Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ludovica Marinelli, Camille Martin-Gallausiaux, Jean-Marie Bourhis, Fabienne Béguet-Crespel, Hervé M. Blottière, Nicolas Lapaque

ABSTRACT

The ligand activated transcription factor, aryl hydrocarbon receptor (AhR) emerged as a critical regulator of immune and metabolic processes in the gastrointestinal tract. In the gut, a main source of AhR ligands derives from commensal bacteria. However, many of the reported microbiota-derived ligands have been restricted to indolyl metabolites. Here, by screening commensal bacteria supernatants on an AhR reporter system expressed in human intestinal epithelial cell line (IEC), we found that the short chain fatty acid (SCFA) butyrate induced AhR activity and the transcription of AhR-dependent genes in IECs. We showed that AhR ligand antagonists reduced the effects of butyrate on IEC suggesting that butyrate could act as a ligand of AhR, which was supported by the nuclear translocation of AhR induced by butyrate and in silico structural modelling. In conclusion, our findings suggest that (i) butyrate activates AhR pathway and AhR-dependent genes in human intestinal epithelial cell-lines (ii) butyrate is a potential ligand for AhR which is an original mechanism of gene regulation by SCFA. More... »

PAGES

643

References to SciGraph publications

  • 2017-02-01. Feedback control of AHR signalling regulates intestinal immunity in NATURE
  • 2013-11. Aryl hydrocarbon receptor promotes RORγt+ Group 3 ILCs and controls intestinal immunity and inflammation in SEMINARS IN IMMUNOPATHOLOGY
  • 2008-12. HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures in BMC STRUCTURAL BIOLOGY
  • 2014-08. AhR sensing of bacterial pigments regulates antibacterial defence in NATURE
  • 2007-03. HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics in CELL RESEARCH
  • 2015-07. Influence of nutrient-derived metabolites on lymphocyte immunity in NATURE MEDICINE
  • 2007-11. Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences in AMINO ACIDS
  • 2012-12. WeNMR: Structural Biology on the Grid in JOURNAL OF GRID COMPUTING
  • 2016-06. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands in NATURE MEDICINE
  • 2015-08. Structural integration in hypoxia-inducible factors in NATURE
  • 2015-08. Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation in CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
  • 2012-08. Template-based protein structure modeling using the RaptorX web server in NATURE PROTOCOLS
  • 2011-09. A Role of the Aryl Hydrocarbon Receptor in Attenuation of Colitis in DIGESTIVE DISEASES AND SCIENCES
  • 2014-05. Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis in IMMUNOLOGY AND CELL BIOLOGY
  • 2015-10. Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles in SCIENTIFIC REPORTS
  • 2017-12. Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-37019-2

    DOI

    http://dx.doi.org/10.1038/s41598-018-37019-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111652904

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30679727


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sorbonne University", 
              "id": "https://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France", 
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, IFD, 4 place Jussieu, 75252, Paris, cedex 05, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marinelli", 
            "givenName": "Ludovica", 
            "id": "sg:person.010347616223.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347616223.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne University", 
              "id": "https://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France", 
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, IFD, 4 place Jussieu, 75252, Paris, cedex 05, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martin-Gallausiaux", 
            "givenName": "Camille", 
            "id": "sg:person.01152150511.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152150511.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "French National Centre for Scientific Research", 
              "id": "https://www.grid.ac/institutes/grid.4444.0", 
              "name": [
                "University Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bourhis", 
            "givenName": "Jean-Marie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherches de Jouy-en-Josas", 
              "id": "https://www.grid.ac/institutes/grid.417961.c", 
              "name": [
                "Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "B\u00e9guet-Crespel", 
            "givenName": "Fabienne", 
            "id": "sg:person.0614432474.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614432474.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherches de Jouy-en-Josas", 
              "id": "https://www.grid.ac/institutes/grid.417961.c", 
              "name": [
                "Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France", 
                "MetaGenoPolis, INRA, Universit\u00e9 Paris-Saclay, 78350, Jouy en Josas, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blotti\u00e8re", 
            "givenName": "Herv\u00e9 M.", 
            "id": "sg:person.01311104560.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311104560.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherches de Jouy-en-Josas", 
              "id": "https://www.grid.ac/institutes/grid.417961.c", 
