Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Zongming Liu, Yanzhi Wang, Sheheryar Kabraji, Shaozhen Xie, Peichen Pan, Zhenning Liu, Jing Ni, Jean J. Zhao

ABSTRACT

Breast cancer brain metastasis (BCBM) remains a major clinical problem. Approximately 10-16% of patients with breast cancer develop brain metastases (BCBM). However, no systemic therapy has gained regulatory approval for the specific treatment of BCBM and this remains an area of persistent, unmet medical need. Rapid, predictive and clinically-relevant animal models are critical to study the biology of brain metastases and to identify effective therapeutic approaches for patients with BCBM. Here, we describe a method for efficient establishment of orthotopic mouse models of patient-derived brain metastases via an improved intracarotid injection protocol that permits tumor cell growth in the unique brain microenvironment without compromising the blood-brain barrier (BBB). We demonstrate that our newly improved models of patient-derived brain metastases recapitulate the histologic, molecular, and genetic characteristics of their matched patient tumor specimens and thus represent a potentially powerful tool for pre-clinical and translational research. More... »

PAGES

622

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36874-3

DOI

http://dx.doi.org/10.1038/s41598-018-36874-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111644275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30679540


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