Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jorge Arancibia-Radich, Raquel González-Blázquez, Martín Alcalá, Miriam Martín-Ramos, Marta Viana, Silvia Arribas, Carla Delporte, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega

ABSTRACT

Infusions of murtilla leaves exhibit antioxidant, analgesic, and anti-inflammatory properties. Several compounds that are structurally similar to madecassic acid (MA), a component of murtilla leaf extract (ethyl acetate extract, EAE), have been shown to inhibit protein tyrosine phosphatase 1B (PTP1P). The aim of this study was to evaluate if EAE and two compounds identified in EAE (MA and myricetin [MYR]) could have a beneficial effect on systemic and vascular insulin sensitivity and endothelial function in a model of diet-induced obesity. Experiments were performed in 5-week-old male C57BL6J mice fed with a standard (LF) or a very high-fat diet (HF) for 4 weeks and treated with EAE, MA, MYR, or the vehicle as control (C). EAE significantly inhibited PTP1B. EAE and MA, but not MYR, significantly improved systemic insulin sensitivity in HF mice and vascular relaxation to Ach in aorta segments, due to a significant increase of eNOS phosphorylation and enhanced nitric oxide availability. EAE, MA, and MYR also accounted for increased relaxant responses to insulin in HF mice, thus evidencing that the treatments significantly improved aortic insulin sensitivity. This study shows for the first time that EAE and MA could constitute interesting candidates for treating insulin resistance and endothelial dysfunction associated with obesity. More... »

PAGES

599

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36555-1

DOI

http://dx.doi.org/10.1038/s41598-018-36555-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111649678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30679477


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Chile", 
          "id": "https://www.grid.ac/institutes/grid.443909.3", 
          "name": [
            "Laboratorio de Productos Naturales, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, PO Box 8380492, Santos Dumont 964, Santiago, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arancibia-Radich", 
        "givenName": "Jorge", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEU San Pablo University", 
          "id": "https://www.grid.ac/institutes/grid.8461.b", 
          "name": [
            "Departamento de Ciencias Farmac\u00e9uticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez-Bl\u00e1zquez", 
        "givenName": "Raquel", 
        "id": "sg:person.011666066334.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011666066334.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEU San Pablo University", 
          "id": "https://www.grid.ac/institutes/grid.8461.b", 
          "name": [
            "Departamento de Qu\u00edmica y Bioqu\u00edmica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alcal\u00e1", 
        "givenName": "Mart\u00edn", 
        "id": "sg:person.0617126215.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617126215.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Complutense University of Madrid", 
          "id": "https://www.grid.ac/institutes/grid.4795.f", 
          "name": [
            "Departamento de Farmacolog\u00eda, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain", 
            "Instituto Pluridisciplinar, Unidad de Cartograf\u00eda Cerebral, Universidad Complutense de Madrid, 28040, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00edn-Ramos", 
        "givenName": "Miriam", 
        "id": "sg:person.0657620674.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657620674.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEU San Pablo University", 
          "id": "https://www.grid.ac/institutes/grid.8461.b", 
          "name": [
            "Departamento de Qu\u00edmica y Bioqu\u00edmica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viana", 
        "givenName": "Marta", 
        "id": "sg:person.01052017550.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052017550.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Madrid", 
          "id": "https://www.grid.ac/institutes/grid.5515.4", 
          "name": [
            "Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, 28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arribas", 
        "givenName": "Silvia", 
        "id": "sg:person.01107740037.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107740037.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chile", 
          "id": "https://www.grid.ac/institutes/grid.443909.3", 
          "name": [
            "Laboratorio de Productos Naturales, Departamento de Qu\u00edmica Farmacol\u00f3gica y Toxicol\u00f3gica, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas, Universidad de Chile, PO Box 8380492, Santos Dumont 964, Santiago, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delporte", 
        "givenName": "Carla", 
        "id": "sg:person.01345477065.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345477065.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Complutense University of Madrid", 
          "id": "https://www.grid.ac/institutes/grid.4795.f", 
          "name": [
            "Departamento de Farmacolog\u00eda, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain", 
            "Instituto Pluridisciplinar, Unidad de Cartograf\u00eda Cerebral, Universidad Complutense de Madrid, 28040, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fern\u00e1ndez-Alfonso", 
        "givenName": "Mar\u00eda S.", 
        "id": "sg:person.01002647647.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002647647.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEU San Pablo University", 
