The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ichrak Riahi-Chebbi, Soumaya Souid, Houcemeddine Othman, Meriam Haoues, Habib Karoui, Alain Morel, Najet Srairi-Abid, Makram Essafi, Khadija Essafi-Benkhadir

ABSTRACT

Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of drug resistance. For this purpose, we investigated the anti-tumoral effect of thirteen phenolic compounds, from the Tunisian quince Cydonia oblonga Miller, alone or combined to 5-FU, on the human 5-FU-resistant LS174-R colon cancer cells in comparison to parental cells. Our results showed that only Kaempferol was able to chemo-sensitize 5-FU-resistant LS174-R cells. This phenolic compound combined with 5-FU exerted synergistic inhibitory effect on cell viability. This combination enhanced the apoptosis and induced cell cycle arrest of both chemo-resistant and sensitive cells through impacting the expression levels of different cellular effectors. Kaempferol also blocked the production of reactive oxygen species (ROS) and modulated the expression of JAK/STAT3, MAPK, PI3K/AKT and NF-κB. In silico docking analysis suggested that the potent anti-tumoral effect of Kaempferol, compared to its two analogs (Kaempferol 3-O-glucoside and Kampferol 3-O-rutinoside), can be explained by the absence of glucosyl groups. Overall, our data propose Kaempferol as a potential chemotherapeutic agent to be used alone or in combination with 5-FU to overcome colon cancer drug resistance. More... »

PAGES

195

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36808-z

DOI

http://dx.doi.org/10.1038/s41598-018-36808-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111390322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30655588


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d\u2019Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale appliqu\u00e9es aux Maladies infectieuses, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riahi-Chebbi", 
        "givenName": "Ichrak", 
        "id": "sg:person.01340764137.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340764137.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d\u2019Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale appliqu\u00e9es aux Maladies infectieuses, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Souid", 
        "givenName": "Soumaya", 
        "id": "sg:person.013023753721.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013023753721.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT08/LR16IPT08 Laboratoire des Venins et Biomol\u00e9cules th\u00e9rapeutiques, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Othman", 
        "givenName": "Houcemeddine", 
        "id": "sg:person.01343430250.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343430250.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT02/ LR16IPT02 Laboratoire de Recherche sur la Transmission, le Contr\u00f4le et l\u2019Immunobiologie des Infections, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haoues", 
        "givenName": "Meriam", 
        "id": "sg:person.01043344650.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043344650.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d\u2019Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale appliqu\u00e9es aux Maladies infectieuses, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karoui", 
        "givenName": "Habib", 
        "id": "sg:person.0751744622.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751744622.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Angers", 
          "id": "https://www.grid.ac/institutes/grid.7252.2", 
          "name": [
            "CRCINA, INSERM U892, Universit\u00e9 de Nantes, Universit\u00e9 d\u2019Angers, Paul Papin ICO cancer center, Angers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morel", 
        "givenName": "Alain", 
        "id": "sg:person.01265325543.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265325543.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT08/LR16IPT08 Laboratoire des Venins et Biomol\u00e9cules th\u00e9rapeutiques, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Srairi-Abid", 
        "givenName": "Najet", 
        "id": "sg:person.01177017304.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177017304.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT02/ LR16IPT02 Laboratoire de Recherche sur la Transmission, le Contr\u00f4le et l\u2019Immunobiologie des Infections, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Essafi", 
        "givenName": "Makram", 
        "id": "sg:person.01261607005.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261607005.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunis El Manar University", 
          "id": "https://www.grid.ac/institutes/grid.12574.35", 
          "name": [
            "Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d\u2019Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale appliqu\u00e9es aux Maladies infectieuses, 1002, Tunis, Tunisia", 
            "Universit\u00e9 de Tunis El Manar, 1068, Tunis, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Essafi-Benkhadir", 
        "givenName": "Khadija", 
        "id": "sg:person.0763016605.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763016605.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m009493200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000210176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000491787", 
          "https://doi.org/10.1038/nrm3758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/11839088_22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000565374", 
          "https://doi.org/10.1007/11839088_22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/11839088_22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000565374", 
          "https://doi.org/10.1007/11839088_22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001313806", 
          "https://doi.org/10.1038/ncomms8972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers6031769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001854687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5487/tr.2015.31.2.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002808333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0115686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003398519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0115686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003398519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tpj.2014.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004911775", 
          "https://doi.org/10.1038/tpj.2014.45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu8090581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006572382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-2023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006899726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-1854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007323785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-14-0207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007523456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18010197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008475415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5114/wo.2014.44296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008896411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011667685", 
          "https://doi.org/10.1186/1471-2407-10-425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2012.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011991649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-015-4740-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013023176", 
          "https://doi.org/10.1007/s13277-015-4740-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12935-016-0276-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014965763", 
          "https://doi.org/10.1186/s12935-016-0276-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules13081551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015504674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules13081551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015504674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu8120762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017154079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017516403", 
          "https://doi.org/10.1038/cddis.2013.509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2016.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019099698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4172/2167-7700.1000137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023767774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023808517", 
          "https://doi.org/10.1038/nrm3567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2015.403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024340889", 
          "https://doi.org/10.1038/cddis.2015.403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5fo00120j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025282934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2011.4414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025659194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026725549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0076693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026976862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fon.10.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027496755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1560-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027499332", 
          "https://doi.org/10.1186/s12885-015-1560-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2012.11.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028619308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201000487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029145463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201000487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029145463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-14-599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030201273", 
          "https://doi.org/10.1186/1471-2407-14-599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01635581.2016.1192201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030500968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-015-2296-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031268148", 
