Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSNikolaos Papachristou, Payam Barnaghi, Bruce Cooper, Kord M. Kober, Roma Maguire, Steven M. Paul, Marilyn Hammer, Fay Wright, Jo Armes, Eileen P. Furlong, Lisa McCann, Yvette P. Conley, Elisabeth Patiraki, Stylianos Katsaragakis, Jon D. Levine, Christine Miaskowski
ABSTRACTOncology patients undergoing cancer treatment experience an average of fifteen unrelieved symptoms that are highly variable in both their severity and distress. Recent advances in Network Analysis (NA) provide a novel approach to gain insights into the complex nature of co-occurring symptoms and symptom clusters and identify core symptoms. We present findings from the first study that used NA to examine the relationships among 38 common symptoms in a large sample of oncology patients undergoing chemotherapy. Using two different models of Pairwise Markov Random Fields (PMRF), we examined the nature and structure of interactions for three different dimensions of patients' symptom experience (i.e., occurrence, severity, distress). Findings from this study provide the first direct evidence that the connections between and among symptoms differ depending on the symptom dimension used to create the network. Based on an evaluation of the centrality indices, nausea appears to be a structurally important node in all three networks. Our findings can be used to guide the development of symptom management interventions based on the identification of core symptoms and symptom clusters within a network. More... »
PAGES2258
http://scigraph.springernature.com/pub.10.1038/s41598-018-36973-1
DOIhttp://dx.doi.org/10.1038/s41598-018-36973-1
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112225971
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30783135
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Download the RDF metadata as: json-ld nt turtle xml License info
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400 TRIPLES
21 PREDICATES
96 URIs
21 LITERALS
9 BLANK NODES