          "id": "https://www.grid.ac/institutes/grid.8461.b", 
          "name": [
            "Departamento de Ciencias Farmac\u00e9uticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Somoza", 
        "givenName": "Beatriz", 
        "id": "sg:person.01161350347.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161350347.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CEU San Pablo University", 
          "id": "https://www.grid.ac/institutes/grid.8461.b", 
          "name": [
            "Departamento de Ciencias Farmac\u00e9uticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gil-Ortega", 
        "givenName": "Marta", 
        "id": "sg:person.0627754361.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627754361.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.lfs.2007.08.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000622453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf103461k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001219240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf103461k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001219240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.3203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001765568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.3203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001765568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mnfr.201400539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002394000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0095312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003737440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/6513416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004685158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005149524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-3623(95)02010-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007352262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-014-3315-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007924902", 
          "https://doi.org/10.1007/s00125-014-3315-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-014-3315-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007924902", 
          "https://doi.org/10.1007/s00125-014-3315-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2009.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009700769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bph.13483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010513583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2010.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010540814", 
          "https://doi.org/10.1038/hr.2010.11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejmech.2011.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010680767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2006.04.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013934754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014490795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014490795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00394-016-1185-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016862399", 
          "https://doi.org/10.1007/s00394-016-1185-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2010.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017073663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.01030.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018832572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3841.2012.02692.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019177906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199509143331101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020753058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jep.2007.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021587903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2011.06.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023357166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3283642384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029169850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hjh.0b013e3283642384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029169850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0702694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029765011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032950599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pathophys.2008.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033087986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu7125512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035437761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2005.00505.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035916674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2005.00505.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035916674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db12-0162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036561169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2014.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037374668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00299.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043741775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2016.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046626086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00406.