Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-30

AUTHORS

Bi-He Cai, Po-Han Wu, Chi-Kan Chou, Hsiang-Chi Huang, Chia-Chun Chao, Hsiao-Yu Chung, Hsueh-Yi Lee, Jang-Yi Chen, Reiji Kannagi

ABSTRACT

More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells. More... »

PAGES

950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7

DOI

http://dx.doi.org/10.1038/s41598-018-37521-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111773887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700826


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial-Mesenchymal Transition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuraminidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sialyl Lewis X Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Protein p73", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cai", 
        "givenName": "Bi-He", 
        "id": "sg:person.01034375557.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034375557.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Po-Han", 
        "id": "sg:person.015103027647.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015103027647.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "Chi-Kan", 
        "id": "sg:person.011035263507.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035263507.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Hsiang-Chi", 
        "id": "sg:person.015700410247.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015700410247.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Research Center, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.506938.1", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Genomics Research Center, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "Chia-Chun", 
        "id": "sg:person.014305447247.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305447247.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Hsiao-Yu", 
        "id": "sg:person.016475770647.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016475770647.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hsueh-Yi", 
        "id": "sg:person.014023165507.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014023165507.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jang-Yi", 
        "id": "sg:person.0745762142.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745762142.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kannagi", 
        "givenName": "Reiji", 
        "id": "sg:person.01057632060.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057632060.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1201374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032075271", 
          "https://doi.org/10.1038/sj.onc.1201374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029919109", 
          "https://doi.org/10.1038/sj.onc.1209250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508003", 
          "https://doi.org/10.1038/nrc3982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/342705a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041126170", 
          "https://doi.org/10.1038/342705a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025353103", 
          "https://doi.org/10.1038/sj.onc.1204373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003074932", 
          "https://doi.org/10.1038/sj.cdd.4401205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049134278", 
          "https://doi.org/10.1038/bjc.2013.699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2010.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021653488", 
          "https://doi.org/10.1038/cdd.2010.35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-8-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023938999", 
          "https://doi.org/10.1186/1479-5876-8-15"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-30", 
    "datePublishedReg": "2019-01-30", 
    "description": "More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-37521-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "p53/p63", 
      "colon cancer cells", 
      "tumor suppressor", 
      "protein-protein interactions", 
      "important tumor suppressor", 
      "cancer cells", 
      "AP2 family", 
      "family member p63", 
      "interaction of p53", 
      "starvation conditions", 
      "terminal sialic acid residues", 
      "homologous residues", 
      "cancer-associated glycans", 
      "target glycans", 
      "acid residues", 
      "serum starvation", 
      "AP2", 
      "synergistic activation", 
