DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Alessandro Corti, Raina Sota, Matteo Dugo, Raffaele A. Calogero, Benedetta Terragni, Massimo Mantegazza, Silvana Franceschetti, Michela Restelli, Patrizia Gasparini, Daniele Lecis, Krystyna H. Chrzanowska, Domenico Delia

ABSTRACT

Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed on human iPSC-derived neurons whether the abnormal accumulation of DNA-Topoisomerase 1 adducts (Top1ccs) found in A-T impairs transcription elongation, thus favoring neurodegeneration. Furthermore, whether neuronal activity-induced immediate early genes (IEGs), a process involving the formation of DNA breaks, is affected by ATM deficiency. We found that Top1cc trapping by CPT induces an ATM-dependent DDR as well as an ATM-independent induction of IEGs and repression especially of long genes. As revealed by nascent RNA sequencing, transcriptional elongation and recovery were found to proceed with the same rate, irrespective of gene length and ATM status. Neuronal activity induced by glutamate receptors stimulation, or membrane depolarization with KCl, triggered a DDR and expression of IEGs, the latter independent of ATM. In unperturbed A-T neurons a set of genes (FN1, DCN, RASGRF1, FZD1, EOMES, SHH, NR2E1) implicated in the development, maintenance and physiology of central nervous system was specifically downregulated, underscoring their potential involvement in the neurodegenerative process in A-T patients. More... »

PAGES

651

References to SciGraph publications

  • 2015. Fractionation of Non-polyadenylated and Ribosomal-Free RNAs from Mammalian Cells in REGULATORY NON-CODING RNAS
  • 2013-01-16. Activity-dependent neuronal signalling and autism spectrum disorder in NATURE
  • 2004-06. Gene regulation and DNA damage in the ageing human brain in NATURE
  • 2013-05. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β in NATURE NEUROSCIENCE
  • 2015-10. ATM functions at the peroxisome to induce pexophagy in response to ROS in NATURE CELL BIOLOGY
  • 2016-12. Ataxia telangiectasia: a review in ORPHANET JOURNAL OF RARE DISEASES
  • 2016-11. Roles of eukaryotic topoisomerases in transcription, replication and genomic stability in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2016-01. Sonic hedgehog patterning during cerebellar development in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2014-06. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes in NATURE NEUROSCIENCE
  • 2016-07. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience in NATURE REVIEWS NEUROSCIENCE
  • 2016-03-31. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration in NATURE COMMUNICATIONS
  • 2013-09. Topoisomerases facilitate transcription of long genes linked to autism in NATURE
  • 2018-01. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex in NATURE NEUROSCIENCE
  • 2015-12. Comparison of GENCODE and RefSeq gene annotation and the impact of reference geneset on variant effect prediction in BMC GENOMICS
  • 2015-12. Transcriptional elongation requires DNA break-induced signalling in NATURE COMMUNICATIONS
  • 2014-07. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency in CELL DEATH & DISEASE
  • 2011-05. A more efficient method to generate integration-free human iPS cells in NATURE METHODS
  • 2012-03-01. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks in NATURE PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-36912-0

    DOI

    http://dx.doi.org/10.1038/s41598-018-36912-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111644205

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30679601


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Corti", 
            "givenName": "Alessandro", 
            "id": "sg:person.0750067412.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750067412.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sota", 
            "givenName": "Raina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dugo", 
            "givenName": "Matteo", 
            "id": "sg:person.01037047326.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037047326.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Turin", 
              "id": "https://www.grid.ac/institutes/grid.7605.4", 
              "name": [
                "Universita\u2019 degli Studi di Torino, Bioinformatics and Genomics Unit, Molecular Biotechnology Centre, Via Nizza 52, 10126, Torino, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Calogero", 
            "givenName": "Raffaele A.", 
            "id": "sg:person.01141035251.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141035251.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Neurologico Carlo Besta", 
              "id": "https://www.grid.ac/institutes/grid.417894.7", 
              "name": [
                "Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Neurophysiopathology and Diagnostic Epileptology, Via Celoria 11, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Terragni", 
            "givenName": "Benedetta", 
            "id": "sg:person.01263431626.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263431626.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 C\u00f4te d'Azur", 
              "id": "https://www.grid.ac/institutes/grid.460782.f", 
              "name": [
                "Institute of Molecular and Cellular Pharmacology (IPMC) LabEx ICST, CNRS UMR7275, Route des Lucioles, 06560, Valbonne, Sophia Antipolis, France", 
                "University C\u00f4te d\u2019Azur, 660 Route des Lucioles, 06560, Valbonne, Sophia Antipolis, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mantegazza", 
            "givenName": "Massimo", 
            "id": "sg:person.01115066213.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115066213.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Neurologico Carlo Besta", 
              "id": "https://www.grid.ac/institutes/grid.417894.7", 
              "name": [
                "Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Neurophysiopathology and Diagnostic Epileptology, Via Celoria 11, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franceschetti", 
            "givenName": "Silvana", 
            "id": "sg:person.01206770037.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206770037.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Restelli", 
            "givenName": "Michela", 
            "id": "sg:person.0632365535.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632365535.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via G Venezian 1, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gasparini", 
            "givenName": "Patrizia", 
            "id": "sg:person.01226200702.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226200702.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Nazionale dei Tumori", 
              "id": "https://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lecis", 
            "givenName": "Daniele", 
            "id": "sg:person.01131722273.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131722273.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Memorial Health Institute", 