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053393320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf051571j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055904159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf051571j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055904159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2012-2029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064251757"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Infusions of murtilla leaves exhibit antioxidant, analgesic, and anti-inflammatory properties. Several compounds that are structurally similar to madecassic acid (MA), a component of murtilla leaf extract (ethyl acetate extract, EAE), have been shown to inhibit protein tyrosine phosphatase 1B (PTP1P). The aim of this study was to evaluate if EAE and two compounds identified in EAE (MA and myricetin [MYR]) could have a beneficial effect on systemic and vascular insulin sensitivity and endothelial function in a model of diet-induced obesity. Experiments were performed in 5-week-old male C57BL6J mice fed with a standard (LF) or a very high-fat diet (HF) for 4 weeks and treated with EAE, MA, MYR, or the vehicle as control (C). EAE significantly inhibited PTP1B. EAE and MA, but not MYR, significantly improved systemic insulin sensitivity in HF mice and vascular relaxation to Ach in aorta segments, due to a significant increase of eNOS phosphorylation and enhanced nitric oxide availability. EAE, MA, and MYR also accounted for increased relaxant responses to insulin in HF mice, thus evidencing that the treatments significantly improved aortic insulin sensitivity. This study shows for the first time that EAE and MA could constitute interesting candidates for treating insulin resistance and endothelial dysfunction associated with obesity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36555-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity", 
    "pagination": "599", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c47100f60af1a35ac9b311536385d444df5dfaa1b243e1828b7d580c34416a22"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30679477"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36555-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111649678"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36555-1", 
      "https://app.dimensions.ai/details/publication/pub.1111649678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68463_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36555-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36555-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36555-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36555-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36555-1'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      64 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36555-1 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N73559384f19044b29f76af207adb69e3
4 schema:citation sg:pub.10.1007/s00125-014-3315-8
5 sg:pub.10.1007/s00394-016-1185-1
6 sg:pub.10.1038/hr.2010.11
7 https://doi.org/10.1002/mnfr.201400539
8 https://doi.org/10.1002/ptr.3203
9 https://doi.org/10.1016/0306-3623(95)02010-1
10 https://doi.org/10.1016/j.bcp.2014.10.008
11 https://doi.org/10.1016/j.biochi.2011.06.020
12 https://doi.org/10.1016/j.bmc.2006.04.021
13 https://doi.org/10.1016/j.ejmech.2011.03.005
14 https://doi.org/10.1016/j.freeradbiomed.2010.04.022
15 https://doi.org/10.1016/j.jep.2007.02.018
16 https://doi.org/10.1016/j.lfs.2007.08.045
17 https://doi.org/10.1016/j.pathophys.2008.04.007
18 https://doi.org/10.1016/j.yjmcc.2016.09.002
19 https://doi.org/10.1021/jf051571j
20 https://doi.org/10.1021/jf103461k
21 https://doi.org/10.1038/oby.2009.195
22 https://doi.org/10.1038/sj.bjp.0702694
23 https://doi.org/10.1042/cs20070361
24 https://doi.org/10.1056/nejm199509143331101
25 https://doi.org/10.1097/hjh.0b013e3283642384
26 https://doi.org/10.1111/bph.13483
27 https://doi.org/10.1111/j.1463-1326.2005.00505.x
28 https://doi.org/10.1111/j.1476-5381.2010.01030.x
29 https://doi.org/10.1111/j.1750-3841.2012.02692.x
30 https://doi.org/10.1152/ajpcell.00406.2010
31 https://doi.org/10.1152/ajpendo.00299.2007
32 https://doi.org/10.1155/2016/6513416
33 https://doi.org/10.1172/jci118709
34 https://doi.org/10.1210/en.2012-2029
35 https://doi.org/10.1371/journal.pone.0095312
36 https://doi.org/10.2337/db07-1111
37 https://doi.org/10.2337/db12-0162
38 https://doi.org/10.3390/nu7125512
39 schema:datePublished 2019-12
40 schema:datePublishedReg 2019-12-01
41 schema:description Infusions of murtilla leaves exhibit antioxidant, analgesic, and anti-inflammatory properties. Several compounds that are structurally similar to madecassic acid (MA), a component of murtilla leaf extract (ethyl acetate extract, EAE), have been shown to inhibit protein tyrosine phosphatase 1B (PTP1P). The aim of this study was to evaluate if EAE and two compounds identified in EAE (MA and myricetin [MYR]) could have a beneficial effect on systemic and vascular insulin sensitivity and endothelial function in a model of diet-induced obesity. Experiments were performed in 5-week-old male C57BL6J mice fed with a standard (LF) or a very high-fat diet (HF) for 4 weeks and treated with EAE, MA, MYR, or the vehicle as control (C). EAE significantly inhibited PTP1B. EAE and MA, but not MYR, significantly improved systemic insulin sensitivity in HF mice and vascular relaxation to Ach in aorta segments, due to a significant increase of eNOS phosphorylation and enhanced nitric oxide availability. EAE, MA, and MYR also accounted for increased relaxant responses to insulin in HF mice, thus evidencing that the treatments significantly improved aortic insulin sensitivity. This study shows for the first time that EAE and MA could constitute interesting candidates for treating insulin resistance and endothelial dysfunction associated with obesity.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree true
