Impaired non-homologous end joining in human primary alveolar type II cells in emphysema View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Beata Kosmider, Chih-Ru Lin, Liudmila Vlasenko, Nathaniel Marchetti, Sudhir Bolla, Gerard J. Criner, Elise Messier, Nichole Reisdorph, Roger L. Powell, Muniswamy Madesh, Steven Kelsen, Nathaniel Xander, Kelly A. Correll, Robert J. Mason, Karim Bahmed

ABSTRACT

Emphysema is characterized by alveolar wall destruction induced mainly by cigarette smoke. Oxidative damage of DNA may contribute to the pathophysiology of this disease. We studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar type II (ATII) cells and emphysema development. We isolated primary ATII cells from control smokers, nonsmokers, and patients with emphysema to determine DNA damage and repair. We found higher reactive oxygen species generation and DNA damage in ATII cells obtained from individuals with this disease in comparison with controls. We also observed low phosphorylation of H2AX, which activates DSBs repair signaling, in emphysema. Our results indicate the impairement of NHEJ, as detected by low XLF expression. We also analyzed the role of DJ-1, which has a cytoprotective activity. We detected DJ-1 and XLF interaction in ATII cells in emphysema, which suggests the impairment of their function. Moreover, we found that DJ-1 KO mice are more susceptible to DNA damage induced by cigarette smoke. Our results suggest that oxidative DNA damage and ineffective the DSBs repair via the impaired NHEJ may contribute to ATII cell death in emphysema. More... »

PAGES

920

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-37000-z

DOI

http://dx.doi.org/10.1038/s41598-018-37000-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111759918

