Bacterial DNA translocation contributes to systemic inflammation and to minor changes in the clinical outcome of liver transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Gonzalo P. Rodríguez-Laiz, Pedro Zapater, Paola Melgar, Cándido Alcázar, Mariano Franco, Paula Giménez, Sonia Pascual, Pablo Bellot, José M. Palazón, María Rodríguez, Fernando Carnicer, Patricio Más-Serrano, José M. González-Navajas, Luís Gómez, José Such, Félix Lluís, Rubén Francés,

ABSTRACT

Bacterial (bact)DNA is an immunogenic product that frequently translocates into the blood in cirrhosis. We evaluated bactDNA clearance in patients undergoing liver transplantation (LT) and its association with inflammation and clinically relevant complications. We prospectively included patients consecutively admitted for LT in a one-year follow-up study. We evaluated bactDNA before and during the first month after LT, quantifying cytokine response at 30 days. One hundred patients were included. BactDNA was present in the blood of twenty-six patients undergoing LT. Twenty-four of these showed bactDNA in the portal vein, matching peripheral blood-identified bactDNA in 18 cases. Thirty-four patients showed bactDNA in blood during the first month after LT. Median TNF-α and IL-6 levels one month after LT were significantly increased in patients with versus without bactDNA. Serum TNF-α at baseline was an independent risk factor for bactDNA translocation during the first month after LT in the multivariate analysis (Odds ratio (OR) 1.14 [1.04 to 1.29], P = 0.015). One-year readmission was independently associated with the presence of bactDNA during the first month after LT (Hazard ratio (HR) 2.75 [1.39 to 5.45], P = 0.004). The presence of bactDNA in the blood of LT recipients was not shown to have any impact on complications such as death, graft rejection, bacterial or CMV infections. The rate of bactDNA translocation persists during the first month after LT and contributes to sustained inflammation. This is associated with an increased rate of readmissions in the one-year clinical outcome after LT. More... »

PAGES

835

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36904-0

DOI

http://dx.doi.org/10.1038/s41598-018-36904-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111760493

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30696924


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