Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Luis Emilio Tavernelli, Maria Cristina M. Motta, Camila Silva Gonçalves, Marcelo Santos da Silva, Maria Carolina Elias, Victoria Lucia Alonso, Esteban Serra, Pamela Cribb

ABSTRACT

Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control. We have previously shown that High Mobility Group B protein from Trypanosoma cruzi (TcHMGB) can bind DNA in vitro. Here, we show that TcHMGB also acts as an architectural protein in vivo, since the overexpression of this protein induces changes in the nuclear structure, mainly the reduction of the nucleolus and a decrease in the heterochromatin:euchromatin ratio. Epimastigote replication rate was markedly reduced presumably due to a delayed cell cycle progression with accumulation of parasites in G2/M phase and impaired cytokinesis. Some functions involved in pathogenesis were also altered in TcHMGB-overexpressing parasites, like the decreased efficiency of trypomastigotes to infect cells in vitro, the reduction of intracellular amastigotes replication and the number of released trypomastigotes. Taken together, our results suggest that the TcHMGB protein is a pleiotropic player that controls cell phenotype and it is involved in key cellular processes. More... »

PAGES

192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36718-0

DOI

http://dx.doi.org/10.1038/s41598-018-36718-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111390319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30655631


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Scientific and Technical Research Council", 
          "id": "https://www.grid.ac/institutes/grid.423606.5", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tavernelli", 
        "givenName": "Luis Emilio", 
        "id": "sg:person.015615700147.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015615700147.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Laboratorio de Ultraestrutura Celular Hertha Meyer, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Motta", 
        "givenName": "Maria Cristina M.", 
        "id": "sg:person.010405562352.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010405562352.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio de Janeiro", 
          "id": "https://www.grid.ac/institutes/grid.8536.8", 
          "name": [
            "Instituto de Biof\u00edsica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Laboratorio de Ultraestrutura Celular Hertha Meyer, Rio de Janeiro, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gon\u00e7alves", 
        "givenName": "Camila Silva", 
        "id": "sg:person.016106621274.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016106621274.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Butantan", 
          "id": "https://www.grid.ac/institutes/grid.418514.d", 
          "name": [
            "Laborat\u00f3rio Especial de Ciclo Celular, Instituto Butantan, 05503-900, S\u00e3o Paulo, SP, Brazil", 
            "Center of Toxins, Immune Response and Cell Signaling \u2013 CeTICS, Instituto Butantan, 05503-900, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Silva", 
        "givenName": "Marcelo Santos", 
        "id": "sg:person.01003201144.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003201144.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Butantan", 
          "id": "https://www.grid.ac/institutes/grid.418514.d", 
          "name": [
            "Laborat\u00f3rio Especial de Ciclo Celular, Instituto Butantan, 05503-900, S\u00e3o Paulo, SP, Brazil", 
            "Center of Toxins, Immune Response and Cell Signaling \u2013 CeTICS, Instituto Butantan, 05503-900, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elias", 
        "givenName": "Maria Carolina", 
        "id": "sg:person.015630553012.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015630553012.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Universidad Nacional de Rosario (UNR), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, C\u00e1tedra de Parasitolog\u00eda, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Victoria Lucia", 
        "id": "sg:person.01333233120.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333233120.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Rosario, Argentina", 
            "Universidad Nacional de Rosario (UNR), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, C\u00e1tedra de Parasitolog\u00eda, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serra", 
        "givenName": "Esteban", 
        "id": "sg:person.01306025340.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306025340.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Rosario", 
          "id": "https://www.grid.ac/institutes/grid.10814.3c", 
          "name": [
            "Instituto de Biolog\u00eda Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Rosario, Argentina", 
            "Universidad Nacional de Rosario (UNR), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, C\u00e1tedra de Parasitolog\u00eda, Rosario, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cribb", 
        "givenName": "Pamela", 
        "id": "sg:person.01261055370.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261055370.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pt.2003.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000194607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2003.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000194607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003369975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2014.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006516689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mbio.02097-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007437217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.05185-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008436528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/09680519010070041401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014080409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/09680519010070041401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014080409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.5.1.92-102.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015224887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(00)01738-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015680790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/mmi.12458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017931570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-6851(00)00349-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019086083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019947595", 
          "https://doi.org/10.1038/ncomms12059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020871902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-6851(85)90073-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020871902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1112631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021102160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.4.5.960-970.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021246693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2006.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021819885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv1459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022665156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molbiopara.2015.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025419968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2012.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026979908", 
