Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-30

AUTHORS

Bi-He Cai, Po-Han Wu, Chi-Kan Chou, Hsiang-Chi Huang, Chia-Chun Chao, Hsiao-Yu Chung, Hsueh-Yi Lee, Jang-Yi Chen, Reiji Kannagi

ABSTRACT

More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells. More... »

PAGES

950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7

DOI

http://dx.doi.org/10.1038/s41598-018-37521-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111773887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700826


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial-Mesenchymal Transition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuraminidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sialyl Lewis X Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Protein p73", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cai", 
        "givenName": "Bi-He", 
        "id": "sg:person.01034375557.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034375557.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Po-Han", 
        "id": "sg:person.015103027647.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015103027647.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chou", 
        "givenName": "Chi-Kan", 
        "id": "sg:person.011035263507.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035263507.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Hsiang-Chi", 
        "id": "sg:person.015700410247.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015700410247.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Research Center, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.506938.1", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
            "Genomics Research Center, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "Chia-Chun", 
        "id": "sg:person.014305447247.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305447247.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Hsiao-Yu", 
        "id": "sg:person.016475770647.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016475770647.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hsueh-Yi", 
        "id": "sg:person.014023165507.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014023165507.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.260565.2", 
          "name": [
            "Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jang-Yi", 
        "id": "sg:person.0745762142.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745762142.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan", 
          "id": "http://www.grid.ac/institutes/grid.482251.8", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kannagi", 
        "givenName": "Reiji", 
        "id": "sg:person.01057632060.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057632060.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.cdd.4401205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003074932", 
          "https://doi.org/10.1038/sj.cdd.4401205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049134278", 
          "https://doi.org/10.1038/bjc.2013.699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032075271", 
          "https://doi.org/10.1038/sj.onc.1201374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/342705a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041126170", 
          "https://doi.org/10.1038/342705a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-8-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023938999", 
          "https://doi.org/10.1186/1479-5876-8-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029919109", 
          "https://doi.org/10.1038/sj.onc.1209250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025353103", 
          "https://doi.org/10.1038/sj.onc.1204373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508003", 
          "https://doi.org/10.1038/nrc3982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2010.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021653488", 
          "https://doi.org/10.1038/cdd.2010.35"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-30", 
    "datePublishedReg": "2019-01-30", 
    "description": "More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-37521-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "p53/p63", 
      "colon cancer cells", 
      "tumor suppressor", 
      "protein-protein interactions", 
      "important tumor suppressor", 
      "cancer cells", 
      "AP2 family", 
      "family member p63", 
      "interaction of p53", 
      "starvation conditions", 
      "terminal sialic acid residues", 
      "homologous residues", 
      "cancer-associated glycans", 
      "target glycans", 
      "acid residues", 
      "serum starvation", 
      "AP2", 
      "synergistic activation", 
      "p73", 
      "sialic acid residues", 
      "NEU4", 
      "mutations", 
      "colon cancer", 
      "genes", 