              "name": [
                "Micalis Institute, INRA, AgroParisTech, Universit\u00e9 Paris-Saclay, 78350, Jouy-en-Josas, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lapaque", 
            "givenName": "Nicolas", 
            "id": "sg:person.0761752245.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761752245.72"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.2337/db11-1019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000203022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002453770", 
              "https://doi.org/10.1038/nature13684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/282356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003275185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1327.1999.00188.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006249523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2011.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006857588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007130362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007130362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007130362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep12689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008653548", 
              "https://doi.org/10.1038/srep12689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009155421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(78)90305-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010035463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2672.2005.02605.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011611212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2672.2005.02605.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011611212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.115.064246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012082457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ctg.2015.34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013676824", 
              "https://doi.org/10.1038/ctg.2015.34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mbio.00889-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014337412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.22.9.763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015665338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.113.007823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016794656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2004.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016919263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.113.091165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017137893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017362425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6807-8-49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017381549", 
              "https://doi.org/10.1186/1472-6807-8-49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017481425", 
              "https://doi.org/10.1038/nm.4102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2013-304833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018584442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.09.082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021246731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.09.082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021246731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-013-0393-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021352382", 
              "https://doi.org/10.1007/s00281-013-0393-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fimmu.2013.00226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022410221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.110.178392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-011-1643-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022800440", 
              "https://doi.org/10.1007/s10620-011-1643-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023212695", 
              "https://doi.org/10.1038/sj.cr.7310149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cr.7310149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023212695", 
              "https://doi.org/10.1038/sj.cr.7310149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(78)90306-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023789700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024143838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.28.10.1221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024645746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025352359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10723-012-9246-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025653754", 
              "https://doi.org/10.1007/s10723-012-9246-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-006-0477-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026049943", 
              "https://doi.org/10.1007/s00726-006-0477-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-006-0477-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026049943", 
              "https://doi.org/10.1007/s00726-006-0477-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-006-0477-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026049943", 