          "https://doi.org/10.1038/cdd.2012.12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05008.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027807345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.05008.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027807345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2006.08.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031330347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/0074-0276140238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032662110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0003725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033341395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-385863-4.00011-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033455142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.13719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034707895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.2010.02117.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037727542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.2010.02117.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037727542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2009.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038427014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m802081200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038612664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2958.2007.05866.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040510704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2012.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040569809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-6-32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042623798", 
          "https://doi.org/10.1186/1472-6750-6-32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m511504200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042718482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2009.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042990771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.00123-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043704898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044802489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fmb.09.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045477313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.protis.2006.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045899470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2015.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047403837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2015.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047403837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3002(60)90496-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047463934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-3002(60)90496-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047463934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01277-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047767184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050116376", 
          "https://doi.org/10.1038/nrmicro2149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-0495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050577350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2016.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051335936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.5.4.672-682.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051731457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051920017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpara.2011.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051964541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0111993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052707129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.13.6000-6010.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053470254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m116.061200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058216119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15384101.2016.1181882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058402322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2008-00034.klune", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068965082", 
          "https://doi.org/10.2119/2008-00034.klune"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/2008-00034.klune", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068965082", 
          "https://doi.org/10.2119/2008-00034.klune"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612023396276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069164742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182017000038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083687393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2017.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083697910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0005350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083734617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jeu.12408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084214628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21769/bioprotoc.2299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085625096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2017.11.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092956688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-018-2664-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100858173", 
          "https://doi.org/10.1186/s13071-018-2664-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/0074-02760170404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103370327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1007059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104386015"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control. We have previously shown that High Mobility Group B protein from Trypanosoma cruzi (TcHMGB) can bind DNA in vitro. Here, we show that TcHMGB also acts as an architectural protein in vivo, since the overexpression of this protein induces changes in the nuclear structure, mainly the reduction of the nucleolus and a decrease in the heterochromatin:euchromatin ratio. Epimastigote replication rate was markedly reduced presumably due to a delayed cell cycle progression with accumulation of parasites in G2/M phase and impaired cytokinesis. Some functions involved in pathogenesis were also altered in TcHMGB-overexpressing parasites, like the decreased efficiency of trypomastigotes to infect cells in vitro, the reduction of intracellular amastigotes replication and the number of released trypomastigotes. Taken together, our results suggest that the TcHMGB protein is a pleiotropic player that controls cell phenotype and it is involved in key cellular processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36718-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4573234", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity", 
    "pagination": "192", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "18c0b4b61b3ba15fae7a3d588cbf8c087ad1588d568db52bf928e743b5620d17"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30655631"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36718-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111390319"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36718-0", 
      "https://app.dimensions.ai/details/publication/pub.1111390319"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000322_0000000322/records_65005_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36718-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36718-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36718-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36718-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36718-0'


