Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Julia González-Rincón, Sagrario Gómez, Nerea Martinez, Kevin Troulé, Javier Perales-Patón, Sophia Derdak, Sergi Beltrán, Belén Fernández-Cuevas, Nuria Pérez-Sanz, Sara Nova-Gurumeta, Ivo Gut, Fátima Al-Shahrour, Miguel A. Piris, José A. García-Marco, Margarita Sánchez-Beato

ABSTRACT

Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops over several years. Here we report an analysis by deep sequencing of sequential samples taken at different times from the affected organs of two patients with 12- and 7-year disease courses, respectively. One of the patients followed a linear pattern of clonal evolution, acquiring and selecting new mutations in response to salvage therapy and/or allogeneic transplantation, while the other suffered loss of cellular tumoral clones during progression and histological transformation. More... »

PAGES

975

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37389-7

DOI

http://dx.doi.org/10.1038/s41598-018-37389-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111772759

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30700761


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JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37389-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37389-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37389-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37389-7'


 

This table displays all metadata directly associated to this object as RDF triples.

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