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30696938


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA", 
            "Department of Physiology, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kosmider", 
        "givenName": "Beata", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Chih-Ru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vlasenko", 
        "givenName": "Liudmila", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchetti", 
        "givenName": "Nathaniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bolla", 
        "givenName": "Sudhir", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Criner", 
        "givenName": "Gerard J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Jewish Health", 
          "id": "https://www.grid.ac/institutes/grid.240341.0", 
          "name": [
            "National Jewish Health, 80206, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Messier", 
        "givenName": "Elise", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Jewish Health", 
          "id": "https://www.grid.ac/institutes/grid.240341.0", 
          "name": [
            "National Jewish Health, 80206, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reisdorph", 
        "givenName": "Nichole", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Jewish Health", 
          "id": "https://www.grid.ac/institutes/grid.240341.0", 
          "name": [
            "National Jewish Health, 80206, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Powell", 
        "givenName": "Roger L.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Medical Genetics and Molecular Biochemistry, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madesh", 
        "givenName": "Muniswamy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kelsen", 
        "givenName": "Steven", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xander", 
        "givenName": "Nathaniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Jewish Health", 
          "id": "https://www.grid.ac/institutes/grid.240341.0", 
          "name": [
            "National Jewish Health, 80206, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Correll", 
        "givenName": "Kelly A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Jewish Health", 
          "id": "https://www.grid.ac/institutes/grid.240341.0", 
          "name": [
            "National Jewish Health, 80206, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mason", 
        "givenName": "Robert J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA", 
            "Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bahmed", 
        "givenName": "Karim", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4161/oxim.2.1.7985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000079568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2012.05.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000194773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci60324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000835529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001577212", 
          "https://doi.org/10.1038/nature12930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12930", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001577212", 
          "https://doi.org/10.1038/nature12930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2012-0295oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002134997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4061/2010/920161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002348403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003061837", 
          "https://doi.org/10.1038/cddis.2013.96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2010.05600.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003379241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2010.05600.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003379241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2004.00162.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005485408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00462.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005635627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.06-1040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005971584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00298.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009665903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2006.062802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010383804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/thx.2006.062802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010383804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2015-0171oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011943977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.5.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013536789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)00602-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013678176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm.154.1.8680679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015496178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.019117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015828914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.25.14440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015989129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017161096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2013.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017378194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-0296-2_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017755535", 
          "https://doi.org/10.1007/978-1-4419-0296-2_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-0296-2_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017755535", 
          "https://doi.org/10.1007/978-1-4419-0296-2_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018989351", 
          "https://doi.org/10.1038/sj.cdd.4400918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4400918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018989351", 
          "https://doi.org/10.1038/sj.cdd.4400918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2008.06.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019089230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.010908.163257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022813465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022937373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0051697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023904333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025134238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.07-1490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025714209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.73.011303.073723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026178756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2006.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026201497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15412550903499522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026683853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.redox.2013.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028603209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fgene.2015.00157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029506180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-014-3403-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031560322", 
          "https://doi.org/10.1007/s11033-014-3403-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15412555.2010.541306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032326957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033071584", 
          "https://doi.org/10.1038/nsmb1338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033294736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2005.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033294736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90499-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037227223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00144208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038253514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.250357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038606694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-13-43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039154505", 
          "https://doi.org/10.1186/1465-9921-13-43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m806902200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039276889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gm367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040053405", 
          "https://doi.org/10.1186/gm367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci68782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040259078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040676987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040676987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20101695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041857222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20101695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041857222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00567-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043198083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.iac.2009.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045231992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2015-0304oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048162039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122228699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048193879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.20426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048665337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00050211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049345125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00133805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050254635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0026059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051123907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.138099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053297083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.98106s1289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064747122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156800906776842957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069190742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077625250", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078780643", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201605-0904oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084237068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20160487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090391073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20160487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090391073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-21790-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101113735", 
          "https://doi.org/10.1038/s41598-018-21790-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-21790-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101113735", 
          "https://doi.org/10.1038/s41598-018-21790-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-21790-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101113735", 
          "https://doi.org/10.1038/s41598-018-21790-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-8570-8_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105422497", 
          "https://doi.org/10.1007/978-1-4939-8570-8_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-8570-8_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105422497", 
          "https://doi.org/10.1007/978-1-4939-8570-8_7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Emphysema is characterized by alveolar wall destruction induced mainly by cigarette smoke. Oxidative damage of DNA may contribute to\u00a0the pathophysiology of this disease. We studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar type II (ATII) cells and emphysema development. We isolated primary ATII cells from control smokers, nonsmokers, and patients with emphysema to determine DNA damage and repair. We found higher reactive oxygen species generation and DNA damage in ATII cells obtained from individuals with this disease\u00a0 in comparison with controls. We also observed low phosphorylation of H2AX, which activates DSBs repair signaling, in emphysema. Our results indicate the impairement\u00a0 of NHEJ, as detected by low XLF expression. We also analyzed the role of DJ-1, which has a cytoprotective activity. We detected DJ-1 and\u00a0 XLF\u00a0interaction in ATII cells in emphysema, which suggests the impairment of their function. Moreover, we found that DJ-1 KO mice are more susceptible to DNA damage induced by cigarette smoke. Our results suggest that oxidative DNA damage and ineffective the DSBs repair via the impaired NHEJ may contribute to ATII cell death in emphysema.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-37000-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3807031", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Impaired non-homologous end joining in human primary alveolar type II cells in emphysema", 
    "pagination": "920", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "060ab4bb29070b02916fa327e5a646ff6d1c9213f7cf0b0423325c8574d1c559"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30696938"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-37000-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111759918"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-37000-z", 
      "https://app.dimensions.ai/details/publication/pub.1111759918"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000327_0000000327/records_114973_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-37000-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37000-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37000-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37000-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-37000-z'


 

This table displays all metadata directly associated to this object as RDF triples.