 

This table displays all metadata directly associated to this object as RDF triples.

316 TRIPLES      21 PREDICATES      89 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36718-0 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N63b7956896ad45bb988d071330188a8d
4 schema:citation sg:pub.10.1038/cdd.2012.12
5 sg:pub.10.1038/ncomms12059
6 sg:pub.10.1038/nrmicro2149
7 sg:pub.10.1186/1472-6750-6-32
8 sg:pub.10.1186/s13071-018-2664-4
9 sg:pub.10.2119/2008-00034.klune
10 https://doi.org/10.1016/0006-3002(60)90496-0
11 https://doi.org/10.1016/0166-6851(85)90073-8
12 https://doi.org/10.1016/b978-0-12-385863-4.00011-3
13 https://doi.org/10.1016/j.actatropica.2017.02.007
14 https://doi.org/10.1016/j.actatropica.2017.11.013
15 https://doi.org/10.1016/j.bbagrm.2009.09.008
16 https://doi.org/10.1016/j.bbagrm.2009.11.010
17 https://doi.org/10.1016/j.bbagrm.2014.05.028
18 https://doi.org/10.1016/j.celrep.2012.06.007
19 https://doi.org/10.1016/j.clinthera.2016.02.029
20 https://doi.org/10.1016/j.devcel.2015.03.015
21 https://doi.org/10.1016/j.gde.2005.08.007
22 https://doi.org/10.1016/j.gene.2006.08.034
23 https://doi.org/10.1016/j.ijpara.2006.11.016
24 https://doi.org/10.1016/j.ijpara.2011.06.009
25 https://doi.org/10.1016/j.molbiopara.2015.10.004
26 https://doi.org/10.1016/j.protis.2006.10.002
27 https://doi.org/10.1016/j.pt.2003.09.001
28 https://doi.org/10.1016/s0166-6851(00)00349-2
29 https://doi.org/10.1016/s0962-8924(00)01738-4
30 https://doi.org/10.1017/s0031182017000038
31 https://doi.org/10.1074/jbc.m511504200
32 https://doi.org/10.1074/jbc.m802081200
33 https://doi.org/10.1074/mcp.m116.061200
34 https://doi.org/10.1080/15384101.2016.1181882
35 https://doi.org/10.1093/nar/gks1469
36 https://doi.org/10.1093/nar/gkv1459
37 https://doi.org/10.1111/febs.13719
38 https://doi.org/10.1111/j.1365-2958.2007.05866.x
39 https://doi.org/10.1111/j.1574-6968.2010.02117.x
40 https://doi.org/10.1111/j.1749-6632.2009.05008.x
41 https://doi.org/10.1111/jeu.12408
42 https://doi.org/10.1111/mmi.12458
43 https://doi.org/10.1126/science.1112631
44 https://doi.org/10.1128/ec.00123-08
45 https://doi.org/10.1128/ec.05185-11
46 https://doi.org/10.1128/ec.4.5.960-970.2005
47 https://doi.org/10.1128/ec.5.1.92-102.2006
48 https://doi.org/10.1128/ec.5.4.672-682.2006
49 https://doi.org/10.1128/mbio.02097-14
50 https://doi.org/10.1128/mcb.01277-10
51 https://doi.org/10.1128/mcb.24.13.6000-6010.2004
52 https://doi.org/10.1158/1078-0432.ccr-13-0495
53 https://doi.org/10.1177/09680519010070041401
54 https://doi.org/10.1371/journal.pntd.0003725
55 https://doi.org/10.1371/journal.pntd.0005350
56 https://doi.org/10.1371/journal.pone.0111993
57 https://doi.org/10.1371/journal.ppat.1003010
58 https://doi.org/10.1371/journal.ppat.1007059
59 https://doi.org/10.1590/0074-02760170404
60 https://doi.org/10.1590/0074-0276140238
61 https://doi.org/10.2174/1381612023396276
62 https://doi.org/10.21769/bioprotoc.2299
63 https://doi.org/10.2217/fmb.09.74
64 schema:datePublished 2019-12
65 schema:datePublishedReg 2019-12-01
66 schema:description Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control. We have previously shown that High Mobility Group B protein from Trypanosoma cruzi (TcHMGB) can bind DNA in vitro. Here, we show that TcHMGB also acts as an architectural protein in vivo, since the overexpression of this protein induces changes in the nuclear structure, mainly the reduction of the nucleolus and a decrease in the heterochromatin:euchromatin ratio. Epimastigote replication rate was markedly reduced presumably due to a delayed cell cycle progression with accumulation of parasites in G2/M phase and impaired cytokinesis. Some functions involved in pathogenesis were also altered in TcHMGB-overexpressing parasites, like the decreased efficiency of trypomastigotes to infect cells in vitro, the reduction of intracellular amastigotes replication and the number of released trypomastigotes. Taken together, our results suggest that the TcHMGB protein is a pleiotropic player that controls cell phenotype and it is involved in key cellular processes.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N00f63f01ad27461e91682b2f4f54b9af
71 Nc22733a6030b4039b23f4e4ce7acf36c
72 sg:journal.1045337
73 schema:name Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity
74 schema:pagination 192
75 schema:productId N2422f2d9a50e476d9cc7ee53eaa16148
76 N24481e6a45b6440297234a629608eb16
77 N2d06141f20e7444bb2b2c86cb9e92e4b
78 N435cd696823f467bb3ed00879e15b365
79 Nf4e7b4891ac94ce0bf71dffb6ef18f01
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111390319
81 https://doi.org/10.1038/s41598-018-36718-0
82 schema:sdDatePublished 2019-04-11T08:43
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N795b10b97e5b4ab1b9d0f73462fc87ab
85 schema:url https://www.nature.com/articles/s41598-018-36718-0
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N00f63f01ad27461e91682b2f4f54b9af schema:issueNumber 1
90 rdf:type schema:PublicationIssue
91 N2422f2d9a50e476d9cc7ee53eaa16148 schema:name readcube_id
92 schema:value 18c0b4b61b3ba15fae7a3d588cbf8c087ad1588d568db52bf928e743b5620d17
93 rdf:type schema:PropertyValue
94 N24481e6a45b6440297234a629608eb16 schema:name nlm_unique_id
95 schema:value 101563288
96 rdf:type schema:PropertyValue
97 N2d06141f20e7444bb2b2c86cb9e92e4b schema:name dimensions_id
98 schema:value pub.1111390319
99 rdf:type schema:PropertyValue
100 N2fd0ffddf7744a6192b534892bff8d77 rdf:first sg:person.01306025340.48
101 rdf:rest Nc409baa57c4741638b6a04016e29c456
102 N435cd696823f467bb3ed00879e15b365 schema:name doi
103 schema:value 10.1038/s41598-018-36718-0
104 rdf:type schema:PropertyValue
105 N53a8728470134dc484718dcd99c33161 rdf:first sg:person.015630553012.87
106 rdf:rest Nd8c918d27c394eb7a6fddf3901071b7a
107 N63b7956896ad45bb988d071330188a8d rdf:first sg:person.015615700147.69
108 rdf:rest Nd704fb6a1ace4cdf8ed041208f4d55e8
109 N795b10b97e5b4ab1b9d0f73462fc87ab schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N7af27ca889194b3181291edbf302e0d8 rdf:first sg:person.016106621274.63
112 rdf:rest Nbf53614acfd24750874d34b4efce3d7c
113 Nbf53614acfd24750874d34b4efce3d7c rdf:first sg:person.01003201144.48
114 rdf:rest N53a8728470134dc484718dcd99c33161