              "https://doi.org/10.1007/s00726-006-0477-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032713-120245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027654684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00112.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030123550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00112.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030123550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031492026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032241508", 
              "https://doi.org/10.1038/nm.3894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032241508", 
              "https://doi.org/10.1038/nm.3894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/dmdi-2011-0035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033380254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.109.054825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033390642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/icb.2014.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033834158", 
              "https://doi.org/10.1038/icb.2014.2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034502364", 
              "https://doi.org/10.1038/nature14883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034502364", 
              "https://doi.org/10.1038/nature14883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034502364", 
              "https://doi.org/10.1038/nature14883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/biology3040645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036708561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2005.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036774484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-291x(02)00294-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036797469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00858-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037073825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042229476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.20903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042229476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pa.35.040195.001515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043883190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044328821", 
              "https://doi.org/10.1038/nprot.2012.085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.63.2.392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047781217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.1999.1620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048545115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi047433p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi047433p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055198523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi061460t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055202476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi061460t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055202476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi801637q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi801637q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm900199u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055956348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm900199u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055956348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/dna.2006.25.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059252103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v19.i22.3404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071369343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.2000.279.4.g775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074703894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/132.5.1012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075043502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076919431", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature21080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083401659", 
              "https://doi.org/10.1038/nature21080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cotox.2017.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083406068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2017.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086031577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1706464114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091295931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-10824-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091356772", 
              "https://doi.org/10.1038/s41598-017-10824-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-10824-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091356772", 