      "promoter", 
      "suppressor", 
      "p53", 
      "neuraminidase gene", 
      "glycans", 
      "residues", 
      "cells", 
      "p63", 
      "sialyl Lewis X", 
      "synergistic effect", 
      "starvation", 
      "Lewis X", 
      "p21", 
      "cancer", 
      "interaction", 
      "activation", 
      "family", 
      "progression", 
      "effect", 
      "levels", 
      "conditions", 
      "members p63", 
      "NEU4 target glycans", 
      "Sialyl Lewis X levels", 
      "Lewis X levels", 
      "X levels", 
      "AP2-knockdown cells", 
      "L350P mutation", 
      "L423", 
      "L377", 
      "L350P/L423P mutation", 
      "L423P mutation", 
      "L377P mutation", 
      "normal synergistic effects", 
      "NEU4 promoter"
    ], 
    "name": "Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells", 
    "pagination": "950", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111773887"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-37521-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30700826"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-37521-7", 
      "https://app.dimensions.ai/details/publication/pub.1111773887"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_816.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-37521-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37521-7'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      114 URIs      95 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-37521-7 schema:about N12b6255fd7da4e689eda05646f2748f7
2 N3018b7d029fb47a58435d44df6ef0d31
3 N3e89bac3a0ee4ad480ad173900aedbd7
4 N5a5b8e53991f4719affcc6d37a933434
5 N5bc84baaf9f74b31aaefb2f7c8bb8167
6 N69707e378c4b4209b17081c2f41ecd7d
7 N8c8a457d78a447cbb2f8b2b3dead6301
8 N8edbc20f63fb4ac3b1eb7d11630391d0
9 N8f102d0708c3427083dc482feaf6953f
10 Nac752ac07b6448baaaa27d80af5a3f84
11 Nbc835f5d5d474917b8d2d09c86350cbe
12 Nbdf938264f4b446298f1bd1e238540b0
13 Nc280c4cf06a8494a97321310a84b3084
14 Nc50c38a23dcc4b52bd5b2133765edc2e
15 Nc527062a0eb84041baa2c01b88866e8f
16 Nc91b686f57e14f59b8a52714d3824485
17 Ndd6d45161ce14cfdaf730be10242368f
18 Nfe6f3d8e24af4c8cba8193b02ca94b1d
19 anzsrc-for:06
20 anzsrc-for:0601
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Nfb18377e3bc64fad934f88bad0b2f16f
24 schema:citation sg:pub.10.1038/342705a0
25 sg:pub.10.1038/bjc.2013.699
26 sg:pub.10.1038/cdd.2010.35
27 sg:pub.10.1038/nrc3982
28 sg:pub.10.1038/sj.cdd.4401205
29 sg:pub.10.1038/sj.onc.1201374
30 sg:pub.10.1038/sj.onc.1204373
31 sg:pub.10.1038/sj.onc.1209250
32 sg:pub.10.1186/1479-5876-8-15
33 schema:datePublished 2019-01-30
34 schema:datePublishedReg 2019-01-30
35 schema:description More than 50% of colon cancers bear mutations in p53, one of the most important tumor suppressors, and its family members p63 or p73 are expected to contribute to inhibiting the progression of colon cancers. The AP2 family also acts as a tumor suppressor. Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans. Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated. Sialyl Lewis X levels were not, however, decreased under starvation conditions in p73- or AP2-knockdown cells. p53 and AP2 underwent protein-protein interactions, exerting synergistic effects to activate p21, and interaction of p53 with AP2 was lost in cells expressing the L350P mutation of p53. The homologous residues in p63 and p73 are L423 and L377, respectively. The synergistic effect of p53/p63 with AP2 to activate genes was lost with the L350P/L423P mutation in p53/p63, but p73 bearing the L377P mutation was able to interact with AP2 and exerted its normal synergistic effects. We propose that p73 and AP2 synergistically activate the NEU4 promoter in colon cancer cells.
36 schema:genre article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf Nbe7b4b8aff944081903b775f1dea4ecd
40 Ne0824a4daced4fb5a65dd529a3b3639a
41 sg:journal.1045337
42 schema:keywords AP2
43 AP2 family
44 AP2-knockdown cells
45 L350P mutation
46 L350P/L423P mutation
47 L377
48 L377P mutation
49 L423
50 L423P mutation
51 Lewis X
52 Lewis X levels
53 NEU4
54 NEU4 promoter
55 NEU4 target glycans
56 Sialyl Lewis X levels
57 X levels
58 acid residues
59 activation
60 cancer
61 cancer cells
62 cancer-associated glycans
63 cells
64 colon cancer
65 colon cancer cells
66 conditions
67 effect
68 family
69 family member p63
70 genes
71 glycans
72 homologous residues
73 important tumor suppressor
74 interaction
75 interaction of p53
76 levels
77 members p63
78 mutations
79 neuraminidase gene
80 normal synergistic effects
81 p21
82 p53
83 p53/p63
84 p63
85 p73
86 progression
87 promoter
88 protein-protein interactions
89 residues
90 serum starvation
91 sialic acid residues
92 sialyl Lewis X
93 starvation
94 starvation conditions
95 suppressor
96 synergistic activation
97 synergistic effect
98 target glycans
99 terminal sialic acid residues
100 tumor suppressor
