Counting circulating endothelial cells in allo-HSCT: an ad hoc designed polychromatic flowcytometry-based panel versus the CellSearch System View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Camillo Almici, Arabella Neva, Cristina Skert, Benedetto Bruno, Rosanna Verardi, Andrea Di Palma, Andrea Bianchetti, Simona Braga, Giovanna Piovani, Valeria Cancelli, Paola Omedè, Kurt Baeten, Gianluca Rotta, Domenico Russo, Mirella Marini

ABSTRACT

Physio-pathologic interrelationships between endothelial layer and graft-versus-host disease (GVHD) have been described leading to assess the entity "endothelial GVHD" as the early step for clinical manifestations of acute GVHD. The availability of the CellSearch system has allowed us to monitor Circulating Endothelial Cells (CEC) changes in allogeneic hematopoietic stem cell transplantation (allo-HSCT) as useful tool to help clinicians in GVHD diagnostic definition. We have compared CEC counts generated by an ad hoc designed polychromatic-flowcytometry (PFC) Lyotube with those of the CellSearch system. CEC were counted in parallel at 5 timepoints in 50 patients with malignant hematologic disorders undergoing allo-HSCT (ClinicalTrials.gov, NCT02064972). Spearman rank correlation showed significant association between CEC values at all time points (p = 0.0001). The limits of agreement was demonstrated by Bland Altman plot analysis, showing bias not significant at T1, T3, T4, while at T2 and T5 resulted not estimable. Moreover, Passing Bablok regression analysis showed not significant differences between BD Lyotube and CellSearch system. We show that CEC counts, generated with either the CellSearch system or the PFC-based panel, have a superimposable kinetic in allo-HSCT patients and that both counting procedures hold the potential to enter clinical routine as a suitable tool to assist clinicians in GVHD diagnosis. More... »

PAGES

87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36442-9

DOI

http://dx.doi.org/10.1038/s41598-018-36442-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111273924

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30643152


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almici", 
        "givenName": "Camillo", 
        "id": "sg:person.01016576340.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016576340.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neva", 
        "givenName": "Arabella", 
        "id": "sg:person.0577517450.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577517450.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Skert", 
        "givenName": "Cristina", 
        "id": "sg:person.0755042432.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755042432.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "BMT Unit, Department of Molecular Biotechnology and Health Sciences, University of Torino, A.O.U Citt\u00e0 della Salute e della Scienza di Torino, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruno", 
        "givenName": "Benedetto", 
        "id": "sg:person.01210010761.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210010761.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verardi", 
        "givenName": "Rosanna", 
        "id": "sg:person.01026367350.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026367350.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Palma", 
        "givenName": "Andrea", 
        "id": "sg:person.01330322164.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330322164.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bianchetti", 
        "givenName": "Andrea", 
        "id": "sg:person.0776210424.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776210424.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braga", 
        "givenName": "Simona", 
        "id": "sg:person.0645632650.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645632650.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Biology and Genetics Division, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piovani", 
        "givenName": "Giovanna", 
        "id": "sg:person.01076702372.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076702372.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cancelli", 
        "givenName": "Valeria", 
        "id": "sg:person.0764421335.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764421335.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turin", 
          "id": "https://www.grid.ac/institutes/grid.7605.4", 
          "name": [
            "BMT Unit, Department of Molecular Biotechnology and Health Sciences, University of Torino, A.O.U Citt\u00e0 della Salute e della Scienza di Torino, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omed\u00e8", 
        "givenName": "Paola", 
        "id": "sg:person.012161416633.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161416633.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Global Scientific and Medical Affairs, Janssen Diagnostics, Beerse, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baeten", 
        "givenName": "Kurt", 
        "id": "sg:person.015753154057.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015753154057.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Scientific Affairs, BD Biosciences Italia, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rotta", 
        "givenName": "Gianluca", 
        "id": "sg:person.01300574155.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300574155.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Brescia", 
          "id": "https://www.grid.ac/institutes/grid.7637.5", 
          "name": [
            "Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Domenico", 
        "id": "sg:person.01033477037.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033477037.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marini", 
