Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Mengxi Lv, Yilu Zhou, Shawn W. Polson, Leo Q. Wan, Meiqing Wang, Lin Han, Liyun Wang, X. Lucas Lu

ABSTRACT

Traumatic joint injuries often result in elevated proinflammatory cytokine (such as IL-1β) levels in the joint cavity, which can increase the catabolic activities of chondrocytes and damage cartilage. This study investigated the early genetic responses of healthy in situ chondrocytes under IL-1β attack with a focus on cell cycle and calcium signaling pathways. RNA sequencing analysis identified 2,232 significantly changed genes by IL-1β, with 1,259 upregulated and 973 downregulated genes. Catabolic genes related to ECM degeneration were promoted by IL-1β, consistent with our observations of matrix protein loss and mechanical property decrease during 24-day in vitro culture of cartilage explants. IL-1β altered the cell cycle (108 genes) and Rho GTPases signaling (72 genes) in chondrocytes, while chondrocyte phenotypic shift was observed with histology, cell volume measurement, and MTT assay. IL-1β inhibited the spontaneous calcium signaling in chondrocytes, a fundamental signaling event in chondrocyte metabolic activities. The expression of 24 genes from 6 calcium-signaling related pathways were changed by IL-1β exposure. This study provided a comprehensive list of differentially expressed genes of healthy in situ chondrocytes in response to IL-1β attack, which represents a useful reference to verify and guide future cartilage studies related to the acute inflammation after joint trauma. More... »

PAGES

93

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-36500-2

    DOI

    http://dx.doi.org/10.1038/s41598-018-36500-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111273934

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30643177


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