In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Salvatore Smirni, Alison D. McNeilly, Michael P. MacDonald, Rory J. McCrimmon, Faisel Khan

ABSTRACT

Arterioles in the cutaneous microcirculation frequently display an oscillatory phenomenon defined vasomotion, consistent with periodic diameter variations in the micro-vessels associated with particular physiological or abnormal conditions. The cellular mechanisms underlying vasomotion and its physiological role have not been completely elucidated. Various mechanisms were demonstrated, based on cell Ca2+ oscillations determined by the activity of channels in the plasma membrane or sarcoplasmic reticulum of vascular cells. However, the possible engagement in vasomotion of cell metabolic oscillations of mitochondrial or glycolytic origin has been poorly explored. Metabolic oscillations associated with the production of ATP energy were previously described in cells, while limited studies have investigated these fluctuations in-vivo. Here, we characterised a low-frequency metabolic oscillator (MO-1) in skin from live wild-type and Nrf2-/- mice, by combination of fluorescence spectroscopy and wavelet transform processing technique. Furthermore, the relationships between metabolic and microvascular oscillators were examined during phenylephrine-induced vasoconstriction. We found a significant interaction between MO-1 and the endothelial EDHF vasomotor mechanism that was reduced in the presence of oxidative stress (Nrf2-/- mice). Our findings suggest indirectly that metabolic oscillations may be involved in the mechanisms underlying endothelium-mediated skin vasomotion, which might be altered in the presence of metabolic disturbance. More... »

PAGES

186

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

9

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-36970-4

    DOI

    http://dx.doi.org/10.1038/s41598-018-36970-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111390325