              "id": "https://www.grid.ac/institutes/grid.413923.e", 
              "name": [
                "Department of Medical Genetics, The Children\u2019s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730, Warsaw, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chrzanowska", 
            "givenName": "Krystyna H.", 
            "id": "sg:person.01037035230.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037035230.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "FIRC Institute of Molecular Oncology", 
              "id": "https://www.grid.ac/institutes/grid.7678.e", 
              "name": [
                "Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy", 
                "IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milano, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delia", 
            "givenName": "Domenico", 
            "id": "sg:person.0775601411.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775601411.31"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.1406779111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001538804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001579376", 
              "https://doi.org/10.1038/nature02661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001579376", 
              "https://doi.org/10.1038/nature02661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2013.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003176185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.14709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003255039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005328414", 
              "https://doi.org/10.1038/nn.3715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn.2016.46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338479", 
              "https://doi.org/10.1038/nrn.2016.46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13023-016-0543-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008625221", 
              "https://doi.org/10.1186/s13023-016-0543-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13023-016-0543-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008625221", 
              "https://doi.org/10.1186/s13023-016-0543-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gpb.2016.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009337041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jnc.12487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009951991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2012.11.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012695617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1789.2011.01263.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012905384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015387114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2005.08.091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015668873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms11173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016935247", 
              "https://doi.org/10.1038/ncomms11173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aab1785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017106459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aab1785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017106459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm.2016.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020424125", 
              "https://doi.org/10.1038/nrm.2016.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2008.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023368175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci64145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026609086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.475408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028539446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2012.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030124536", 
              "https://doi.org/10.1038/nprot.2012.016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2014.310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030127830", 
              "https://doi.org/10.1038/cddis.2014.310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw1138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033346264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0058239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033834517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-1369-5_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036928062", 
              "https://doi.org/10.1007/978-1-4939-1369-5_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.02.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040538702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2013.00175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040704125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-015-2065-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043627381", 
              "https://doi.org/10.1007/s00018-015-2065-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043992225", 
              "https://doi.org/10.1038/ncb3230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.05.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045048759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045191511", 
              "https://doi.org/10.1038/nature12504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1004602107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046321730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1004602107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046321730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-16-s8-s2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047556219", 
              "https://doi.org/10.1186/1471-2164-16-s8-s2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047978239", 
              "https://doi.org/10.1038/nn.3356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048290884", 
              "https://doi.org/10.1038/nature11860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0156439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048369719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048806355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stemcr.2015.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049812564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0008962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049876811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050108156", 
              "https://doi.org/10.1038/nmeth.1591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050569693", 