115 Nc22733a6030b4039b23f4e4ce7acf36c schema:volumeNumber 9
116 rdf:type schema:PublicationVolume
117 Nc409baa57c4741638b6a04016e29c456 rdf:first sg:person.01261055370.66
118 rdf:rest rdf:nil
119 Nd704fb6a1ace4cdf8ed041208f4d55e8 rdf:first sg:person.010405562352.48
120 rdf:rest N7af27ca889194b3181291edbf302e0d8
121 Nd8c918d27c394eb7a6fddf3901071b7a rdf:first sg:person.01333233120.60
122 rdf:rest N2fd0ffddf7744a6192b534892bff8d77
123 Nf4e7b4891ac94ce0bf71dffb6ef18f01 schema:name pubmed_id
124 schema:value 30655631
125 rdf:type schema:PropertyValue
126 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
127 schema:name Biological Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
130 schema:name Genetics
131 rdf:type schema:DefinedTerm
132 sg:grant.4573234 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36718-0
133 rdf:type schema:MonetaryGrant
134 sg:journal.1045337 schema:issn 2045-2322
135 schema:name Scientific Reports
136 rdf:type schema:Periodical
137 sg:person.01003201144.48 schema:affiliation https://www.grid.ac/institutes/grid.418514.d
138 schema:familyName da Silva
139 schema:givenName Marcelo Santos
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003201144.48
141 rdf:type schema:Person
142 sg:person.010405562352.48 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
143 schema:familyName Motta
144 schema:givenName Maria Cristina M.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010405562352.48
146 rdf:type schema:Person
147 sg:person.01261055370.66 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
148 schema:familyName Cribb
149 schema:givenName Pamela
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261055370.66
151 rdf:type schema:Person
152 sg:person.01306025340.48 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
153 schema:familyName Serra
154 schema:givenName Esteban
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306025340.48
156 rdf:type schema:Person
157 sg:person.01333233120.60 schema:affiliation https://www.grid.ac/institutes/grid.10814.3c
158 schema:familyName Alonso
159 schema:givenName Victoria Lucia
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333233120.60
161 rdf:type schema:Person
162 sg:person.015615700147.69 schema:affiliation https://www.grid.ac/institutes/grid.423606.5
163 schema:familyName Tavernelli
164 schema:givenName Luis Emilio
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015615700147.69
166 rdf:type schema:Person
167 sg:person.015630553012.87 schema:affiliation https://www.grid.ac/institutes/grid.418514.d
168 schema:familyName Elias
169 schema:givenName Maria Carolina
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015630553012.87
171 rdf:type schema:Person
172 sg:person.016106621274.63 schema:affiliation https://www.grid.ac/institutes/grid.8536.8
173 schema:familyName Gonçalves
174 schema:givenName Camila Silva
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016106621274.63
176 rdf:type schema:Person
177 sg:pub.10.1038/cdd.2012.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026979908
178 https://doi.org/10.1038/cdd.2012.12
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/ncomms12059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019947595
181 https://doi.org/10.1038/ncomms12059
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nrmicro2149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050116376
184 https://doi.org/10.1038/nrmicro2149
185 rdf:type schema:CreativeWork
186 sg:pub.10.1186/1472-6750-6-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042623798
187 https://doi.org/10.1186/1472-6750-6-32
188 rdf:type schema:CreativeWork
189 sg:pub.10.1186/s13071-018-2664-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100858173
190 https://doi.org/10.1186/s13071-018-2664-4
191 rdf:type schema:CreativeWork
192 sg:pub.10.2119/2008-00034.klune schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965082
193 https://doi.org/10.2119/2008-00034.klune
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0006-3002(60)90496-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047463934
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/0166-6851(85)90073-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020871902
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/b978-0-12-385863-4.00011-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033455142
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.actatropica.2017.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083697910
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.actatropica.2017.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092956688
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.bbagrm.2009.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042990771
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.bbagrm.2009.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038427014
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.bbagrm.2014.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006516689
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.celrep.2012.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040569809
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.clinthera.2016.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051335936
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.devcel.2015.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047403837
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.gde.2005.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003369975
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.gene.2006.08.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031330347
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ijpara.2006.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021819885
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ijpara.2011.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051964541
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.molbiopara.2015.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025419968
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.protis.2006.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045899470