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30655574


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Dundee", 
              "id": "https://www.grid.ac/institutes/grid.8241.f", 
              "name": [
                "University of Dundee, School of Medicine, Dundee, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smirni", 
            "givenName": "Salvatore", 
            "id": "sg:person.01230034424.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230034424.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Dundee", 
              "id": "https://www.grid.ac/institutes/grid.8241.f", 
              "name": [
                "University of Dundee, School of Medicine, Dundee, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McNeilly", 
            "givenName": "Alison D.", 
            "id": "sg:person.01056212137.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056212137.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Dundee", 
              "id": "https://www.grid.ac/institutes/grid.8241.f", 
              "name": [
                "University of Dundee, School of Medicine, Dundee, Scotland, UK", 
                "University of Dundee, School of Science and Engineering, Dundee, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "MacDonald", 
            "givenName": "Michael P.", 
            "id": "sg:person.01343504563.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343504563.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Dundee", 
              "id": "https://www.grid.ac/institutes/grid.8241.f", 
              "name": [
                "University of Dundee, School of Medicine, Dundee, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCrimmon", 
            "givenName": "Rory J.", 
            "id": "sg:person.01252203221.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252203221.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Dundee", 
              "id": "https://www.grid.ac/institutes/grid.8241.f", 
              "name": [
                "University of Dundee, School of Medicine, Dundee, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khan", 
            "givenName": "Faisel", 
            "id": "sg:person.0641703461.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641703461.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.mvr.2006.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001019005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m302673200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001650895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2001.013698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001815092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mvr.2008.07.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003442332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hh0801.089603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004561175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2015.10.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005420163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200305000-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008265886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-200305000-00019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008265886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.giec.2009.02.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008470698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01084.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009384707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(01)76043-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009810883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2012.11.3809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010829156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2014.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010880695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dsp.2015.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010927037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mvr.2012.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012356526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehr304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012520966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4081/ejh.2014.2461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017005484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.bjp.0706084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018143511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neo.2015.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019515892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.115.305364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019822831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.115.305364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019822831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1529/biophysj.106.097154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020279185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2005.101766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020439528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023646360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:care.0000025126.63253.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026089208", 
              "https://doi.org/10.1023/b:care.0000025126.63253.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9780470942390.mo100159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026575979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/01.ane.0000281932.09660.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026657029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/01.ane.0000281932.09660.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026657029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0026-2862(03)00006-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031529977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0026-2862(03)00006-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031529977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/bmm.10.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032545281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-0527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032744435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep29584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033297851", 
              "https://doi.org/10.1038/srep29584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034375011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20070431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034375011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.508127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034900468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10669-005-4271-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036137250", 
              "https://doi.org/10.1007/s10669-005-4271-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10669-005-4271-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036137250", 
              "https://doi.org/10.1007/s10669-005-4271-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2006.11.068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039169511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0024-3205(02)02014-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039508366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep12825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040712536", 