        "givenName": "Mirella", 
        "id": "sg:person.01074502550.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074502550.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2008.02931.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000580797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2012.09129.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004230577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2011.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005121103", 
          "https://doi.org/10.1038/bmt.2011.65"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2015.261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009949148", 
          "https://doi.org/10.1038/bmt.2015.261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011252653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-08-355990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011604424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2016.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011768641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014041351", 
          "https://doi.org/10.1038/nri3212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014354917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014354917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jim.2010.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014713591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.20364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027803244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-06-364265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028962151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/588660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029792985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.22730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034553005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036565271", 
          "https://doi.org/10.1038/bmt.2012.143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmp078166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037709846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa022287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042976289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08907-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043553149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.111.243386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044143569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.111.243386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044143569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0609.2000.065004215.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044484077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2012.04681.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046145248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0000000000000385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050601295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/tp.0000000000000385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050601295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5302.964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3003451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th06-04-0185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063290817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/157488810793351721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069215815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327481101800407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078459446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/107327481101800407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078459446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082422699", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0172800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084763714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2017.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086248029", 
          "https://doi.org/10.1038/bmt.2017.121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2017.194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091516651", 
          "https://doi.org/10.1038/bmt.2017.194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-24234-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103221822", 
          "https://doi.org/10.1038/s41598-018-24234-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Physio-pathologic interrelationships between endothelial layer and graft-versus-host disease (GVHD) have been described leading to assess the entity \"endothelial GVHD\" as the early step for clinical manifestations of acute GVHD. The availability of the CellSearch system has allowed us to monitor Circulating Endothelial Cells (CEC) changes in allogeneic hematopoietic stem cell transplantation (allo-HSCT) as useful tool to help clinicians in GVHD diagnostic definition. We have compared CEC counts generated by an ad hoc designed polychromatic-flowcytometry (PFC) Lyotube with those of the CellSearch system. CEC were counted in parallel at 5 timepoints in 50 patients with malignant hematologic disorders undergoing allo-HSCT (ClinicalTrials.gov, NCT02064972). Spearman rank correlation showed significant association between CEC values at all time points (p\u2009=\u20090.0001). The limits of agreement was demonstrated by Bland Altman plot analysis, showing bias not significant at T1, T3, T4, while at T2 and T5 resulted not estimable. Moreover, Passing Bablok regression analysis showed not significant differences between BD Lyotube and CellSearch system. We show that CEC counts, generated with either the CellSearch system or the PFC-based panel, have a superimposable kinetic in allo-HSCT patients and that both counting procedures hold the potential to enter clinical routine as a suitable tool to assist clinicians in GVHD diagnosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36442-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Counting circulating endothelial cells in allo-HSCT: an ad hoc designed polychromatic flowcytometry-based panel versus the CellSearch System", 
