New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hae Seong Song, Young Ho Song, Nem Singh, Hyunuk Kim, Hyelin Jeon, Inhye Kim, Chan Kang, Ki-Whan Chi

ABSTRACT

We report herein on the design, synthesis and biological activity of Ru-based self-assembled supramolecular bowls as a potent anticancer therapeutic in human hepatocellular cancer. The potent complex induces production of reactive oxygen species (ROS) by higher fatty acid β-oxidation and down-regulation of glucose transporter-mediated pyruvate dehydrogenase kinase 1 via reduced hypoxia-inducible factor 1α. Also, overexpressed acetyl-CoA activates the tricarboxylic acid cycle and the electron transport system and induces hypergeneration of ROS. Finally, ROS overexpressed through this pathway leads to apoptosis. Furthermore, we demonstrate that the naphthalene derived molecular bowl activates classical apoptosis via crosstalk between the extrinsic and intrinsic signal pathway. Our work into the mechanism of Ru-based self-assembled supramolecular bowls can provide valuable insight into the potential for use as a promising anticancer agent. More... »

PAGES

242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36755-9

DOI

http://dx.doi.org/10.1038/s41598-018-36755-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111418090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30659228


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