              "https://doi.org/10.1038/srep12825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcm.2008.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044616440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2005.04582.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044753421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1748-1716.2011.02320.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044807026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00249.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047138142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1748-1716.2010.02198.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049314109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jproc.2015.2491262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051643869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceca.2007.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051912149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep25086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052110054", 
              "https://doi.org/10.1038/srep25086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2009.02.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052750397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0967-3334/35/4/607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059124186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/pdb.prot5563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060411389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.01035.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063194832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1364/oe.18.007857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065193171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1364/oe.18.007857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065193171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1615/critrevbiomedeng.v39.i5.50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068130819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2017.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084904941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2017.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084904941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-21038-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100951756", 
              "https://doi.org/10.1038/s41598-018-21038-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1117/12.2289814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101025170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1117/1.jbo.23.7.076006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105454292"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Arterioles in the cutaneous microcirculation frequently display an oscillatory phenomenon defined vasomotion, consistent with periodic diameter variations in the micro-vessels associated with particular physiological or abnormal conditions. The cellular mechanisms underlying vasomotion and its physiological role have not been completely elucidated. Various mechanisms were demonstrated, based on cell Ca2+ oscillations determined by the activity of channels in the plasma membrane or sarcoplasmic reticulum of vascular cells. However, the possible engagement in vasomotion of cell metabolic oscillations of mitochondrial or glycolytic origin has been poorly explored. Metabolic oscillations associated with the production of ATP energy were previously described in cells, while limited studies have investigated these fluctuations in-vivo. Here, we characterised a low-frequency metabolic oscillator (MO-1) in skin from live wild-type and Nrf2-/- mice, by combination of fluorescence spectroscopy and wavelet transform processing technique. Furthermore, the relationships between metabolic and microvascular oscillators were examined during phenylephrine-induced vasoconstriction. We found a significant interaction between MO-1 and the endothelial EDHF vasomotor mechanism that was reduced in the presence of oxidative stress (Nrf2-/- mice). Our findings suggest indirectly that metabolic oscillations may be involved in the mechanisms underlying endothelium-mediated skin vasomotion, which might be altered in the presence of metabolic disturbance.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-36970-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3794006", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress", 
        "pagination": "186", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ee36cfae2bbe78af92a2fa0e37535be6ee438273ffcf1de278955ffa9ea63cce"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30655574"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-36970-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111390325"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-36970-4", 
          "https://app.dimensions.ai/details/publication/pub.1111390325"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000322_0000000322/records_65014_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-36970-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36970-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36970-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36970-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36970-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    264 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-36970-4 schema:about anzsrc-for:11
    2 anzsrc-for:1116
    3 schema:author N1b1f12a43d9a4043a32a0dc80ba4c66f
    4 schema:citation sg:pub.10.1007/s10669-005-4271-0
    5 sg:pub.10.1023/b:care.0000025126.63253.43
    6 sg:pub.10.1038/s41598-018-21038-0
    7 sg:pub.10.1038/srep12825
    8 sg:pub.10.1038/srep25086
    9 sg:pub.10.1038/srep29584
    10 https://doi.org/10.1002/9780470942390.mo100159
    11 https://doi.org/10.1016/j.bpj.2009.02.026
    12 https://doi.org/10.1016/j.bpj.2012.11.3809
    13 https://doi.org/10.1016/j.ceca.2007.01.007
    14 https://doi.org/10.1016/j.celrep.2014.09.022
    15 https://doi.org/10.1016/j.dsp.2015.03.004
    16 https://doi.org/10.1016/j.febslet.2006.11.068
    17 https://doi.org/10.1016/j.freeradbiomed.2015.10.409
    18 https://doi.org/10.1016/j.giec.2009.02.008
    19 https://doi.org/10.1016/j.mvr.2006.05.006
    20 https://doi.org/10.1016/j.mvr.2008.07.006
    21 https://doi.org/10.1016/j.mvr.2012.10.008
    22 https://doi.org/10.1016/j.neo.2015.11.006
    23 https://doi.org/10.1016/j.tcm.2008.02.001
    24 https://doi.org/10.1016/j.tibs.2014.02.002
    25 https://doi.org/10.1016/j.ymeth.2017.04.013
    26 https://doi.org/10.1016/s0006-3495(01)76043-2
    27 https://doi.org/10.1016/s0024-3205(02)02014-3
    28 https://doi.org/10.1016/s0026-2862(03)00006-2
    29 https://doi.org/10.1038/sj.bjp.0706084
    30 https://doi.org/10.1042/cs20070431
    31 https://doi.org/10.1074/jbc.m113.508127
    32 https://doi.org/10.1074/jbc.m302673200
    33 https://doi.org/10.1088/0967-3334/35/4/607
    34 https://doi.org/10.1093/eurheartj/ehr304
    35 https://doi.org/10.1097/00000542-200305000-00019
    36 https://doi.org/10.1101/pdb.prot5563
    37 https://doi.org/10.1109/jproc.2015.2491262
