Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Zhangqian Wang, Haribalan Perumalsamy, Xue Wang, Young-Joon Ahn

ABSTRACT

This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC50, 6.13-7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H+-ATPase and aquaporin 4, indicating that it may disturb the Na+, Cl- and K+ co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations. More... »

PAGES

411

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36558-y

DOI

http://dx.doi.org/10.1038/s41598-018-36558-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111612944

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30674912


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.49470.3e", 
          "name": [
            "Department of Agricultural Biotechnology, Seoul National University, 08826, Seoul, Republic of Korea", 
            "Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, 430071, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Zhangqian", 
        "id": "sg:person.0737364061.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737364061.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Research Institute of Agriculture and Life Sciences, Seoul National University, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perumalsamy", 
        "givenName": "Haribalan", 
        "id": "sg:person.0637001361.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637001361.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xue", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Agricultural Biotechnology, Seoul National University, 08826, Seoul, Republic of Korea", 
            "Research Institute of Agriculture and Life Sciences, Seoul National University, 08826, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Young-Joon", 
        "id": "sg:person.0643271705.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643271705.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.envint.2005.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000242684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.envint.2005.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000242684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ps.1557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000610836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0040-8166(93)90036-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0040-8166(93)90036-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1020938001272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001341200", 
          "https://doi.org/10.1023/a:1020938001272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.00072-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003001724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2583.1998.00069.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003012051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2583.1998.00069.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003012051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004869272", 
          "https://doi.org/10.1038/nature12060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2013.12.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005543028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinsphys.2006.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006965537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61687-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007191151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.indcrop.2015.06.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008532787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.indcrop.2015.06.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008532787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.01287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009777108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrc.1260230602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010190443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrc.1260230602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010190443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tplants.2013.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011492156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1744-8603-9-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012081850", 
          "https://doi.org/10.1186/1744-8603-9-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00219894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012294288", 
          "https://doi.org/10.1007/bf00219894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actatropica.2009.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012909546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2008.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013708974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.08347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017881973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jipa.1998.4810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019309421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ibmb.2004.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019496449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01013489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019637200", 
          "https://doi.org/10.1007/bf01013489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yrtph.2014.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020224225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-015-0848-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022416793", 
          "https://doi.org/10.1186/s13071-015-0848-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-015-0848-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022416793", 
          "https://doi.org/10.1186/s13071-015-0848-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-013-3687-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022519298", 
          "https://doi.org/10.1007/s00436-013-3687-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-013-3687-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022519298", 
          "https://doi.org/10.1007/s00436-013-3687-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.17.1.208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024183842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules15096452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024262558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules15096452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024262558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0080226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025169087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ps.3265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025742004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027424136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027424136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027424136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(16)00026-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027424136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.02551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027911094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1110/ps.9.7.1347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027988741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.01422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029429854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.00709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033323568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00360-012-0679-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035649172", 