          "https://doi.org/10.1007/s00384-015-2296-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules190913848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033968631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules190913848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033968631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034154336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2015.2324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034407846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.2015.2324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034407846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2015.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034755542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1093-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038695369", 
          "https://doi.org/10.1186/s12885-015-1093-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1093-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038695369", 
          "https://doi.org/10.1186/s12885-015-1093-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000452525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039441069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0366-6999.176069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039497983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2395-3977.184320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040631466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040649933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.100115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040967297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12935-015-0194-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041109242", 
          "https://doi.org/10.1186/s12935-015-0194-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12935-015-0194-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041109242", 
          "https://doi.org/10.1186/s12935-015-0194-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ott.s118272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041976895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044275351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044402199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045899264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/150845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046550962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0167491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049103008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0064961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049377354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1758-2946-2-s1-p43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051016264", 
          "https://doi.org/10.1186/1758-2946-2-s1-p43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cells5020016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051330189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep24675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051526170", 
          "https://doi.org/10.1038/srep24675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052152545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052731842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdd.677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052939895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdd.677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052939895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci800420z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055404643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci800420z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055404643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm049353p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055949016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm049353p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055949016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834015614530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834015614530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21873/anticanres.11147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069267190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/e86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070919277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v20.i29.9744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071371162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i41.11777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071373133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2016.3725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2015.4035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071526831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2015.4035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071526831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2016.4862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071527627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2016.5099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071527845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4062/biomolther.2016.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072177546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4251/wjgo.v8.i7.532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072402158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4331/wjbc.v5.i3.346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072525641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4331/wjbc.v5.i3.346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072525641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077627630", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/117955490800200101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078444406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/117955490800200101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078444406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078926541", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079256325", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.15303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083847067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neo.2017.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084098099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neo.2017.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084098099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18030656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084435948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317697553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084611713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317697553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084611713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317698368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085126175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1010428317698368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085126175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkx374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085320769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1090901633", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/jca.19079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091013890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-19384-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100351941", 
          "https://doi.org/10.1038/s41598-018-19384-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2018.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105851807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2018.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105851807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106916204"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of drug resistance. For this purpose, we investigated the anti-tumoral effect of thirteen phenolic compounds, from the Tunisian quince Cydonia oblonga Miller, alone or combined to 5-FU, on the human 5-FU-resistant LS174-R colon cancer cells in comparison to parental cells. Our results showed that only Kaempferol was able to chemo-sensitize 5-FU-resistant LS174-R cells. This phenolic compound combined with 5-FU exerted synergistic inhibitory effect on cell viability. This combination enhanced the apoptosis and induced cell cycle arrest of both chemo-resistant and sensitive cells through impacting the expression levels of different cellular effectors. Kaempferol also blocked the production of reactive oxygen species (ROS) and modulated the expression of JAK/STAT3, MAPK, PI3K/AKT and NF-\u03baB. In silico docking analysis suggested that the potent anti-tumoral effect of Kaempferol, compared to its two analogs (Kaempferol 3-O-glucoside and Kampferol 3-O-rutinoside), can be explained by the absence of glucosyl groups. Overall, our data propose Kaempferol as a potential chemotherapeutic agent to be used alone or in combination with 5-FU to overcome colon cancer drug resistance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36808-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells", 
    "pagination": "195", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "18fb46a823b89e5b421a91a63821b9036e380ca700f914a64906c3998f95561d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30655588"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36808-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111390322"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36808-z", 
      "https://app.dimensions.ai/details/publication/pub.1111390322"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000322_0000000322/records_65024_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36808-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36808-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36808-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36808-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36808-z'


 

This table displays all metadata directly associated to this object as RDF triples.