              "https://doi.org/10.1038/s41598-017-10824-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1700105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091618315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijmm.2017.3341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099998773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcimb.2018.00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100831625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2018.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101057422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/ijbs.22259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101122243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2018.02.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101290532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1109538289", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "The ligand activated transcription factor, aryl hydrocarbon receptor (AhR) emerged as a critical regulator of immune and metabolic processes in the gastrointestinal tract. In the gut, a main source of AhR ligands derives from commensal bacteria. However, many of the reported microbiota-derived ligands have been restricted to indolyl metabolites. Here, by screening commensal bacteria supernatants on an AhR reporter system expressed in human intestinal epithelial cell line (IEC), we found that the short chain fatty acid (SCFA) butyrate induced AhR activity and the transcription of AhR-dependent genes in IECs. We showed that AhR ligand antagonists reduced the effects of butyrate on IEC suggesting that butyrate could act as a ligand of AhR, which was supported by the nuclear translocation of AhR induced by butyrate and in silico structural modelling. In conclusion, our findings suggest that (i) butyrate activates AhR pathway and AhR-dependent genes in human intestinal epithelial cell-lines (ii) butyrate is a potential ligand for AhR which is an original mechanism of gene regulation by SCFA.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-37019-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells", 
        "pagination": "643", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ef8d6e12566ba83c066c7c10a2c37d161fed536e0bdc2dc34a385b87be41e5a6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30679727"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-37019-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111652904"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-37019-2", 
          "https://app.dimensions.ai/details/publication/pub.1111652904"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68454_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-37019-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37019-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37019-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37019-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37019-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    337 TRIPLES      21 PREDICATES      100 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-37019-2 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Ned99c78a149644e280c6d40deb47e23d
    4 schema:citation sg:pub.10.1007/s00281-013-0393-5
    5 sg:pub.10.1007/s00726-006-0477-9
    6 sg:pub.10.1007/s10620-011-1643-9
    7 sg:pub.10.1007/s10723-012-9246-z
    8 sg:pub.10.1038/ctg.2015.34
    9 sg:pub.10.1038/icb.2014.2
    10 sg:pub.10.1038/nature13684
    11 sg:pub.10.1038/nature14883
    12 sg:pub.10.1038/nature21080
    13 sg:pub.10.1038/nm.3894
    14 sg:pub.10.1038/nm.4102
    15 sg:pub.10.1038/nprot.2012.085
    16 sg:pub.10.1038/s41598-017-10824-x
    17 sg:pub.10.1038/sj.cr.7310149
    18 sg:pub.10.1038/srep12689
    19 sg:pub.10.1186/1472-6807-8-49
    20 https://app.dimensions.ai/details/publication/pub.1076919431
    21 https://app.dimensions.ai/details/publication/pub.1109538289
    22 https://doi.org/10.1002/ibd.20903
    23 https://doi.org/10.1002/ibd.21108
    24 https://doi.org/10.1006/abbi.1999.1620
    25 https://doi.org/10.1016/0092-8674(78)90305-7
    26 https://doi.org/10.1016/0092-8674(78)90306-9
    27 https://doi.org/10.1016/j.ajpath.2018.01.011
    28 https://doi.org/10.1016/j.bcp.2018.02.031
    29 https://doi.org/10.1016/j.celrep.2016.09.082
    30 https://doi.org/10.1016/j.cmet.2017.05.008
    31 https://doi.org/10.1016/j.cotox.2017.01.011
    32 https://doi.org/10.1016/j.immuni.2013.08.002
    33 https://doi.org/10.1016/j.immuni.2013.08.003
    34 https://doi.org/10.1016/j.jmb.2015.09.014
    35 https://doi.org/10.1016/j.tim.2005.06.009
    36 https://doi.org/10.1016/s0006-291x(02)00294-2
    37 https://doi.org/10.1021/bi047433p
    38 https://doi.org/10.1021/bi061460t
    39 https://doi.org/10.1021/bi801637q
    40 https://doi.org/10.1021/jm900199u
    41 https://doi.org/10.1046/j.1432-1327.1999.00188.x
    42 https://doi.org/10.1053/j.gastro.2004.12.003
    43 https://doi.org/10.1053/j.gastro.2011.04.007
    44 https://doi.org/10.1073/pnas.1706464114
    45 https://doi.org/10.1089/dna.2006.25.49
    46 https://doi.org/10.1093/bioinformatics/bts213
    47 https://doi.org/10.1093/jn/132.5.1012
    48 https://doi.org/10.1111/j.1365-2672.2005.02605.x
    49 https://doi.org/10.1124/dmd.115.064246
    50 https://doi.org/10.1124/jpet.110.178392
    51 https://doi.org/10.1124/mol.109.054825
    52 https://doi.org/10.1124/mol.113.091165
    53 https://doi.org/10.1124/mol.63.2.392
    54 https://doi.org/10.1124/pr.113.007823
    55 https://doi.org/10.1128/mbio.00889-14
    56 https://doi.org/10.1128/mcb.00858-12
    57 https://doi.org/10.1136/gut.22.9.763
    58 https://doi.org/10.1136/gut.28.10.1221
    59 https://doi.org/10.1136/gutjnl-2013-304833
    60 https://doi.org/10.1146/annurev-immunol-032713-120245
    61 https://doi.org/10.1146/annurev.pa.35.040195.001515
    62 https://doi.org/10.1152/ajpcell.00112.2005
    63 https://doi.org/10.1152/ajpgi.2000.279.4.g775
    64 https://doi.org/10.1155/2011/282356
    65 https://doi.org/10.1371/journal.pcbi.1002708
    66 https://doi.org/10.1515/dmdi-2011-0035
    67 https://doi.org/10.2337/db11-1019