          "https://doi.org/10.1007/s00360-012-0679-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ento.51.110104.151146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036137913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ento.51.110104.151146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036137913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ps.548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037083562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1572-5995(00)80056-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037729214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0048-3575(85)90100-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038533673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-4-83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039408479", 
          "https://doi.org/10.1186/1756-3305-4-83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2011(92)90098-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041295214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0040-8166(89)90070-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041600478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-4-89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042456450", 
          "https://doi.org/10.1186/1756-3305-4-89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0001760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042596488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0705542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045234548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-3305-7-172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045680770", 
          "https://doi.org/10.1186/1756-3305-7-172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biortech.2005.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045962004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.063719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047404592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ympev.2008.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048863938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00994367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049898354", 
          "https://doi.org/10.1007/bf00994367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ps.4064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050110993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.26.1.77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050340643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199912000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050444766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-199912000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050444766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf011457a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055899452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf011457a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055899452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf102193k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055908486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf102193k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055908486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np000371t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056227884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np000371t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056227884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157340613804488323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069209629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075018008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077221418", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077261258", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078512540", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080155836", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2903/sp.efsa.2009.en-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084417989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-017-2154-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085137462", 
          "https://doi.org/10.1186/s13071-017-2154-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13071-017-2154-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085137462", 
          "https://doi.org/10.1186/s13071-017-2154-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/9781845933531.0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089220631"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC50, 6.13-7.37\u2009mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H+-ATPase and aquaporin 4, indicating that it may disturb the Na+, Cl- and K+ co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36558-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species", 
    "pagination": "411", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0412e75d1a3cfe2705246e776a106e925a4432312f8415240a4a05f30d2b972f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30674912"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36558-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111612944"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36558-y", 
      "https://app.dimensions.ai/details/publication/pub.1111612944"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68442_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36558-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36558-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36558-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36558-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36558-y'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      94 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36558-y schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nb92ef8132ff744b6a7250f992d0dd3b6
4 schema:citation sg:pub.10.1007/bf00219894
5 sg:pub.10.1007/bf00994367
6 sg:pub.10.1007/bf01013489
7 sg:pub.10.1007/s00360-012-0679-2
8 sg:pub.10.1007/s00436-013-3687-6
9 sg:pub.10.1023/a:1020938001272
10 sg:pub.10.1038/nature12060
11 sg:pub.10.1186/1744-8603-9-10
12 sg:pub.10.1186/1756-3305-4-83
13 sg:pub.10.1186/1756-3305-4-89
14 sg:pub.10.1186/1756-3305-7-172
15 sg:pub.10.1186/s13071-015-0848-8
16 sg:pub.10.1186/s13071-017-2154-0
17 https://app.dimensions.ai/details/publication/pub.1075018008
18 https://app.dimensions.ai/details/publication/pub.1077221418
19 https://app.dimensions.ai/details/publication/pub.1077261258
20 https://app.dimensions.ai/details/publication/pub.1078512540
21 https://app.dimensions.ai/details/publication/pub.1080155836
22 https://doi.org/10.1002/mrc.1260230602
23 https://doi.org/10.1002/ps.1557
24 https://doi.org/10.1002/ps.3265
25 https://doi.org/10.1002/ps.4064
26 https://doi.org/10.1002/ps.548
27 https://doi.org/10.1006/jipa.1998.4810
28 https://doi.org/10.1016/0022-2011(92)90098-o
29 https://doi.org/10.1016/0040-8166(89)90070-0
30 https://doi.org/10.1016/0040-8166(93)90036-k
31 https://doi.org/10.1016/0048-3575(85)90100-2
32 https://doi.org/10.1016/j.actatropica.2009.08.023
33 https://doi.org/10.1016/j.biortech.2005.10.003