101 schema:name Synergistic activation of the NEU4 promoter by p73 and AP2 in colon cancer cells
102 schema:pagination 950
103 schema:productId N780566dc7c3446f3932d7d2b971ee9e6
104 N9e983ea2ff654037a78201666d86ce25
105 Ndfc25d379dcf4cc99b77700802330d38
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111773887
107 https://doi.org/10.1038/s41598-018-37521-7
108 schema:sdDatePublished 2021-11-01T18:37
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N852dca69209048f2a7024728d93a6e2c
111 schema:url https://doi.org/10.1038/s41598-018-37521-7
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N12b6255fd7da4e689eda05646f2748f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Models, Biological
117 rdf:type schema:DefinedTerm
118 N20b402f27b9049bc86d3b9ccce2645bf rdf:first sg:person.015103027647.77
119 rdf:rest Naf4099bc00b74705ac91e581a5375ca0
120 N3018b7d029fb47a58435d44df6ef0d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Tumor Protein p73
122 rdf:type schema:DefinedTerm
123 N3ba6cc3139ed4727a0a6ce3bd39a5c2b rdf:first sg:person.015700410247.19
124 rdf:rest N95177669ed444a8fab36712ce94fe1bb
125 N3e89bac3a0ee4ad480ad173900aedbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Down-Regulation
127 rdf:type schema:DefinedTerm
128 N5a5b8e53991f4719affcc6d37a933434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Line, Tumor
130 rdf:type schema:DefinedTerm
131 N5bc84baaf9f74b31aaefb2f7c8bb8167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Response Elements
133 rdf:type schema:DefinedTerm
134 N5efb72e4c0ae49beaf9e9b7c6ff5ef65 rdf:first sg:person.01057632060.21
135 rdf:rest rdf:nil
136 N69707e378c4b4209b17081c2f41ecd7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Gene Expression Regulation, Neoplastic
138 rdf:type schema:DefinedTerm
139 N72fa8c6c22fd4322a7dda191d6590719 rdf:first sg:person.016475770647.22
140 rdf:rest Nf2967d1c4c8a40ad8388d07c78cc4c49
141 N780566dc7c3446f3932d7d2b971ee9e6 schema:name dimensions_id
142 schema:value pub.1111773887
143 rdf:type schema:PropertyValue
144 N852dca69209048f2a7024728d93a6e2c schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N8c8a457d78a447cbb2f8b2b3dead6301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Protein Binding
148 rdf:type schema:DefinedTerm
149 N8edbc20f63fb4ac3b1eb7d11630391d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Epithelial-Mesenchymal Transition
151 rdf:type schema:DefinedTerm
152 N8f102d0708c3427083dc482feaf6953f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Base Sequence
154 rdf:type schema:DefinedTerm
155 N95177669ed444a8fab36712ce94fe1bb rdf:first sg:person.014305447247.01
156 rdf:rest N72fa8c6c22fd4322a7dda191d6590719
157 N9e983ea2ff654037a78201666d86ce25 schema:name doi
158 schema:value 10.1038/s41598-018-37521-7
159 rdf:type schema:PropertyValue
160 Nac170b387c3c4693b54350efdf2ffca6 rdf:first sg:person.0745762142.23
161 rdf:rest N5efb72e4c0ae49beaf9e9b7c6ff5ef65
162 Nac752ac07b6448baaaa27d80af5a3f84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Protein Interaction Mapping
164 rdf:type schema:DefinedTerm
165 Naf4099bc00b74705ac91e581a5375ca0 rdf:first sg:person.011035263507.55
166 rdf:rest N3ba6cc3139ed4727a0a6ce3bd39a5c2b
167 Nbc835f5d5d474917b8d2d09c86350cbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neuraminidase
169 rdf:type schema:DefinedTerm
170 Nbdf938264f4b446298f1bd1e238540b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Transcription Factor AP-2
172 rdf:type schema:DefinedTerm
173 Nbe7b4b8aff944081903b775f1dea4ecd schema:volumeNumber 9
174 rdf:type schema:PublicationVolume
175 Nc280c4cf06a8494a97321310a84b3084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Amino Acid Sequence
177 rdf:type schema:DefinedTerm
178 Nc50c38a23dcc4b52bd5b2133765edc2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Tumor Suppressor Protein p53
180 rdf:type schema:DefinedTerm
181 Nc527062a0eb84041baa2c01b88866e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Promoter Regions, Genetic
183 rdf:type schema:DefinedTerm
184 Nc91b686f57e14f59b8a52714d3824485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Colonic Neoplasms
186 rdf:type schema:DefinedTerm
187 Ndd6d45161ce14cfdaf730be10242368f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Sialyl Lewis X Antigen
189 rdf:type schema:DefinedTerm
190 Ndfc25d379dcf4cc99b77700802330d38 schema:name pubmed_id
191 schema:value 30700826
192 rdf:type schema:PropertyValue
193 Ne0824a4daced4fb5a65dd529a3b3639a schema:issueNumber 1
194 rdf:type schema:PublicationIssue
195 Nf2967d1c4c8a40ad8388d07c78cc4c49 rdf:first sg:person.014023165507.35
196 rdf:rest Nac170b387c3c4693b54350efdf2ffca6
197 Nfb18377e3bc64fad934f88bad0b2f16f rdf:first sg:person.01034375557.65
198 rdf:rest N20b402f27b9049bc86d3b9ccce2645bf
199 Nfe6f3d8e24af4c8cba8193b02ca94b1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Humans
201 rdf:type schema:DefinedTerm