362 TRIPLES      21 PREDICATES      94 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-37000-z schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N1470ffa0f81d4faea8a79e2fd3b1ca7e
4 schema:citation sg:pub.10.1007/978-1-4419-0296-2_4
5 sg:pub.10.1007/978-1-4939-8570-8_7
6 sg:pub.10.1007/s11033-014-3403-3
7 sg:pub.10.1038/cddis.2013.96
8 sg:pub.10.1038/nature12930
9 sg:pub.10.1038/nsmb1338
10 sg:pub.10.1038/s41598-018-21790-3
11 sg:pub.10.1038/sj.cdd.4400918
12 sg:pub.10.1186/1465-9921-13-43
13 sg:pub.10.1186/gm367
14 https://app.dimensions.ai/details/publication/pub.1077625250
15 https://app.dimensions.ai/details/publication/pub.1078780643
16 https://doi.org/10.1002/cyto.a.20426
17 https://doi.org/10.1016/0092-8674(93)90499-g
18 https://doi.org/10.1016/j.biocel.2013.08.009
19 https://doi.org/10.1016/j.canlet.2005.07.016
20 https://doi.org/10.1016/j.cell.2007.02.005
21 https://doi.org/10.1016/j.dnarep.2006.05.022
22 https://doi.org/10.1016/j.dnarep.2008.06.018
23 https://doi.org/10.1016/j.iac.2009.10.004
24 https://doi.org/10.1016/j.molcel.2012.05.052
25 https://doi.org/10.1016/j.molcel.2016.02.010
26 https://doi.org/10.1016/j.redox.2013.12.020
27 https://doi.org/10.1016/s0065-2776(08)00602-0
28 https://doi.org/10.1016/s0092-8674(03)00567-1
29 https://doi.org/10.1042/bj20101695
30 https://doi.org/10.1042/cs20160487
31 https://doi.org/10.1073/pnas.122228699
32 https://doi.org/10.1073/pnas.93.25.14440
33 https://doi.org/10.1074/jbc.m110.138099
34 https://doi.org/10.1074/jbc.m111.250357
35 https://doi.org/10.1074/jbc.m806902200
36 https://doi.org/10.1093/carcin/23.5.687
37 https://doi.org/10.1111/j.0105-2896.2004.00162.x
38 https://doi.org/10.1111/j.1749-6632.2010.05600.x
39 https://doi.org/10.1126/science.1069398
40 https://doi.org/10.1136/thx.2006.062802
41 https://doi.org/10.1146/annurev.biochem.73.011303.073723
42 https://doi.org/10.1146/annurev.physiol.010908.163257
43 https://doi.org/10.1152/ajpcell.00462.2010
44 https://doi.org/10.1152/ajplung.00298.2013
45 https://doi.org/10.1164/ajrccm.154.1.8680679
46 https://doi.org/10.1164/rccm.201605-0904oc
47 https://doi.org/10.1165/rcmb.2012-0295oc
48 https://doi.org/10.1165/rcmb.2015-0171oc
49 https://doi.org/10.1165/rcmb.2015-0304oc
50 https://doi.org/10.1172/jci60324
51 https://doi.org/10.1172/jci68782
52 https://doi.org/10.1183/09031936.00050211
53 https://doi.org/10.1183/09031936.00133805
54 https://doi.org/10.1183/09031936.00144208
55 https://doi.org/10.1242/dmm.019117
56 https://doi.org/10.1289/ehp.98106s1289
57 https://doi.org/10.1371/journal.pgen.1000110
58 https://doi.org/10.1371/journal.pone.0007380
59 https://doi.org/10.1371/journal.pone.0026059
60 https://doi.org/10.1371/journal.pone.0051697
61 https://doi.org/10.1378/chest.06-1040
62 https://doi.org/10.1378/chest.07-1490
63 https://doi.org/10.2174/156800906776842957
64 https://doi.org/10.3109/15412550903499522
65 https://doi.org/10.3109/15412555.2010.541306
66 https://doi.org/10.3389/fgene.2015.00157
67 https://doi.org/10.4061/2010/920161
68 https://doi.org/10.4161/oxim.2.1.7985
69 schema:datePublished 2019-12
70 schema:datePublishedReg 2019-12-01
71 schema:description Emphysema is characterized by alveolar wall destruction induced mainly by cigarette smoke. Oxidative damage of DNA may contribute to the pathophysiology of this disease. We studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar type II (ATII) cells and emphysema development. We isolated primary ATII cells from control smokers, nonsmokers, and patients with emphysema to determine DNA damage and repair. We found higher reactive oxygen species generation and DNA damage in ATII cells obtained from individuals with this disease  in comparison with controls. We also observed low phosphorylation of H2AX, which activates DSBs repair signaling, in emphysema. Our results indicate the impairement  of NHEJ, as detected by low XLF expression. We also analyzed the role of DJ-1, which has a cytoprotective activity. We detected DJ-1 and  XLF interaction in ATII cells in emphysema, which suggests the impairment of their function. Moreover, we found that DJ-1 KO mice are more susceptible to DNA damage induced by cigarette smoke. Our results suggest that oxidative DNA damage and ineffective the DSBs repair via the impaired NHEJ may contribute to ATII cell death in emphysema.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N7bc98c6b0468480b8bb615cb43510282
76 Ndff0f3dac1d540e1bbeb4a9e06ee829b
77 sg:journal.1045337
78 schema:name Impaired non-homologous end joining in human primary alveolar type II cells in emphysema
79 schema:pagination 920
80 schema:productId N1b014798550c4fa39a03c950b051effc
81 N6569b952dcca4259a3100779b4c14c7d
82 N7fd04bb84c264fd6a6ede5a3705a4db7
83 Ndb07e604606f4efba1f9483ae4d432c4
84 Neb08d9a8c9464677b1dd26677550ae3a
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111759918
86 https://doi.org/10.1038/s41598-018-37000-z
87 schema:sdDatePublished 2019-04-11T08:59
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N716320901db143a5bb61072dd20f7b52
90 schema:url https://www.nature.com/articles/s41598-018-37000-z