    68 https://doi.org/10.3389/fcimb.2018.00013
    69 https://doi.org/10.3389/fimmu.2013.00226
    70 https://doi.org/10.3390/biology3040645
    71 https://doi.org/10.3748/wjg.v19.i22.3404
    72 https://doi.org/10.3892/ijmm.2017.3341
    73 https://doi.org/10.4049/jimmunol.1700105
    74 https://doi.org/10.7150/ijbs.22259
    75 schema:datePublished 2019-12
    76 schema:datePublishedReg 2019-12-01
    77 schema:description The ligand activated transcription factor, aryl hydrocarbon receptor (AhR) emerged as a critical regulator of immune and metabolic processes in the gastrointestinal tract. In the gut, a main source of AhR ligands derives from commensal bacteria. However, many of the reported microbiota-derived ligands have been restricted to indolyl metabolites. Here, by screening commensal bacteria supernatants on an AhR reporter system expressed in human intestinal epithelial cell line (IEC), we found that the short chain fatty acid (SCFA) butyrate induced AhR activity and the transcription of AhR-dependent genes in IECs. We showed that AhR ligand antagonists reduced the effects of butyrate on IEC suggesting that butyrate could act as a ligand of AhR, which was supported by the nuclear translocation of AhR induced by butyrate and in silico structural modelling. In conclusion, our findings suggest that (i) butyrate activates AhR pathway and AhR-dependent genes in human intestinal epithelial cell-lines (ii) butyrate is a potential ligand for AhR which is an original mechanism of gene regulation by SCFA.
    78 schema:genre research_article
    79 schema:inLanguage en
    80 schema:isAccessibleForFree true
    81 schema:isPartOf N4513c7137b44463fab3c99fb05fabdac
    82 Nfdd8c7574e144722832b62da09b65add
    83 sg:journal.1045337
    84 schema:name Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
    85 schema:pagination 643
    86 schema:productId N3bce13093145421497abae5c19a87b34
    87 Na0c300a052bc42458ff497c3df49fd11
    88 Nccef1919579a4f598e6e56888aa90c46
    89 Nd3a574afee8b46268aa53910d52ba0b7
    90 Nea162e7c34a1440bbc2ab653ab084891
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111652904
    92 https://doi.org/10.1038/s41598-018-37019-2
    93 schema:sdDatePublished 2019-04-11T08:58
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher Naca8e0e59119487e887ee2bf7d9273ae
    96 schema:url https://www.nature.com/articles/s41598-018-37019-2
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N0d8120a6c05d42cc96158f278869bdf1 rdf:first sg:person.01311104560.09
    101 rdf:rest Nf826d3036edf45a49b26b5b204b3eb87
    102 N3bce13093145421497abae5c19a87b34 schema:name pubmed_id
    103 schema:value 30679727
    104 rdf:type schema:PropertyValue
    105 N4485becaa88341ceab4f1957df10a74b rdf:first N61f000ce781b4f559b0c1835c8081ca3
    106 rdf:rest N59885d902ae942b9a91478cf38c7c2ea
    107 N4513c7137b44463fab3c99fb05fabdac schema:issueNumber 1
    108 rdf:type schema:PublicationIssue
    109 N58ded3eae9e148aa8a726f7fb6a7e09a rdf:first sg:person.01152150511.52
    110 rdf:rest N4485becaa88341ceab4f1957df10a74b
    111 N59885d902ae942b9a91478cf38c7c2ea rdf:first sg:person.0614432474.19
    112 rdf:rest N0d8120a6c05d42cc96158f278869bdf1
    113 N61f000ce781b4f559b0c1835c8081ca3 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
    114 schema:familyName Bourhis
    115 schema:givenName Jean-Marie
    116 rdf:type schema:Person
    117 Na0c300a052bc42458ff497c3df49fd11 schema:name nlm_unique_id
    118 schema:value 101563288
    119 rdf:type schema:PropertyValue
    120 Naca8e0e59119487e887ee2bf7d9273ae schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 Nccef1919579a4f598e6e56888aa90c46 schema:name doi
    123 schema:value 10.1038/s41598-018-37019-2
    124 rdf:type schema:PropertyValue
    125 Nd3a574afee8b46268aa53910d52ba0b7 schema:name readcube_id
    126 schema:value ef8d6e12566ba83c066c7c10a2c37d161fed536e0bdc2dc34a385b87be41e5a6
    127 rdf:type schema:PropertyValue
    128 Nea162e7c34a1440bbc2ab653ab084891 schema:name dimensions_id
    129 schema:value pub.1111652904
    130 rdf:type schema:PropertyValue
    131 Ned99c78a149644e280c6d40deb47e23d rdf:first sg:person.010347616223.14
    132 rdf:rest N58ded3eae9e148aa8a726f7fb6a7e09a
    133 Nf826d3036edf45a49b26b5b204b3eb87 rdf:first sg:person.0761752245.72
    134 rdf:rest rdf:nil
    135 Nfdd8c7574e144722832b62da09b65add schema:volumeNumber 9
    136 rdf:type schema:PublicationVolume
    137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Biological Sciences
    139 rdf:type schema:DefinedTerm
    140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Biochemistry and Cell Biology
    142 rdf:type schema:DefinedTerm
    143 sg:journal.1045337 schema:issn 2045-2322
    144 schema:name Scientific Reports
    145 rdf:type schema:Periodical
    146 sg:person.010347616223.14 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
    147 schema:familyName Marinelli
    148 schema:givenName Ludovica
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347616223.14
    150 rdf:type schema:Person
    151 sg:person.01152150511.52 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
    152 schema:familyName Martin-Gallausiaux
    153 schema:givenName Camille
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152150511.52
    155 rdf:type schema:Person
    156 sg:person.01311104560.09 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
    157 schema:familyName Blottière
    158 schema:givenName Hervé M.