      "p73", 
      "sialic acid residues", 
      "NEU4", 
      "mutations", 
      "colon cancer", 
      "genes", 
      "promoter", 
      "suppressor", 
      "p53", 
      "neuraminidase gene", 
      "glycans", 
      "residues", 
      "cells", 
      "p63", 
      "sialyl Lewis X", 
      "synergistic effect", 
      "starvation", 
      "Lewis X", 
      "p21", 
      "cancer", 
      "interaction", 
      "activation", 
      "family", 
      "progression", 
      "effect", 
      "levels", 
      "conditions", 
      "members p63", 
      "NEU4 target glycans", 
      "Sialyl Lewis X levels", 
      "Lewis X levels", 
      "X levels", 
      "AP2-knockdown cells", 
      "L350P mutation", 
      "L423", 
      "L377", 
      "L350P/L423P mutation", 
      "L423P mutation", 
      "L377P mutation", 
      "normal synergistic effects", 
      "NEU4 promoter"
    ], 
    "name": "Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells", 
    "pagination": "950", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111773887"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-37521-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30700826"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-37521-7", 
      "https://app.dimensions.ai/details/publication/pub.1111773887"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_801.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-37521-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      114 URIs      95 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-37521-7 schema:about N1189d5a0a4f943129f061730ed0df223
2 N19daa128b89642e892f89c796e1dd7a9
3 N382e3568d5b343a6a87ebaecfc34fc2d
4 N38386f3f9fe947b4980a605bc7773416
5 N54a8ca393f244ed79e845f8e8aca84e3
6 N76e7fa1b1fec40d0b2546432be16101c
7 N88a6e4fa459745f78c60f6c665c05290
8 N88f25f652a494017ae384c62c3784d0d
9 N92f698a490f84adf8c99c1a36acaae0a
10 N97281cf2a6da44939a4f16890ebbd403
11 Nbebadb8f23664b6a9c78b609c81b2460
12 Nc18ed35176cf44b09a7ced8fb72ad868
13 Ndf92dd50d7fc410a8216650b583e4c34
14 Ne0289de10d2847e6b43dd3b2dbd67a0e
15 Ne3476af84f524ee7ad17b3e07cc02267
16 Ned4bd55840db4a08a5f1227ec88737e7
17 Nf5618d005ac84aa89d75adbf3e7094d5
18 Nf69c5da62905412a9f34ef8370a036ad
19 anzsrc-for:06
20 anzsrc-for:0601
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N29510d2cafd84292b0857cf5a170342f
24 schema:citation sg:pub.10.1038/342705a0
25 sg:pub.10.1038/bjc.2013.699
26 sg:pub.10.1038/cdd.2010.35
27 sg:pub.10.1038/nrc3982
28 sg:pub.10.1038/sj.cdd.4401205
29 sg:pub.10.1038/sj.onc.1201374
30 sg:pub.10.1038/sj.onc.1204373
31 sg:pub.10.1038/sj.onc.1209250
32 sg:pub.10.1186/1479-5876-8-15
33 schema:datePublished 2019-01-30
34 schema:datePublishedReg 2019-01-30
35 schema:description More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N24265b9caaef4599a5f62dee1e668643
40 Nd135a48ab15c4e0583f27df400b9573b
41 sg:journal.1045337
42 schema:keywords AP2
43 AP2 family
44 AP2-knockdown cells
45 L350P mutation
46 L350P/L423P mutation
47 L377
48 L377P mutation
49 L423
50 L423P mutation
51 Lewis X
52 Lewis X levels
53 NEU4
54 NEU4 promoter
55 NEU4 target glycans
56 Sialyl Lewis X levels
57 X levels
58 acid residues
59 activation
60 cancer
61 cancer cells
62 cancer-associated glycans
63 cells
64 colon cancer
65 colon cancer cells
66 conditions
67 effect
68 family
69 family member p63
70 genes
71 glycans
72 homologous residues
73 important tumor suppressor
74 interaction
75 interaction of p53
76 levels
77 members p63
78 mutations
79 neuraminidase gene
80 normal synergistic effects
81 p21
82 p53
83 p53/p63
84 p63
85 p73
86 progression
87 promoter
88 protein-protein interactions
89 residues
90 serum starvation
91 sialic acid residues
92 sialyl Lewis X
93 starvation
94 starvation conditions
95 suppressor
96 synergistic activation
97 synergistic effect
98 target glycans
99 terminal sialic acid residues
100 tumor suppressor
101 schema:name Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells
102 schema:pagination 950
103 schema:productId N3f8a1752233e4e2387d522f94c982bad
104 N94935a1cb62242f79b8c1b456d7b2ae6
105 Ncd82af05ecb949248ba7c76cbc7ad029
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111773887
107 https://doi.org/10.1038/s41598-018-37521-7
108 schema:sdDatePublished 2022-01-01T18:52
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N5cbda1fab9fc4cb6b9e981ef2078bf92
111 schema:url https://doi.org/10.1038/s41598-018-37521-7
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N0ab3e799c82343b887e5bf6ea3d8a0a7 rdf:first sg:person.014023165507.35