414 TRIPLES      21 PREDICATES      119 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36808-z schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc3ddb90845ab495ab6657f64c932c290
4 schema:citation sg:pub.10.1007/11839088_22
5 sg:pub.10.1007/s00384-015-2296-5
6 sg:pub.10.1007/s13277-015-4740-0
7 sg:pub.10.1038/cddis.2013.509
8 sg:pub.10.1038/cddis.2015.403
9 sg:pub.10.1038/ncomms8972
10 sg:pub.10.1038/nrm3567
11 sg:pub.10.1038/nrm3758
12 sg:pub.10.1038/s41598-018-19384-0
13 sg:pub.10.1038/srep24675
14 sg:pub.10.1038/tpj.2014.45
15 sg:pub.10.1186/1471-2407-10-425
16 sg:pub.10.1186/1471-2407-14-599
17 sg:pub.10.1186/1758-2946-2-s1-p43
18 sg:pub.10.1186/s12885-015-1093-4
19 sg:pub.10.1186/s12885-015-1560-y
20 sg:pub.10.1186/s12935-015-0194-0
21 sg:pub.10.1186/s12935-016-0276-7
22 https://app.dimensions.ai/details/publication/pub.1077627630
23 https://app.dimensions.ai/details/publication/pub.1078926541
24 https://app.dimensions.ai/details/publication/pub.1079256325
25 https://app.dimensions.ai/details/publication/pub.1090901633
26 https://doi.org/10.1002/bdd.677
27 https://doi.org/10.1002/cbic.201000487
28 https://doi.org/10.1002/ijc.10146
29 https://doi.org/10.1002/jcp.20350
30 https://doi.org/10.1006/meth.2001.1262
31 https://doi.org/10.1016/j.bbcan.2016.03.005
32 https://doi.org/10.1016/j.ccr.2011.10.001
33 https://doi.org/10.1016/j.cell.2012.04.026
34 https://doi.org/10.1016/j.cgh.2018.07.030
35 https://doi.org/10.1016/j.foodchem.2012.08.023
36 https://doi.org/10.1016/j.foodchem.2012.11.139
37 https://doi.org/10.1016/j.neo.2017.01.007
38 https://doi.org/10.1016/j.semcancer.2015.01.001
39 https://doi.org/10.1021/ci800420z
40 https://doi.org/10.1021/jm049353p
41 https://doi.org/10.1039/c5fo00120j
42 https://doi.org/10.1074/jbc.m009493200
43 https://doi.org/10.1080/01635581.2016.1192201
44 https://doi.org/10.1089/ars.2011.4414
45 https://doi.org/10.1093/nar/gkl999
46 https://doi.org/10.1093/nar/gks1147
47 https://doi.org/10.1093/nar/gku443
48 https://doi.org/10.1093/nar/gkx374
49 https://doi.org/10.1155/2014/150845
50 https://doi.org/10.1158/0008-5472.can-08-2023
51 https://doi.org/10.1158/1078-0432.ccr-13-1854
52 https://doi.org/10.1158/1535-7163.mct-06-0397
53 https://doi.org/10.1158/1535-7163.mct-14-0207
54 https://doi.org/10.1159/000452525
55 https://doi.org/10.1177/1010428317697553
56 https://doi.org/10.1177/1010428317698368
57 https://doi.org/10.1177/117955490800200101
58 https://doi.org/10.1177/1758834015614530
59 https://doi.org/10.1242/jcs.100115
60 https://doi.org/10.1371/journal.pone.0064961
61 https://doi.org/10.1371/journal.pone.0076693
62 https://doi.org/10.1371/journal.pone.0115686
