Transcriptome-derived investigation of biosynthesis of quinolizidine alkaloids in narrow-leafed lupin (Lupinus angustifolius L.) highlights candidate genes linked to iucundus locus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Magdalena Kroc, Grzegorz Koczyk, Katarzyna A. Kamel, Katarzyna Czepiel, Olga Fedorowicz-Strońska, Paweł Krajewski, Joanna Kosińska, Jan Podkowiński, Paulina Wilczura, Wojciech Święcicki

ABSTRACT

Unravelling the biosynthetic pathway of quinolizidine alkaloids (QAs), regarded as antinutritional compounds of narrow-leafed lupin (NLL) seeds, is fundamental to best exploit NLL as food or feed. We investigated 12 candidate genes connected to QA biosynthesis, selecting them by transcriptomic and genomic approaches, from the landscape of genes differentially expressed in leaves of the high- and low-alkaloid NLL accessions. Linkage analysis enabled the assessment of the location of the candidate genes in relation to iucundus, a major locus of unknown identity, that confers reduced QA content in seeds. The key finding was the identification of APETALA2/ethylene response transcription factor, RAP2-7, cosegregating with the iucundus locus and located within a region with highly significant QTLs that affect QA composition. We additionally identified a 4-hydroxy-tetrahydrodipicolinate synthase (DHDPS) gene involved in L-lysine biosynthesis as being closely linked to iucundus. The distributed location of other remaining candidates (including previously known QA genes) across different linkage groups, also indirectly supports the transcription factor as a possible regulator of lupin alkaloid biosynthesis. Our findings provide crucial insight into QA biosynthesis in NLL. Additionally, we evaluated and selected appropriate reference genes for qRT-PCRs to analyse the expression levels of QA genes in NLL. More... »

PAGES

2231

References to SciGraph publications

  • 2016-02-15. GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway in NATURE COMMUNICATIONS
  • 2012-12. SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler in GIGASCIENCE
  • 2016-04. Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites in PHYTOCHEMISTRY REVIEWS
  • 2013-08. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis in NATURE PROTOCOLS
  • 2016-09. Integration of Lupinus angustifolius L. (narrow-leafed lupin) genome maps and comparative mapping within legumes in CHROMOSOME RESEARCH
  • 2011-12. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome in BMC BIOINFORMATICS
  • 1984-05. The lupin — ancient and modern crop plant in THEORETICAL AND APPLIED GENETICS
  • 2016-07-05. Engineering biosynthesis of the anticancer alkaloid noscapine in yeast in NATURE COMMUNICATIONS
  • 2016-12. Crowdsourcing the nodulation gene network discovery environment in BMC BIOINFORMATICS
  • 2006-12. On the design of early generation variety trials with correlated data in JOURNAL OF AGRICULTURAL, BIOLOGICAL AND ENVIRONMENTAL STATISTICS
  • 2006-07. The first gene-based map of Lupinus angustifolius L.-location of domestication genes and conserved synteny with Medicago truncatula in THEORETICAL AND APPLIED GENETICS
  • 2016-04. Quantitative and qualitative content of alkaloids in seeds of a narrow-leafed lupin (Lupinus angustifolius L.) collection in GENETIC RESOURCES AND CROP EVOLUTION
  • 2015-02. Remnants of the Legume Ancestral Genome Preserved in Gene-Rich Regions: Insights from Lupinus angustifolius Physical, Genetic, and Comparative Mapping in PLANT MOLECULAR BIOLOGY REPORTER
  • 2013-12. Comparative genomics of Lupinus angustifolius gene-rich regions: BAC library exploration, genetic mapping and cytogenetics in BMC GENOMICS
  • 2014-05. New evidence of ancestral polyploidy in the Genistoid legume Lupinus angustifolius L. (narrow-leafed lupin) in THEORETICAL AND APPLIED GENETICS
  • 2001-12. Map Manager QTX, cross-platform software for genetic mapping in MAMMALIAN GENOME
  • 2017-12. Quantitative and qualitative analysis of alkaloids composition in the seeds of a white lupin (Lupinus albus L.) collection in GENETIC RESOURCES AND CROP EVOLUTION
  • 2018-01. Construction of an ultra-high density consensus genetic map, and enhancement of the physical map from genome sequencing in Lupinus angustifolius in THEORETICAL AND APPLIED GENETICS
  • 2011-12. Cross-species protein sequence and gene structure prediction with fine-tuned Webscipio 2.0 and Scipio in BMC RESEARCH NOTES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37701-5

    DOI

    http://dx.doi.org/10.1038/s41598-018-37701-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112222109

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30783128


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