    "pagination": "87", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "970b353334b837d5d70b8c4ae42b117ad1591adf45c88b4384c427c5d966018f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30643152"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36442-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111273924"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36442-9", 
      "https://app.dimensions.ai/details/publication/pub.1111273924"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101392_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36442-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36442-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36442-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36442-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36442-9'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      61 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36442-9 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N667f8c1bec374b0784c966f66077ec78
4 schema:citation sg:pub.10.1038/bmt.2011.65
5 sg:pub.10.1038/bmt.2012.143
6 sg:pub.10.1038/bmt.2015.261
7 sg:pub.10.1038/bmt.2017.121
8 sg:pub.10.1038/bmt.2017.194
9 sg:pub.10.1038/nri3212
10 sg:pub.10.1038/s41598-018-24234-0
11 https://app.dimensions.ai/details/publication/pub.1082422699
12 https://doi.org/10.1002/cyto.a.20364
13 https://doi.org/10.1002/cyto.a.22730
14 https://doi.org/10.1016/j.atherosclerosis.2016.05.028
15 https://doi.org/10.1016/j.jim.2010.03.015
16 https://doi.org/10.1016/s0140-6736(02)08907-9
17 https://doi.org/10.1034/j.1600-0609.2000.065004215.x
18 https://doi.org/10.1056/nejmoa022287
19 https://doi.org/10.1056/nejmp078166
20 https://doi.org/10.1086/588660
21 https://doi.org/10.1093/cvr/cvq119
22 https://doi.org/10.1097/tp.0000000000000385
23 https://doi.org/10.1111/j.1365-2141.2012.09129.x
24 https://doi.org/10.1111/j.1538-7836.2008.02931.x
25 https://doi.org/10.1111/j.1538-7836.2012.04681.x
26 https://doi.org/10.1126/science.275.5302.964
27 https://doi.org/10.1126/scitranslmed.3003451
28 https://doi.org/10.1158/1078-0432.ccr-08-0432
29 https://doi.org/10.1160/th06-04-0185
30 https://doi.org/10.1161/circresaha.111.243386
31 https://doi.org/10.1177/107327481101800407
32 https://doi.org/10.1182/blood-2011-06-364265
33 https://doi.org/10.1182/blood-2012-08-355990
34 https://doi.org/10.1371/journal.pone.0172800
35 https://doi.org/10.2174/157488810793351721
36 schema:datePublished 2019-12
37 schema:datePublishedReg 2019-12-01
38 schema:description Physio-pathologic interrelationships between endothelial layer and graft-versus-host disease (GVHD) have been described leading to assess the entity "endothelial GVHD" as the early step for clinical manifestations of acute GVHD. The availability of the CellSearch system has allowed us to monitor Circulating Endothelial Cells (CEC) changes in allogeneic hematopoietic stem cell transplantation (allo-HSCT) as useful tool to help clinicians in GVHD diagnostic definition. We have compared CEC counts generated by an ad hoc designed polychromatic-flowcytometry (PFC) Lyotube with those of the CellSearch system. CEC were counted in parallel at 5 timepoints in 50 patients with malignant hematologic disorders undergoing allo-HSCT (ClinicalTrials.gov, NCT02064972). Spearman rank correlation showed significant association between CEC values at all time points (p = 0.0001). The limits of agreement was demonstrated by Bland Altman plot analysis, showing bias not significant at T1, T3, T4, while at T2 and T5 resulted not estimable. Moreover, Passing Bablok regression analysis showed not significant differences between BD Lyotube and CellSearch system. We show that CEC counts, generated with either the CellSearch system or the PFC-based panel, have a superimposable kinetic in allo-HSCT patients and that both counting procedures hold the potential to enter clinical routine as a suitable tool to assist clinicians in GVHD diagnosis.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N2211facc2bf345e089ce2d7ca75835e6
43 N24ced054749f4a51a5f9dd53cb7ae3c8
44 sg:journal.1045337
45 schema:name Counting circulating endothelial cells in allo-HSCT: an ad hoc designed polychromatic flowcytometry-based panel versus the CellSearch System
46 schema:pagination 87
47 schema:productId N2560687dcf2849e5b2fbd67912224fc6
48 N275ae45e9bde47a190c7016702adabfc
49 N5fb5eb09c033421a98780954509ba695
50 Nbbbdcf8c69474910a1223ebaeed44720
51 Nbd27ec29a7d74c40ae38bdf172cf97a3
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111273924
53 https://doi.org/10.1038/s41598-018-36442-9
54 schema:sdDatePublished 2019-04-11T08:41
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Nc69f03d8e97d4ccda1171ac67afc5e16
57 schema:url https://www.nature.com/articles/s41598-018-36442-9
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N03b14c72e14843d9919d386541a89718 rdf:first sg:person.01076702372.81
62 rdf:rest Na0de1c4a5cc74e0abff2b44468ced05b
63 N0509c78841864a3bba971dc6860ae881 rdf:first sg:person.01033477037.24
64 rdf:rest Ncd6c28ec86ae48f388b1323d31f78352
65 N08961b951646428e9314da3dcffc2efc rdf:first sg:person.0577517450.04
66 rdf:rest N7a2255ef8d2943e3ae347062f426d2d8
67 N2211facc2bf345e089ce2d7ca75835e6 schema:volumeNumber 9
68 rdf:type schema:PublicationVolume
69 N24ced054749f4a51a5f9dd53cb7ae3c8 schema:issueNumber 1
70 rdf:type schema:PublicationIssue
