Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Maria Caroline Alves Coelho, Marina Lipkin Vasquez, Luiz Eduardo Wildemberg, Mari C. Vázquez-Borrego, Luciana Bitana, Aline Helen da Silva Camacho, Débora Silva, Liana Lumi Ogino, Nina Ventura, Rafael Sánchez-Sánchez, Leila Chimelli, Leandro Kasuki, Raul M. Luque, Mônica R. Gadelha

ABSTRACT

Filamin-A (FLNA) plays a crucial role in somatostatin receptor (sst) subtype-2 signaling in somatotropinomas. Our objective was to investigate the in vivo association between FLNA and sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin receptor ligand (SRL) responsiveness and tumor invasiveness in somatotropinomas. Quantitative real-time PCR was used to evaluate the absolute mRNA copy numbers of FLNA/sst2/sst5/D2 in 96 somatotropinomas. FLNA, sst2 and sst5 protein expression levels were also evaluated using immunohistochemistry. The Knosp-Steiner criteria were used to evaluate tumor invasiveness. Median FLNA, sst2, sst5 and D2 copy numbers were 4,244, 731, 156 and 3,989, respectively. Thirty-one of the 35 available tumors (89%) were immune positive for FLNA in the cytoplasm and membrane but not in the nucleus. FLNA and sst5 expression were positively correlated at the mRNA and protein levels (p < 0.001 and p = 0.033, respectively). FLNA was positively correlated with sst2 mRNA in patients who were responsive to SRL (p = 0.014, R = 0.659). No association was found between FLNA and tumor invasiveness. Our findings show that in somatotropinomas FLNA expression positively correlated with in vivo sst5 and D2 expression. Notably, FLNA was only correlated with sst2 in patients who were controlled with SRL. FLNA was not associated with tumor invasiveness. More... »

PAGES

1122

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37692-3

DOI

http://dx.doi.org/10.1038/s41598-018-37692-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111918918

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30718563


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