    38 https://doi.org/10.1111/j.1742-4658.2005.04582.x
    39 https://doi.org/10.1111/j.1748-1716.2010.02198.x
    40 https://doi.org/10.1111/j.1748-1716.2011.02320.x
    41 https://doi.org/10.1113/jphysiol.2001.013698
    42 https://doi.org/10.1113/jphysiol.2005.101766
    43 https://doi.org/10.1117/1.jbo.23.7.076006
    44 https://doi.org/10.1117/12.2289814
    45 https://doi.org/10.1152/ajpcell.00249.2006
    46 https://doi.org/10.1152/ajpheart.01035.2001
    47 https://doi.org/10.1152/ajpheart.01084.2003
    48 https://doi.org/10.1158/0008-5472.can-13-0527
    49 https://doi.org/10.1161/circresaha.115.305364
    50 https://doi.org/10.1161/hh0801.089603
    51 https://doi.org/10.1213/01.ane.0000281932.09660.96
    52 https://doi.org/10.1364/oe.18.007857
    53 https://doi.org/10.1529/biophysj.106.097154
    54 https://doi.org/10.1615/critrevbiomedeng.v39.i5.50
    55 https://doi.org/10.2217/bmm.10.1
    56 https://doi.org/10.4081/ejh.2014.2461
    57 schema:datePublished 2019-12
    58 schema:datePublishedReg 2019-12-01
    59 schema:description Arterioles in the cutaneous microcirculation frequently display an oscillatory phenomenon defined vasomotion, consistent with periodic diameter variations in the micro-vessels associated with particular physiological or abnormal conditions. The cellular mechanisms underlying vasomotion and its physiological role have not been completely elucidated. Various mechanisms were demonstrated, based on cell Ca<sup>2+</sup> oscillations determined by the activity of channels in the plasma membrane or sarcoplasmic reticulum of vascular cells. However, the possible engagement in vasomotion of cell metabolic oscillations of mitochondrial or glycolytic origin has been poorly explored. Metabolic oscillations associated with the production of ATP energy were previously described in cells, while limited studies have investigated these fluctuations in-vivo. Here, we characterised a low-frequency metabolic oscillator (MO-1) in skin from live wild-type and Nrf2<sup>-/-</sup> mice, by combination of fluorescence spectroscopy and wavelet transform processing technique. Furthermore, the relationships between metabolic and microvascular oscillators were examined during phenylephrine-induced vasoconstriction. We found a significant interaction between MO-1 and the endothelial EDHF vasomotor mechanism that was reduced in the presence of oxidative stress (Nrf2<sup>-/-</sup> mice). Our findings suggest indirectly that metabolic oscillations may be involved in the mechanisms underlying endothelium-mediated skin vasomotion, which might be altered in the presence of metabolic disturbance.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree true
    63 schema:isPartOf Nd8288dad0c4e48cf8d03839990c76d7e
    64 Ne62666d2e7c945c680dd1c507d57a093
    65 sg:journal.1045337
    66 schema:name In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress
    67 schema:pagination 186
    68 schema:productId N2d2f12b2d6094aefb0bd2bd66aae6648
    69 N6ff6a9b551c447238b5bb3632da3c481
    70 N90a441db463b420bb6cd8e7c4de07132
    71 Nd492b4d46d654c72aa353e23fed12461
    72 Ne133493b6d3f493fb2817705b2bf287d
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111390325
    74 https://doi.org/10.1038/s41598-018-36970-4
    75 schema:sdDatePublished 2019-04-11T08:43
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher N2176b369e7794018bd7d04a8e1b87764
    78 schema:url https://www.nature.com/articles/s41598-018-36970-4
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N1b1f12a43d9a4043a32a0dc80ba4c66f rdf:first sg:person.01230034424.69
    83 rdf:rest N5a7001fcf0ab40bea2a21ec65a29c4d9
    84 N2176b369e7794018bd7d04a8e1b87764 schema:name Springer Nature - SN SciGraph project
    85 rdf:type schema:Organization
    86 N2d2f12b2d6094aefb0bd2bd66aae6648 schema:name doi
    87 schema:value 10.1038/s41598-018-36970-4
    88 rdf:type schema:PropertyValue
    89 N3f464344c62a4818b573ee745087dc04 rdf:first sg:person.01252203221.14
    90 rdf:rest Nfd4aff24e590405ea9cad12c2f17fb64
    91 N5a7001fcf0ab40bea2a21ec65a29c4d9 rdf:first sg:person.01056212137.38
    92 rdf:rest Na1b79bcaf27e43ac9135809aec54567c
    93 N6ff6a9b551c447238b5bb3632da3c481 schema:name nlm_unique_id
    94 schema:value 101563288
    95 rdf:type schema:PropertyValue
    96 N90a441db463b420bb6cd8e7c4de07132 schema:name readcube_id
    97 schema:value ee36cfae2bbe78af92a2fa0e37535be6ee438273ffcf1de278955ffa9ea63cce
    98 rdf:type schema:PropertyValue
    99 Na1b79bcaf27e43ac9135809aec54567c rdf:first sg:person.01343504563.73
    100 rdf:rest N3f464344c62a4818b573ee745087dc04
    101 Nd492b4d46d654c72aa353e23fed12461 schema:name dimensions_id
    102 schema:value pub.1111390325
    103 rdf:type schema:PropertyValue
    104 Nd8288dad0c4e48cf8d03839990c76d7e schema:issueNumber 1
    105 rdf:type schema:PublicationIssue
    106 Ne133493b6d3f493fb2817705b2bf287d schema:name pubmed_id
    107 schema:value 30655574
    108 rdf:type schema:PropertyValue
    109 Ne62666d2e7c945c680dd1c507d57a093 schema:volumeNumber 9
    110 rdf:type schema:PublicationVolume
    111 Nfd4aff24e590405ea9cad12c2f17fb64 rdf:first sg:person.0641703461.30
    112 rdf:rest rdf:nil
    113 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    114 schema:name Medical and Health Sciences
    115 rdf:type schema:DefinedTerm
    116 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    117 schema:name Medical Physiology
    118 rdf:type schema:DefinedTerm
    119 sg:grant.3794006 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36970-4
    120 rdf:type schema:MonetaryGrant
    121 sg:journal.1045337 schema:issn 2045-2322
    122 schema:name Scientific Reports
    123 rdf:type schema:Periodical
    124 sg:person.01056212137.38 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
    125 schema:familyName McNeilly
    126 schema:givenName Alison D.
    127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056212137.38
    128 rdf:type schema:Person
    129 sg:person.01230034424.69 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
    130 schema:familyName Smirni
    131 schema:givenName Salvatore
    132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230034424.69
    133 rdf:type schema:Person
    134 sg:person.01252203221.14 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
    135 schema:familyName McCrimmon
    136 schema:givenName Rory J.
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252203221.14
    138 rdf:type schema:Person
    139 sg:person.01343504563.73 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
    140 schema:familyName MacDonald
    141 schema:givenName Michael P.
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343504563.73
    143 rdf:type schema:Person
    144 sg:person.0641703461.30 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
    145 schema:familyName Khan
    146 schema:givenName Faisel
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641703461.30
    148 rdf:type schema:Person
    149 sg:pub.10.1007/s10669-005-4271-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036137250
    150 https://doi.org/10.1007/s10669-005-4271-0
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1023/b:care.0000025126.63253.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026089208
    153 https://doi.org/10.1023/b:care.0000025126.63253.43
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1038/s41598-018-21038-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100951756