63 https://doi.org/10.1371/journal.pone.0167491
64 https://doi.org/10.18632/oncotarget.15303
65 https://doi.org/10.2147/ott.s118272
66 https://doi.org/10.21873/anticanres.11147
67 https://doi.org/10.2217/fon.10.106
68 https://doi.org/10.2741/e86
69 https://doi.org/10.3322/caac.21492
70 https://doi.org/10.3390/cancers6031769
71 https://doi.org/10.3390/cells5020016
72 https://doi.org/10.3390/ijms18010197
73 https://doi.org/10.3390/ijms18030656
74 https://doi.org/10.3390/molecules13081551
75 https://doi.org/10.3390/molecules190913848
76 https://doi.org/10.3390/nu8090581
77 https://doi.org/10.3390/nu8120762
78 https://doi.org/10.3748/wjg.v20.i29.9744
79 https://doi.org/10.3748/wjg.v21.i41.11777
80 https://doi.org/10.3892/ijmm.2015.2324
81 https://doi.org/10.3892/ijo.2016.3725
82 https://doi.org/10.3892/ol.2015.4035
83 https://doi.org/10.3892/ol.2016.4862
84 https://doi.org/10.3892/ol.2016.5099
85 https://doi.org/10.4062/biomolther.2016.028
86 https://doi.org/10.4103/0366-6999.176069
87 https://doi.org/10.4103/2395-3977.184320
88 https://doi.org/10.4172/2167-7700.1000137
89 https://doi.org/10.4251/wjgo.v8.i7.532
90 https://doi.org/10.4331/wjbc.v5.i3.346
91 https://doi.org/10.5114/wo.2014.44296
92 https://doi.org/10.5487/tr.2015.31.2.151
93 https://doi.org/10.7150/jca.19079
94 schema:datePublished 2019-12
95 schema:datePublishedReg 2019-12-01
96 schema:description Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of drug resistance. For this purpose, we investigated the anti-tumoral effect of thirteen phenolic compounds, from the Tunisian quince Cydonia oblonga Miller, alone or combined to 5-FU, on the human 5-FU-resistant LS174-R colon cancer cells in comparison to parental cells. Our results showed that only Kaempferol was able to chemo-sensitize 5-FU-resistant LS174-R cells. This phenolic compound combined with 5-FU exerted synergistic inhibitory effect on cell viability. This combination enhanced the apoptosis and induced cell cycle arrest of both chemo-resistant and sensitive cells through impacting the expression levels of different cellular effectors. Kaempferol also blocked the production of reactive oxygen species (ROS) and modulated the expression of JAK/STAT3, MAPK, PI3K/AKT and NF-κB. In silico docking analysis suggested that the potent anti-tumoral effect of Kaempferol, compared to its two analogs (Kaempferol 3-O-glucoside and Kampferol 3-O-rutinoside), can be explained by the absence of glucosyl groups. Overall, our data propose Kaempferol as a potential chemotherapeutic agent to be used alone or in combination with 5-FU to overcome colon cancer drug resistance.
