POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yuki Hitomi, Kazuko Ueno, Yosuke Kawai, Nao Nishida, Kaname Kojima, Minae Kawashima, Yoshihiro Aiba, Hitomi Nakamura, Hiroshi Kouno, Hirotaka Kouno, Hajime Ohta, Kazuhiro Sugi, Toshiki Nikami, Tsutomu Yamashita, Shinji Katsushima, Toshiki Komeda, Keisuke Ario, Atsushi Naganuma, Masaaki Shimada, Noboru Hirashima, Kaname Yoshizawa, Fujio Makita, Kiyoshi Furuta, Masahiro Kikuchi, Noriaki Naeshiro, Hironao Takahashi, Yutaka Mano, Haruhiro Yamashita, Kouki Matsushita, Seiji Tsunematsu, Iwao Yabuuchi, Hideo Nishimura, Yusuke Shimada, Kazuhiko Yamauchi, Tatsuji Komatsu, Rie Sugimoto, Hironori Sakai, Eiji Mita, Masaharu Koda, Yoko Nakamura, Hiroshi Kamitsukasa, Takeaki Sato, Makoto Nakamuta, Naohiko Masaki, Hajime Takikawa, Atsushi Tanaka, Hiromasa Ohira, Mikio Zeniya, Masanori Abe, Shuichi Kaneko, Masao Honda, Kuniaki Arai, Teruko Arinaga-Hino, Etsuko Hashimoto, Makiko Taniai, Takeji Umemura, Satoru Joshita, Kazuhiko Nakao, Tatsuki Ichikawa, Hidetaka Shibata, Akinobu Takaki, Satoshi Yamagiwa, Masataka Seike, Shotaro Sakisaka, Yasuaki Takeyama, Masaru Harada, Michio Senju, Osamu Yokosuka, Tatsuo Kanda, Yoshiyuki Ueno, Hirotoshi Ebinuma, Takashi Himoto, Kazumoto Murata, Shinji Shimoda, Shinya Nagaoka, Seigo Abiru, Atsumasa Komori, Kiyoshi Migita, Masahiro Ito, Hiroshi Yatsuhashi, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura

ABSTRACT

Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate the genetic architecture of PBC, a GWAS was performed on an additional independent sample set, then a genome-wide meta-analysis with our previous GWAS was performed based on a whole-genome single nucleotide polymorphism (SNP) imputation analysis of a total of 4,045 Japanese individuals (2,060 cases and 1,985 healthy controls). A susceptibility locus on chromosome 3q13.33 (including ARHGAP31, TMEM39A, POGLUT1, TIMMDC1, and CD80) was previously identified both in the European and Chinese populations and was replicated in the Japanese population (OR = 0.7241, P = 3.5 × 10-9). Subsequent in silico and in vitro functional analyses identified rs2293370, previously reported as the top-hit SNP in this locus in the European population, as the primary functional SNP. Moreover, e-QTL analysis indicated that the effector gene of rs2293370 was Protein O-Glucosyltransferase 1 (POGLUT1) (P = 3.4 × 10-8). This is the first study to demonstrate that POGLUT1 and not CD80 is the effector gene regulated by the primary functional SNP rs2293370, and that increased expression of POGLUT1 might be involved in the pathogenesis of PBC. More... »

PAGES

102

References to SciGraph publications

  • 2010-04. Multiple common variants for celiac disease influencing immune gene expression in NATURE GENETICS
  • 2015-10. Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals in JOURNAL OF HUMAN GENETICS
  • 1997-07. Mutations in the human Jagged1 gene are responsible for Alagille syndrome in NATURE GENETICS
  • 1997-07. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 in NATURE GENETICS
  • 2013-06. The Genotype-Tissue Expression (GTEx) project in NATURE GENETICS
  • 2016-11. Reference-based phasing using the Haplotype Reference Consortium panel in NATURE GENETICS
  • 2011-08. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis in NATURE
  • 2013-06. Regulation of innate and adaptive immunity by Notch in NATURE REVIEWS IMMUNOLOGY
  • 2017-04-20. A genome-wide association study identifies six novel risk loci for primary biliary cholangitis in NATURE COMMUNICATIONS
  • 2012-10. Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis in NATURE GENETICS
  • 2015-12. International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways in NATURE COMMUNICATIONS
  • 2015-12. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals in NATURE COMMUNICATIONS
  • 2011-04. From expression QTLs to personalized transcriptomics in NATURE REVIEWS GENETICS
  • 2015-07. Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1 in HUMAN GENETICS
  • 2017-12. Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis in SCIENTIFIC REPORTS
  • 2015-12. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing in HUMAN GENOME VARIATION
  • 2016-11. Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants in NATURE GENETICS
  • 2012-06. Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes in GENES & IMMUNITY
  • 2010-08. Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis in NATURE GENETICS
  • 2010-08. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis in NATURE GENETICS
  • 2011-03-13. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-36490-1

    DOI

    http://dx.doi.org/10.1038/s41598-018-36490-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111273932

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30643196


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