Live imaging of leukocyte recruitment in a zebrafish model of chemical liver injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Michelina Stoddard, Cong Huang, Balázs Enyedi, Philipp Niethammer

ABSTRACT

Studying early immune responses to organ damage in situ requires animal models amenable to intravital imaging. Here, we used transparent zebrafish larvae, a powerful animal model for innate immunity, to measure leukocyte recruitment to damaged livers. Bath application of metronidazole (Mtz) to fish expressing nitroreductase (NTR) under a liver-specific promoter damaged the organ within 24 hours causing oxidative stress, distorted liver morphology, accumulation of TUNEL-positive cells, and transcriptional upregulation of apoptotic and antioxidant genes. Inflammatory gene transcription in damaged hepatocytes was attenuated. In line with predominant apoptosis, macrophages were massively recruited into Mtz/NTR-damaged livers. By contrast, neutrophil infiltration was more variable and delayed, consistent with less abundant necrosis and an attenuated inflammatory capacity of damaged hepatocytes. More... »

PAGES

28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36771-9

DOI

http://dx.doi.org/10.1038/s41598-018-36771-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111164813

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30631093


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