97 schema:genre research_article
98 schema:inLanguage en
99 schema:isAccessibleForFree true
100 schema:isPartOf N5eaab1e03e454419a1609d46dba2b0cb
101 Ne0e3ac1192c0435ba56c0331aeea7740
102 sg:journal.1045337
103 schema:name The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells
104 schema:pagination 195
105 schema:productId N03421c9454f14bfdb9fd3fc96dd38078
106 N13b1e95426604ed281824bd897bd4302
107 N5e476257dd0a48fcba003f50c82f61dc
108 Nf2e0c3e273fb41bd936c0e19b9b05eb7
109 Nfbe7bddae0a241bea6dda5ffa8211a3c
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111390322
111 https://doi.org/10.1038/s41598-018-36808-z
112 schema:sdDatePublished 2019-04-11T08:43
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N7e00a827b7874491b6e32ae7178413ba
115 schema:url https://www.nature.com/articles/s41598-018-36808-z
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N03421c9454f14bfdb9fd3fc96dd38078 schema:name readcube_id
120 schema:value 18fb46a823b89e5b421a91a63821b9036e380ca700f914a64906c3998f95561d
121 rdf:type schema:PropertyValue
122 N12accf3491304a1fa96a04ee06a5c2ae rdf:first sg:person.0763016605.50
123 rdf:rest rdf:nil
124 N13b1e95426604ed281824bd897bd4302 schema:name nlm_unique_id
125 schema:value 101563288
126 rdf:type schema:PropertyValue
127 N17b699ac5c2e4c37af60671f197efbdf rdf:first sg:person.0751744622.55
128 rdf:rest N404a71f23aef440a887896d773c8e496
129 N404a71f23aef440a887896d773c8e496 rdf:first sg:person.01265325543.03
130 rdf:rest Ndd3e0ce5bbf446079af3f5fea6082761
131 N5e476257dd0a48fcba003f50c82f61dc schema:name doi
132 schema:value 10.1038/s41598-018-36808-z
133 rdf:type schema:PropertyValue
134 N5eaab1e03e454419a1609d46dba2b0cb schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 N71fa41a1b8a1482582664550fbcf0921 rdf:first sg:person.01261607005.38
137 rdf:rest N12accf3491304a1fa96a04ee06a5c2ae
138 N7ac721a27c224816886e74cd8fae408c rdf:first sg:person.013023753721.59
139 rdf:rest Nb7db62e136b24a2aa254db4d8866a66a
140 N7e00a827b7874491b6e32ae7178413ba schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nb7db62e136b24a2aa254db4d8866a66a rdf:first sg:person.01343430250.32
143 rdf:rest Nf372c31f496343998a5397db286f358e
144 Nc3ddb90845ab495ab6657f64c932c290 rdf:first sg:person.01340764137.02
145 rdf:rest N7ac721a27c224816886e74cd8fae408c
146 Ndd3e0ce5bbf446079af3f5fea6082761 rdf:first sg:person.01177017304.42
147 rdf:rest N71fa41a1b8a1482582664550fbcf0921
148 Ne0e3ac1192c0435ba56c0331aeea7740 schema:volumeNumber 9
149 rdf:type schema:PublicationVolume
150 Nf2e0c3e273fb41bd936c0e19b9b05eb7 schema:name dimensions_id
151 schema:value pub.1111390322
152 rdf:type schema:PropertyValue
153 Nf372c31f496343998a5397db286f358e rdf:first sg:person.01043344650.09
154 rdf:rest N17b699ac5c2e4c37af60671f197efbdf
155 Nfbe7bddae0a241bea6dda5ffa8211a3c schema:name pubmed_id
156 schema:value 30655588
157 rdf:type schema:PropertyValue
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
162 schema:name Oncology and Carcinogenesis
163 rdf:type schema:DefinedTerm
164 sg:journal.1045337 schema:issn 2045-2322
165 schema:name Scientific Reports
166 rdf:type schema:Periodical
167 sg:person.01043344650.09 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
168 schema:familyName Haoues
169 schema:givenName Meriam
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043344650.09
171 rdf:type schema:Person
172 sg:person.01177017304.42 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
173 schema:familyName Srairi-Abid
174 schema:givenName Najet
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177017304.42
176 rdf:type schema:Person
177 sg:person.01261607005.38 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
178 schema:familyName Essafi
179 schema:givenName Makram
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261607005.38
181 rdf:type schema:Person
182 sg:person.01265325543.03 schema:affiliation https://www.grid.ac/institutes/grid.7252.2
183 schema:familyName Morel
184 schema:givenName Alain
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265325543.03
186 rdf:type schema:Person
187 sg:person.013023753721.59 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
188 schema:familyName Souid
189 schema:givenName Soumaya
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013023753721.59
191 rdf:type schema:Person
192 sg:person.01340764137.02 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
193 schema:familyName Riahi-Chebbi
194 schema:givenName Ichrak
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340764137.02
196 rdf:type schema:Person
197 sg:person.01343430250.32 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
198 schema:familyName Othman
199 schema:givenName Houcemeddine
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343430250.32
201 rdf:type schema:Person
202 sg:person.0751744622.55 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
203 schema:familyName Karoui
204 schema:givenName Habib
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751744622.55
206 rdf:type schema:Person
207 sg:person.0763016605.50 schema:affiliation https://www.grid.ac/institutes/grid.12574.35
208 schema:familyName Essafi-Benkhadir
209 schema:givenName Khadija
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763016605.50
211 rdf:type schema:Person
212 sg:pub.10.1007/11839088_22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000565374
213 https://doi.org/10.1007/11839088_22
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s00384-015-2296-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031268148
216 https://doi.org/10.1007/s00384-015-2296-5
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s13277-015-4740-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013023176
219 https://doi.org/10.1007/s13277-015-4740-0
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/cddis.2013.509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017516403
222 https://doi.org/10.1038/cddis.2013.509
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/cddis.2015.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024340889
225 https://doi.org/10.1038/cddis.2015.403
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ncomms8972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001313806