    156 https://doi.org/10.1038/s41598-018-21038-0
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1038/srep12825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040712536
    159 https://doi.org/10.1038/srep12825
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1038/srep25086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052110054
    162 https://doi.org/10.1038/srep25086
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1038/srep29584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033297851
    165 https://doi.org/10.1038/srep29584
    166 rdf:type schema:CreativeWork
    167 https://doi.org/10.1002/9780470942390.mo100159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026575979
    168 rdf:type schema:CreativeWork
    169 https://doi.org/10.1016/j.bpj.2009.02.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052750397
    170 rdf:type schema:CreativeWork
    171 https://doi.org/10.1016/j.bpj.2012.11.3809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010829156
    172 rdf:type schema:CreativeWork
    173 https://doi.org/10.1016/j.ceca.2007.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051912149
    174 rdf:type schema:CreativeWork
    175 https://doi.org/10.1016/j.celrep.2014.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023646360
    176 rdf:type schema:CreativeWork
    177 https://doi.org/10.1016/j.dsp.2015.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010927037
    178 rdf:type schema:CreativeWork
    179 https://doi.org/10.1016/j.febslet.2006.11.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039169511
    180 rdf:type schema:CreativeWork
    181 https://doi.org/10.1016/j.freeradbiomed.2015.10.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005420163
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/j.giec.2009.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008470698
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/j.mvr.2006.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001019005
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.mvr.2008.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003442332
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.mvr.2012.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012356526
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.neo.2015.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019515892
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.tcm.2008.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044616440
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/j.tibs.2014.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010880695
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/j.ymeth.2017.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084904941
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/s0006-3495(01)76043-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009810883
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s0024-3205(02)02014-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039508366
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/s0026-2862(03)00006-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031529977
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1038/sj.bjp.0706084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018143511
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1042/cs20070431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034375011
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1074/jbc.m113.508127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900468
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1074/jbc.m302673200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001650895
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1088/0967-3334/35/4/607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059124186
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1093/eurheartj/ehr304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012520966
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1097/00000542-200305000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008265886
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1101/pdb.prot5563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060411389
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1109/jproc.2015.2491262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051643869
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1111/j.1742-4658.2005.04582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044753421
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1111/j.1748-1716.2010.02198.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049314109
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1111/j.1748-1716.2011.02320.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044807026
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1113/jphysiol.2001.013698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001815092
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1113/jphysiol.2005.101766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020439528
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1117/1.jbo.23.7.076006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105454292
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1117/12.2289814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101025170
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1152/ajpcell.00249.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047138142
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1152/ajpheart.01035.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063194832
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1152/ajpheart.01084.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009384707
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1158/0008-5472.can-13-0527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032744435
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1161/circresaha.115.305364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019822831
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1161/hh0801.089603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004561175
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1213/01.ane.0000281932.09660.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026657029
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1364/oe.18.007857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065193171
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1529/biophysj.106.097154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020279185
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1615/critrevbiomedeng.v39.i5.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068130819
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.2217/bmm.10.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032545281
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.4081/ejh.2014.2461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017005484
    260 rdf:type schema:CreativeWork
    261 https://www.grid.ac/institutes/grid.8241.f schema:alternateName University of Dundee
    262 schema:name University of Dundee, School of Medicine, Dundee, Scotland, UK
    263 University of Dundee, School of Science and Engineering, Dundee, Scotland, UK
    264 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...