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.pt.2003.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000194607
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0166-6851(00)00349-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019086083
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0962-8924(00)01738-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015680790
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1017/s0031182017000038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083687393
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1074/jbc.m511504200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042718482
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1074/jbc.m802081200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038612664
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/mcp.m116.061200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058216119
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1080/15384101.2016.1181882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058402322
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/nar/gks1469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044802489
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/nar/gkv1459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022665156
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/febs.13719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034707895
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.1365-2958.2007.05866.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040510704
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/j.1574-6968.2010.02117.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037727542
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1749-6632.2009.05008.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027807345
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/jeu.12408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084214628
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/mmi.12458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017931570
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1126/science.1112631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021102160
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1128/ec.00123-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043704898
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1128/ec.05185-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008436528
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1128/ec.4.5.960-970.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021246693
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1128/ec.5.1.92-102.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015224887
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1128/ec.5.4.672-682.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051731457
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1128/mbio.02097-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007437217
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1128/mcb.01277-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047767184
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1128/mcb.24.13.6000-6010.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053470254
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1158/1078-0432.ccr-13-0495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050577350
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1177/09680519010070041401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014080409
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1371/journal.pntd.0003725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033341395
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1371/journal.pntd.0005350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083734617
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1371/journal.pone.0111993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052707129
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1371/journal.ppat.1003010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051920017
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1371/journal.ppat.1007059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104386015
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1590/0074-02760170404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103370327
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1590/0074-0276140238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032662110
296 rdf:type schema:CreativeWork
297 https://doi.org/10.2174/1381612023396276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069164742
298 rdf:type schema:CreativeWork
299 https://doi.org/10.21769/bioprotoc.2299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085625096
300 rdf:type schema:CreativeWork
301 https://doi.org/10.2217/fmb.09.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045477313
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.10814.3c schema:alternateName National University of Rosario
304 schema:name Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Argentina
305 Universidad Nacional de Rosario (UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Cátedra de Parasitología, Rosario, Argentina
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.418514.d schema:alternateName Instituto Butantan
308 schema:name Center of Toxins, Immune Response and Cell Signaling – CeTICS, Instituto Butantan, 05503-900, São Paulo, SP, Brazil
309 Laboratório Especial de Ciclo Celular, Instituto Butantan, 05503-900, São Paulo, SP, Brazil
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.423606.5 schema:alternateName National Scientific and Technical Research Council
312 schema:name Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rosario, Argentina
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.8536.8 schema:alternateName Federal University of Rio de Janeiro
315 schema:name Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Laboratorio de Ultraestrutura Celular Hertha Meyer, Rio de Janeiro, Brazil
316 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...