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0866744d2a004b6994e9a3121c2a78b7 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
95 schema:familyName Criner
96 schema:givenName Gerard J.
97 rdf:type schema:Person
98 N0d391ef4581a4364948588464311590d rdf:first Nebe6c418b5da4a03a506afca690cdd37
99 rdf:rest rdf:nil
100 N1470ffa0f81d4faea8a79e2fd3b1ca7e rdf:first Nadf3b08b48814a0d9c96eec1d930cf1e
101 rdf:rest N7395e6d7b2e245c28480946dd517802e
102 N1b014798550c4fa39a03c950b051effc schema:name readcube_id
103 schema:value 060ab4bb29070b02916fa327e5a646ff6d1c9213f7cf0b0423325c8574d1c559
104 rdf:type schema:PropertyValue
105 N3c1738b40a094221a79237496cd9b9f2 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
106 schema:familyName Kelsen
107 schema:givenName Steven
108 rdf:type schema:Person
109 N4823b53d75934c2a88aa047c1e7cff26 rdf:first N4cec8cacb07c4442a21b08d9a150dd3c
110 rdf:rest Nfb716d63178c45feafcede49f50c3b58
111 N49f40958d0a242ac8b49bd8ca242ca1a schema:affiliation https://www.grid.ac/institutes/grid.264727.2
112 schema:familyName Xander
113 schema:givenName Nathaniel
114 rdf:type schema:Person
115 N4cec8cacb07c4442a21b08d9a150dd3c schema:affiliation https://www.grid.ac/institutes/grid.240341.0
116 schema:familyName Powell
117 schema:givenName Roger L.
118 rdf:type schema:Person
119 N510ab4d52c064234bdb75d9407e6da01 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
120 schema:familyName Bolla
121 schema:givenName Sudhir
122 rdf:type schema:Person
123 N55f5915677114f13aa0c545357492357 schema:affiliation https://www.grid.ac/institutes/grid.240341.0
124 schema:familyName Reisdorph
125 schema:givenName Nichole
126 rdf:type schema:Person
127 N588a819c695b4e648bda95d36c1ae54b rdf:first N510ab4d52c064234bdb75d9407e6da01
128 rdf:rest N8ece2a49c84d41f69677d44e2a304d92
129 N5eda71bbbc914d5eb4cbc23e222c6b63 rdf:first N55f5915677114f13aa0c545357492357
130 rdf:rest N4823b53d75934c2a88aa047c1e7cff26
131 N655a3fc775d7408fbe3b3f0990b0ce14 schema:affiliation https://www.grid.ac/institutes/grid.240341.0
132 schema:familyName Mason
133 schema:givenName Robert J.
134 rdf:type schema:Person
135 N6569b952dcca4259a3100779b4c14c7d schema:name pubmed_id
136 schema:value 30696938
137 rdf:type schema:PropertyValue
138 N716320901db143a5bb61072dd20f7b52 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N7395e6d7b2e245c28480946dd517802e rdf:first Nb367b9b203e74edd9dd3909f837c74b7
141 rdf:rest Ne77a71e1c6604118aca59b08dfe6813b
142 N777bc2d4998043fa886983896f1a2d12 rdf:first N3c1738b40a094221a79237496cd9b9f2
143 rdf:rest Nefe8bfbb79e6455ca35b38bcda0895ee
144 N7bc98c6b0468480b8bb615cb43510282 schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 N7fd04bb84c264fd6a6ede5a3705a4db7 schema:name dimensions_id
147 schema:value pub.1111759918
148 rdf:type schema:PropertyValue
149 N8ece2a49c84d41f69677d44e2a304d92 rdf:first N0866744d2a004b6994e9a3121c2a78b7
150 rdf:rest N912f5262b03341baa328336f4a3bbfef
151 N912f5262b03341baa328336f4a3bbfef rdf:first Nc96d1789592c44598f1bebb919209728
152 rdf:rest N5eda71bbbc914d5eb4cbc23e222c6b63
153 Na2116f3a7bc647039a347d9c06f99ab6 schema:affiliation https://www.grid.ac/institutes/grid.240341.0
154 schema:familyName Correll
155 schema:givenName Kelly A.
156 rdf:type schema:Person
157 Nadf3b08b48814a0d9c96eec1d930cf1e schema:affiliation https://www.grid.ac/institutes/grid.264727.2
158 schema:familyName Kosmider
159 schema:givenName Beata
160 rdf:type schema:Person
161 Nb367b9b203e74edd9dd3909f837c74b7 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
162 schema:familyName Lin
163 schema:givenName Chih-Ru
164 rdf:type schema:Person
165 Nc42358e396d243b6b3cebfc65d3e896e rdf:first Na2116f3a7bc647039a347d9c06f99ab6
166 rdf:rest Nec443b9b17274999b12c46442c0c1595
167 Nc96d1789592c44598f1bebb919209728 schema:affiliation https://www.grid.ac/institutes/grid.240341.0
168 schema:familyName Messier
169 schema:givenName Elise
170 rdf:type schema:Person
171 Nd316759e8b2545e88aeab7683c6ba0a4 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
172 schema:familyName Vlasenko
173 schema:givenName Liudmila
174 rdf:type schema:Person
175 Nd3d12a3f1c7e4e728127fb4c75347686 rdf:first Nf9c20f5411ec44789c87fd79a39e24f2
176 rdf:rest N588a819c695b4e648bda95d36c1ae54b
177 Ndb07e604606f4efba1f9483ae4d432c4 schema:name nlm_unique_id
178 schema:value 101563288
179 rdf:type schema:PropertyValue
180 Ndff0f3dac1d540e1bbeb4a9e06ee829b schema:volumeNumber 9
181 rdf:type schema:PublicationVolume
182 Ne5d7521788d9436d88db88ecfc6c41ba schema:affiliation https://www.grid.ac/institutes/grid.264727.2
183 schema:familyName Madesh
184 schema:givenName Muniswamy
185 rdf:type schema:Person
186 Ne77a71e1c6604118aca59b08dfe6813b rdf:first Nd316759e8b2545e88aeab7683c6ba0a4
187 rdf:rest Nd3d12a3f1c7e4e728127fb4c75347686
188 Neb08d9a8c9464677b1dd26677550ae3a schema:name doi
189 schema:value 10.1038/s41598-018-37000-z
190 rdf:type schema:PropertyValue
191 Nebe6c418b5da4a03a506afca690cdd37 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
192 schema:familyName Bahmed
193 schema:givenName Karim
194 rdf:type schema:Person
195 Nec443b9b17274999b12c46442c0c1595 rdf:first N655a3fc775d7408fbe3b3f0990b0ce14
196 rdf:rest N0d391ef4581a4364948588464311590d
