Acidogenesis, solventogenesis, metabolic stress response and life cycle changes in Clostridium beijerinckii NRRL B-598 at the transcriptomic level View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Petra Patakova, Barbora Branska, Karel Sedlar, Maryna Vasylkivska, Katerina Jureckova, Jan Kolek, Pavlina Koscova, Ivo Provaznik

ABSTRACT

Clostridium beijerinckii NRRL B-598 is a sporulating, butanol and hydrogen producing strain that utilizes carbohydrates by the acetone-butanol-ethanol (ABE) fermentative pathway. The pathway consists of two metabolic phases, acidogenesis and solventogenesis, from which the latter one can be coupled with sporulation. Thorough transcriptomic profiling during a complete life cycle and both metabolic phases completed with flow cytometry, microscopy and a metabolites analysis helped to find out key genes involved in particular cellular events. The description of genes/operons that are closely involved in metabolism or the cell cycle is a necessary condition for metabolic engineering of the strain and will be valuable for all C. beijerinckii strains and other Clostridial species. The study focused on glucose transport and catabolism, hydrogen formation, metabolic stress response, binary fission, motility/chemotaxis and sporulation, which resulted in the composition of the unique image reflecting clostridial population changes. Surprisingly, the main change in expression of individual genes was coupled with the sporulation start and not with the transition from acidogenic to solventogenic metabolism. As expected, solvents formation started at pH decrease and the accumulation of butyric and acetic acids in the cultivation medium. More... »

PAGES

1371

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37679-0

    DOI

    http://dx.doi.org/10.1038/s41598-018-37679-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111915449

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30718562


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