228 https://doi.org/10.1038/ncomms8972
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nrm3567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023808517
231 https://doi.org/10.1038/nrm3567
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/nrm3758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000491787
234 https://doi.org/10.1038/nrm3758
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/s41598-018-19384-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100351941
237 https://doi.org/10.1038/s41598-018-19384-0
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/srep24675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051526170
240 https://doi.org/10.1038/srep24675
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/tpj.2014.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004911775
243 https://doi.org/10.1038/tpj.2014.45
244 rdf:type schema:CreativeWork
245 sg:pub.10.1186/1471-2407-10-425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011667685
246 https://doi.org/10.1186/1471-2407-10-425
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/1471-2407-14-599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030201273
249 https://doi.org/10.1186/1471-2407-14-599
250 rdf:type schema:CreativeWork
251 sg:pub.10.1186/1758-2946-2-s1-p43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051016264
252 https://doi.org/10.1186/1758-2946-2-s1-p43
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/s12885-015-1093-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038695369
255 https://doi.org/10.1186/s12885-015-1093-4
256 rdf:type schema:CreativeWork
257 sg:pub.10.1186/s12885-015-1560-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027499332
258 https://doi.org/10.1186/s12885-015-1560-y
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/s12935-015-0194-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041109242
261 https://doi.org/10.1186/s12935-015-0194-0
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/s12935-016-0276-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014965763
264 https://doi.org/10.1186/s12935-016-0276-7
265 rdf:type schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1077627630 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1078926541 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1079256325 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1090901633 schema:CreativeWork
270 https://doi.org/10.1002/bdd.677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052939895
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/cbic.201000487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029145463
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/ijc.10146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026725549
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/jcp.20350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052731842
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.bbcan.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019099698
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ccr.2011.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052152545
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.cell.2012.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034154336
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.cgh.2018.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105851807
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.foodchem.2012.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011991649
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.foodchem.2012.11.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028619308
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.neo.2017.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084098099
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.semcancer.2015.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034755542
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1021/ci800420z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055404643
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1021/jm049353p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949016
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1039/c5fo00120j schema:sameAs https://app.dimensions.ai/details/publication/pub.1025282934
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m009493200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000210176
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1080/01635581.2016.1192201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030500968
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1089/ars.2011.4414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025659194
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/nar/gkl999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045899264
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/nar/gks1147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044402199
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/nar/gku443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044275351
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/nar/gkx374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085320769
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1155/2014/150845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046550962
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/0008-5472.can-08-2023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006899726
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1158/1078-0432.ccr-13-1854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007323785
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1158/1535-7163.mct-06-0397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040649933
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1158/1535-7163.mct-14-0207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007523456
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1159/000452525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039441069
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1177/1010428317697553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084611713