116 rdf:rest N8aad30dfdd5d4c218fabbb5156c6449e
117 N1189d5a0a4f943129f061730ed0df223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Colonic Neoplasms
119 rdf:type schema:DefinedTerm
120 N19daa128b89642e892f89c796e1dd7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N24265b9caaef4599a5f62dee1e668643 schema:volumeNumber 9
124 rdf:type schema:PublicationVolume
125 N29510d2cafd84292b0857cf5a170342f rdf:first sg:person.01034375557.65
126 rdf:rest Na21d8c40103340b593115311817bfd8b
127 N382e3568d5b343a6a87ebaecfc34fc2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Response Elements
129 rdf:type schema:DefinedTerm
130 N38386f3f9fe947b4980a605bc7773416 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Down-Regulation
132 rdf:type schema:DefinedTerm
133 N3f8a1752233e4e2387d522f94c982bad schema:name dimensions_id
134 schema:value pub.1111773887
135 rdf:type schema:PropertyValue
136 N54a8ca393f244ed79e845f8e8aca84e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Gene Expression Regulation, Neoplastic
138 rdf:type schema:DefinedTerm
139 N5bbd1562e7ea420a8b91afe29d7bc760 rdf:first sg:person.01057632060.21
140 rdf:rest rdf:nil
141 N5cbda1fab9fc4cb6b9e981ef2078bf92 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N76e7fa1b1fec40d0b2546432be16101c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Neuraminidase
145 rdf:type schema:DefinedTerm
146 N7ac52e4ab8c2470caadb60ae3f57f532 rdf:first sg:person.015700410247.19
147 rdf:rest Nc8f6ceca7703457d9a1fc388e413c8d2
148 N88a6e4fa459745f78c60f6c665c05290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Interaction Mapping
150 rdf:type schema:DefinedTerm
151 N88f25f652a494017ae384c62c3784d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Epithelial-Mesenchymal Transition
153 rdf:type schema:DefinedTerm
154 N8aad30dfdd5d4c218fabbb5156c6449e rdf:first sg:person.0745762142.23
155 rdf:rest N5bbd1562e7ea420a8b91afe29d7bc760
156 N92f698a490f84adf8c99c1a36acaae0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Tumor Protein p73
158 rdf:type schema:DefinedTerm
159 N94935a1cb62242f79b8c1b456d7b2ae6 schema:name pubmed_id
160 schema:value 30700826
161 rdf:type schema:PropertyValue
162 N97281cf2a6da44939a4f16890ebbd403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Models, Biological
164 rdf:type schema:DefinedTerm
165 Na21d8c40103340b593115311817bfd8b rdf:first sg:person.015103027647.77
166 rdf:rest Nf6d989f307684d4a9069c303b5c1c6b1
167 Nbebadb8f23664b6a9c78b609c81b2460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Amino Acid Sequence
169 rdf:type schema:DefinedTerm
170 Nc18ed35176cf44b09a7ced8fb72ad868 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Transcription Factor AP-2
172 rdf:type schema:DefinedTerm
173 Nc8f6ceca7703457d9a1fc388e413c8d2 rdf:first sg:person.014305447247.01
174 rdf:rest Nf1dd7d862d8a48ce9608ee5e2c7cc4da
175 Ncd82af05ecb949248ba7c76cbc7ad029 schema:name doi
176 schema:value 10.1038/s41598-018-37521-7
177 rdf:type schema:PropertyValue
178 Nd135a48ab15c4e0583f27df400b9573b schema:issueNumber 1
179 rdf:type schema:PublicationIssue
180 Ndf92dd50d7fc410a8216650b583e4c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Base Sequence
182 rdf:type schema:DefinedTerm
183 Ne0289de10d2847e6b43dd3b2dbd67a0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Protein Binding
185 rdf:type schema:DefinedTerm
186 Ne3476af84f524ee7ad17b3e07cc02267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Sialyl Lewis X Antigen
188 rdf:type schema:DefinedTerm
189 Ned4bd55840db4a08a5f1227ec88737e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Promoter Regions, Genetic
191 rdf:type schema:DefinedTerm
192 Nf1dd7d862d8a48ce9608ee5e2c7cc4da rdf:first sg:person.016475770647.22
193 rdf:rest N0ab3e799c82343b887e5bf6ea3d8a0a7
194 Nf5618d005ac84aa89d75adbf3e7094d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Cell Line, Tumor
196 rdf:type schema:DefinedTerm
197 Nf69c5da62905412a9f34ef8370a036ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Tumor Suppressor Protein p53
199 rdf:type schema:DefinedTerm
200 Nf6d989f307684d4a9069c303b5c1c6b1 rdf:first sg:person.011035263507.55
201 rdf:rest N7ac52e4ab8c2470caadb60ae3f57f532
202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biological Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biochemistry and Cell Biology
207 rdf:type schema:DefinedTerm
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:journal.1045337 schema:issn 2045-2322
215 schema:name Scientific Reports
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01034375557.65 schema:affiliation grid-institutes:grid.260565.2
