Acute and chronic demyelinated CNS lesions exhibit opposite elastic properties View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Mateusz M. Urbanski, Matthew B. Brendel, Carmen V. Melendez-Vasquez

ABSTRACT

Increased deposition of extracellular matrix (ECM) is a known inhibitor of axonal regrowth and remyelination. Recent in vitro studies have demonstrated that oligodendrocyte differentiation is impacted by the physical properties of the ECM. However, characterization of the mechanical properties of the healthy and injured CNS myelin is challenging, and has largely relied on non-invasive, low-resolution methods. To address this, we have employed atomic force microscopy to perform micro-indentation measurements of demyelinated tissue at cellular scale. Analysis of mouse and human demyelinated brains indicate that acute demyelination results in decreased tissue stiffness that recovers with remyelination; while chronic demyelination is characterized by increased tissue stiffness, which correlates with augmented ECM deposition. Thus, changes in the mechanical properties of the acutely (softer) or chronically (stiffer) demyelinated brain might contribute to differences in their regenerative capacity. Our findings are relevant to the optimization of cell-based therapies aimed at promoting CNS regeneration and remyelination. More... »

PAGES

999

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37745-7

DOI

http://dx.doi.org/10.1038/s41598-018-37745-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111775145

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700777


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RDF/XML is a standard XML format for linked data.

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