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1177/1010428317698368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085126175
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1177/117955490800200101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078444406
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1177/1758834015614530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064077370
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1242/jcs.100115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040967297
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1371/journal.pone.0064961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049377354
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1371/journal.pone.0076693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026976862
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1371/journal.pone.0115686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003398519
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1371/journal.pone.0167491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049103008
345 rdf:type schema:CreativeWork
346 https://doi.org/10.18632/oncotarget.15303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083847067
347 rdf:type schema:CreativeWork
348 https://doi.org/10.2147/ott.s118272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041976895
349 rdf:type schema:CreativeWork
350 https://doi.org/10.21873/anticanres.11147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069267190
351 rdf:type schema:CreativeWork
352 https://doi.org/10.2217/fon.10.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027496755
353 rdf:type schema:CreativeWork
354 https://doi.org/10.2741/e86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070919277
355 rdf:type schema:CreativeWork
356 https://doi.org/10.3322/caac.21492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106916204
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3390/cancers6031769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001854687
359 rdf:type schema:CreativeWork
360 https://doi.org/10.3390/cells5020016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051330189
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3390/ijms18010197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008475415
363 rdf:type schema:CreativeWork
364 https://doi.org/10.3390/ijms18030656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084435948
365 rdf:type schema:CreativeWork
366 https://doi.org/10.3390/molecules13081551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015504674
367 rdf:type schema:CreativeWork
368 https://doi.org/10.3390/molecules190913848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033968631
369 rdf:type schema:CreativeWork
370 https://doi.org/10.3390/nu8090581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006572382
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3390/nu8120762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017154079
373 rdf:type schema:CreativeWork
374 https://doi.org/10.3748/wjg.v20.i29.9744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371162
375 rdf:type schema:CreativeWork
376 https://doi.org/10.3748/wjg.v21.i41.11777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071373133
377 rdf:type schema:CreativeWork
378 https://doi.org/10.3892/ijmm.2015.2324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034407846
379 rdf:type schema:CreativeWork
380 https://doi.org/10.3892/ijo.2016.3725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514560
381 rdf:type schema:CreativeWork
382 https://doi.org/10.3892/ol.2015.4035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071526831
383 rdf:type schema:CreativeWork
384 https://doi.org/10.3892/ol.2016.4862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071527627
385 rdf:type schema:CreativeWork
386 https://doi.org/10.3892/ol.2016.5099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071527845
387 rdf:type schema:CreativeWork
388 https://doi.org/10.4062/biomolther.2016.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072177546
389 rdf:type schema:CreativeWork
390 https://doi.org/10.4103/0366-6999.176069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039497983
391 rdf:type schema:CreativeWork
392 https://doi.org/10.4103/2395-3977.184320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040631466
393 rdf:type schema:CreativeWork
394 https://doi.org/10.4172/2167-7700.1000137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023767774
395 rdf:type schema:CreativeWork
396 https://doi.org/10.4251/wjgo.v8.i7.532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072402158
397 rdf:type schema:CreativeWork
398 https://doi.org/10.4331/wjbc.v5.i3.346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072525641
399 rdf:type schema:CreativeWork
400 https://doi.org/10.5114/wo.2014.44296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008896411
401 rdf:type schema:CreativeWork
402 https://doi.org/10.5487/tr.2015.31.2.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002808333
403 rdf:type schema:CreativeWork
404 https://doi.org/10.7150/jca.19079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091013890
405 rdf:type schema:CreativeWork
406 https://www.grid.ac/institutes/grid.12574.35 schema:alternateName Tunis El Manar University
407 schema:name Institut Pasteur de Tunis, LR11IPT02/ LR16IPT02 Laboratoire de Recherche sur la Transmission, le Contrôle et l’Immunobiologie des Infections, 1002, Tunis, Tunisia
408 Institut Pasteur de Tunis, LR11IPT04/LR16IPT04 Laboratoire d’Epidémiologie Moléculaire et de Pathologie Expérimentale appliquées aux Maladies infectieuses, 1002, Tunis, Tunisia
409 Institut Pasteur de Tunis, LR11IPT08/LR16IPT08 Laboratoire des Venins et Biomolécules thérapeutiques, 1002, Tunis, Tunisia
410 Université de Tunis El Manar, 1068, Tunis, Tunisia
411 rdf:type schema:Organization
412 https://www.grid.ac/institutes/grid.7252.2 schema:alternateName University of Angers
413 schema:name CRCINA, INSERM U892, Université de Nantes, Université d’Angers, Paul Papin ICO cancer center, Angers, France
414 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...