71 N2560687dcf2849e5b2fbd67912224fc6 schema:name nlm_unique_id
72 schema:value 101563288
73 rdf:type schema:PropertyValue
74 N275ae45e9bde47a190c7016702adabfc schema:name dimensions_id
75 schema:value pub.1111273924
76 rdf:type schema:PropertyValue
77 N39524f0f2b9f4a53b77f9a977d61f857 rdf:first sg:person.01026367350.36
78 rdf:rest Nca3484265cea4edfb9dbd22ea820bd57
79 N39a66c0c393d4b1c80395ae038bbc3e2 rdf:first sg:person.01210010761.12
80 rdf:rest N39524f0f2b9f4a53b77f9a977d61f857
81 N4f3e8f093d8a463dac599eab918a1cb3 schema:name Scientific Affairs, BD Biosciences Italia, Milano, Italy
82 rdf:type schema:Organization
83 N54b2c6901d734f9082c633d409905ec8 schema:name Global Scientific and Medical Affairs, Janssen Diagnostics, Beerse, Belgium
84 rdf:type schema:Organization
85 N5fb5eb09c033421a98780954509ba695 schema:name pubmed_id
86 schema:value 30643152
87 rdf:type schema:PropertyValue
88 N667f8c1bec374b0784c966f66077ec78 rdf:first sg:person.01016576340.43
89 rdf:rest N08961b951646428e9314da3dcffc2efc
90 N6d88cbca66e241c49180c7c50ed9470a rdf:first sg:person.012161416633.73
91 rdf:rest Na7773c20c18e41f7b59a476e9d67fda7
92 N7a2255ef8d2943e3ae347062f426d2d8 rdf:first sg:person.0755042432.88
93 rdf:rest N39a66c0c393d4b1c80395ae038bbc3e2
94 Na0de1c4a5cc74e0abff2b44468ced05b rdf:first sg:person.0764421335.42
95 rdf:rest N6d88cbca66e241c49180c7c50ed9470a
96 Na70bb924fdc14e5d9309d41bf901cf8a rdf:first sg:person.01300574155.79
97 rdf:rest N0509c78841864a3bba971dc6860ae881
98 Na7773c20c18e41f7b59a476e9d67fda7 rdf:first sg:person.015753154057.12
99 rdf:rest Na70bb924fdc14e5d9309d41bf901cf8a
100 Nbbbdcf8c69474910a1223ebaeed44720 schema:name doi
101 schema:value 10.1038/s41598-018-36442-9
102 rdf:type schema:PropertyValue
103 Nbd27ec29a7d74c40ae38bdf172cf97a3 schema:name readcube_id
104 schema:value 970b353334b837d5d70b8c4ae42b117ad1591adf45c88b4384c427c5d966018f
105 rdf:type schema:PropertyValue
106 Nc69f03d8e97d4ccda1171ac67afc5e16 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 Nca3484265cea4edfb9dbd22ea820bd57 rdf:first sg:person.01330322164.25
109 rdf:rest Ndf3538b4d3144394b5ba8ad3d6527ca3
110 Ncd6c28ec86ae48f388b1323d31f78352 rdf:first sg:person.01074502550.02
111 rdf:rest rdf:nil
112 Nd80badfc58294f059557302cb989afa3 rdf:first sg:person.0645632650.52
113 rdf:rest N03b14c72e14843d9919d386541a89718
114 Ndf3538b4d3144394b5ba8ad3d6527ca3 rdf:first sg:person.0776210424.67
115 rdf:rest Nd80badfc58294f059557302cb989afa3
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
120 schema:name Cardiorespiratory Medicine and Haematology
121 rdf:type schema:DefinedTerm
122 sg:journal.1045337 schema:issn 2045-2322
123 schema:name Scientific Reports
124 rdf:type schema:Periodical
125 sg:person.01016576340.43 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
126 schema:familyName Almici
127 schema:givenName Camillo
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016576340.43
129 rdf:type schema:Person
130 sg:person.01026367350.36 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
131 schema:familyName Verardi
132 schema:givenName Rosanna
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026367350.36
134 rdf:type schema:Person
135 sg:person.01033477037.24 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
136 schema:familyName Russo
137 schema:givenName Domenico
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033477037.24
139 rdf:type schema:Person
140 sg:person.01074502550.02 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
141 schema:familyName Marini
142 schema:givenName Mirella
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074502550.02
144 rdf:type schema:Person
145 sg:person.01076702372.81 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
146 schema:familyName Piovani
147 schema:givenName Giovanna
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076702372.81
149 rdf:type schema:Person
150 sg:person.01210010761.12 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
151 schema:familyName Bruno
152 schema:givenName Benedetto
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210010761.12
154 rdf:type schema:Person
155 sg:person.012161416633.73 schema:affiliation https://www.grid.ac/institutes/grid.7605.4
156 schema:familyName Omedè
157 schema:givenName Paola
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161416633.73
159 rdf:type schema:Person
160 sg:person.01300574155.79 schema:affiliation N4f3e8f093d8a463dac599eab918a1cb3
161 schema:familyName Rotta
162 schema:givenName Gianluca
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300574155.79
164 rdf:type schema:Person
165 sg:person.01330322164.25 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
166 schema:familyName Di Palma
167 schema:givenName Andrea
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330322164.25
169 rdf:type schema:Person
170 sg:person.015753154057.12 schema:affiliation N54b2c6901d734f9082c633d409905ec8
171 schema:familyName Baeten
172 schema:givenName Kurt
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015753154057.12
174 rdf:type schema:Person
175 sg:person.0577517450.04 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
176 schema:familyName Neva
177 schema:givenName Arabella
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577517450.04
179 rdf:type schema:Person
180 sg:person.0645632650.52 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
181 schema:familyName Braga
182 schema:givenName Simona
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645632650.52
184 rdf:type schema:Person
185 sg:person.0755042432.88 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
186 schema:familyName Skert
187 schema:givenName Cristina
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755042432.88
189 rdf:type schema:Person
190 sg:person.0764421335.42 schema:affiliation https://www.grid.ac/institutes/grid.7637.5