219 schema:familyName Cai
220 schema:givenName Bi-He
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034375557.65
222 rdf:type schema:Person
223 sg:person.01057632060.21 schema:affiliation grid-institutes:grid.482251.8
224 schema:familyName Kannagi
225 schema:givenName Reiji
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057632060.21
227 rdf:type schema:Person
228 sg:person.011035263507.55 schema:affiliation grid-institutes:grid.482251.8
229 schema:familyName Chou
230 schema:givenName Chi-Kan
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035263507.55
232 rdf:type schema:Person
233 sg:person.014023165507.35 schema:affiliation grid-institutes:grid.482251.8
234 schema:familyName Lee
235 schema:givenName Hsueh-Yi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014023165507.35
237 rdf:type schema:Person
238 sg:person.014305447247.01 schema:affiliation grid-institutes:grid.506938.1
239 schema:familyName Chao
240 schema:givenName Chia-Chun
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305447247.01
242 rdf:type schema:Person
243 sg:person.015103027647.77 schema:affiliation grid-institutes:grid.482251.8
244 schema:familyName Wu
245 schema:givenName Po-Han
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015103027647.77
247 rdf:type schema:Person
248 sg:person.015700410247.19 schema:affiliation grid-institutes:grid.28665.3f
249 schema:familyName Huang
250 schema:givenName Hsiang-Chi
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015700410247.19
252 rdf:type schema:Person
253 sg:person.016475770647.22 schema:affiliation grid-institutes:grid.482251.8
254 schema:familyName Chung
255 schema:givenName Hsiao-Yu
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016475770647.22
257 rdf:type schema:Person
258 sg:person.0745762142.23 schema:affiliation grid-institutes:grid.260565.2
259 schema:familyName Chen
260 schema:givenName Jang-Yi
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745762142.23
262 rdf:type schema:Person
263 sg:pub.10.1038/342705a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041126170
264 https://doi.org/10.1038/342705a0
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/bjc.2013.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049134278
267 https://doi.org/10.1038/bjc.2013.699
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/cdd.2010.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021653488
270 https://doi.org/10.1038/cdd.2010.35
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nrc3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508003
273 https://doi.org/10.1038/nrc3982
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/sj.cdd.4401205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003074932
276 https://doi.org/10.1038/sj.cdd.4401205
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/sj.onc.1201374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032075271
279 https://doi.org/10.1038/sj.onc.1201374
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.onc.1204373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025353103
282 https://doi.org/10.1038/sj.onc.1204373
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.onc.1209250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029919109
285 https://doi.org/10.1038/sj.onc.1209250
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1479-5876-8-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023938999
288 https://doi.org/10.1186/1479-5876-8-15
289 rdf:type schema:CreativeWork
290 grid-institutes:grid.260565.2 schema:alternateName Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan
291 schema:name Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan
292 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
293 rdf:type schema:Organization
294 grid-institutes:grid.28665.3f schema:alternateName Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
295 schema:name Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
296 Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
297 rdf:type schema:Organization
298 grid-institutes:grid.482251.8 schema:alternateName Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
299 schema:name Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
300 rdf:type schema:Organization
301 grid-institutes:grid.506938.1 schema:alternateName Genomics Research Center, Academia Sinica, Taipei, Taiwan
302 schema:name Genomics Research Center, Academia Sinica, Taipei, Taiwan
303 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...