45 schema:isPartOf N05111d85e2594d95bff56057a724ea26
46 N49542e58766346c3ba4225efd8112a7f
47 sg:journal.1045337
48 schema:name Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity
49 schema:pagination 599
50 schema:productId N16f86414f8634521860f67430e836e0c
51 N46b9bef46e4f4a42a126be7c209028b8
52 N692463c3d4e148e1871af4d0ca7913c3
53 N92e8a2f519b84153a983d9561262eac0
54 N98076ea72cc3457393758cfc16aa4dee
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111649678
56 https://doi.org/10.1038/s41598-018-36555-1
57 schema:sdDatePublished 2019-04-11T08:58
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N5ed7f037cad146b497db7094a4aa10f6
60 schema:url https://www.nature.com/articles/s41598-018-36555-1
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N05111d85e2594d95bff56057a724ea26 schema:volumeNumber 9
65 rdf:type schema:PublicationVolume
66 N06fa55df0a0d4a08821dac604ccbfb42 rdf:first sg:person.01002647647.94
67 rdf:rest N2b5962ffb3654f7a937b5bf5f22a56af
68 N07cfc1407a294148b809e9774378606b rdf:first sg:person.0617126215.81
69 rdf:rest N4823f45b9c4843ebbcacdeeff1481277
70 N16f86414f8634521860f67430e836e0c schema:name doi
71 schema:value 10.1038/s41598-018-36555-1
72 rdf:type schema:PropertyValue
73 N2b5962ffb3654f7a937b5bf5f22a56af rdf:first sg:person.01161350347.54
74 rdf:rest Nc63ab617a33f46f5be86d44976f60708
75 N35b2c07dd15f49f9a3c489fe4cba252d rdf:first sg:person.011666066334.61
76 rdf:rest N07cfc1407a294148b809e9774378606b
77 N46b9bef46e4f4a42a126be7c209028b8 schema:name readcube_id
78 schema:value c47100f60af1a35ac9b311536385d444df5dfaa1b243e1828b7d580c34416a22
79 rdf:type schema:PropertyValue
80 N4823f45b9c4843ebbcacdeeff1481277 rdf:first sg:person.0657620674.58
81 rdf:rest Na0172051a362408cb0a7dc8f50ebd87f
82 N49542e58766346c3ba4225efd8112a7f schema:issueNumber 1
83 rdf:type schema:PublicationIssue
84 N5ed7f037cad146b497db7094a4aa10f6 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N692463c3d4e148e1871af4d0ca7913c3 schema:name nlm_unique_id
87 schema:value 101563288
88 rdf:type schema:PropertyValue
89 N73559384f19044b29f76af207adb69e3 rdf:first Nd41235af7c45493faf61f9eef1e4251b
90 rdf:rest N35b2c07dd15f49f9a3c489fe4cba252d
91 N92e8a2f519b84153a983d9561262eac0 schema:name pubmed_id
92 schema:value 30679477
93 rdf:type schema:PropertyValue
94 N98076ea72cc3457393758cfc16aa4dee schema:name dimensions_id
95 schema:value pub.1111649678
96 rdf:type schema:PropertyValue
97 N9b5c5dbc63f541959ac89eda50ba764f rdf:first sg:person.01107740037.23
98 rdf:rest Nc7f8aa198f0249d5b181df67afc34c87
99 Na0172051a362408cb0a7dc8f50ebd87f rdf:first sg:person.01052017550.14
100 rdf:rest N9b5c5dbc63f541959ac89eda50ba764f
101 Nc63ab617a33f46f5be86d44976f60708 rdf:first sg:person.0627754361.82
102 rdf:rest rdf:nil
103 Nc7f8aa198f0249d5b181df67afc34c87 rdf:first sg:person.01345477065.20
104 rdf:rest N06fa55df0a0d4a08821dac604ccbfb42
105 Nd41235af7c45493faf61f9eef1e4251b schema:affiliation https://www.grid.ac/institutes/grid.443909.3
106 schema:familyName Arancibia-Radich
107 schema:givenName Jorge
108 rdf:type schema:Person
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
113 schema:name Clinical Sciences
114 rdf:type schema:DefinedTerm
115 sg:journal.1045337 schema:issn 2045-2322
116 schema:name Scientific Reports
117 rdf:type schema:Periodical
118 sg:person.01002647647.94 schema:affiliation https://www.grid.ac/institutes/grid.4795.f
119 schema:familyName Fernández-Alfonso
120 schema:givenName María S.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002647647.94
122 rdf:type schema:Person
123 sg:person.01052017550.14 schema:affiliation https://www.grid.ac/institutes/grid.8461.b
124 schema:familyName Viana
125 schema:givenName Marta
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052017550.14
127 rdf:type schema:Person
128 sg:person.01107740037.23 schema:affiliation https://www.grid.ac/institutes/grid.5515.4
129 schema:familyName Arribas
130 schema:givenName Silvia
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107740037.23
132 rdf:type schema:Person
133 sg:person.01161350347.54 schema:affiliation https://www.grid.ac/institutes/grid.8461.b
134 schema:familyName Somoza
135 schema:givenName Beatriz
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161350347.54
137 rdf:type schema:Person
138 sg:person.011666066334.61 schema:affiliation https://www.grid.ac/institutes/grid.8461.b
139 schema:familyName González-Blázquez
140 schema:givenName Raquel
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011666066334.61
142 rdf:type schema:Person
143 sg:person.01345477065.20 schema:affiliation https://www.grid.ac/institutes/grid.443909.3
144 schema:familyName Delporte
145 schema:givenName Carla
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345477065.20
147 rdf:type schema:Person
148 sg:person.0617126215.81 schema:affiliation https://www.grid.ac/institutes/grid.8461.b
149 schema:familyName Alcalá
150 schema:givenName Martín
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617126215.81
152 rdf:type schema:Person
153 sg:person.0627754361.82 schema:affiliation https://www.grid.ac/institutes/grid.8461.b
154 schema:familyName Gil-Ortega
155 schema:givenName Marta
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627754361.82
157 rdf:type schema:Person
158 sg:person.0657620674.58 schema:affiliation https://www.grid.ac/institutes/grid.4795.f
159 schema:familyName Martín-Ramos
160 schema:givenName Miriam
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657620674.58
162 rdf:type schema:Person
163 sg:pub.10.1007/s00125-014-3315-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007924902