191 schema:familyName Cancelli
192 schema:givenName Valeria
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764421335.42
194 rdf:type schema:Person
195 sg:person.0776210424.67 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
196 schema:familyName Bianchetti
197 schema:givenName Andrea
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776210424.67
199 rdf:type schema:Person
200 sg:pub.10.1038/bmt.2011.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005121103
201 https://doi.org/10.1038/bmt.2011.65
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/bmt.2012.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036565271
204 https://doi.org/10.1038/bmt.2012.143
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/bmt.2015.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009949148
207 https://doi.org/10.1038/bmt.2015.261
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/bmt.2017.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086248029
210 https://doi.org/10.1038/bmt.2017.121
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/bmt.2017.194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091516651
213 https://doi.org/10.1038/bmt.2017.194
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nri3212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014041351
216 https://doi.org/10.1038/nri3212
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/s41598-018-24234-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103221822
219 https://doi.org/10.1038/s41598-018-24234-0
220 rdf:type schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1082422699 schema:CreativeWork
222 https://doi.org/10.1002/cyto.a.20364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027803244
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/cyto.a.22730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553005
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.atherosclerosis.2016.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011768641
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.jim.2010.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014713591
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0140-6736(02)08907-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043553149
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1034/j.1600-0609.2000.065004215.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044484077
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1056/nejmoa022287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042976289
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1056/nejmp078166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037709846
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1086/588660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029792985
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/cvr/cvq119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014354917
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1097/tp.0000000000000385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050601295
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1365-2141.2012.09129.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004230577
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1538-7836.2008.02931.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000580797
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1111/j.1538-7836.2012.04681.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046145248
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1126/science.275.5302.964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555783
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1126/scitranslmed.3003451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687345
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1158/1078-0432.ccr-08-0432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011252653
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1160/th06-04-0185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063290817
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/circresaha.111.243386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044143569
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1177/107327481101800407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078459446
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1182/blood-2011-06-364265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028962151
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1182/blood-2012-08-355990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011604424
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1371/journal.pone.0172800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084763714
267 rdf:type schema:CreativeWork
268 https://doi.org/10.2174/157488810793351721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069215815
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.412725.7 schema:alternateName Spedali Civili di Brescia
271 schema:name Laboratory for Stem Cells Manipulation and Cryopreservation, Dpt of Transfusion Medicine, ASST Spedali Civili, Brescia, Italy
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.7605.4 schema:alternateName University of Turin
274 schema:name BMT Unit, Department of Molecular Biotechnology and Health Sciences, University of Torino, A.O.U Città della Salute e della Scienza di Torino, Torino, Italy
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.7637.5 schema:alternateName University of Brescia
277 schema:name Biology and Genetics Division, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
278 Chair of Hematology, Unit of Blood Diseases and Stem Cell Transplantation, University of Brescia, ASST Spedali Civili, Brescia, Italy
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...