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056152651
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1021/la200551g schema:sameAs https://app.dimensions.ai/details/publication/pub.1056154090
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1021/la201760w schema:sameAs https://app.dimensions.ai/details/publication/pub.1056154517
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1021/la303649u schema:sameAs https://app.dimensions.ai/details/publication/pub.1056157028
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1021/nn305574e schema:sameAs https://app.dimensions.ai/details/publication/pub.1056224980
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1021/nn901657w schema:sameAs https://app.dimensions.ai/details/publication/pub.1056227550
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1039/b901745c schema:sameAs https://app.dimensions.ai/details/publication/pub.1021639468
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1039/c4ob00164h schema:sameAs https://app.dimensions.ai/details/publication/pub.1041387576
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1039/c6nr08486a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044556399
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1071/ch15315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020679087
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1111/j.1749-6632.2000.tb07020.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031578146
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1124/pr.115.012070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052472227
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1517/17425247.4.2.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014395735
239 rdf:type schema:CreativeWork
240 https://doi.org/10.3109/1061186x.2015.1051049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012192806
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
243 schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
244 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 3052, Parkville, Victoria, Australia
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.21941.3f schema:alternateName National Institute for Materials Science
247 schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
248 International Centre for Materials Nanoarchitectonics, National Institute for Materials Science, 1-2-1, Sengen, 305-0047, Tsukuba, Ibaraki, Japan
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.410660.5 schema:alternateName Melbourne Centre for Nanofabrication
251 schema:name Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing, 3168, Clayton, Victoria, Australia
252 Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 3052, Parkville, Victoria, Australia
253 Melbourne Centre for Nanofabrication, Victorian Node of Australian National Fabrication Facility, Clayton, 3168, Victoria, Australia
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...