34 https://doi.org/10.1016/j.envint.2005.03.003
35 https://doi.org/10.1016/j.fitote.2008.01.005
36 https://doi.org/10.1016/j.ibmb.2004.03.018
37 https://doi.org/10.1016/j.indcrop.2015.06.050
38 https://doi.org/10.1016/j.jinsphys.2006.09.014
39 https://doi.org/10.1016/j.tplants.2013.11.005
40 https://doi.org/10.1016/j.vaccine.2013.12.061
41 https://doi.org/10.1016/j.ympev.2008.06.004
42 https://doi.org/10.1016/j.yrtph.2014.11.007
43 https://doi.org/10.1016/s0140-6736(07)61687-0
44 https://doi.org/10.1016/s1473-3099(16)00026-8
45 https://doi.org/10.1016/s1572-5995(00)80056-3
46 https://doi.org/10.1021/jf011457a
47 https://doi.org/10.1021/jf102193k
48 https://doi.org/10.1021/np000371t
49 https://doi.org/10.1038/sj.bjp.0705542
50 https://doi.org/10.1079/9781845933531.0032
51 https://doi.org/10.1083/jcb.17.1.208
52 https://doi.org/10.1097/00024382-199912000-00012
53 https://doi.org/10.1110/ps.9.7.1347
54 https://doi.org/10.1111/j.1365-2583.1998.00069.x
55 https://doi.org/10.1128/cmr.00072-15
56 https://doi.org/10.1136/jcp.26.1.77
57 https://doi.org/10.1146/annurev.ento.51.110104.151146
58 https://doi.org/10.1242/jeb.00709
59 https://doi.org/10.1242/jeb.01287
60 https://doi.org/10.1242/jeb.01422
61 https://doi.org/10.1242/jeb.02551
62 https://doi.org/10.1242/jeb.063719
63 https://doi.org/10.1371/journal.pntd.0001760
64 https://doi.org/10.1371/journal.pone.0080226
65 https://doi.org/10.2174/157340613804488323
66 https://doi.org/10.2903/sp.efsa.2009.en-7
67 https://doi.org/10.3390/molecules15096452
68 https://doi.org/10.7554/elife.08347
69 schema:datePublished 2019-12
70 schema:datePublishedReg 2019-12-01
71 schema:description This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC<sub>50</sub>, 6.13-7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H<sup>+</sup>-ATPase and aquaporin 4, indicating that it may disturb the Na<sup>+</sup>, Cl<sup>-</sup> and K<sup>+</sup> co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N99e5281b910e42cdb7952ed59934d441
76 Nd561aba299574ea6bf417a8649940ed8
77 sg:journal.1045337
78 schema:name Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species
79 schema:pagination 411
80 schema:productId N0774341a0c8a425f86e4cfa7e3ca14df
81 N0dfdadfbe3454871b0a72713ca03be4b
82 N2e52b1d1bb3f45998de4a20a98416dc6
83 N655f023c2c0744a5bee115ece9eb7154
84 Nc24ac6bc5ad44ae3ae02d29a8082a176
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111612944
86 https://doi.org/10.1038/s41598-018-36558-y
87 schema:sdDatePublished 2019-04-11T08:58
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N4cf7067a44584bcba06f014f425bab98
90 schema:url https://www.nature.com/articles/s41598-018-36558-y
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0774341a0c8a425f86e4cfa7e3ca14df schema:name readcube_id
95 schema:value 0412e75d1a3cfe2705246e776a106e925a4432312f8415240a4a05f30d2b972f
96 rdf:type schema:PropertyValue
97 N0dfdadfbe3454871b0a72713ca03be4b schema:name dimensions_id
98 schema:value pub.1111612944
99 rdf:type schema:PropertyValue
100 N2e52b1d1bb3f45998de4a20a98416dc6 schema:name doi
101 schema:value 10.1038/s41598-018-36558-y
102 rdf:type schema:PropertyValue
103 N4cf7067a44584bcba06f014f425bab98 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N655f023c2c0744a5bee115ece9eb7154 schema:name pubmed_id
106 schema:value 30674912
107 rdf:type schema:PropertyValue
108 N6acbf014991d4056b47f857fa15366ea schema:affiliation https://www.grid.ac/institutes/grid.268099.c
109 schema:familyName Wang
110 schema:givenName Xue
111 rdf:type schema:Person
112 N767266c4b9ab441c861af3f99506e6f9 rdf:first sg:person.0643271705.06
113 rdf:rest rdf:nil
114 N99e5281b910e42cdb7952ed59934d441 schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N9c32c192193b42d8ae0a46b386058543 rdf:first N6acbf014991d4056b47f857fa15366ea
117 rdf:rest N767266c4b9ab441c861af3f99506e6f9
118 Na18604a69acb4c349fe0113d1780920c rdf:first sg:person.0637001361.32
119 rdf:rest N9c32c192193b42d8ae0a46b386058543
120 Nb92ef8132ff744b6a7250f992d0dd3b6 rdf:first sg:person.0737364061.77
121 rdf:rest Na18604a69acb4c349fe0113d1780920c
122 Nc24ac6bc5ad44ae3ae02d29a8082a176 schema:name nlm_unique_id
123 schema:value 101563288
124 rdf:type schema:PropertyValue
125 Nd561aba299574ea6bf417a8649940ed8 schema:volumeNumber 9
126 rdf:type schema:PublicationVolume
127 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biological Sciences
129 rdf:type schema:DefinedTerm
130 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
131 schema:name Genetics
132 rdf:type schema:DefinedTerm
133 sg:journal.1045337 schema:issn 2045-2322
134 schema:name Scientific Reports
135 rdf:type schema:Periodical
136 sg:person.0637001361.32 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
137 schema:familyName Perumalsamy
138 schema:givenName Haribalan
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637001361.32
140 rdf:type schema:Person
141 sg:person.0643271705.06 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
142 schema:familyName Ahn
143 schema:givenName Young-Joon
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643271705.06
145 rdf:type schema:Person
146 sg:person.0737364061.77 schema:affiliation https://www.grid.ac/institutes/grid.49470.3e
147 schema:familyName Wang
148 schema:givenName Zhangqian
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737364061.77
150 rdf:type schema:Person
151 sg:pub.10.1007/bf00219894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012294288
152 https://doi.org/10.1007/bf00219894
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/bf00994367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049898354
155 https://doi.org/10.1007/bf00994367
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/bf01013489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019637200
158 https://doi.org/10.1007/bf01013489
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s00360-012-0679-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035649172
161 https://doi.org/10.1007/s00360-012-0679-2
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s00436-013-3687-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022519298
164 https://doi.org/10.1007/s00436-013-3687-6
165 rdf:type schema:CreativeWork
166 sg:pub.10.1023/a:1020938001272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001341200
167 https://doi.org/10.1023/a:1020938001272
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nature12060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004869272
170 https://doi.org/10.1038/nature12060
171 rdf:type schema:CreativeWork
172 sg:pub.10.1186/1744-8603-9-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012081850
173 https://doi.org/10.1186/1744-8603-9-10
174 rdf:type schema:CreativeWork
175 sg:pub.10.1186/1756-3305-4-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039408479
176 https://doi.org/10.1186/1756-3305-4-83
177 rdf:type schema:CreativeWork
178 sg:pub.10.1186/1756-3305-4-89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042456450
179 https://doi.org/10.1186/1756-3305-4-89
180 rdf:type schema:CreativeWork
181 sg:pub.10.1186/1756-3305-7-172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045680770
182 https://doi.org/10.1186/1756-3305-7-172
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/s13071-015-0848-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022416793
185 https://doi.org/10.1186/s13071-015-0848-8
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/s13071-017-2154-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085137462