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311104560.09
    160 rdf:type schema:Person
    161 sg:person.0614432474.19 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
    162 schema:familyName Béguet-Crespel
    163 schema:givenName Fabienne
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614432474.19
    165 rdf:type schema:Person
    166 sg:person.0761752245.72 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
    167 schema:familyName Lapaque
    168 schema:givenName Nicolas
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761752245.72
    170 rdf:type schema:Person
    171 sg:pub.10.1007/s00281-013-0393-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021352382
    172 https://doi.org/10.1007/s00281-013-0393-5
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1007/s00726-006-0477-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026049943
    175 https://doi.org/10.1007/s00726-006-0477-9
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s10620-011-1643-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022800440
    178 https://doi.org/10.1007/s10620-011-1643-9
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s10723-012-9246-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1025653754
    181 https://doi.org/10.1007/s10723-012-9246-z
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/ctg.2015.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013676824
    184 https://doi.org/10.1038/ctg.2015.34
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/icb.2014.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033834158
    187 https://doi.org/10.1038/icb.2014.2
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/nature13684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002453770
    190 https://doi.org/10.1038/nature13684
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nature14883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034502364
    193 https://doi.org/10.1038/nature14883
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature21080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083401659
    196 https://doi.org/10.1038/nature21080
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nm.3894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032241508
    199 https://doi.org/10.1038/nm.3894
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nm.4102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017481425
    202 https://doi.org/10.1038/nm.4102
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nprot.2012.085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044328821
    205 https://doi.org/10.1038/nprot.2012.085
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/s41598-017-10824-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1091356772
    208 https://doi.org/10.1038/s41598-017-10824-x
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/sj.cr.7310149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023212695
    211 https://doi.org/10.1038/sj.cr.7310149
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/srep12689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008653548
    214 https://doi.org/10.1038/srep12689
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1186/1472-6807-8-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017381549
    217 https://doi.org/10.1186/1472-6807-8-49
    218 rdf:type schema:CreativeWork
    219 https://app.dimensions.ai/details/publication/pub.1076919431 schema:CreativeWork
    220 https://app.dimensions.ai/details/publication/pub.1109538289 schema:CreativeWork
    221 https://doi.org/10.1002/ibd.20903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042229476
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1002/ibd.21108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007130362
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1006/abbi.1999.1620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048545115
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/0092-8674(78)90305-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010035463
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/0092-8674(78)90306-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023789700
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.ajpath.2018.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101057422
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.bcp.2018.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101290532
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.celrep.2016.09.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021246731
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.cmet.2017.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086031577
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.cotox.2017.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083406068
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.immuni.2013.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017362425
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.immuni.2013.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025352359
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.jmb.2015.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009155421
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.tim.2005.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036774484
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/s0006-291x(02)00294-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036797469
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1021/bi047433p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055198523
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1021/bi061460t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055202476
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1021/bi801637q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209092
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1021/jm900199u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055956348
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1046/j.1432-1327.1999.00188.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006249523
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1053/j.gastro.2004.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016919263
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1053/j.gastro.2011.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006857588
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1073/pnas.1706464114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091295931
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1089/dna.2006.25.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059252103
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/bioinformatics/bts213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024143838
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1093/jn/132.5.1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075043502
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1111/j.1365-2672.2005.02605.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011611212
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1124/dmd.115.064246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012082457
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1124/jpet.110.178392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762778
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1124/mol.109.054825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033390642
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1124/mol.113.091165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017137893
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1124/mol.63.2.392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047781217
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1124/pr.113.007823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016794656
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1128/mbio.00889-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014337412
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1128/mcb.00858-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037073825
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1136/gut.22.9.763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015665338
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1136/gut.28.10.1221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024645746
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1136/gutjnl-2013-304833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018584442
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1146/annurev-immunol-032713-120245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027654684
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1146/annurev.pa.35.040195.001515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043883190
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1152/ajpcell.00112.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030123550
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1152/ajpgi.2000.279.4.g775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074703894
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1155/2011/282356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003275185
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1371/journal.pcbi.1002708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031492026
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1515/dmdi-2011-0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033380254
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.2337/db11-1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000203022
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.3389/fcimb.2018.00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100831625
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.3389/fimmu.2013.00226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022410221
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.3390/biology3040645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036708561
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.3748/wjg.v19.i22.3404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071369343
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.3892/ijmm.2017.3341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099998773
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.4049/jimmunol.1700105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091618315
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.7150/ijbs.22259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101122243
    326 rdf:type schema:CreativeWork
    327 https://www.grid.ac/institutes/grid.417961.c schema:alternateName Centre de Recherches de Jouy-en-Josas
    328 schema:name MetaGenoPolis, INRA, Université Paris-Saclay, 78350, Jouy en Josas, France
    329 Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France
    330 rdf:type schema:Organization
    331 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
    332 schema:name University Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France
    333 rdf:type schema:Organization
    334 https://www.grid.ac/institutes/grid.462844.8 schema:alternateName Sorbonne University
    335 schema:name Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France
    336 Sorbonne Universités, UPMC Univ Paris 06, IFD, 4 place Jussieu, 75252, Paris, cedex 05, France
    337 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...