              "https://doi.org/10.1038/ncomms10191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053365587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14806/ej.17.1.200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067372670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2015.3411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071526368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2015.3411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071526368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.19693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072289472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.24522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085460019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2016.0283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091437141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aao4426", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099620389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2017.11.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099683239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2017.11.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099683239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41593-017-0029-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099718517", 
              "https://doi.org/10.1038/s41593-017-0029-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1716892115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100076723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aan5598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100278476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aan5598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100278476"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed on human iPSC-derived neurons whether the abnormal accumulation of DNA-Topoisomerase 1 adducts (Top1ccs) found in A-T impairs transcription elongation, thus favoring neurodegeneration. Furthermore, whether neuronal activity-induced immediate early genes (IEGs), a process involving the formation of DNA breaks, is affected by ATM deficiency. We found that Top1cc trapping by CPT induces an ATM-dependent DDR as well as an ATM-independent induction of IEGs and repression especially of long genes. As revealed by nascent RNA sequencing, transcriptional elongation and recovery were found to proceed with the same rate, irrespective of gene length and ATM status. Neuronal activity induced by glutamate receptors stimulation, or membrane depolarization with KCl, triggered a DDR and expression of IEGs, the latter independent of ATM. In unperturbed A-T neurons a set of genes (FN1, DCN, RASGRF1, FZD1, EOMES, SHH, NR2E1) implicated in the development, maintenance and physiology of central nervous system was specifically downregulated, underscoring their potential involvement in the neurodegenerative process in A-T patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-36912-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5153434", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients", 
        "pagination": "651", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7aa10863ce8fe2a1492fc475dc35a7034992ed366c717ef3f3727f67bfd1e0d1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30679601"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-36912-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111644205"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-36912-0", 
          "https://app.dimensions.ai/details/publication/pub.1111644205"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68454_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-36912-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36912-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36912-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36912-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36912-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    337 TRIPLES      21 PREDICATES      80 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-36912-0 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N920d519be14e418b95904ed064eb52c5
    4 schema:citation sg:pub.10.1007/978-1-4939-1369-5_6
    5 sg:pub.10.1007/s00018-015-2065-1
    6 sg:pub.10.1038/cddis.2014.310
    7 sg:pub.10.1038/nature02661
    8 sg:pub.10.1038/nature11860
    9 sg:pub.10.1038/nature12504
    10 sg:pub.10.1038/ncb3230
    11 sg:pub.10.1038/ncomms10191
    12 sg:pub.10.1038/ncomms11173
    13 sg:pub.10.1038/nmeth.1591
    14 sg:pub.10.1038/nn.3356
    15 sg:pub.10.1038/nn.3715
    16 sg:pub.10.1038/nprot.2012.016
    17 sg:pub.10.1038/nrm.2016.111
    18 sg:pub.10.1038/nrn.2016.46
    19 sg:pub.10.1038/s41593-017-0029-5
    20 sg:pub.10.1186/1471-2164-16-s8-s2
    21 sg:pub.10.1186/s13023-016-0543-7
    22 https://doi.org/10.1002/dvdy.24522
    23 https://doi.org/10.1016/j.cell.2015.05.032
    24 https://doi.org/10.1016/j.cell.2016.02.036
    25 https://doi.org/10.1016/j.celrep.2016.12.018
    26 https://doi.org/10.1016/j.dnarep.2008.03.005
    27 https://doi.org/10.1016/j.dnarep.2013.04.013
    28 https://doi.org/10.1016/j.gpb.2016.04.003
    29 https://doi.org/10.1016/j.mcn.2017.11.009
    30 https://doi.org/10.1016/j.neurobiolaging.2012.11.024
    31 https://doi.org/10.1016/j.neuroscience.2005.08.091
    32 https://doi.org/10.1016/j.stemcr.2015.02.004
    33 https://doi.org/10.1073/pnas.1004602107
    34 https://doi.org/10.1073/pnas.1406779111
    35 https://doi.org/10.1073/pnas.1716892115
    36 https://doi.org/10.1093/bioinformatics/bts635
    37 https://doi.org/10.1093/nar/gkw1138
    38 https://doi.org/10.1098/rstb.2016.0283
    39 https://doi.org/10.1101/gad.475408
    40 https://doi.org/10.1111/j.1440-1789.2011.01263.x
    41 https://doi.org/10.1111/jnc.12487
    42 https://doi.org/10.1126/science.aab1785
    43 https://doi.org/10.1126/science.aao4426
    44 https://doi.org/10.1126/scisignal.aan5598
    45 https://doi.org/10.1158/1078-0432.ccr-03-0490
    46 https://doi.org/10.1172/jci64145
    47 https://doi.org/10.1371/journal.pone.0008962
    48 https://doi.org/10.1371/journal.pone.0058239
    49 https://doi.org/10.1371/journal.pone.0156439
    50 https://doi.org/10.14806/ej.17.1.200
    51 https://doi.org/10.3389/fncel.2013.00175
    52 https://doi.org/10.3892/ol.2015.3411
    53 https://doi.org/10.4161/auto.19693
    54 https://doi.org/10.7554/elife.14709
    55 schema:datePublished 2019-12
    56 schema:datePublishedReg 2019-12-01
    57 schema:description Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed on human iPSC-derived neurons whether the abnormal accumulation of DNA-Topoisomerase 1 adducts (Top1ccs) found in A-T impairs transcription elongation, thus favoring neurodegeneration. Furthermore, whether neuronal activity-induced immediate early genes (IEGs), a process involving the formation of DNA breaks, is affected by ATM deficiency. We found that Top1cc trapping by CPT induces an ATM-dependent DDR as well as an ATM-independent induction of IEGs and repression especially of long genes. As revealed by nascent RNA sequencing, transcriptional elongation and recovery were found to proceed with the same rate, irrespective of gene length and ATM status. Neuronal activity induced by glutamate receptors stimulation, or membrane depolarization with KCl, triggered a DDR and expression of IEGs, the latter independent of ATM. In unperturbed A-T neurons a set of genes (FN1, DCN, RASGRF1, FZD1, EOMES, SHH, NR2E1) implicated in the development, maintenance and physiology of central nervous system was specifically downregulated, underscoring their potential involvement in the neurodegenerative process in A-T patients.
