Chronic sleep restriction in the rotenone Parkinson’s disease model in rats reveals peripheral early-phase biomarkers View Full Text


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Article Info

DATE

2019-12

AUTHORS

Juliane Fagotti, Adriano D. S. Targa, Lais S. Rodrigues, Ana Carolina D. Noseda, Flávia W. C. Dorieux, Franciele F. Scarante, Jessica L. Ilkiw, Fernando M. Louzada, Namrata R. Chowdhury, Daan R. van der Veen, Benita Middleton, Jeroen L. A. Pennings, Jonathan R. Swann, Debra J. Skene, Marcelo M. S. Lima

ABSTRACT

Parkinson's disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key non-motor features of the disease. Increasing evidence of a possible association between sleep disruption and the neurodegenerative process suggests that sleep impairment could produce a detectable metabolic signature on the disease. In order to integrate neurocognitive and metabolic parameters, we performed untargeted and targeted metabolic profiling of the rotenone PD model in a chronic sleep restriction (SR) (6 h/day for 21 days) condition. We found that SR combined with PD altered several behavioural (reversal of locomotor activity impairment; cognitive impairment; delay of rest-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, pointing to mitochondrial impairment). If combined, our results bring a plethora of parameters that represents reliable early-phase PD biomarkers which can easily be measured and could be translated to human studies. More... »

PAGES

1898

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37657-6

    DOI

    http://dx.doi.org/10.1038/s41598-018-37657-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112088363

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30760786


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