197 Nefe8bfbb79e6455ca35b38bcda0895ee rdf:first N49f40958d0a242ac8b49bd8ca242ca1a
198 rdf:rest Nc42358e396d243b6b3cebfc65d3e896e
199 Nf9c20f5411ec44789c87fd79a39e24f2 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
200 schema:familyName Marchetti
201 schema:givenName Nathaniel
202 rdf:type schema:Person
203 Nfb716d63178c45feafcede49f50c3b58 rdf:first Ne5d7521788d9436d88db88ecfc6c41ba
204 rdf:rest N777bc2d4998043fa886983896f1a2d12
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biochemistry and Cell Biology
210 rdf:type schema:DefinedTerm
211 sg:grant.3807031 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-37000-z
212 rdf:type schema:MonetaryGrant
213 sg:journal.1045337 schema:issn 2045-2322
214 schema:name Scientific Reports
215 rdf:type schema:Periodical
216 sg:pub.10.1007/978-1-4419-0296-2_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017755535
217 https://doi.org/10.1007/978-1-4419-0296-2_4
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/978-1-4939-8570-8_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105422497
220 https://doi.org/10.1007/978-1-4939-8570-8_7
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s11033-014-3403-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031560322
223 https://doi.org/10.1007/s11033-014-3403-3
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/cddis.2013.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003061837
226 https://doi.org/10.1038/cddis.2013.96
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature12930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001577212
229 https://doi.org/10.1038/nature12930
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nsmb1338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033071584
232 https://doi.org/10.1038/nsmb1338
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/s41598-018-21790-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101113735
235 https://doi.org/10.1038/s41598-018-21790-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/sj.cdd.4400918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018989351
238 https://doi.org/10.1038/sj.cdd.4400918
239 rdf:type schema:CreativeWork
240 sg:pub.10.1186/1465-9921-13-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039154505
241 https://doi.org/10.1186/1465-9921-13-43
242 rdf:type schema:CreativeWork
243 sg:pub.10.1186/gm367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040053405
244 https://doi.org/10.1186/gm367
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1077625250 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1078780643 schema:CreativeWork
248 https://doi.org/10.1002/cyto.a.20426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048665337
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0092-8674(93)90499-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836400
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.biocel.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017378194
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.canlet.2005.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033294736
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.dnarep.2006.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026201497
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.dnarep.2008.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019089230
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.iac.2009.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045231992
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.molcel.2012.05.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000194773
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.molcel.2016.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040676987
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.redox.2013.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028603209
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0065-2776(08)00602-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013678176
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(03)00567-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043198083
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1042/bj20101695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041857222
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1042/cs20160487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090391073
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.122228699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048193879
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.93.25.14440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015989129
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1074/jbc.m110.138099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053297083
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.m111.250357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038606694
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1074/jbc.m806902200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039276889
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/carcin/23.5.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013536789