    58 schema:genre research_article
    59 schema:inLanguage en
    60 schema:isAccessibleForFree true
    61 schema:isPartOf N303d8059edbf4df9bbba7c3d1ac36c08
    62 Ndbe54faae3794bbebcba4f5ce83bdeb6
    63 sg:journal.1045337
    64 schema:name DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients
    65 schema:pagination 651
    66 schema:productId N1d3aaea44f3546c8bceded4b0d48b721
    67 N346ebdcb510b450a83497107228e19ff
    68 N85bbd49185194cc99b513415ec35d4ca
    69 Nae7e5f78ad56414ea041a2cdae93c5c7
    70 Ndd53d21014944d289b12aa67e1e8c4ca
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111644205
    72 https://doi.org/10.1038/s41598-018-36912-0
    73 schema:sdDatePublished 2019-04-11T08:58
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher Na575678812664fd4824012b0070f3f8d
    76 schema:url https://www.nature.com/articles/s41598-018-36912-0
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N1547e68434dd49d6a8ea07604aa88248 rdf:first sg:person.01206770037.08
    81 rdf:rest N780996924e684947bb67807d1d738298
    82 N1ad59fc29414418e8fd77ef60bfa609d rdf:first sg:person.01263431626.86
    83 rdf:rest N45ef9f63cef6418c92caf4df605dc990
    84 N1d3aaea44f3546c8bceded4b0d48b721 schema:name pubmed_id
    85 schema:value 30679601
    86 rdf:type schema:PropertyValue
    87 N231f8898f90d4562b92ce5c030bc3148 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    88 schema:familyName Sota
    89 schema:givenName Raina
    90 rdf:type schema:Person
    91 N303d8059edbf4df9bbba7c3d1ac36c08 schema:issueNumber 1
    92 rdf:type schema:PublicationIssue
    93 N346ebdcb510b450a83497107228e19ff schema:name readcube_id
    94 schema:value 7aa10863ce8fe2a1492fc475dc35a7034992ed366c717ef3f3727f67bfd1e0d1
    95 rdf:type schema:PropertyValue
    96 N45ef9f63cef6418c92caf4df605dc990 rdf:first sg:person.01115066213.09
    97 rdf:rest N1547e68434dd49d6a8ea07604aa88248
    98 N5666f5f325c2408eb3d39efd0afbb155 rdf:first sg:person.01037047326.51
    99 rdf:rest Nd35d7095cbfc4ee1ac3783f07b780cdf
    100 N749c5102b90f47c6b893ab2d267a2de4 rdf:first sg:person.01037035230.75
    101 rdf:rest Na1573acd8cb24a2795a508cab5a4c54c
    102 N780996924e684947bb67807d1d738298 rdf:first sg:person.0632365535.12
    103 rdf:rest Ne62b4f4a64ee4598bf7a8a84f101c354
    104 N85bbd49185194cc99b513415ec35d4ca schema:name dimensions_id
    105 schema:value pub.1111644205
    106 rdf:type schema:PropertyValue
    107 N920d519be14e418b95904ed064eb52c5 rdf:first sg:person.0750067412.88
    108 rdf:rest Nfa0d50cd64d5443e8d1122d793b553e0
    109 Na1573acd8cb24a2795a508cab5a4c54c rdf:first sg:person.0775601411.31
    110 rdf:rest rdf:nil
    111 Na575678812664fd4824012b0070f3f8d schema:name Springer Nature - SN SciGraph project
    112 rdf:type schema:Organization
    113 Nae7e5f78ad56414ea041a2cdae93c5c7 schema:name doi
    114 schema:value 10.1038/s41598-018-36912-0
    115 rdf:type schema:PropertyValue
    116 Nd1336f566a8648c89780ceef74975383 rdf:first sg:person.01131722273.65
    117 rdf:rest N749c5102b90f47c6b893ab2d267a2de4
    118 Nd35d7095cbfc4ee1ac3783f07b780cdf rdf:first sg:person.01141035251.11
    119 rdf:rest N1ad59fc29414418e8fd77ef60bfa609d
    120 Ndbe54faae3794bbebcba4f5ce83bdeb6 schema:volumeNumber 9
    121 rdf:type schema:PublicationVolume
    122 Ndd53d21014944d289b12aa67e1e8c4ca schema:name nlm_unique_id
    123 schema:value 101563288
    124 rdf:type schema:PropertyValue
    125 Ne62b4f4a64ee4598bf7a8a84f101c354 rdf:first sg:person.01226200702.47
    126 rdf:rest Nd1336f566a8648c89780ceef74975383
    127 Nfa0d50cd64d5443e8d1122d793b553e0 rdf:first N231f8898f90d4562b92ce5c030bc3148
    128 rdf:rest N5666f5f325c2408eb3d39efd0afbb155
    129 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    130 schema:name Biological Sciences
    131 rdf:type schema:DefinedTerm
    132 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    133 schema:name Genetics
    134 rdf:type schema:DefinedTerm
    135 sg:grant.5153434 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36912-0
    136 rdf:type schema:MonetaryGrant
    137 sg:journal.1045337 schema:issn 2045-2322
    138 schema:name Scientific Reports
    139 rdf:type schema:Periodical
    140 sg:person.01037035230.75 schema:affiliation https://www.grid.ac/institutes/grid.413923.e
    141 schema:familyName Chrzanowska
    142 schema:givenName Krystyna H.
    143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037035230.75
    144 rdf:type schema:Person
    145 sg:person.01037047326.51 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    146 schema:familyName Dugo
    147 schema:givenName Matteo
    148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037047326.51
    149 rdf:type schema:Person
    150 sg:person.01115066213.09 schema:affiliation https://www.grid.ac/institutes/grid.460782.f
    151 schema:familyName Mantegazza
    152 schema:givenName Massimo
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115066213.09
    154 rdf:type schema:Person
    155 sg:person.01131722273.65 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    156 schema:familyName Lecis
    157 schema:givenName Daniele
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131722273.65
    159 rdf:type schema:Person
    160 sg:person.01141035251.11 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
    161 schema:familyName Calogero
    162 schema:givenName Raffaele A.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141035251.11
    164 rdf:type schema:Person