188 https://doi.org/10.1186/s13071-017-2154-0
189 rdf:type schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1075018008 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1077221418 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1077261258 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1078512540 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1080155836 schema:CreativeWork
195 https://doi.org/10.1002/mrc.1260230602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010190443
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/ps.1557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000610836
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/ps.3265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025742004
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/ps.4064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050110993
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/ps.548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037083562
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1006/jipa.1998.4810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019309421
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0022-2011(92)90098-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1041295214
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0040-8166(89)90070-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041600478
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0040-8166(93)90036-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929941
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0048-3575(85)90100-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038533673
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.actatropica.2009.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012909546
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.biortech.2005.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045962004
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.envint.2005.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000242684
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.fitote.2008.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013708974
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.ibmb.2004.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019496449
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.indcrop.2015.06.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008532787
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.jinsphys.2006.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006965537
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.tplants.2013.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011492156
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.vaccine.2013.12.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005543028
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.ympev.2008.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048863938
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.yrtph.2014.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020224225
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0140-6736(07)61687-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007191151
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s1473-3099(16)00026-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027424136
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s1572-5995(00)80056-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037729214
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1021/jf011457a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055899452
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1021/jf102193k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055908486
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1021/np000371t schema:sameAs https://app.dimensions.ai/details/publication/pub.1056227884
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1038/sj.bjp.0705542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045234548
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1079/9781845933531.0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089220631
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1083/jcb.17.1.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024183842
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00024382-199912000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050444766
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1110/ps.9.7.1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027988741
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1365-2583.1998.00069.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003012051
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/cmr.00072-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003001724
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1136/jcp.26.1.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050340643
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1146/annurev.ento.51.110104.151146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036137913
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1242/jeb.00709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033323568
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1242/jeb.01287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009777108
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1242/jeb.01422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029429854
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1242/jeb.02551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027911094
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1242/jeb.063719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047404592
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1371/journal.pntd.0001760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042596488
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1371/journal.pone.0080226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025169087
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2174/157340613804488323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069209629
282 rdf:type schema:CreativeWork
283 https://doi.org/10.2903/sp.efsa.2009.en-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084417989
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3390/molecules15096452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024262558
286 rdf:type schema:CreativeWork
287 https://doi.org/10.7554/elife.08347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017881973
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.268099.c schema:alternateName Wenzhou Medical College
290 schema:name School of Pharmaceutical Science, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China
291 rdf:type schema:Organization
292 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
293 schema:name Department of Agricultural Biotechnology, Seoul National University, 08826, Seoul, Republic of Korea
294 Research Institute of Agriculture and Life Sciences, Seoul National University, 08826, Seoul, Republic of Korea
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.49470.3e schema:alternateName Wuhan University
297 schema:name Department of Agricultural Biotechnology, Seoul National University, 08826, Seoul, Republic of Korea
298 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, 430071, Wuhan, Hubei, China
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...