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1111/j.0105-2896.2004.00162.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005485408
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1111/j.1749-6632.2010.05600.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003379241
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.1069398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017161096
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/thx.2006.062802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010383804
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1146/annurev.biochem.73.011303.073723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026178756
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1146/annurev.physiol.010908.163257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022813465
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1152/ajpcell.00462.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005635627
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1152/ajplung.00298.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009665903
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1164/ajrccm.154.1.8680679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015496178
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1164/rccm.201605-0904oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1084237068
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1165/rcmb.2012-0295oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1002134997
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1165/rcmb.2015-0171oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1011943977
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1165/rcmb.2015-0304oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1048162039
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1172/jci60324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000835529
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1172/jci68782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040259078
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1183/09031936.00050211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049345125
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1183/09031936.00133805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050254635
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1183/09031936.00144208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038253514
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1242/dmm.019117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015828914
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1289/ehp.98106s1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064747122
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1371/journal.pgen.1000110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037227223
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.pone.0007380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025134238
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1371/journal.pone.0026059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051123907
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1371/journal.pone.0051697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023904333
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1378/chest.06-1040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005971584
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1378/chest.07-1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025714209
341 rdf:type schema:CreativeWork
342 https://doi.org/10.2174/156800906776842957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069190742
343 rdf:type schema:CreativeWork
344 https://doi.org/10.3109/15412550903499522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026683853
345 rdf:type schema:CreativeWork
346 https://doi.org/10.3109/15412555.2010.541306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032326957
347 rdf:type schema:CreativeWork
348 https://doi.org/10.3389/fgene.2015.00157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029506180
349 rdf:type schema:CreativeWork
350 https://doi.org/10.4061/2010/920161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002348403
351 rdf:type schema:CreativeWork
352 https://doi.org/10.4161/oxim.2.1.7985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000079568
353 rdf:type schema:CreativeWork
354 https://www.grid.ac/institutes/grid.240341.0 schema:alternateName National Jewish Health
355 schema:name National Jewish Health, 80206, Denver, CO, USA
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.264727.2 schema:alternateName Temple University
358 schema:name Center for Inflammation, Translational and Clinical Lung Research, Temple University, 19140, Philadelphia, PA, USA
359 Department of Physiology, Temple University, 19140, Philadelphia, PA, USA
360 Department of Thoracic Medicine and Surgery, Temple University, 19140, Philadelphia, PA, USA
361 Medical Genetics and Molecular Biochemistry, Temple University, 19140, Philadelphia, PA, USA
362 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...