    165 sg:person.01206770037.08 schema:affiliation https://www.grid.ac/institutes/grid.417894.7
    166 schema:familyName Franceschetti
    167 schema:givenName Silvana
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206770037.08
    169 rdf:type schema:Person
    170 sg:person.01226200702.47 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    171 schema:familyName Gasparini
    172 schema:givenName Patrizia
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226200702.47
    174 rdf:type schema:Person
    175 sg:person.01263431626.86 schema:affiliation https://www.grid.ac/institutes/grid.417894.7
    176 schema:familyName Terragni
    177 schema:givenName Benedetta
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263431626.86
    179 rdf:type schema:Person
    180 sg:person.0632365535.12 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    181 schema:familyName Restelli
    182 schema:givenName Michela
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632365535.12
    184 rdf:type schema:Person
    185 sg:person.0750067412.88 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
    186 schema:familyName Corti
    187 schema:givenName Alessandro
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750067412.88
    189 rdf:type schema:Person
    190 sg:person.0775601411.31 schema:affiliation https://www.grid.ac/institutes/grid.7678.e
    191 schema:familyName Delia
    192 schema:givenName Domenico
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775601411.31
    194 rdf:type schema:Person
    195 sg:pub.10.1007/978-1-4939-1369-5_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036928062
    196 https://doi.org/10.1007/978-1-4939-1369-5_6
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/s00018-015-2065-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043627381
    199 https://doi.org/10.1007/s00018-015-2065-1
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/cddis.2014.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030127830
    202 https://doi.org/10.1038/cddis.2014.310
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nature02661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001579376
    205 https://doi.org/10.1038/nature02661
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nature11860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048290884
    208 https://doi.org/10.1038/nature11860
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature12504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045191511
    211 https://doi.org/10.1038/nature12504
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/ncb3230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043992225
    214 https://doi.org/10.1038/ncb3230
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/ncomms10191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050569693
    217 https://doi.org/10.1038/ncomms10191
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/ncomms11173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016935247
    220 https://doi.org/10.1038/ncomms11173
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nmeth.1591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050108156
    223 https://doi.org/10.1038/nmeth.1591
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nn.3356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047978239
    226 https://doi.org/10.1038/nn.3356
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nn.3715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005328414
    229 https://doi.org/10.1038/nn.3715
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nprot.2012.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030124536
    232 https://doi.org/10.1038/nprot.2012.016
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nrm.2016.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020424125
    235 https://doi.org/10.1038/nrm.2016.111
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nrn.2016.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008338479
    238 https://doi.org/10.1038/nrn.2016.46
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/s41593-017-0029-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099718517
    241 https://doi.org/10.1038/s41593-017-0029-5
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1186/1471-2164-16-s8-s2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047556219
    244 https://doi.org/10.1186/1471-2164-16-s8-s2
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1186/s13023-016-0543-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008625221
    247 https://doi.org/10.1186/s13023-016-0543-7
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/dvdy.24522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085460019
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.cell.2015.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045048759
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.cell.2016.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040538702
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.celrep.2016.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015387114
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.dnarep.2008.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023368175
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.dnarep.2013.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003176185
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.gpb.2016.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009337041