202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biological Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biochemistry and Cell Biology
207 rdf:type schema:DefinedTerm
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
212 schema:name Oncology and Carcinogenesis
213 rdf:type schema:DefinedTerm
214 sg:journal.1045337 schema:issn 2045-2322
215 schema:name Scientific Reports
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.01034375557.65 schema:affiliation grid-institutes:grid.260565.2
219 schema:familyName Cai
220 schema:givenName Bi-He
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034375557.65
222 rdf:type schema:Person
223 sg:person.01057632060.21 schema:affiliation grid-institutes:grid.482251.8
224 schema:familyName Kannagi
225 schema:givenName Reiji
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057632060.21
227 rdf:type schema:Person
228 sg:person.011035263507.55 schema:affiliation grid-institutes:grid.482251.8
229 schema:familyName Chou
230 schema:givenName Chi-Kan
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035263507.55
232 rdf:type schema:Person
233 sg:person.014023165507.35 schema:affiliation grid-institutes:grid.482251.8
234 schema:familyName Lee
235 schema:givenName Hsueh-Yi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014023165507.35
237 rdf:type schema:Person
238 sg:person.014305447247.01 schema:affiliation grid-institutes:grid.506938.1
239 schema:familyName Chao
240 schema:givenName Chia-Chun
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305447247.01
242 rdf:type schema:Person
243 sg:person.015103027647.77 schema:affiliation grid-institutes:grid.482251.8
244 schema:familyName Wu
245 schema:givenName Po-Han
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015103027647.77
247 rdf:type schema:Person
248 sg:person.015700410247.19 schema:affiliation grid-institutes:grid.28665.3f
249 schema:familyName Huang
250 schema:givenName Hsiang-Chi
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015700410247.19
252 rdf:type schema:Person
253 sg:person.016475770647.22 schema:affiliation grid-institutes:grid.482251.8
254 schema:familyName Chung
255 schema:givenName Hsiao-Yu
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016475770647.22
257 rdf:type schema:Person
258 sg:person.0745762142.23 schema:affiliation grid-institutes:grid.260565.2
259 schema:familyName Chen
260 schema:givenName Jang-Yi
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745762142.23
262 rdf:type schema:Person
263 sg:pub.10.1038/342705a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041126170
264 https://doi.org/10.1038/342705a0
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/bjc.2013.699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049134278
267 https://doi.org/10.1038/bjc.2013.699
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/cdd.2010.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021653488
270 https://doi.org/10.1038/cdd.2010.35
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nrc3982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508003
273 https://doi.org/10.1038/nrc3982
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/sj.cdd.4401205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003074932
276 https://doi.org/10.1038/sj.cdd.4401205
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/sj.onc.1201374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032075271
279 https://doi.org/10.1038/sj.onc.1201374
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/sj.onc.1204373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025353103
282 https://doi.org/10.1038/sj.onc.1204373
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/sj.onc.1209250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029919109
285 https://doi.org/10.1038/sj.onc.1209250
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1479-5876-8-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023938999
288 https://doi.org/10.1186/1479-5876-8-15
289 rdf:type schema:CreativeWork
290 grid-institutes:grid.260565.2 schema:alternateName Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan
291 schema:name Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan
292 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
293 rdf:type schema:Organization
294 grid-institutes:grid.28665.3f schema:alternateName Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
295 schema:name Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
296 Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
297 rdf:type schema:Organization
298 grid-institutes:grid.482251.8 schema:alternateName Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
299 schema:name Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
300 rdf:type schema:Organization
301 grid-institutes:grid.506938.1 schema:alternateName Genomics Research Center, Academia Sinica, Taipei, Taiwan
302 schema:name Genomics Research Center, Academia Sinica, Taipei, Taiwan
303 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...