164 https://doi.org/10.1007/s00125-014-3315-8
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s00394-016-1185-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016862399
167 https://doi.org/10.1007/s00394-016-1185-1
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/hr.2010.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010540814
170 https://doi.org/10.1038/hr.2010.11
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/mnfr.201400539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002394000
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/ptr.3203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001765568
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0306-3623(95)02010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007352262
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.bcp.2014.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037374668
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.biochi.2011.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023357166
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.bmc.2006.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013934754
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.ejmech.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010680767
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.freeradbiomed.2010.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017073663
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jep.2007.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021587903
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.lfs.2007.08.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000622453
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.pathophys.2008.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033087986
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.yjmcc.2016.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046626086
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1021/jf051571j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055904159
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1021/jf103461k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001219240
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1038/oby.2009.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009700769
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1038/sj.bjp.0702694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029765011
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1042/cs20070361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014490795
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1056/nejm199509143331101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020753058
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/hjh.0b013e3283642384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029169850
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/bph.13483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010513583
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1463-1326.2005.00505.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035916674
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1476-5381.2010.01030.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018832572
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1750-3841.2012.02692.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019177906
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1152/ajpcell.00406.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053393320
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1152/ajpendo.00299.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043741775
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1155/2016/6513416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004685158
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1172/jci118709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005149524
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1210/en.2012-2029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064251757
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1371/journal.pone.0095312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003737440
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2337/db07-1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032950599
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2337/db12-0162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036561169
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3390/nu7125512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035437761
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.443909.3 schema:alternateName University of Chile
237 schema:name Laboratorio de Productos Naturales, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, PO Box 8380492, Santos Dumont 964, Santiago, Chile
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.4795.f schema:alternateName Complutense University of Madrid
240 schema:name Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain
241 Instituto Pluridisciplinar, Unidad de Cartografía Cerebral, Universidad Complutense de Madrid, 28040, Madrid, Spain
242 rdf:type schema:Organization
243 https://www.grid.ac/institutes/grid.5515.4 schema:alternateName Autonomous University of Madrid
244 schema:name Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029, Madrid, Spain
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.8461.b schema:alternateName CEU San Pablo University
247 schema:name Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain
248 Departamento de Química y Bioquímica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28925, Madrid, Spain
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...