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.mcn.2017.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099683239
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.neurobiolaging.2012.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012695617
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.neuroscience.2005.08.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015668873
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.stemcr.2015.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049812564
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1073/pnas.1004602107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046321730
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1073/pnas.1406779111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001538804
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1073/pnas.1716892115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100076723
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1093/bioinformatics/bts635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365587
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1093/nar/gkw1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033346264
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1098/rstb.2016.0283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091437141
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1101/gad.475408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028539446
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1111/j.1440-1789.2011.01263.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012905384
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1111/jnc.12487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009951991
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1126/science.aab1785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017106459
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1126/science.aao4426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099620389
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1126/scisignal.aan5598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100278476
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1158/1078-0432.ccr-03-0490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048806355
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1172/jci64145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026609086
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1371/journal.pone.0008962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049876811
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1371/journal.pone.0058239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033834517
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1371/journal.pone.0156439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048369719
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.14806/ej.17.1.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067372670
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.3389/fncel.2013.00175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040704125
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.3892/ol.2015.3411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071526368
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.4161/auto.19693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289472
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.7554/elife.14709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003255039
    314 rdf:type schema:CreativeWork
    315 https://www.grid.ac/institutes/grid.413923.e schema:alternateName Children's Memorial Health Institute
    316 schema:name Department of Medical Genetics, The Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730, Warsaw, Poland
    317 rdf:type schema:Organization
    318 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
    319 schema:name Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, 20133, Milano, Italy
    320 Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy
    321 Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via G Venezian 1, 20133, Milano, Italy
    322 Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, 20133, Milano, Italy
    323 rdf:type schema:Organization
    324 https://www.grid.ac/institutes/grid.417894.7 schema:alternateName Istituto Neurologico Carlo Besta
    325 schema:name Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Neurophysiopathology and Diagnostic Epileptology, Via Celoria 11, 20133, Milano, Italy
    326 rdf:type schema:Organization
    327 https://www.grid.ac/institutes/grid.460782.f schema:alternateName Université Côte d'Azur
    328 schema:name Institute of Molecular and Cellular Pharmacology (IPMC) LabEx ICST, CNRS UMR7275, Route des Lucioles, 06560, Valbonne, Sophia Antipolis, France
    329 University Côte d’Azur, 660 Route des Lucioles, 06560, Valbonne, Sophia Antipolis, France
    330 rdf:type schema:Organization
    331 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
    332 schema:name Universita’ degli Studi di Torino, Bioinformatics and Genomics Unit, Molecular Biotechnology Centre, Via Nizza 52, 10126, Torino, Italy
    333 rdf:type schema:Organization
    334 https://www.grid.ac/institutes/grid.7678.e schema:alternateName FIRC Institute of Molecular Oncology
    335 schema:name Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Via Amadeo 42, 20133, Milano, Italy
    336 IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milano, Italy
    337 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...